Pyridine hydrochloride supplier

Name
Pyridine hydrochloride
EINECS 211-027-4
CAS No. 628-13-7
Article Data170
CAS DataBase
Density 1.34 g/cm3
Solubility 85 g/100 mL in water
Melting Point 145-147 °C(lit.)
Formula C₅H₆ClN
Boiling Point 115.3 °C at 760 mmHg
Molecular Weight 115.562
Flash Point 20 °C
Transport Information
Appearance white to tan crystals
Safety 26-36-37/39
Risk Codes 20/21/22-36/37/38-22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Pyridine,hydrochloride (6CI,8CI,9CI);Pyridine, compd. with hydrogen chloride (1:1);Pyridinium chloride;Pyridinium monohydrochloride;
PSA 12.89000
LogP 1.88360

Synthetic route

: 110-86-1
pyridine

: 31562-43-3
tert-butylsulfinyl chloride

A: 628-13-7
pyridine hydrochloride

B: 67-64-1
acetone

C: pyridinium tert-butylsulfonate

D: 75-65-0
tert-butyl alcohol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In chloroform at 20℃; for 2h; Further byproducts given;	A 100% B 20% C 40% D 55%

...Expand

: 31562-43-3
tert-butylsulfinyl chloride

: 68409-52-9
tert-butyl hydrodisulfide

A: 62383-66-8
tert-butylsulfenic tert-butylsulfinic dithioanhydride

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 2h;	A 90% B 100%

...Expand

: 54562-14-0
z,z,z-octadeca-6,9,12-trienoyl chloride

: 56-81-5
glycerol

A: 628-13-7
pyridine hydrochloride

B: 14465-68-0
tri-γ-linolenin

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20 - 35℃;	A n/a B 96.3%
Stage #1: z,z,z-octadeca-6,9,12-trienoyl chloride; glycerol With pyridine In dichloromethane at 35℃; Stage #2: dmap In dichloromethane at 20℃; Product distribution / selectivity;	A n/a B 65%

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: 110-86-1
pyridine

A: 628-13-7
pyridine hydrochloride

B: N-sulfonic acid pyridinium chloride

Conditions

Conditions	Yield
With chlorosulfonic acid In dichloromethane at 0℃; for 0.5h;	A n/a B 95%

: 110-86-1
pyridine

: 95058-77-8
2-deoxy-2,2-difluoro-1-carbonylribose

: 75-36-5
acetyl chloride

A: 946424-26-6
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With dmap In ethyl acetate at 60 - 65℃;	A 94% B n/a

...Expand

: 933-88-0
ortho-toluoyl chloride

: 58-61-7
adenosine

A: 628-13-7
pyridine hydrochloride

B: 104579-36-4
N6,2',3',5'-tetra-O-toluoyladenosine

C: 527-85-5
o-Methylbenzamid

Conditions

Conditions	Yield
With methanol; ammonia In pyridine at 0℃;	A n/a B 93% C n/a

...Expand

: 110-86-1
pyridine

: 866108-64-7
(2Z,4R,5R)-3-amino-4,5-dimethyl-oct-2-enoic acid ethyl ester

: 75-36-5
acetyl chloride

A: 866108-66-9
(2Z,4R,5R)-3-acetylamino-4,5-dimethyl-oct-2-enoic acid ethyl ester

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
In dichloromethane at -20 - 0℃; for 2.5h;	A 93% B n/a

...Expand

: 110-86-1
pyridine

: 95058-77-8
2-deoxy-2,2-difluoro-1-carbonylribose

: 103-80-0
phenylacetyl chloride

A: 946424-25-5
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-bis(phenylacetate)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With dmap In ethyl acetate at 60 - 65℃;	A 92.9% B n/a

...Expand

: 110-86-1
pyridine

: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With acetyl chloride In methanol; diethyl ether at 0℃; for 1h; Inert atmosphere;	92%
With chlorosulfonic acid In 1,2-dichloro-ethane at 25℃; Thermodynamic data; ΔH(formation of product);
With hydrogenchloride In 1,2-dichloro-ethane at 25℃; Thermodynamic data; ΔH(formation of product);

: 112-13-0
n-decanoyl chloride

: 56-81-5
glycerol

A: 621-71-6
capric acid triglyceride

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
Stage #1: n-decanoyl chloride; glycerol With pyridine In dichloromethane at 20 - 35℃; for 0.0833333 - 0.25h; Stage #2: With dmap at 20℃;	A 86% B n/a

