Succinic anhydride supplier

Name
Succinic anhydride
EINECS 203-570-0
CAS No. 108-30-5
Article Data196
CAS DataBase
Density 1.375 g/cm³
Solubility water: <0.1 g/100 mL at 21 oC (decomposes)
Melting Point 118-120 °C(lit.)
Formula C₄H₄O₃
Boiling Point 261 °C at 760 mmHg
Molecular Weight 100.074
Flash Point 122.1 °C
Transport Information
Appearance fine white crystalline solid
Safety 25
Risk Codes 36/37-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Succinicanhydride (8CI);2,5-Diketotetrahydrofuran;Butanedioic anhydride;Dihydro-2,5-furandione;NSC 8518;Rikacid SA;Succinic acid anhydride;Succinylanhydride;Succinyl oxide;Tetrahydro-2,5-dioxofuran;Tetrahydro-2,5-furandione;Succinic anhydride;
PSA 43.37000
LogP -0.15000

Synthetic route

: 108-31-6
maleic anhydride

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With acetic anhydride; zinc In toluene at 40 - 86℃; for 48h; Reagent/catalyst; Inert atmosphere; chemoselective reaction;	100%
With fac-[Mn(1,2-bis(di-isopropylphosphino)ethane)(CO)3(CH2CH2CH3)]; hydrogen In tetrahydrofuran; dichloromethane at 60℃; under 37503.8 Torr; for 24h;	99%
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran for 0.0833333h; Ambient temperature;	96%

: 110-15-6
succinic acid

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With acetic anhydride at 80℃; for 2h;	100%
at 240℃; under 180 Torr; Rate constant; Equilibrium constant; var. temperature, var. pressure;	97%
2,6-bis[(2,2,6,6-tetramethylpiperidin-1-yl)methyl]phenylboronic acid In butryonitrile for 12h; Reflux;	96%

: 201230-82-2
carbon monoxide

: 75-56-9, 16033-71-9
methyloxirane

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With [(tetra(4-chlorophenyl)porphyrinato)aluminium(III)bis(tetrahydrofuran)][tetracarbonylcobaltate] In 1,4-dioxane at 90℃; under 43958.7 Torr; for 3h;	98%

: 108-31-6
maleic anhydride

: WH2(η-cyclopentadienyl)2

A: 108-30-5
succinic acid anhydride

B: (C5H5)2W(C4H2O3)

Conditions

Conditions	Yield
In toluene Irradiation (UV/VIS); (Ar); addn. of maleic anhydride to soln. of W-compd. in toluene portionwise, irradn. (500 W Hg-lamp, 550 nm, 58 h); removal of solid product by centrifugation, recrystn. (CH3CN); elem. anal.;	A 95% B 22%

...Expand

: 638-32-4
succinamic acid

: 18698-97-0
ortho-bromophenylacetic acid

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With nitromethane; copper(l) chloride at 75℃; for 5h; Concentration; Temperature;	91%

: 75-21-8
oxirane

: 201230-82-2
carbon monoxide

A: 108-30-5
succinic acid anhydride

B: 57-57-8
β-Propiolactone

Conditions

Conditions	Yield
Hexamethylbenzene; [(C1TPP)Al][Co(CO)4] In tetrahydrofuran at -78 - 60℃; under 31029.7 Torr; for 3h; Product distribution / selectivity; Molecular sieve; Inert atmosphere;	A 8% B 88%
Hexamethylbenzene; [(C1TPP)Al][Co(CO)4] In tetrahydrofuran at -78 - 60℃; under 31029.7 Torr; for 3h; Product distribution / selectivity; Molecular sieve; Inert atmosphere;	A 13% B 81%
With Hexamethylbenzene; [(tetra(4-chlorophenyl)porphyrinato)aluminium(III)][tetracarbonylcobaltate] In tetrahydrofuran at 60℃; under 31029.7 Torr; for 3h; Glovebox; Inert atmosphere;	A 8 %Spectr. B 88 %Spectr.

...Expand

: 543-20-4
succinoyl dichloride

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With pyridine; 1,1,1-trichloro-3,3,3-trifluoro-propan-2-one; water In toluene for 0.5h; Ambient temperature;	85%
With diethyl ether; sodium acetate
With oxalic acid

: 147-85-3
L-proline

A: 123-56-8
Succinimide

B: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In water for 50h; pH=10; Reflux;	A 81% B 19%

: 108-31-6
maleic anhydride

A: 96-48-0
4-butanolide

B: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With hydrogen at 180℃; under 7500.75 Torr; for 2h; Pressure; Temperature;	A n/a B 79.87%
With hydrogen at 150℃; under 7500.75 Torr;	A n/a B 78.36%
With hydrogen at 250℃; Conversion of starting material;

