Sulfosalicylic acid supplier

Name
Sulfosalicylic acid
EINECS 202-555-6
CAS No. 97-05-2
Density 1.771 g/cm³
Solubility 987g/L at 20℃
Melting Point 120 °C
Formula C₇H₆O₆S
Boiling Point 328.86°C (rough estimate)
Molecular Weight 218.187
Flash Point
Transport Information UN 1760
Appearance White to off-white, hygroscopic, crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Salicylicacid, 5-sulfo- (8CI);2-Hydroxy-5-sulfobenzoic acid;3-Carboxy-4-hydroxybenzenesulfonic acid;5-(Hydroxysulfonyl)salicylic acid;5-Sulfosalicylic acid;5-Sulphosalicylic acid;NSC 190565;NSC 4741;SSA;Salicylsulfonic acid;Sulfosalicylic acid;Sulphosalicylic acid;
PSA 120.28000
LogP 1.41790

Synthetic route

: 118-55-8
phenyl Salicylate

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With sulfuric acid

: 69-72-7
salicylic acid

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With sulfuric acid
With sulfur trioxide
With sulfuric acid
With sulfuric acid Abpressen des entstandenen Krystallbreis und Eintragen in gesaettigte Kochsalzloesung;
With chlorosulfonic acid at 160℃; Zersetzung des Produktes mit Wasser;

: 27279-86-3
2-oxo-2H-chromene-6-sulfonic acid

alkaline permanganate solution: alkaline permanganate solution

: 97-05-2
5-sulfosalicylic Acid

: 69089-38-9
2-oxo-2H-chromene-3,6-disulfonic acid

alkaline permanganate solution: alkaline permanganate solution

: 97-05-2
5-sulfosalicylic Acid

: 4-methyl-2-oxo-2H-chromene-6-sulfonic acid

permanganate: permanganate

barytesalkali: barytesalkali

: 97-05-2
5-sulfosalicylic Acid

...Expand

: 4-methyl-2-oxo-2H-chromene-3,6-disulfonic acid

permanganate: permanganate

barytesalkali: barytesalkali

: 97-05-2
5-sulfosalicylic Acid

...Expand

: 118-55-8
phenyl Salicylate

sulfuric acid (excess): sulfuric acid (excess)

: 97-05-2
5-sulfosalicylic Acid

: 7790-94-5
chlorosulfonic acid

: 69-72-7
salicylic acid

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
at 160℃;

: 7664-93-9
sulfuric acid

: 69-72-7
salicylic acid

: 97-05-2
5-sulfosalicylic Acid

: 7446-11-9
sulfur trioxide

: 69-72-7
salicylic acid

: 97-05-2
5-sulfosalicylic Acid

coumarin-disulfonic acid-(3.6): coumarin-disulfonic acid-(3.6)

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With potassium hydroxide; permanganate(VII) ion

coumarin-sulfonic acid-(6): coumarin-sulfonic acid-(6)

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With potassium hydroxide; permanganate(VII) ion

monopotassium-salt of/the/ 6-bromo-3-sulfo-benzoic acid: monopotassium-salt of/the/ 6-bromo-3-sulfo-benzoic acid

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With water; copper; potassium carbonate at 170℃;

monopotassium-salt of/the/ 6-chloro-3-sulfo-benzoic acid: monopotassium-salt of/the/ 6-chloro-3-sulfo-benzoic acid

: 97-05-2
5-sulfosalicylic Acid

Conditions

Conditions	Yield
With water; copper; potassium carbonate at 170℃;

