Product Name

  • Name

    Resorcinol

  • EINECS 203-585-2
  • CAS No. 108-46-3
  • Article Data351
  • CAS DataBase
  • Density 1.27 g/cm3
  • Solubility Water solubility: 140 g/100 mL
  • Melting Point 109-112 °C(lit.)
  • Formula C6H6O2
  • Boiling Point 279.999 °C at 760 mmHg
  • Molecular Weight 110.112
  • Flash Point 131.928 °C
  • Transport Information UN 2876 6.1/PG 3
  • Appearance crystals or powder
  • Safety 26-61
  • Risk Codes 22-36/38-50-50/53
  • Molecular Structure Molecular Structure of 108-46-3 (Resorcinol)
  • Hazard Symbols HarmfulXn,DangerousN
  • Synonyms Resorcinol (USP);1,3-Dihydroxybenzene;Developer O;Fourrine EW;Fouramine RS;Dihydroxybenzol;C.I. 76505;m-Hydroquinone;C.I. Oxidation Base 31;3-Hydroxyphenol;Pelagol Grey RS;m-Dioxybenzene;Developer RS;Benzene, m-dihydroxy-;Benzene, 1,3-dihydroxy-;Developer R;C.I. Developer 4;RS 11H;Resorcin (JAN);Nako TGG;Resorcine, technical;3-Hydroxycyclohexadien-1-one;.alpha.-Resorcinol;Durafur Developer G;benzene-1,3-diol;m-Benzenediol;m-hydroxyphenol;1,3-benzenediol;Phenol, m-hydroxy-;Resorcin(indspec);Jarocol RL;NCI-C05970;Resorcin (TN) , resorcinol;
  • PSA 40.46000
  • LogP 1.09780

Synthetic route

3-allyloxyphenol
1616-51-9

3-allyloxyphenol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Heating;98%
3-hydroxyphenylboronic acid
87199-18-6

3-hydroxyphenylboronic acid

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With oxygen; triethylamine In 2-methyltetrahydrofuran at 20℃; under 760.051 Torr; for 48h; Green chemistry;98%
With oxygen; triethylamine In 2-methyltetrahydrofuran at 20℃; under 760.051 Torr; for 48h; UV-irradiation;98%
With dihydrogen peroxide In water at 20℃; for 0.5h;91%
m-phenylenediamine
108-45-2

m-phenylenediamine

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With sulfuric acid; water at 230℃; for 6h; Large scale;96.46%
Stage #1: m-phenylenediamine In water at 20℃; for 0.5h;
Stage #2: With sodium nitrite In water at 20℃; for 5h; Time;
80%
With hydrogenchloride at 180℃;
With sulfuric acid In water at 230℃; under 15001.5 Torr; for 7.5h; Reagent/catalyst; Temperature; Pressure; Autoclave;372 g
4-Bromoresorcinol
6626-15-9

4-Bromoresorcinol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With sodium sulfite In water at 20℃; for 18h; Kinetics; Mechanism; Temperature; Green chemistry;96%
1,3-Dimethoxybenzene
151-10-0

1,3-Dimethoxybenzene

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With sodium trimethylsilanethiolate In various solvent(s) at 185℃; for 24h; Mechanism; Product distribution; other reagents, other aryl methyl ethers;95%
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 185℃; for 24h;95%
With L-Selectride In tetrahydrofuran at 67℃; for 96h;93%
With hydrogenchloride In water at 250℃; under 37503.8 Torr; for 3h; Concentration; Autoclave; Inert atmosphere; Green chemistry;92%
With pyridinium p-toluenesulfonate for 0.025h; microwave irradiation;75%
O-methylresorcine
150-19-6