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: 78775-72-1
2-tert-butylmalonyl dichloride

: 540-51-2
2-bromoethanol

A: 628-13-7
pyridine hydrochloride

B: 78775-97-0
tert-Butylmalonsaeure-bis(2-bromethylester)

Conditions

Conditions	Yield
With pyridine In benzene for 41h;	A n/a B 83%

...Expand

: 4342-61-4
1,2-dichlorotetramethylsilane

A: 17865-73-5
octamethyl-1,4-dioxa-2,3,5,6-tetrasilacyclohexane

B: 628-13-7
pyridine hydrochloride

C NiCl2*4Py: NiCl2*4Py

Conditions

Conditions	Yield
With pyridine; nickel dihydroxide In toluene; acetonitrile Heating;	A 69% B 70.6% C n/a

...Expand

: 62147-49-3
1,3-dihydroxyacetone dimer

: 112-13-0
n-decanoyl chloride

A: 73312-67-1
1,3-dicaproyloxypropan-2-one

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20 - 30℃;	A 60% B n/a

...Expand

: 17598-93-5
1, 3-dicaprin

: 54562-14-0
z,z,z-octadeca-6,9,12-trienoyl chloride

A: 847019-77-6
glycerol 1,3-didecanoate 2-octadecatri(6-Z, 9-Z, 12-Z)enoate

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 10 - 20℃;	A 56% B n/a

...Expand

: 17598-93-5
1, 3-dicaprin

: 57303-04-5
arachidonoyl chloride

A: glycerol 1,3-didecanoate 2-eicosatetra-(5-Z, 8-Z, 11-Z, 14-Z)enoate

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 10 - 20℃;	A 56% B n/a

...Expand

: 110-86-1
pyridine

: 122-01-0
4-chloro-benzoyl chloride

: 95058-77-8
2-deoxy-2,2-difluoro-1-carbonylribose

A: 2-deoxy-2,2-difluoro-D-erythro-pentofiranos-1-ulose-3,5-di(4-chlorobenzoate)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With dmap In ethyl acetate at 60 - 65℃; for 370h;	A 54.1% B n/a

...Expand

: 2465-32-9, 98168-52-6
1,3-diolein

: 54562-14-0
z,z,z-octadeca-6,9,12-trienoyl chloride

A: 628-13-7
pyridine hydrochloride

B: 1,3-dioleoyl-2-dihomo-γ-linolenoyl glyceride

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 10 - 20℃;	A n/a B 54%

...Expand

: 57303-04-5
arachidonoyl chloride

: 56-81-5
glycerol

A: 628-13-7
pyridine hydrochloride

B: 23314-57-0
1,2,3-tris[(cis,cis,cis,cis)-5,8,11,14-eicosatetraenoyl]glycerol

Conditions

Conditions	Yield
With pyridine; dmap at 25 - 42℃; for 2h; Neat (no solvent);	A n/a B 43%

...Expand

: 62147-49-3
1,3-dihydroxyacetone dimer

: 112-77-6
(Z)-9-octadecenoyl chloride

A: 24472-44-4
2-oxopropane-1,3-diyl dioleate

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃;	A 27% B n/a

...Expand

: 118773-91-4
tetraethylammonium pentachloro(pyridine)iridate(IV)

: 75-18-3
dimethylsulfide

: 50-81-7
ascorbic acid

A: 118773-83-4
tetraethylammonium pentachloro(dimethylsulphide)iridate(IV)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With HCl; chlorine In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;	A 20% B n/a

Yield

With HCl; chlorine In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;

A 20%
B n/a

...Expand

: 118773-91-4
tetraethylammonium pentachloro(pyridine)iridate(IV)

: 593-79-3
dimethylselenide

: 50-81-7
ascorbic acid

A: 118773-79-8
tetraethylammonium pentachloro(dimethylselenide)iridate(IV)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With HCl; chlorine In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;	A 20% B n/a

Yield

A 20%
B n/a

...Expand

: 118773-91-4
tetraethylammonium pentachloro(pyridine)iridate(IV)

: 50-81-7
ascorbic acid

A: 118773-77-6
tetraethylammonium pentachloro(triphenylphosphine)iridate(IV)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With P(C6H5)3; chlorine; HCl In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;	A 20% B n/a

Yield

With P(C6H5)3; chlorine; HCl In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;

A 20%
B n/a

...Expand

: 118773-91-4
tetraethylammonium pentachloro(pyridine)iridate(IV)

