Conditions | Yield |
---|---|
Heating; | 99.5% |
In neat (no solvent) 1mol B(OCH3)3, 4mol NaH, 225-275°C;; 90-96% NaBH4;; | 94% |
In neat (no solvent) 1mol B(OCH3)3, 4mol NaH, 225-275°C;; 90-96% NaBH4;; | 94% |
sodium hydride
sodium tetrahydroborate
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: NaF; addn. of B(OCH3)3*THF to NaH at 60-65°C (stirring, N2-atmosphere), NaH dissolves, boiling, cooling to ambient temp., addn. of BF3*THF, distn. of THF and B(OCH3), extractn. of residue with isopropyl amine;; pure product;; | 99% |
In tetrahydrofuran byproducts: NaF; addn. of B(OCH3)3*THF to NaH at 60-65°C (stirring, N2-atmosphere), NaH dissolves, boiling, cooling to ambient temp., addn. of BF3*THF, distn. of THF and B(OCH3), extractn. of residue with isopropyl amine;; pure product;; | 99% |
A
sodium tetrahydroborate
Conditions | Yield |
---|---|
In tetrahydrofuran (Ar); a flask charged with Nd complex, THF condensed, C4H4S2(SNa)2 added, stirred for 3 d at 20°C; filtered, evapd., extd. (THF), filtered; obtained impure; | A n/a B 99% |
Conditions | Yield |
---|---|
In further solvent(s) react. of NaH with B2H6 in alkylene glycol dialkylether at 35-75°C;; | 98% |
In tetrahydrofuran in abs. tetrahydrofurane; 4 h, under shaking; good yield; Na(BH4) suspension distilled, filtered and dried in oil pump vacuum at 130°C; purity = 97.5 %; | 93% |
In tetrahydrofuran in abs. tetrahydrofurane; 4 h, under shaking; good yield; Na(BH4) suspension distilled, filtered and dried in oil pump vacuum at 130°C; purity = 97.5 %; | 93% |
N,N,N,N,-tetramethylethylenediamine
A
sodium tetrahydroborate
Conditions | Yield |
---|---|
In benzene org. compd. soln. addn. dropwise (magnetic stirring) to Zn-complex soln., NaBH4 ppt. filtration off after 1 h, solvent evapn. from filtrate (vac.); residue washing (pentane), drying (vac.); elem. anal; thermal anal.; | A 77% B 97% |
trifluoroborane diethyl ether
sodium hydride
A
sodium tetrahydroborate
B
diborane
Conditions | Yield |
---|---|
In diethylene glycol method for preparation of diborane, addn. of BF3-etherate (frehly distd.) to NaH in diglyme;; | A n/a B 92% |
In diethylene glycol method for preparation of diborane, addn. of BF3-etherate (frehly distd.) to NaH in diglyme;; | A n/a B 92% |
In diethyl ether at 110°C, method for preparation of diborane;; | |
In diethyl ether at 110°C, method for preparation of diborane;; |
Conditions | Yield |
---|---|
magnesium In water byproducts: MgO; process starts from borax and NaOH by exothermal steam process (H2O); dread at 270°C; H2 at surface of Mg particles generated protide to form NaBH4; process dependent on of rate temp. change, size of Mg particles; XRD; | 90% |
Conditions | Yield |
---|---|
With catalyst: Na-alcoholate In neat (no solvent) passing BF3 over NaH in presence of a Na-alcoholate, 250-300°C;; | 90% |
In neat (no solvent) byproducts: B2H6; on passing a mixture of BF3 and H2 (ratio=1:2) over powdered NaH at about 180°C;; | |
In diethyl ether react. of NaH with a soln. of BF3 in ether in an autoclave (about 10 at), 24h, about 120°C;; | |
In mineral oil at 250-265°C;; washing with petroleum ether, extractn. of NaBH4 from the residue with liquid NH3 at -33°C;; | |
In neat (no solvent) byproducts: B2H6; on passing a mixture of BF3 and H2 (ratio=1:2) over powdered NaH at about 180°C;; |