O-methylresorcine

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With aluminium(III) iodide; diisopropyl-carbodiimide In acetonitrile at 80℃; for 18h;95%
With aluminium(III) iodide; diisopropyl-carbodiimide In acetonitrile at 80℃; for 18h;95%
With aluminium(III) iodide In dimethyl sulfoxide; acetonitrile at 80℃; for 48h;78%
With aluminium(III) iodide; dimethyl sulfoxide In acetonitrile at 80℃; for 18h;78%
With aluminium(III) iodide; calcium oxide In acetonitrile at 80℃; for 18h;18%
resorcin bis(tetrahydropyranyl)ether
30778-88-2

resorcin bis(tetrahydropyranyl)ether

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With montmorillonite K-10 In methanol at 40 - 50℃; for 0.6h;94%
1,3-di(2-hydroperoxy-2-propyl)benzene
721-26-6

1,3-di(2-hydroperoxy-2-propyl)benzene

A

acetone
67-64-1

acetone

B

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
sulfur trioxide In 4-methyl-2-pentanone at 70℃; for 0.166667h; Product distribution / selectivity;A n/a
B 94%
3-Iodophenol
626-02-8

3-Iodophenol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;93%
With formic acid; oxygen; triethylamine; copper(ll) bromide In acetonitrile at 20℃; for 48h; Irradiation;90%
With cesium hydroxide In water; dimethyl sulfoxide at 120℃; for 24h; Sealed tube; Inert atmosphere;88%
With copper(I) oxide; 2-(N,N-dimethylamino)ethanol; water; potassium hydroxide In dimethyl sulfoxide at 100℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;87%
Kalischmelze;
1,3-bis(allyloxy)benzene
13594-95-1

1,3-bis(allyloxy)benzene

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In methanol for 1h; Heating;92%
m-Hydroxyaniline
591-27-5

m-Hydroxyaniline

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite at 12.5 - 90℃;91.8%
With sulfuric acid; water; sodium nitrite at -5 - 40℃; for 2h; Reagent/catalyst; Temperature;74.5%
Stage #1: m-Hydroxyaniline With sulfuric acid; sodium nitrite In water at -8 - 25℃; for 0.25h;
Stage #2: With water In acetic acid butyl ester at 75 - 80℃; for 0.25h;
55%
With sulfuric acid Diazotization.Verkochen der Diazoniumsulfatloesung;
Stage #1: m-Hydroxyaniline With hydrogenchloride; sodium nitrite In water at 1℃; for 0.5h;
Stage #2: With potassium carbonate In water at 30℃; for 0.5h; Temperature;
1,3-O-bis(tert-butyldimethylsilyl)resorcinol
120951-86-2

1,3-O-bis(tert-butyldimethylsilyl)resorcinol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With potassium fluoride; hydrogen bromide In N,N-dimethyl-formamide at 25℃; for 2h;91%
1,3-phenylenediboronic acid
4612-28-6

1,3-phenylenediboronic acid

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With Fe2O3-SiO2 nanoparticles; air In water at 50℃; for 3h; Green chemistry;89%
With [Cu6I2(μ4-I)2(μ4-5-phpymt)2]; triethylamine In water; acetonitrile for 48h; Catalytic behavior; Solvent; Time; UV-irradiation;74%
C18H30O4

C18H30O4

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With aluminum (III) chloride; sodium iodide In methanol at 60℃; for 24h; Reagent/catalyst; Solvent;89%
allyl 3-acetoxyphenyl ether
3993-32-6

allyl 3-acetoxyphenyl ether

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In methanol for 1.5h; Heating;86%
3-Bromophenol
591-20-8

3-Bromophenol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With copper(I) oxide; tetra(n-butyl)ammonium hydroxide; 1,10-phenanthroline-4,7-diol In water at 110℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;86%
1,3-bis(methoxymethyl)resorcinol
57234-29-4

1,3-bis(methoxymethyl)resorcinol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With bismuth(III) chloride In water; acetonitrile at 50℃; for 2h;85%
1,3-Dimethoxybenzene
151-10-0

1,3-Dimethoxybenzene

A

O-methylresorcine
150-19-6

O-methylresorcine

B

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With hydrogen iodide at 25℃; for 24h; Inert atmosphere;A 12%
B 85%
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;A 50%
B 43%
1,3-bis(trimethylsiloxy)benzene
4520-29-0