: 25149-61-5
5-sulpho-2-hydroxybenzaldehyde

silver oxide: silver oxide

: 97-05-2
5-sulfosalicylic Acid

: 83957-15-7
2-hydroxy-5-methoxysulfonylbenzoicacid methyl ester

alcoholic KOH-solution: alcoholic KOH-solution

: 97-05-2
5-sulfosalicylic Acid

: 7647-01-0
hydrogenchloride

: 64-17-5
ethanol

: diboric acid-1,2-bis-(2-carboxy-4-sulfo-phenyl ester); disodium salt

A: 13460-50-9
metaboric acid

B: 97-05-2
5-sulfosalicylic Acid

...Expand

: 97-05-2
5-sulfosalicylic Acid

: 50390-26-6
3-bromo-2-hydroxy-5-sulfobenzoic acid

Conditions

Conditions	Yield
With bromine In water	100%
With water; bromine

: 97-05-2
5-sulfosalicylic Acid

: 113665-84-2
(S)-(+)-clopidogrel

: 1010080-15-5
methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate

Conditions

Conditions	Yield
In methanol at 30℃; for 0.5h;	100%
In dichloromethane at 20℃; for 0.5 - 1h; Product distribution / selectivity; Heating / reflux;	100%

: 67-56-1
methanol

: 97-05-2
5-sulfosalicylic Acid

: 92333-05-6
5-sulfosalicylic methyl ester

Conditions

Conditions	Yield
for 18h; Reflux;	100%

: 3858-83-1
p-aminobenzamidine

: 97-05-2
5-sulfosalicylic Acid

: 4-aminobenzamidinium bis(5-sulfosalicylate)monohydrate

Conditions

Conditions	Yield
With water In methanol	95%

: 24016-03-3
2-amino-3-benzyloxypyridine

: 97-05-2
5-sulfosalicylic Acid

: C12H12N2O*C7H6O6S

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	95%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 97-05-2
5-sulfosalicylic Acid

: 60473-74-7
2-Hydroxy-5-sulfo-benzoic acid; compound with 1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione

Conditions

Conditions	Yield
In methanol; water at 20℃; for 0.5h;	94.36%

: 142-71-2
copper diacetate

: 111-40-0
1,5-diamino-3-azapentane

: 97-05-2
5-sulfosalicylic Acid

: Cu(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*6H2O = Cu[(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*6H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:2:2; refluxing (2 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	94%

...Expand

: 2588-88-7
pentaphenylphosphorane

: 97-05-2
5-sulfosalicylic Acid

: tetraphenylphosphonium sulfosalicylate

Conditions

Conditions	Yield
In benzene at 80℃; for 0.166667h;	93%

: 97-05-2
5-sulfosalicylic Acid

: 21901-29-1
6-amino-5-nitro-2-picoline

: C6H7N3O2*C7H6O6S

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	93%

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: 111-40-0
1,5-diamino-3-azapentane

: 97-05-2
5-sulfosalicylic Acid

: Ni(2+)*2(O3SC6H3OCOO)Ni(C4H13N3)(H2O)(1-)*6H2O = Ni[(O3SC6H3OCOO)Ni(C4H13N3)(H2O)]2*6H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ni-salt/triamine/salicylic acid molar ratio 3:2:2; refluxing (2.5 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	92%

...Expand

: 142-71-2
copper diacetate

: 111-40-0
1,5-diamino-3-azapentane

: 97-05-2
5-sulfosalicylic Acid

: Cu(C4H13N3)(H2O)3(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*5H2O = [Cu(C4H13N3)(H2O)3][(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*5H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:3:2; refluxing; recrystn. (water), drying (room temp., red. pressure); elem. anal.;	92%

...Expand

: 97-05-2
5-sulfosalicylic Acid

: 129722-12-9
aripiprazole

: 1246273-26-6
7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone 5-sulfosalicylate

Conditions

Conditions	Yield
In chloroform for 2h; Product distribution / selectivity; Reflux;	91%

: 2170-05-0
pentaphenylantimony

: 97-05-2
5-sulfosalicylic Acid

: 194939-13-4
tetraphenylstibonium sulfosalicylate

Conditions

Conditions	Yield
In ethanol; toluene byproducts: C6H6; room temp., several min; evapn., recrystn. (ethanol-water, 5:1);	90.6%