Conditions | Yield |
---|---|
With tetrahydrofuran In neat (no solvent) byproducts: DME; 140-160°C, vac., 2 h; extn. (THF), filtration off of NaBH4, distn. off of solvent; elem. anal.; | A n/a B 89% |
Trimethyl borate
sodium hydride
A
sodium tetrahydroborate
B
sodium tetramethoxyborate
Conditions | Yield |
---|---|
In tetrahydrofuran with excess NaH; at 65°C; | A 83% B n/a |
In tetrahydrofuran on boiling in THF, pptn. of NaBH4;; | |
In tetrahydrofuran on boiling in THF, pptn. of NaBH4;; |
Conditions | Yield |
---|---|
In neat (no solvent) heating to 250-270°C, excess NaH;; | 78% |
In neat (no solvent) heating to 250-270°C, excess NaH;; | 78% |
In neat (no solvent) molar ratio NaH:NaB(OCH3)4=4:1, 250.C;; 91% NaBH4;; | 66% |
In neat (no solvent) molar ratio NaH:NaB(OCH3)4=4:1, 250.C;; 91% NaBH4;; | 66% |
Conditions | Yield |
---|---|
In neat (no solvent) molar ratio NaH:NaBH(OCH3)3=3:1, 250-270°C;; | 78% |
In neat (no solvent) heating to 250-270°C, excess NaH;; | 78% |
In neat (no solvent) molar ratio NaH:NaBH(OCH3)3=3:1, 250-270°C;; | 78% |
Conditions | Yield |
---|---|
With sodium carbonate In neat (no solvent) byproducts: MgO, CO2; ball milled at room temp. for 60 min; extn. by anhyd. ethylendiamine under Ar; filtered soln. evapd. in vac. at room temp.; detn. by XRD; | 78% |
With sodium peroxide In neat (no solvent) byproducts: MgO, H2; ball milled at room temp. for 60 min; extn. by anhyd. ethylendiamine under Ar, soln. evapd. in vac. at room temp.; detn. by XRD; | 67% |
With sodium hydroxide In neat (no solvent) byproducts: MgO, H2; ball milled at room temp. for 60 min; extn. by anhyd. ethylendiamine under Ar; filtered soln. evapd. in vac. at room temp.; detn. by XRD; | 64% |
In neat (no solvent) byproducts: MgO, B2O3; ball milled at room temp. for 60 min; extn. by anhyd. ethylendiamine under Ar; filtered soln. evapd. in vac. at room temp.; detn. by XRD; | 43% |
A
sodium tetrahydroborate
Conditions | Yield |
---|---|
With tetrahydrofuran In neat (no solvent) byproducts: DME; 140-160°C, vac., 2 h; extn. (THF), filtration off of NaBH4, distn. off of solvent, drying (vac., 1 h); elem. anal.; | A n/a B 78% |
sodium amidotrihydridoborate
dimethylsulfide borane complex
sodium tetrahydroborate
Conditions | Yield |
---|---|
In tetrahydrofuran for 5h; Inert atmosphere; | 78% |
Conditions | Yield |
---|---|
for 6h; Milling; | 76% |
Conditions | Yield |
---|---|
In neat (no solvent) react. of Na-borate with Na and H2 at 400-500°C, H2-pressure: several atm, addn. of SiO2 to separate excess Na in form of Na2SiO3;; purity up to 96%;; | 75% |
Conditions | Yield |
---|---|
In neat (no solvent) react. of Na-borate with Na and H2 at 400-500°C, H2-pressure: several atm, addn. of SiO2 to separate excess Na in form of Na2SiO3;; purity up to 96%;; | 75% |
Conditions | Yield |
---|---|
In neat (no solvent) react. of Na-borate with Na and H2 at 400-500°C, H2-pressure: several atm, addn. of SiO2 to separate excess Na in form of Na2SiO3;; purity up to 96%;; | 75% |
sodium tetrafluoroborate
hydrogen
sodium
sodium tetrahydroborate
Conditions | Yield |
---|---|
In further solvent(s) introduction of dry H2 under pressure in a dispersion of Na in an inert solvent at 275°C, simultanuous addn. of NaBF4;; | 75% |