1,3-bis(trimethylsiloxy)benzene

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.5h; Green chemistry;85%
(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid
16909-09-4

(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With hydrogenchloride; water at 250℃; under 37503.8 Torr; for 4.5h; Sealed tube; Inert atmosphere;84%
3-monochlorophenol
108-43-0

3-monochlorophenol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane; water at 100℃; for 17h;83%
Kalischmelze;
bei der Kalischmelze;
In water Quantum yield; Ambient temperature; Irradiation; presence of O2 investigated;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
Stage #1: 3,5-dihydroxyphenol With sodium hydroxide; hydrogen; Rh/Al2O3 at 20℃; under 2585.81 Torr; for 12h;
Stage #2: With sulfuric acid for 9h; Heating; Further stages.;
82%
With sodium tetrahydroborate; water
5-methoxyresorcinol
2174-64-3

5-methoxyresorcinol

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
Stage #1: 5-methoxyresorcinol With sodium hydroxide; hydrogen; Rh/Al2O3 In water under 2585.81 Torr; for 12h;
Stage #2: With sulfuric acid for 9h; Heating; Further stages.;
80%
1,3-Diiodobenzene
626-00-6

1,3-Diiodobenzene

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With β-D-glucose; copper(II) acetate monohydrate; potassium hydroxide In water; dimethyl sulfoxide at 20 - 120℃; for 24h;80%
Resorcinol monoacetate
102-29-4

Resorcinol monoacetate

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With copper dichloride In methanol; water for 3h; Heating;75%
2,6-Dihydroxybenzoic acid
303-07-1

2,6-Dihydroxybenzoic acid

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With silver carbonate In dimethyl sulfoxide at 120℃; for 16h;71%
Destillation;
With hydrogenchloride at 120℃; pH=1.40; Activation energy; Kinetics; Further Variations:; Temperatures; pH-values;
3-Benzyloxyphenyl acetate
81499-29-8

3-Benzyloxyphenyl acetate

A

Resorcinol monoacetate
102-29-4

Resorcinol monoacetate

B

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
With pentamethylbenzene,; boron trichloride In dichloromethane at -78℃; for 0.333333h;A 26%
B 71%
hydrogenchloride
7647-01-0

hydrogenchloride

7,7,7,15,15,15-hexamethyl-6,8,14,16-tetraoxa-7,15-distibatricyclo[11.3.1.1.(9,13)]octadeca-1,3,5,9,11,13-hexaene
171001-66-4

7,7,7,15,15,15-hexamethyl-6,8,14,16-tetraoxa-7,15-distibatricyclo[11.3.1.1.(9,13)]octadeca-1,3,5,9,11,13-hexaene

A

trimethylantimony dichloride
13059-67-1, 22810-79-3, 91108-42-8

trimethylantimony dichloride

B

recorcinol
108-46-3

recorcinol

Conditions
ConditionsYield
In ethanol excess soln. of acid addn. to Sb-compd., heating (3 h, reflux, water bath), soln. pouring to petri dish; sepn. by different solubility in benzene;A 70%
B 69%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

recorcinol
108-46-3

recorcinol

7-hydroxy-4-methyl-chromen-2-one
90-33-5, 79566-13-5

7-hydroxy-4-methyl-chromen-2-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 0.5h; Pechmann condensation; Microwave irradiation; regioselective reaction;100%
With silica-supported methanesulfonic acid catalyst In octadecane at 160℃; for 2h; Pechmann reaction;99%
With iron(III) chloride In neat (no solvent) at 70℃; for 12h; Pechmann Condensation; Green chemistry;99%
4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

recorcinol
108-46-3

recorcinol

3-(4-nitrobenzoyloxy)phenyl 4-nitrobenzoate
187264-29-5

3-(4-nitrobenzoyloxy)phenyl 4-nitrobenzoate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 24h;100%
With tetralin at 160℃;
With pyridine at 100℃;
With pyridine In toluene Heating;
isobutyryl chloride
79-30-1