: 2170-05-0
pentaphenylantimony

: 97-05-2
5-sulfosalicylic Acid

: 194939-13-4
5-(tetraphenylantimoniooxysulfonyl)salicylic acid

Conditions

Conditions	Yield
In ethanol; toluene soln. of Sb-compd. in toluene addn. to ethanolic soln. of acid, standingat room temperature for few minutes; solvent removing, residue re-crystn. (ethanol-water);	90.6%

: 142-71-2
copper diacetate

: 111-40-0
1,5-diamino-3-azapentane

: 97-05-2
5-sulfosalicylic Acid

: Cu(C4H13N3)2(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*10H2O = [Cu(C4H13N3)2][(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*10H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:4:2; refluxing (2 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	90%

...Expand

: 106-58-1
N,N'-dimethylpiperazine

: 97-05-2
5-sulfosalicylic Acid

: 0.5C6H14N2*C7H6O6S

Conditions

Conditions	Yield
In water	90%

: terbium

: 97-05-2
5-sulfosalicylic Acid

: terbium(III)(5-sulfosalicylate)3

Conditions

Conditions	Yield
In acetonitrile at 30℃; Inert atmosphere; Sealed tube; Electrochemical reaction; Sonication;	90%

: gadolinium

: 97-05-2
5-sulfosalicylic Acid

: gadolinium(III)(5-sulfosalicylate)3

Conditions

Conditions	Yield
In acetonitrile at 30℃; Inert atmosphere; Sealed tube; Electrochemical reaction; Sonication;	90%

: 16867-03-1
2-amino-3-hydroxypyridine

: 97-05-2
5-sulfosalicylic Acid

: C5H6N2O*C7H6O6S

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	90%

: manganese(II) perchlorate hexahydrate

: 60911-04-8
copper(II) 2,3-dioxo-5,6,14,15-dibenzo-1,4,8,12-tetraazacyclopentadeca-7,13-dien

: 7732-18-5
water

: 97-05-2
5-sulfosalicylic Acid

: Mn(III)Mn(II)2(5-sulfosalicylate(3-))2(Cu(II)(2,3-dioxo-5,6,14,15-dibenzo-1,4,8,12-tetraazacyclopentadeca-7,13-diene))2(OH)(H2O)3

Conditions

Conditions	Yield
With NaOH; air In methanol; water High Pressure; under hydrothermal conditions; mixt. of Mn salt, 5-sulfosalicylic acid, Cu complex, H2O and MeOH stirred at room temp. for 40 min; pH adjusted to 7-8 (1M NaOH); heated at 160°C for 72 h; cooled to room temp. for 36 h; crystals isolated by filtration; washed with H2O; elem. anal.;	89.5%

...Expand

: 142-71-2
copper diacetate

: 97-05-2
5-sulfosalicylic Acid

: Cu(2+)*2(O3SC6H3OCOO)Cu(H2O)4(1-)*8H2O = Cu[(O3SC6H3OCOO)Cu(H2O)4]2*8H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/salicylic acid molar ratio 3:2; refluxing (1 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	89%

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: 111-40-0
1,5-diamino-3-azapentane

: 97-05-2
5-sulfosalicylic Acid

: Ni(C4H13N3)(H2O)3(2+)*2(O3SC6H3OCOO)Ni(C4H13N3)(H2O)(1-)*5H2O = [Ni(C4H13N3)(H2O)3][(O3SC6H3OCOO)Ni(C4H13N3)(H2O)]2*5H2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ni-salt/triamine/salicylic acid molar ratio 3:3:2; refluxing (2.5 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	88%

...Expand

: 29604-34-0
zinc(II) chloride tetrahydrate

: 7732-18-5
water

: 97-05-2
5-sulfosalicylic Acid

: Zn(2+)*2C7H5O6S(1-)*9.1H2O

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; for 24h; Sealed tube; High pressure;	88%