: 603-32-7
triphenyl-arsane

: 50-81-7
ascorbic acid

A: 118773-89-0
tetraethylammonium pentachloro(triphenylarsine)iridate(IV)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With HCl; chlorine In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;	A 20% B n/a

Yield

A 20%
B n/a

...Expand

: 118773-91-4
tetraethylammonium pentachloro(pyridine)iridate(IV)

: 603-36-1
triphenylantimony

: 50-81-7
ascorbic acid

A: 118773-85-6
tetraethylammonium pentachloro(triphenylstibine)iridate(IV)

B: 628-13-7
pyridine hydrochloride

Conditions

Conditions	Yield
With HCl; chlorine In ethanol; dichloromethane Ir-compd. dissolved in warm ethanol, dropwise addn. of ascorbic acid in ethanol, addn. of ligand in CH2Cl2, refluxed for 1 h, ethanol evapd. in vac., dissolved in CH2Cl2, oxidised with chlorine, saturated with HCl, after 1 h purged with nitrogen; partioned with water, organic phase separated and dried over Na2SO4, reduced in vac., addn. of diethyl ether, left at -10°C, liquid decanted off, dried in vac.; elem. anal.;	A 20% B n/a

Yield

A 20%
B n/a

...Expand

: 4-isopropyl-borinine; compound with pyridine

: 628-13-7
pyridine hydrochloride

: C13H17BN(1+)*C5H5N*Cl(1-)

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.25h;	100%

: 930606-42-1
5-methoxy-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine

: 628-13-7
pyridine hydrochloride

: 930606-35-2
4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-ol

Conditions

Conditions	Yield
Stage #1: 5-methoxy-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine; pyridine hydrochloride In pyridine for 3h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In water for 0.5h; Product distribution / selectivity;	100%

: 99589-88-5
trimethylsilylimidovanadium(V)-trichloride

: 628-13-7
pyridine hydrochloride

: pyridinium-nitrido-trichlorovanadate(V)

Conditions

Conditions	Yield
In toluene all manipulations under Ar; pyridinium salt added to soln. of V compd. with stirring, suspn. stirred for 12 h; filtered, washed with toluene, dried in vac.; elem. anal.;	98%

: (N,N′-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene)Pd(acac)Cl

: 628-13-7
pyridine hydrochloride

: [PdCl2{1,3-dimesitylimidazol-2-ylidene}(pyridine)]

Conditions

Conditions	Yield
With air In 1,4-dioxane at 20℃;	98%
In 1,4-dioxane at 20℃; for 24h; Inert atmosphere;	70 mg

: 628-13-7
pyridine hydrochloride

: 18820-83-2
pyridine hydroiodide

Conditions

Conditions	Yield
With methyl iodide In acetonitrile Heating;	97%

: (1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene)Pd(acetylacetonato)Cl

: 628-13-7
pyridine hydrochloride

: SIPr-PdCl2-Py

Conditions

Conditions	Yield
at 20℃;	97%

: C32H45ClN2O2Pd*CHCl3

: 628-13-7
pyridine hydrochloride

: trans-[1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene]PdCl2(NC5H5)

Conditions

Conditions	Yield
With air In 1,4-dioxane at 20℃;	97%

: 110-86-1
pyridine

: 13450-90-3
Gallium trichloride

: 628-13-7
pyridine hydrochloride

: 72794-64-0
pyridine-pyridinium tetrachlorogallate(III)

Conditions

Conditions	Yield
In pyridine (N2); soln. of GaCl3 in pyridine and soln. of C5H5NHCl in pyridine were combined; after 1 h pyridine removed (vac.); residue crystd. (toluene); elem. anal.;	95%

...Expand

: [(IPr)Pd(acac)Cl]

: 628-13-7
pyridine hydrochloride

: {1,3-bis[2,6-bis(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}dichloro(pyridine)palladium

Conditions

Conditions	Yield
at 20℃;	95%

: [(IPr)Pd(acac)Cl]

: 628-13-7
pyridine hydrochloride

: {1,3-bis[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(dichloro)(pyridine)palladium

Conditions

Conditions	Yield
With air In 1,4-dioxane at 20℃;	95%

: 134695-26-4
tris(2,6-dimethylphenylimino)methylrhenium(VII)

: 628-13-7
pyridine hydrochloride

: dichlorobis(2,6-dimethylphenylimido)methyl(pyridine)rhenium(VII)