isobutyryl chloride

recorcinol
108-46-3

recorcinol

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone
29048-54-2

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 20℃;100%
at 90℃;
With aluminium trichloride; nitrobenzene at 40 - 50℃;
ethyl 2-oxocyclohexane carboxylate
1655-07-8

ethyl 2-oxocyclohexane carboxylate

recorcinol
108-46-3

recorcinol

3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one
3722-44-9

3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 1h; Pechmann condensation;100%
With sulfuric acid at 20℃; for 24h;98%
With aluminum oxide; methanesulfonic acid at 20℃; for 0.166667h; Pechmann reaction;96%
isobutyric Acid
79-31-2

isobutyric Acid

recorcinol
108-46-3

recorcinol

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone
29048-54-2

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 90℃; for 1.5h; Inert atmosphere;100%
With zinc(II) chloride at 125 - 140℃;
With boron trifluoride
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

recorcinol
108-46-3

recorcinol

3-chloro-4-methylumbelliferone
6174-86-3

3-chloro-4-methylumbelliferone

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 0.5h; Pechmann condensation; Microwave irradiation; regioselective reaction;100%
With zirconium(IV) oxychloride In ethanol at 60 - 65℃; for 24h; Pechmann reaction;98%
With aluminum potassium sulfate dodecahydrate at 65℃; for 2h; Pechmann condensation; Neat (no solvent);93%
recorcinol
108-46-3

recorcinol

4-Bromoresorcinol
6626-15-9

4-Bromoresorcinol

Conditions
ConditionsYield
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 2h; Heating;100%
With dihydrogen peroxide; potassium bromide In water; acetonitrile96%
With DMd; sulfuric acid; sodium bromide In acetone at 20℃; for 0.0166667h;95%
chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

recorcinol
108-46-3

recorcinol

1,3-bis(methoxymethyl)resorcinol
57234-29-4

1,3-bis(methoxymethyl)resorcinol

Conditions
ConditionsYield
Stage #1: recorcinol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h; Inert atmosphere;
Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; mineral oil at 20℃; for 27h; Inert atmosphere;
100%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;99%
Stage #1: recorcinol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere;
Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 5h;
95%
(4-chlorophenyl)(2-hydroxy-3,3-dimethyl-2,3-dihydroindol-1-yl)methanone
51459-50-8

(4-chlorophenyl)(2-hydroxy-3,3-dimethyl-2,3-dihydroindol-1-yl)methanone

recorcinol
108-46-3

recorcinol

(4-Chloro-phenyl)-[2-(2,4-dihydroxy-phenyl)-3,3-dimethyl-2,3-dihydro-indol-1-yl]-methanone
91751-58-5

(4-Chloro-phenyl)-[2-(2,4-dihydroxy-phenyl)-3,3-dimethyl-2,3-dihydro-indol-1-yl]-methanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In 1,4-dioxane at 40℃; for 10h;100%
With boron trifluoride diethyl etherate In 1,4-dioxane at 40℃; for 10h;100%
Dodecanal
112-54-9

Dodecanal

recorcinol
108-46-3

recorcinol

C-undecylcalix[4]resorcinarene
847018-76-2

C-undecylcalix[4]resorcinarene

Conditions
ConditionsYield
ytterbium (III) tris-[tris-(nonafluorobutanesulfonyl)methide] In ethanol for 48h; Heating / reflux;100%
With hydrogenchloride In ethanol; water at -10 - 90℃; for 20.1667h;82%
With hydrogenchloride In ethanol at 20 - 90℃; for 17h;76%
3-hydroxyphenylacetic acid
621-37-4