...Expand

: 4214-75-9
2-amino-3-nitropyridine

: 97-05-2
5-sulfosalicylic Acid

: C5H5N3O2*C7H6O6S

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	88%

: 3314-32-7
1,2-bis(1H-benzo[d]imidazol-2-yl)ethane-1,2-diol

: 97-05-2
5-sulfosalicylic Acid

: C16H14N4O2*2H2O*C7H6O6S

Conditions

Conditions	Yield
With water In methanol; ethanol at 20℃;	87.51%

: 598-41-4
H-Gly-NH2

: 97-05-2
5-sulfosalicylic Acid

: 1336437-67-2
glycinamide 5-sulfosalicylate

Conditions

Conditions	Yield
In methanol; water	87%

: 6635-86-5
2-amino-4-methyl-3-nitropyridine

: 97-05-2
5-sulfosalicylic Acid

: C6H7N3O2*C7H6O6S

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	87%

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 5743-04-4
cadmium(II) acetate dihydrate

: 97-05-2
5-sulfosalicylic Acid

: Cd(3,5-dimethylpyrazole)2(5-sulfosalicylate)2

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	86.4%

...Expand

: 2170-05-0
pentaphenylantimony

: 97-05-2
5-sulfosalicylic Acid

: bis(tetraphenylstibonium) sulfosalicylate

Conditions

Conditions	Yield
In ethanol; toluene byproducts: C6H6; molar ratio Sb-compd./org. sulfonate 2/1; room temp., several min; evapn., recrystn. (ethanol-water, 5:1);	86%

: 59538-92-0
dichloro(phthalocyaninato)zirconium(IV)

: 97-05-2
5-sulfosalicylic Acid

: 380368-10-5
phthalocyanine Zr(IV) 5-sulfosalicylic acid

Conditions

Conditions	Yield
In further solvent(s) byproducts: HCl; Zr-compd. suspended in 1-heptanol, 5-sulfosalicylic acid added, heated at 170°C for 8 h; filtered, hexane added, cooled, filtered, washed with excess of hexane, dried in air, dried in vac. at 60°C for 8 h;	86%

Sulfosalicylic acid Chemical Properties

Empirical Formula: C₇H₆O₆S
Molecular Weight: 218.1839
EINECS: 202-555-6
Index of Refraction: 1.649
Density: 1.771 g/cm³
Melting point: 120 °C
Appearance: White crystal or crystalline powder
Solubility: Soluble in water and Ethanol, soluble in Ether
Structure of 5-Sulphosalicylic acid (CAS NO.97-05-2):

Sulfosalicylic acid Uses

5-Sulphosalicylic acid (CAS NO.97-05-2) can be used as a pharmaceutical intermediate, and has been used in medicine doxycycline and A production of rare earth mycin.

Sulfosalicylic acid Production

5-Sulphosalicylic acid (CAS NO.97-05-2) can be derived from salicylic acid obtained by sulfonation.

Sulfosalicylic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LDLo	oral	1300mg/kg (1300mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 565, 1969.
rabbit	LDLo	skin	7940mg/kg (7940mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: FOOD INTAKE (ANIMAL)	National Technical Information Service. Vol. OTS0570587,
rat	LD50	oral	1850mg/kg (1850mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0570587,

Sulfosalicylic acid Consensus Reports

Reported in EPA TSCA Inventory.

Sulfosalicylic acid Safety Profile

Moderately toxic by ingestion. Irritating to skin and mucous membranes. When heated to decomposition it emits toxic fumes of SO_x. See also SULFONATES.

Sulfosalicylic acid Specification

5-Sulphosalicylic acid ,its cas register number is 97-05-2. It also can be called 2-Hydroxy-5-sulfo-benzoic acid ; Benzoic acid, 2-hydroxy-5-sulfo- and Sulfosalicylic acid . 2 - hydroxy -5 - methyl-benzoic acid dihydrate is a white crystal or crystalline powder.

Product Name

Sulfosalicylic acid

Synthetic route

Sulfosalicylic acid Chemical Properties

Sulfosalicylic acid Uses

Sulfosalicylic acid Production

Sulfosalicylic acid Toxicity Data With Reference

Sulfosalicylic acid Consensus Reports

Sulfosalicylic acid Safety Profile

Sulfosalicylic acid Specification

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