: 109-99-9
tetrahydrofuran

A: 96-48-0
4-butanolide

B: 50768-69-9
5-hydroxydihydrofuran-2(3H)-one

C: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With 2,6-dichloropyridine N-oxide; dichloro(5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)ruthenium(IV) In 1,2-dichloro-ethane at 40℃; for 20h; Inert atmosphere;	A 69% B 22% C 5%

...Expand

: 75-21-8
oxirane

: 201230-82-2
carbon monoxide

A: 108-30-5
succinic acid anhydride

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
In 1,4-di-tert-butylbenzene at 20 - 80℃; under 10343.2 - 31029.7 Torr; for 0.666667h;	A 62.7% B 7.9%
With [(tetra(4-chlorophenyl)porphyrinato)aluminium(III)bis(tetrahydrofuran)][tetracarbonylcobaltate] at 80℃; under 31029.7 Torr; for 2h; Catalytic behavior; Pressure; Reagent/catalyst; Glovebox; Inert atmosphere;	A 68.8 %Spectr. B 5.4 %Spectr.

...Expand

: (1,2-bis(diphenylphosphino)ethane)Ni(C2H4CO2)

A: 108-30-5
succinic acid anhydride

B: 15793-01-8
Ni(CO)2{1,2-bis(diphenylphosphino)ethane}

Conditions

Conditions	Yield
With carbon monoxide In dichloromethane Schlenk tube contg. CH2Cl2 soln. of educt evacuated and 1 atm of CO introduced; analyzed by GLC, GC-mass, and IR;	A 55% B n/a

: 108-31-6
maleic anhydride

: 625-45-6
2-methoxyacetic acid

A: 108-30-5
succinic acid anhydride

B: (methoxymethyl)succinic anhydride

Conditions

Conditions	Yield
With titanium(IV) oxide In acetonitrile for 18h; UV-irradiation; Inert atmosphere;	A 16% B 54%

...Expand

: 106-97-8
n-butane

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
With triethyl phosphate; water; vanadium-containing catalyst at 393 - 455℃; Gas phase;	51.5%
With vanadium phosphorus oxide supported on TiO2 or SiO2; oxygen at 450℃;
With V-P-Co-O at 450℃; for 8.33333E-05h; Product distribution; Rate constant; various catalysts under different conditions;

: 108-31-6
maleic anhydride

A: 96-48-0
4-butanolide

B: 108-30-5
succinic acid anhydride

C: 71-36-3
butan-1-ol

Conditions

Conditions	Yield
With hydrogen In 1,4-dioxane at 159.84℃; under 37503.8 Torr; Autoclave;	A 49.73% B 35.07% C 12.66%

...Expand

: 50-00-0
formaldehyd

: 106-65-0
Dimethyl succinate

A: 108-30-5
succinic acid anhydride

B: 3878-55-5
methyl hydrogen succinate

C: 616-02-4
citraconic acid anhydride

D: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With gamma-alumina In methanol; water at 380℃; under 3750.38 Torr; Kinetics; Concentration; Temperature; Stobbe Condensation; Autoclave; Flow reactor;	A 8% B 18% C 30% D 10%

...Expand

: 110-88-3
1,3,5-Trioxan

: 3878-55-5
methyl hydrogen succinate

A: 108-30-5
succinic acid anhydride

B: 616-02-4
citraconic acid anhydride

C: 124-38-9
carbon dioxide

D: 106-65-0
Dimethyl succinate

Conditions

Conditions	Yield
With gamma-alumina at 380℃; under 3750.38 Torr; Stobbe Condensation; Autoclave; Flow reactor;	A 9% B 23% C 15% D 30%

...Expand

: 110-88-3
1,3,5-Trioxan

: 106-65-0
Dimethyl succinate

A: 108-30-5
succinic acid anhydride

B: 3878-55-5
methyl hydrogen succinate

C: 616-02-4
citraconic acid anhydride

D: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With gamma-alumina at 380℃; under 3750.38 Torr; Temperature; Pressure; Stobbe Condensation; Autoclave; Flow reactor;	A 8% B 19% C 26% D 18%

...Expand

: 108-31-6
maleic anhydride

: 75-98-9
Trimethylacetic acid

A: 108-30-5
succinic acid anhydride

B: 52685-36-6
2-tert-butylsuccinic anhydride

Conditions

Conditions	Yield
With titanium(IV) oxide In acetonitrile for 26h; UV-irradiation; Inert atmosphere;	A 20% B 16%