3-hydroxyphenylacetic acid

recorcinol
108-46-3

recorcinol

1-(2,4-dihydroxyphenyl)-2-(3-hydroxyphenyl)ethanone
89019-84-1

1-(2,4-dihydroxyphenyl)-2-(3-hydroxyphenyl)ethanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate for 1.5h; Reflux;100%
With boron trifluoride diethyl etherate at 60 - 70℃; for 1h;93%
With boron trifluoride diethyl etherate In toluene at 90℃; for 2h;57%
With boron trifluoride diethyl etherate at 110℃; for 2h; Inert atmosphere;
With boron trifluoride diethyl etherate In N,N-dimethyl-formamide at 90℃; for 2h;
m-methoxyphenylacetic acid
1798-09-0

m-methoxyphenylacetic acid

recorcinol
108-46-3

recorcinol

1-(2,4-dihydroxyphenyl)-2-(3-methoxyphenyl)ethanone
89019-83-0

1-(2,4-dihydroxyphenyl)-2-(3-methoxyphenyl)ethanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 85℃; for 3h;100%
With boron trifluoride diethyl etherate at 60 - 70℃; for 1h;96%
With boron trifluoride diethyl etherate at 80 - 90℃; Inert atmosphere;74%
methylphosphonous acid diphenyl ester
38316-42-6

methylphosphonous acid diphenyl ester

recorcinol
108-46-3

recorcinol

oligomeric resorcinol methylphosphonate

oligomeric resorcinol methylphosphonate

Conditions
ConditionsYield
at 60 - 241℃; under 0.750075 - 15.201 Torr; for 11h;100%
recorcinol
108-46-3

recorcinol

C88H68Br4O8

C88H68Br4O8

C100H76O12

C100H76O12

Conditions
ConditionsYield
With potassium carbonate; copper(II) oxide In pyridine for 168h; Heating;100%
cyclohexylacetic acid chloride
23860-35-7

cyclohexylacetic acid chloride

recorcinol
108-46-3

recorcinol

2-cyclohexyl-1-(2,4-dihydroxyphenyl)ethanone
470485-27-9

2-cyclohexyl-1-(2,4-dihydroxyphenyl)ethanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 20℃; Inert atmosphere;100%
With aluminium trichloride In dichloromethane at 20 - 70℃; for 4h;40%
Conditions
ConditionsYield
With hydrogenchloride In ethanol at 80℃; for 18h;100%
benzyl bromide
100-39-0

benzyl bromide

2-bromo-5-methoxy-benzoic acid
22921-68-2

2-bromo-5-methoxy-benzoic acid

recorcinol
108-46-3

recorcinol

3-(Benzyloxy)-8-methoxy-6H-benzo[c]chromen-6-one
845438-83-7

3-(Benzyloxy)-8-methoxy-6H-benzo[c]chromen-6-one

Conditions
ConditionsYield
Stage #1: 2-bromo-5-methoxy-benzoic acid; recorcinol With sodium hydroxide; copper(II) sulfate
Stage #2: benzyl bromide With caesium carbonate
100%
recorcinol
108-46-3

recorcinol

5,6-dichlorofluorescein
86166-34-9

5,6-dichlorofluorescein

Conditions
ConditionsYield
Stage #1: 4,5-dichlorophthalic acid With methanesulfonic acid at 90℃; for 1h;
Stage #2: recorcinol at 80 - 105℃; for 1h;
100%
2-(1-benzyl-pyrrol-2-yl)-4,6-dichloro-[1,3,5]triazine
35252-49-4

2-(1-benzyl-pyrrol-2-yl)-4,6-dichloro-[1,3,5]triazine

recorcinol
108-46-3

recorcinol

2-(1-benzyl-1H-pyrrole-2-yl)-4,6-bis(2,4-dihydroxyphenyl)-1,3,5-triazine

2-(1-benzyl-1H-pyrrole-2-yl)-4,6-bis(2,4-dihydroxyphenyl)-1,3,5-triazine

Conditions
ConditionsYield
Stage #1: 2-(1-benzyl-pyrrol-2-yl)-4,6-dichloro-[1,3,5]triazine; recorcinol With aluminum (III) chloride In xylene at 50 - 85℃; for 3h; Friedel Crafts Acylation;
Stage #2: With hydrogenchloride In water
100%
1,1'-bis(ethenyl-4-pyridyl)ferrocene
222165-10-8