In further solvent(s) introduction of dry H2 under pressure in a dispersion of Na in an inert solvent at 250-350°C, simultanuous addn. of NaBF4;; |
Conditions | Yield |
---|---|
In neat (no solvent) react. of Na-borate with Na and H2 at 400-500°C, H2-pressure: several atm, addn. of SiO2 to separate excess Na in form of Na2SiO3;; purity up to 96%;; | 75% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 5h; Inert atmosphere; | 75% |
A
aluminum oxide
B
sodium tetrahydroborate
Conditions | Yield |
---|---|
for 20h; Milling; Inert atmosphere; | A n/a B 72% |
3-ethylpentan-3-ol
A
sodium tetrahydroborate
B
ytrrium tetrahydridoborate
C
bis(3-ethyl-3-pentoxy)borane
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: H2; under inert atm.; excess of alcohol in THF added dropwise at room temp. to stirred soln. of tetrahydroborate complex in THF (accompanied by vigorous gas evolution); stirring was continued for 1 h; mixt. allowed to stand for the reaction to be completed; within 5 ds ppt. sepd. by filtration (identified as NaBH4 by X-ray diffraction and IR spectroscopy); filtrate was distd. (vac., 0.1 mmHg) at room temp. to remove solvent and at 50°C; residue pumped out at 100-115°C; volatile collected ...; | A 70% B n/a C 69% |
tetraphenylphosphonium tetrahydroborate
A
sodium tetrahydroborate
Conditions | Yield |
---|---|
In dichloromethane CH2Cl2 was added to mixt. NaLu(BH4)4*4DME andPh4PBH4 and stirred for several minutes; NaBH4 was filtered off, soln. was concd., Et2O was added, ppt. was separated, washed with Et2O and dried in vac.; elem. anal.; | A n/a B 68.5% |
3-ethylpentan-3-ol
A
sodium tetrahydroborate
C
bis(3-ethyl-3-pentoxy)borane
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: H2; under inert atm.; excess of alcohol in THF added dropwise at room temp. to stirred soln. of tetrahydroborate complex in THF (accompanied by vigorous gas evolution); stirring was continued for 1 h; mixt. allowed to stand for the reaction to be completed; within 5 ds ppt. sepd. by filtration (identified as NaBH4 by X-ray diffraction and IR spectroscopy); filtrate was distd. (vac., 0.1 mmHg) at room temp. to remove solvent and at 50°C; residue pumped out at 100-115°C; volatile collected ...; | A 66% B n/a C 65% |
Conditions | Yield |
---|---|
With aluminium at 579.84℃; under 17251.7 Torr; | 65% |
Conditions | Yield |
---|---|
In neat (no solvent) heating to >330°C for 20-48h;; | 60% |
In neat (no solvent) heating to >330°C for 20-48h;; | 60% |
With catalyst: Na-alcoholate In neat (no solvent) at about 350°C;; |
Conditions | Yield |
---|---|
In neat (no solvent) on trituration at 330-350°C for 20-48h;; | A n/a B 60% |
In neat (no solvent) on trituration at 330-350°C for 20-48h;; | A n/a B 60% |
heating at 330 - 350°C; | |
heating at 330 - 350°C; |
Conditions | Yield |
---|---|
With silica gel In solid powders ball milled for 4 h at 400 rpm, SiO2 added, ball-milled for 2 h more, pressed into pellet under 10, 20 or 30 MPa in Ar-filled box, calcined under 0.1 MPa Ar at 480°C for 5 h; extd. by isopropyl amine in modified Soxlet apparatus for 3 h; filtered,evapd. at 50°C; | 32% |
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: sodium chloride; under N2, soln. of CaCl2 and NaBH4 (molar ratio 1:1) in THF stirred with glass beads at 67°C (refluxed) for 1 h; | 100% |