...Expand

: 145178-53-6
2,3-bis(trimethylsilyl)-1,3-butadiene-1,4-dione

A: 108-30-5
succinic acid anhydride

B: (Z)-2,3-bis(trimethylsilyl)succinic anhydride

Conditions

Conditions	Yield
With water In acetone at 22℃; for 0.5h;	A n/a B 15%

: 110-86-1
pyridine

: 60-29-7
diethyl ether

: 74-90-8
hydrogen cyanide

: 543-20-4
succinoyl dichloride

A: 108-30-5
succinic acid anhydride

B: 63979-84-0
Succinyl Dicyanide

...Expand

: 108-31-6
maleic anhydride

: 141-78-6
ethyl acetate

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
at 20℃; Hydrogenation;

: 56-23-5
tetrachloromethane

: 123-23-9
peroxydicuccinic acid

A: 108-30-5
succinic acid anhydride

B: 124-04-9
Adipic acid

...Expand

: 67-66-3
chloroform

: 3642-16-8
1,2-diisopropylidene-cyclobutane

A: 1073-91-2
Tetramethyl-[1,2,4,5]tetroxan

B: 108-30-5
succinic acid anhydride

C: 67-64-1
acetone

Conditions

Conditions	Yield
at -20℃; bei der Ozonisation;

...Expand

: 42345-82-4
(E)-1,2-dichloro-1-ethoxy-ethene

: 110-15-6
succinic acid

A: 108-30-5
succinic acid anhydride

B: 105-39-5
chloroacetic acid ethyl ester

...Expand

: 110-15-6
succinic acid

A: 108-30-5
succinic acid anhydride

B: 502-50-1
4-Ketopimelic acid

Conditions

Conditions	Yield
5-6 h Erhitzen der Schmelze; anschliessend Eindampfen mit konz. HCl;

: 14794-31-1
ethyl 3-(chloroformyl)propionate

A: 108-30-5
succinic acid anhydride

B: 75-00-3
chloroethane

Conditions

Conditions	Yield
bei der Destillation unter vermindertem Druck;

: 77341-67-4
L-menthylsuccinic acid

A: 108-30-5
succinic acid anhydride

B: 89-78-1
menthol

Conditions

Conditions	Yield
at 300℃;

: 144-62-7
oxalic acid

: 543-20-4
succinoyl dichloride

: 108-30-5
succinic acid anhydride

: 110-15-6
succinic acid

: 108-24-7
acetic anhydride

: 108-30-5
succinic acid anhydride

Conditions

Conditions	Yield
beim Schuetteln der waessr. Loesung von bernsteinsaurem Natrium;
at 120 - 150℃; unter Druck;

: 123-75-1
pyrrolidine

: 108-30-5
succinic acid anhydride

: 69338-35-8
4-oxo-4-(1-pyrrolidinyl)butanoic acid

Conditions

Conditions	Yield
In acetonitrile at 20℃;	100%
In chloroform for 1h; Heating;	83%
With diethyl ether
Reflux;
In toluene for 2.5h; Reflux;

: 108-30-5
succinic acid anhydride

: 67-56-1
methanol

: 3878-55-5
methyl hydrogen succinate

Conditions

Conditions	Yield
at 20℃;	100%
at 64 - 68℃; for 3.8h;	98.5%
at 70℃; for 2h;	98%

: 108-30-5
succinic acid anhydride

: 143-28-2
oleoyl alcohol

: 20060-41-7
oleyl hemisuccinate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
at 120℃;
In pyridine at 20℃;

: 108-30-5
succinic acid anhydride

: 36653-82-4
1-Hexadecanol

: 50893-80-6
hexadecanol monosuccinate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
With dmap In toluene at 110℃; for 1.5h;	79.4%
With pyridine	42%

: 108-30-5
succinic acid anhydride

: 80-97-7
Cholestanol

: 84597-57-9
succinic acid mono-3β-cholestanyl ester

Conditions

Conditions	Yield
With triethylamine In pyridine; dichloromethane for 144h;	100%
With dmap; triethylamine In ethyl acetate at 95℃; for 5h;	47.8%
With pyridine

: 108-30-5
succinic acid anhydride

: 108-91-8
cyclohexylamine

: 21451-32-1
4-(cyclohexylamine)-4-oxobutanoic acid

Conditions

Conditions	Yield
Stage #1: succinic acid anhydride; cyclohexylamine In N,N-dimethyl acetamide at 20℃; for 24h; Stage #2: In N,N-dimethyl acetamide; xylene at 140℃; for 48h;	100%
In 1,4-dioxane at 80℃; for 0.5h;	90%
In dichloromethane at 20℃; for 0.333333h;	89%

: 108-30-5
succinic acid anhydride

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 39662-45-8
N-<2-(3,4-dimethoxyphenyl)ethyl>succinimide

Conditions

Conditions	Yield
With acetic acid for 24h; Reflux;	100%
Stage #1: succinic acid anhydride; 2-(3,4-dimethoxyphenyl)-ethylamine In ethyl acetate at 20℃; for 0.5h; Stage #2: With acetyl chloride In toluene for 1h; Reflux;	84%
With benzene und Erhitzen des Reaktionsprodukts mit Acetanhydrid unter Zusatz von wenig Pyridin;