1,1'-bis(ethenyl-4-pyridyl)ferrocene

recorcinol
108-46-3

recorcinol

1,1'-bis(ethenyl-4-pyridyl)ferrocene resorcinol

1,1'-bis(ethenyl-4-pyridyl)ferrocene resorcinol

Conditions
ConditionsYield
In ethanol at room temp. for 7 d; elem. anal.;100%
9-benzyl-6-chloro-9H-purine
1928-76-3

9-benzyl-6-chloro-9H-purine

recorcinol
108-46-3

recorcinol

4-(9-phenylmethyl-9H-purin-6-yl)-benzene-1,3-diol
1241556-45-5

4-(9-phenylmethyl-9H-purin-6-yl)-benzene-1,3-diol

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; 1,1,1,3',3',3'-hexafluoro-propanol at 60℃; for 24h;100%
With aluminum (III) chloride In 1,2-dichloro-ethane for 0.5h; Reflux;51%
recorcinol
108-46-3

recorcinol

C6H6O2*2C15H22O5

C6H6O2*2C15H22O5

Conditions
ConditionsYield
In methanol100%
1,1,3,3-tetramethyldisilazane
15933-59-2

1,1,3,3-tetramethyldisilazane

recorcinol
108-46-3

recorcinol

1,3-bis(dimethylsilyloxy)benzene
138219-50-8

1,3-bis(dimethylsilyloxy)benzene

Conditions
ConditionsYield
With dimethylmonochlorosilane In tetrahydrofuran Reflux;100%
oxirane
75-21-8

oxirane

methyloxirane
75-56-9, 16033-71-9

methyloxirane

recorcinol
108-46-3

recorcinol

C38H70O14

C38H70O14

Conditions
ConditionsYield
Stage #1: methyloxirane; recorcinol With potassium hydroxide In toluene at 48.8789℃; for 1.5h; Under N2;
Stage #2: oxirane at 48.8789℃; for 2h;
99.7%
acetyl chloride
75-36-5

acetyl chloride

recorcinol
108-46-3

recorcinol

Resorcinol diacetate
108-58-7

Resorcinol diacetate

Conditions
ConditionsYield
Stage #1: acetyl chloride; recorcinol In chloroform at 20 - 65℃; for 4h; Large scale;
Stage #2: In water Temperature; Large scale;
99.5%
bismuth(III) oxychloride at 20℃; for 0.0833333h;98%
zirconium(IV) oxychloride at 20℃; for 0.0833333h;97%
acetic anhydride
108-24-7

acetic anhydride

recorcinol
108-46-3

recorcinol

Resorcinol diacetate
108-58-7

Resorcinol diacetate

Conditions
ConditionsYield
With Sulfate; titanium(IV) oxide In dichloromethane at 40℃; for 0.0666667h;99%
With iron(III) p-toluenesulfonate hexahydrate In acetonitrile at 20℃; for 0.833333h;99%
With bismuth(lll) trifluoromethanesulfonate In acetonitrile at 20℃; for 0.166667h;98%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

recorcinol
108-46-3

recorcinol

1,3-dimesyloxybenzene
59722-31-5

1,3-dimesyloxybenzene

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;99%
With pyridine
Benzotrichlorid
98-07-7

Benzotrichlorid

recorcinol
108-46-3

recorcinol

2,4-dihydroxybenzophenone
131-56-6

2,4-dihydroxybenzophenone

Conditions
ConditionsYield
With ethanol; water at 60 - 80℃; for 9h; Temperature; Green chemistry;99%
With water In ethanol at 40 - 50℃; for 4h; Temperature; Large scale;97.6%
With ethanol und Eintragen des Reaktionsgemisches in heisses Wasser;

Resorcinol Chemical Properties

Empirical Formula: C6H6O2
Molecular Weight: 110.1106 
Index of Refraction: 1.612
Molar Refractivity: 30.01 cm3
Molar Volume: 86.2 cm3
Surface Tension: 57.1 dyne/cm
Density: 1.275 g/cm3
Flash Point: 131.9 °C
Boiling Point: 280 °C at 760 mmHg
Vapour Pressure: 0.00229 mmHg at 25 °C
Melting point: 109-112 °C(lit.)
Storage tempreture: 0-6 °C
Water solubility: 140 g/100 mL
Sensitive: Light sensitive
Appearance: Crystals or powder
Structure of Resorcinol (CAS NO.108-46-3):
                      