In tetrahydrofuran byproducts: sodium chloride; under N2, soln. of CaCl2 and NaBH4 (molar ratio 1:1) in THF stirred with glass beads at 25°C for 8 h; | 99% |
In tetrahydrofuran byproducts: sodium chloride; under N2, soln. of CaCl2 and NaBH4 (molar ratio 1:1) in THF stirred with magnetic stirrer at 67°C (refluxed) for 8i h; | 96% |
Conditions | Yield |
---|---|
byproducts: H2, NaI; Interaction of initial cryst. materials in molar ratio NaBH4:I2 = 1.35 under mechanical activation with a vibration ball mill (dry N2, atm. pressure, 25°C).; Detn. of gas phase formed by infrared and mass spectroscopy, and gas volumetric anal.; | 100% |
byproducts: H2, NaI; Interaction of initial cryst. materials in molar ratio NaBH4:I2 = 1.5 under mechanical activation with a vibration ball mill (dry N2, atm. pressure, 25°C).; Detn. of gas phase formed by infrared and mass spectroscopy, and gas volumetric anal.; | 97.7% |
Kinetics; byproducts: H2, NaI; Interaction of initial cryst. materials in molar ratio NaBH4:I2 = 2.5 under mechanical activation with a vibration ball mill (dry N2, atm. pressure, 25°C).; Detn. of gas phase formed by infrared and mass spectroscopy, and gas volumetric anal.; | 94% |
Kinetics; byproducts: H2, NaI; Interaction of initial cryst. materials in molar ratio NaBH4:I2 = 2.0 under mechanical activation with a vibration ball mill (dry N2, atm. pressure, 25°C).; Detn. of gas phase formed by infrared and mass spectroscopy, and gas volumetric anal.; | 88.7% |
byproducts: H2, HI; Grinding of initial materials (molar ratio = 1) while being cooled withliq. N2, thorough mixing, transferring of mixt. to a thermographic ampoule and heating in vac. or N2.; Sepn. of gas mixt. by fractional condensation. Detn. of composition after the thermography by gas volumetric anal.; |
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: sodium bromide; under N2, soln. of LiBr and NaBH4 (molar ratio 1:1) in THF stirred withglass beads at 67°C (refluxed) for 8 h; | 100% |
In tetrahydrofuran byproducts: sodium bromide; under N2, soln. of LiBr and NaBH4 (molar ratio 1:1) in THF stirred withmagnetic stirrer at 67°C (refluxed) for 16 h; | 99% |
In diethyl ether byproducts: sodium bromide; under N2, soln. of LiBr in Et2O stirred with magnetic stirrer for 2 min, 1 equiv of NaBH4 introduced, maintained at 35°C with stirring for 32 h; | 99% |
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: sodium chloride; under N2, soln. of LiCl and NaBH4 (molar ratio 1:1) in THF stirred withglass beads at 25°C for 24 h or at 67°C (refluxed) for 10h; | 100% |
extraction with ether; purity: 97-98 %; | 75% |
In tetrahydrofuran byproducts: sodium chloride; under N2, soln. of LiCl and NaBH4 (molar ratio 1:1) in THF stirred withmagnetic stirrer at 67°C (refluxed) for 48 h; | 65% |
sodium tetrahydroborate
benzo-2-chloro-1,3,2-diazaborolane
2,3-dihydro-1H-1,3,2-benzodiazaborole
Conditions | Yield |
---|---|
In benzene recrystn. from benzene; | 100% |
sulfur
sodium tetrahydroborate
ammonia
ammonia borane complex
Conditions | Yield |
---|---|
In ammonia to NaBH4 in a flask at -40°C NH3 is condensed, then slowly S8 isadded (5 h), to the mixt. (after 3 h) CH2Cl2 is added, then the mixt. is warmed to room temp.; residue is extd. with CH2Cl2, the soln. is evapd., elem. anal.; | 100% |
sodium tetrahydroborate