Conditions

Conditions	Yield
In dichloromethane addn. of educts; stirred for 1 h at room temp.;; solvent concd. in vacuo; mixed with hexane; elem. anal.;;	94%

: {Re(NC6H3(CH(CH3)2)2)3}(1-)*{Na(C4H8O)2}(1+)={Re(NC6H3(CH(CH3)2)2)3}{Na(C4H8O)2}

: 628-13-7
pyridine hydrochloride

: 71-43-2
benzene

: {Re(NC6H3(CH(CH3)2)2)(C5H5N)2Cl3}*C6H6

Conditions

Conditions	Yield
In tetrahydrofuran; pyridine byproducts: H2NC6H3(CH(CH3)2)2, NaCl; addn. of 22.8 mmol of the Na(THF)2 salt to a stirred slurry of 105 mmol (C5H5NH)Cl in 50 ml THF / 200 ml C5H5N, concn. to 30 ml after 10 min., addn. of 300 ml pentane, washing, drying and refluxing with 150 ml C6H6, 5 days, concn. and addn. of pentane;; drying in vacuum; detn. by elem. anal., (1)H-NMR- and (13)C-NMR spectroscopy;;	94%

...Expand

: pentacyanocyclopentadienyl anion sodium salt

: 628-13-7
pyridine hydrochloride

: pyridium pentacyanocyclopentadienide

Conditions

Conditions	Yield
In water	93%

: palladium(II) hexafluoroacetylacetonate

: 628-13-7
pyridine hydrochloride

: chloro(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)(pyridine)palladium(II)

Conditions

Conditions	Yield
In methanol; dichloromethane CH2Cl2 son. of complex was added to MeOH soln. of Py*HCl; standing 1 d at room temp.; treatment with hexane. cooling;	92%

Pyridine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Pyridine hydrochloride Specification

This chemical has the IUPAC name Pyridine hydrochloride, and it is also known as Pyridinium chloride. Its molecular formula is C₅H₆ClN and its molecular weight is 115.56. The CAS registry number of this chemical is 628-13-7. Additionally, its product categories are Heterocyclic Compounds; Pyridinium Compounds.

Other characteristics of the Pyridine hydrochloride can be summarised as followings: (1)ACD/LogP: 0.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.54; (4)ACD/LogD (pH 7.4): 0.72; (5)ACD/BCF (pH 5.5): 1.37; (6)ACD/BCF (pH 7.4): 2.08; (7)ACD/KOC (pH 5.5): 38.58; (8)ACD/KOC (pH 7.4): 58.76; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 3.88 Å²; (13)Flash Point: 20 °C; (14)Enthalpy of Vaporization: 35.09 kJ/mol; (15)Boiling Point: 115.3 °C at 760 mmHg; (16)Vapour Pressure: 22.8 mmHg at 25°C.

Production method of the Pyridine hydrochloride: It could be obtained by the reactants of 2-methyl-2-propane-sulfinyl chloride and tert-butyl-disulfane. This reaction needs the reagent of pyridine, and the solvent of CHCl₃. The yield is 90 %. In addition, this reaction should be taken for 2 hours at the temperature of 20 °C.

The Pyridine hydrochloride could be obtained by the reactants of 2-methyl-2-propane-sulfinyl chloride and tert-butyl-disulfane

Uses of the Pyridine hydrochloride: It's used as pharmaceutical intermediates, organic synthesis and it's suitable for pure gum rubber. It's also suitable for rubber containing carbon black. For example, it could react with thiocyanic acid; potassium salt to obtain the pyridine; thiocyanate. This reaction needs the solvent of H₂O. The yield is 95 %. In addition, this reaction needs the heating.

The Pyridine hydrochloride could react with thiocyanic acid; potassium salt to obtain the pyridine; thiocyanate

When you are using this chemical, please be cautious about it as the following: This chemical is irritating / harmful to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: [Cl-].[nH+]1ccccc1
2.InChI: InChI=1/C5H5N.ClH/c1-2-4-6-5-3-1;/h1-5H;1H
3.InChIKey: AOJFQRQNPXYVLM-UHFFFAOYAN

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	skin	2500uL/kg (2.5mL/kg)	Kodak Company Reports. Vol. 21MAY1971,
rat	LD50	intraperitoneal	800mg/kg (800mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
rat	LD50	oral	1600mg/kg (1600mg/kg)	Kodak Company Reports. Vol. 21MAY1971,

Product Name

Pyridine hydrochloride

Synthetic route

Pyridine hydrochloride Consensus Reports

Pyridine hydrochloride Specification

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