: 108-30-5
succinic acid anhydride

: 100-63-0
phenylhydrazine

: 14580-01-9
4-oxo-4-(2-phenylhydrazinyl)butanoic acid

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 24h;	100%
With ethanol

: 108-30-5
succinic acid anhydride

: 114-07-8
erythromycin

: 20057-07-2
2'-O-(3-carboxypropanoyl) erythromycin

Conditions

Conditions	Yield
In acetone at 50℃;	100%
With acetone
With dichloromethane

: 108-30-5
succinic acid anhydride

: 75-64-9
tert-butylamine

: 6622-06-6
4-(tert-butylamino)-4-oxobutanoic acid

Conditions

Conditions	Yield
Stage #1: succinic acid anhydride; tert-butylamine In N,N-dimethyl acetamide at 20℃; for 24h; Stage #2: In N,N-dimethyl acetamide; xylene at 140℃; for 48h;	100%
In dichloromethane at 20℃; for 1h;	52%
Stage #1: succinic acid anhydride; tert-butylamine In dichloromethane at 20℃; for 1h; Stage #2: With sodium hydroxide In water at 20℃; for 2h; Stage #3: With hydrogenchloride In water at 0℃;	52%

: 108-30-5
succinic acid anhydride

: 107-18-6
allyl alcohol

: 3882-09-5
4-(allyloxy)-4-oxobutanoic acid

Conditions

Conditions	Yield
With dmap In toluene for 5h; Heating;	100%
With dmap In toluene for 4h; Heating;	90%
With dmap In toluene for 4h; Reflux;	89%

: 108-30-5
succinic acid anhydride

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 93790-78-4
4-oxo-4-(2-(trimethylsilyl)ethoxy)butanoic acid

Conditions

Conditions	Yield
With dmap; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine In toluene for 1.5h; Heating;	100%
With dmap In toluene for 14h; Reflux;	99%
With pyridine In dichloromethane	81%

: 108-30-5
succinic acid anhydride

: 123-30-8
4-amino-phenol

: 62558-67-2
4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid

Conditions

Conditions	Yield
With sodium dodecyl-sulfate In methanol; water at 20℃; for 0.583333h;	100%
With sodium dodecyl-sulfate In water	87%
In water at 50℃;	86%

Succinic anhydride Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 ,1977,p. 265.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Succinic anhydride Specification

Succinic anhydride, its cas register number is 108-30-5. It also can be called 2,5-Dioxotetrahydrofuran; Dihydro-2,5-diketotetrahydrofuran; Dihydro-2,5-furandione; Butanedioic anhydride; Succinic acid anhydride; Succinyloxide; Tetrahydro-2,5-dioxofuran; and SAA. It is an organic compound with the molecular formula C₄H₄O₃. This colorless solid is the acid anhydride of succinic acid. Succinic anhydride is used as a sizing agent or wet strength additive in paper production.

Physical properties about Succinic anhydride are: (1)ACD/LogP: -0.89; (2)ACD/LogD (pH 5.5): -0.89; (3)ACD/LogD (pH 7.4): -0.89; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 7.81; (7)ACD/KOC (pH 7.4): 7.81; (8)#H bond acceptors: 3; (9)Index of Refraction: 1.47; (10)Molar Refractivity: 20.313 cm³; (11)Molar Volume: 72.755 cm³; (12)Polarizability: 8.053 10-24cm³; (13)Surface Tension: 47.7210006713867 dyne/cm; (14)Density: 1.375 g/cm³; (15)Flash Point: 122.071 °C; (16)Enthalpy of Vaporization: 49.871 kJ/mol; (17)Boiling Point: 260.999 °C at 760 mmHg; (18)Vapour Pressure: 0.0120000001043081 mmHg at 25°C

Preparation of Succinic anhydride: Succinic anhydride has been prepared from succinic acid with phosphorus pentachloride, phosphorus oxychloride, phosphorus pentoxide, thionyl chloride, acetyl chloride, or succinyl chloride; from barium or sodium succinate with benzoyl chloride, acetyl chloride, acetic anhydride, or benzophenone dichloride; from succinyl chloride and oxalic acid or sodium acetate; and from ethyl succinate and benzoyl chloride.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H4O3/c5-3-1-2-4(6)7-3/h1-2H2;
(2)InChIKey=RINCXYDBBGOEEQ-UHFFFAOYSA-N;
(3)SmilesC1(OC(=O)CC1)=O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	1510mg/kg (1510mg/kg)		United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0282-0433,

Product Name

Succinic anhydride

Synthetic route

Succinic anhydride Consensus Reports

Succinic anhydride Specification

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