(μ-η(2)-η(2)-HC*CCH3)CoMo(Cp)(CO)5
Conditions | Yield |
---|---|
In dichloromethane Ar-atmosphere; addn. of excess of NaBH4 to soln. of complex at 0°C; extn. (ether), washing org. layer by H2O, drying (MgSO4), evapn.; elem. anal.; | 100% |
sodium tetrahydroborate
IrH2(CH3CN)(C6H5P(CH2CH2CH2P(C6H11)2)2)(1+)*BF4(1-)={IrH2(CH3CN)(C6H5P((CH2)3P(C6H11)2)2)}{BF4}
IrH3(C6H5P(CH2CH2CH2P(C6H11)2)2)*C2H5OH
Conditions | Yield |
---|---|
In tetrahydrofuran nitrogen atmosphere; NaBH4 added to the Ir complex in THF; mixt. stirred for 20 min; addn. of ethanol, stirring (1 h); removal of the solvent (red. pressure); residue dissolved in THF, filtration; elem. anal.; | 100% |
sodium tetrahydroborate
1,3-diferrocenyl-2-propen-1-one
rac-1,3-diferrocenylprop-2-en-1-ol
Conditions | Yield |
---|---|
In 1,4-dioxane; methanol NaBH4 added to soln. of Fe complex (stirring); stirred (14 h); H2O added; cooled (7-8°C); ppt. filtered; washed (H2O); dried (room temp.); recrystd. (hexane); elem.anal.; | 100% |
sodium tetrahydroborate
Pt2Me2(μ-Cl)(μ-N,N'-bis[(2-diphenylphosphino)phenyl]formamidinate)
Pt2(methyl)2(μ-H)(μ-N,N'-bis[2-(diphenylphosphino)phenyl]formamidinate)
Conditions | Yield |
---|---|
In methanol; dichloromethane under N2 atm. to soln. Pt2Me2(μ-Cl)(μ-dpfam) in CH2Cl2 was addedNaBH4 and MeOH at 0°C and mixt. was stirred for 1 h; solvents were removed under reduced pressure, residue was extd. with CH2Cl2 and filtered, soln. was evapd.; elem. anal.; | 100% |
sodium tetrahydroborate
(η(5)-cyclopentadienyl)OsCl(triisopropylphosphine)2
OsH(η(5)-C5H5)(PiPr3)2
Conditions | Yield |
---|---|
With MeOH In toluene air-free atmosphere; stirring (room temp., 15 min); filtering, evapn., pentane addn., filtering, evapn.; | 100% |
sodium tetrahydroborate
borane-THF
diphosphane-borane
sodium 1,1,2-tris(borane)-1,2,2-trihydrogendiphosphide
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: H2, Na2[P2H2(BH3)4]; N2 atm.; molar ratio P2H4BH3:NaBH4 1:1, cooling (-78 to -196°C), stirring (4 h), heating (-78°C, 3 h), stirring (room temp., 6 h); crystn. (-78°C, several d); | 100% |
sodium tetrahydroborate
water
Conditions | Yield |
---|---|
In methanol a 15 equiv of NaBH4 was added to a soln. of complex in methanol, the mixt. was allowed to stir at room temp. for 2 h, ppt. was filtered off, dissolved in H2O, aq. satd. NaClO4 was added dropwise, cooled; ppt. was filtered, washed with ice-cold water and then ether; elem. anal.; | 100% |
sodium tetrahydroborate
Conditions | Yield |
---|---|
In methanol a 15 equiv of NaBH4 was added to a soln. of complex in methanol, the mixt. was allowed to stir at room temp. for 2 h, ppt. was filtered off, dissolved in H2O, aq. satd. NaClO4 was added dropwise, cooled; ppt. was filtered, washed with ice-cold water and then ether; | 100% |
sodium tetrahydroborate
(2,6-bis[(di-t-butylphosphino)methyl]phenyl)chloronickel
(2,6-bis[(di-t-butylphosphino)methyl]phenyl)hydridonickel
Conditions | Yield |
---|---|
In ethanol; benzene excess of NaBH4, stirring in C6H6/EtOH=1:1 for 20 h at 20°C, addn. of further NaBH4. stirring for 3 h; addn. of water and C6H6, evapn. of C6H6-layer; | 100% |
sodium tetrahydroborate
[2,6-bis(2-(2-mercaptophenyl)1-methyl-2-azaethenyl)pyridine]zinc(II)
[2,6-bis(1-(2-mercaptoanilino)ethyl)pyridine]zinc(II)
Conditions | Yield |
---|---|