IUPAC Name: Benzene-1,3-diol
Canonical SMILES: C1=CC(=CC(=C1)O)O
InChI: InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
InChIKey: GHMLBKRAJCXXBS-UHFFFAOYSA-N
Product Category of Resorcinol (CAS NO.108-46-3): Color Former & Related Compounds;Developer;Functional Materials

Resorcinol Uses

 Resorcinol (CAS NO.108-46-3) is used as an antiseptic and disinfectant, and is used 5 to 10% in ointments in the treatment of chronic skin diseases and eczema of a sub-acute character. One emerging use is as a template molecule in supramolecular chemistry. It is used as an analytical reagent for the qualitative determinaion of ketoses, and is the starting material for resorcinarene molecules and the initiating explosive lead styphnate. Resorcinol is also used as a chemical intermediate for the synthesis of pharmaceuticals and other organic compounds. It is used in the production of diazo dyes and plasticizers and as a UV absorber in resins.

Resorcinol Production

 3-Ethylphenol (CAS NO.620-17-7) is obtained on fusing many resins with potassium hydroxide, or by the distillation of Brazilwood extract. It also may be prepared synthetically by fusing 3-iodophenol, phenol-3-sulfonic acid or benzene-1,3-disulfonic acid with potassium carbonate; by the action of nitrous acid on 3-aminophenol; or by the action of 10% hydrochloric acid on 1,3-diaminobenzene. Many ortho- and para-compounds of the aromatic series also yield resorcinol on fusion with potassium hydroxide.

Resorcinol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 110mg/kg (110mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913.
dog LDLo intravenous 700mg/kg (700mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo parenteral 270mg/kg (270mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
CARDIAC: OTHER CHANGES
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
guinea pig LDLo subcutaneous 400mg/kg (400mg/kg) BEHAVIORAL: EXCITEMENT
BEHAVIORAL: TETANY
BEHAVIORAL: COMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
human LDLo oral 29mg/kg (29mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 519, 1969.
mouse LD50 intraperitoneal 215mg/kg (215mg/kg)   Bulletin of Experimental Biology and Medicine Vol. 61, Pg. 291, 1966.
mouse LD50 oral 200mg/kg (200mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse LD50 subcutaneous 213mg/kg (213mg/kg)   Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. Vol. 2, Pg. 333, 1947.
rabbit LD50 skin 3360mg/kg (3360mg/kg) SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE American Industrial Hygiene Association Journal. Vol. 37, Pg. 596, 1976.
rat LCLo inhalation 160mg/m3/1H (160mg/m3)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 11-4/1970,
rat LD50 oral 301mg/kg (301mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 11-4/1970,
rat LDLo subcutaneous 400mg/kg (400mg/kg) BEHAVIORAL: EXCITEMENT
BEHAVIORAL: TETANY
BEHAVIORAL: COMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

Resorcinol Safety Profile

Hazard Codes: Xn,  N
Risk Statements:
22:  Harmful if swallowed 
50:  Very Toxic to aquatic organisms    
36/38:  Irritating to eyes and skin 
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
61:  Avoid release to the environment. Refer to special instructions safety data sheet 

Resorcinol Specification

  Resorcinol , its cas register number is 108-46-3. It also can be called 1,3-Dihydroxybenzene ; 1,3-Benzenediol ; and 3-Hydroxycyclohexadien-1-one . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Resorcinol (CAS NO.108-46-3) absorbs moisture or water from the air. It may discolor on exposure to air and light. It is not compatible with strong oxidizing agents, bases, acid chlorides, iron, ferric salts, acid anhydrides, alkalies, albumin, iron salts, antipyrine, methanol, acetanilide, camphor, urethane, spirit nitrous ether, and you must not take it with incompatible materials, light, dust generation, exposure to air, exposure to moist air or water, heat. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide.

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