In ethanol; N,N-dimethyl-formamide all manipulations under Ar atm.; soln. of NaBH4 in EtOH/DMF (1/4) added dropwise to soln. of complex in DMF at 0°C, stirred at room temp for 2 h; DMF/EtOH removed in vac., residue dissolved in MeOH, pptd. by addn. of water; elem. anal.; | 100% |
sodium tetrahydroborate
(1S,2R,3S,4R)-3-methoxymethyl-2-triphenylstannylbicyclo[2.2.1]heptane(-)
iodine
diphenyl[(1S,2R,3S,4R)-3-(1-methoxymethyl)bicyclo[2.2.1]heptan-2-yl]tin hydride
Conditions | Yield |
---|---|
In dichloromethane I2 addn. to Sn-compd. soln. (DCM), stirring 1 h at room temp., concn. (reduced pressure), B-compd. soln. (EtOH), after 1 h mixt. partitioning between satd. aq. NH4Cl and Et2O, aq. phase extn. (Et2O), extract drying (MgSO4), concn. (reduced pressure); | 100% |
sodium tetrahydroborate
[(5,7-dimethyl-6-benzyl-1,4,8,11-tetraazacyclotetradeca-4,7-diene)nickel(II)] nitrate iodide
water
Conditions | Yield |
---|---|
In methanol a large excess of NaBH4 was added to a soln. of complex in methanol, themixt. was allowed to stir at room temp. for 2 h, ppt. was filtered off, dissolved in H2O, aq. satd. NaClO4 was added dropwise, cooled; ppt. was filtered, washed with ice-cold water and then ether; elem. anal.; | 100% |
sodium tetrahydroborate
diphenyl[(1S,2R,3S,4R)-3-hydroxymethylbicyclo[2.2.1]heptan-2-yl]tin hydride
Conditions | Yield |
---|---|
In ethanol B-compd. soln. addn. to Sn-compd. soln. at ambient temp., mixt. concn. (reduced pressure) after 30 min, residue partitionation between satd. aq.NH4Cl and Et2O, aq. phase extn. (Et2O), org. extract drying (MgSO4), co ncn. (reduced pressure); | 100% |
sodium tetrahydroborate
1,1,1,3',3',3'-hexafluoro-propanol
Conditions | Yield |
---|---|
In tetrahydrofuran at 0℃; | 100% |
sodium tetrahydroborate
carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II)
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; | 100% |
sodium tetrahydroborate
1,2-dimethoxyethane
5-nitro-2H-tetrazole
B
hydrogen
Conditions | Yield |
---|---|
at 20℃; for 4h; Inert atmosphere; | A 100% B 3.9 mmol |
sodium tetrahydroborate
1,2-dimethoxyethane
5-(trinitromethyl)-2H-tetrazole
B
hydrogen
Conditions | Yield |
---|---|
at 20℃; for 4h; Inert atmosphere; | A 100% B 3.8 mmol |
sodium tetrahydroborate
1,2-dimethoxyethane
5-(fluorodinitromethyl)tetrazole
B
hydrogen
Conditions | Yield |
---|---|
at 20℃; for 4h; Inert atmosphere; | A 100% B 3.7 mmol |
sodium tetrahydroborate
1,2-dimethoxyethane
3,5-dinitro-1H-1,2,4-triazole
B
hydrogen
Conditions | Yield |
---|---|
at 20℃; for 4h; Inert atmosphere; | A 100% B 4.1 mmol |
Conditions | Yield |
---|---|
In 1,2-dimethoxyethane Schlenk technique; Inert atmosphere; | 100% |
In tetrahydrofuran at 20℃; for 0.75h; |
sodium tetrahydroborate
trimethylsilyl cyanide
sodium dicyanodihydridoborate
Conditions | Yield |
---|---|
for 48h; Inert atmosphere; Reflux; | 100% |
sodium tetrahydroborate
Conditions | Yield |
---|---|
With ethanol for 1h; Inert atmosphere; Reflux; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran; benzene-d6 at 20℃; for 1h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With zinc(II) chloride In tetrahydrofuran for 4h; Reagent/catalyst; Reflux; | 99.6% |
Empirical Formula: H4BNa
Molecular Weight: 37.8325 g/mol
Flashing point: 69 °C
Density: 1.07 cm3
Melting point: 400 °C (dec.)
Storage tempreture: Store at RT.
Water solubility: 550 g/L (25 ºC)
Sensitive: Hygroscopic
Appearance: White solid
Structure of Sodium borohydride (CAS NO.16940-66-2):
Product Category of Sodium borohydride (CAS NO.16940-66-2): Inorganic Chemicals;Reduction;Synthetic Organic Chemistry;Typical Metal Compounds;Synthetic Reagents;Reducing Reagents
The compound was discovered in the 1940s by H. I. Schlessinger, who led a team that developed metal borohydrides for wartime applications.
Sodium borohydride (CAS NO.16940-66-2) can be used as reducing agent of aldehyde, ketone, and chloride type , and can be used for the foam in plastic industry, paper bleaching agent, as well as the hydrogenation agent of pharmaceutical industry manufacturing dihydrostreptomycin.
The production likes:
H3BO3+3CH3OH→B(OCH3)3+3H2O
2Na+H2→2NaH
4NaH+B(OCH3)3→NaBH4+3CH3ONa
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LCLo | inhalation | 9mg/m3 (9mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
mouse | LD50 | oral | 50mg/kg (50mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
mouse | LDLo | intraperitoneal | 18mg/kg (18mg/kg) | "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. | |
rabbit | LD50 | oral | 50mg/kg (50mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
rabbit | LD50 | skin | 230mg/kg (230mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
rabbit | LDLo | intraperitoneal | 60mg/kg (60mg/kg) | "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. | |
rabbit | LDLo | subcutaneous | 300mg/kg (300mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
rat | LC50 | inhalation | 36mg/m3 (36mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
rat | LD50 | intraperitoneal | 18mg/kg (18mg/kg) | AMA Archives of Industrial Health. Vol. 17, Pg. 124, 1958. | |
rat | LD50 | oral | 162mg/kg (162mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
rat | LD50 | subcutaneous | 177mg/kg (177mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 177, 1999. |
Sodium borohydride (CAS NO.16940-66-2) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
It is highly corrosive, and will cause burns upon contact with any area of the body.
Hazard Codes: F,T,N,C,Xn
Risk Statements: 60-61-15-34-23/24/25-24/25-35-21/22-51/53-42/43-49-63-62-36/38-43
R15:Contact with water liberates extremely flammable gases.
R21/22:Harmful in contact with skin and if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
R36/38:Irritating to eyes and skin.
R42/43:May cause sensitization by inhalation and skin contact.
R43:May cause sensitization by skin contact.
R49:May cause cancer by inhalation.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R60:May impair fertility.
R61:May cause harm to the unborn child.
Safety Statements: 53-43-45-43A-36/37/39-26-22-50-36/37
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S43:In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S50:Do not mix with ...
S53:Avoid exposure - obtain special instructions before use.
Sodium borohydride , its cas register number is 16940-66-2. It also can be called Sodium tetrahydroborate ; Sodium borotritide ; and Sodium borohydrate . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Sodium borohydride (CAS NO.16940-66-2) could be stable under normal temperatures and pressures. It is not compatible with water, water, acids, alcohols, copper, halogenated agents, iron, sulfuric acid, dimethyl formamide, alkalies, nickel, palladium, aluminum chloride + bis(2-methoxyethyl) ether, diborane + bis(2-methoxyethyl) ether, ruthenium salts, anhydrous acids, polyglycols, dimethylacetamide, metal salts, trichlorosilane, aldehydes, activated carbon, ketones, heavy metals, and you must not take it with high temperatures, incompatible materials, ignition sources, excess heat, temperatures above 220 °C, and should be exposured to moist air or water. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide, oxides of boron, borane, hydrogen gas, sodium oxide.
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