THIOCARBOHYDRAZIDE supplier

Name
Thiocarbohydrazide
EINECS 218-769-8
CAS No. 2231-57-4
Article Data61
CAS DataBase
Density 1.415 g/cm³
Solubility
Melting Point 171-174 °C (dec.)(lit.)
Formula CH₆N₄S
Boiling Point 230.1 °C at 760 mmHg
Molecular Weight 106.151
Flash Point 93 °C
Transport Information UN 2811 6.1/PG 1
Appearance white to grey-beige crystalline powder
Safety 28-36/37/39-45-38-36/37-28A-1
Risk Codes 5-26/28-36/38-21
Molecular Structure
Hazard Symbols T+
Synonyms Carbohydrazide,thio- (6CI,7CI,8CI);1,3-Diamino-2-thiourea;Hydrazinecarbohydrazonothioicacid;NSC 689;TCH;Thiocarbazide;Carbonothioicdihydrazide;Thiocarbonicdihydrazide;Thiocarbonohydrazide;
PSA 108.19000
LogP 0.38030

Synthetic route

: 75-15-0
carbon disulfide

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With hydrazine In water at 20℃; for 0.333333h; Green chemistry;	98%
With hydrazine hydrate	89%
With hydrazine hydrate In water at 90℃; for 1h;	83.7%

: 75-15-0
carbon disulfide

: 302-01-2
hydrazine

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
In water at 20℃; for 0.166667h; Green chemistry;	98%

: 16022-57-4
ethyl piperidine-1-carbodithioate

A: 21198-50-5
piperidine-1-carbothioic acid hydrazide

B: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 16022-57-4
ethyl piperidine-1-carbodithioate

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 463-71-8
thiophosgene

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With diethyl ether; hydrazine hydrate
With hydrazine hydrate

: 623-79-0
O,S-Diethyl dithiocarbonate

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 140-89-6
potassium ethyl xanthogenate

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 37527-08-5
O-tert-butyl S-methyl carbonodithioate

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With hydrazine

: Sodium; hydrazinothiocarbonylsulfanyl-acetate

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With hydrazine hydrate Yield given;

hydrazinedithiocarboxylate hydrazine: hydrazinedithiocarboxylate hydrazine

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With water; lead(II) oxide

: 463-71-8
thiophosgene

: 60-29-7
diethyl ether

: 7803-57-8
hydrazine hydrate

: 2231-57-4
Thiocarbohydrazide

...Expand

: 64-17-5
ethanol

: 623-79-0
O,S-Diethyl dithiocarbonate

: 7803-57-8
hydrazine hydrate

A: 2231-57-4
Thiocarbohydrazide

B: 75-08-1
ethanethiol

...Expand

: 7732-18-5
water

: 20469-71-0
dithiocarbonic acid hydrazide, hydrazonium salt

A: 7783-06-4
hydrogen sulfide

B: 7664-41-7
ammonia

C: 2231-57-4
Thiocarbohydrazide

D sulfur: sulfur

...Expand

: 7732-18-5
water

: 20469-71-0
dithiocarbonic acid hydrazide, hydrazonium salt

lead oxide: lead oxide

A: 7783-06-4
hydrogen sulfide

B: 7664-41-7
ammonia

C: 2231-57-4
Thiocarbohydrazide

D sulfur: sulfur

...Expand

: 17356-08-0
thiourea

: 627-70-3
propan-2-one azine

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With water at 100 - 120℃; Green chemistry;	203.8 g

: 7803-57-8
hydrazine hydrate

: 17356-08-0
thiourea

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With ammonia at 100℃; Temperature;	98.6 g

: C3H6N3O2S(1-)*Na(1+)

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With hydrazine hydrate

: 471-32-9
dithiocarbonic acid hydrazide

: 2231-57-4
Thiocarbohydrazide

Conditions

Conditions	Yield
With hydrazine In water
With hydrazine hydrate In water for 0.75h; Reflux;	10.6 g

: 3949-36-8
3-acetylcoumarin

: 2231-57-4
Thiocarbohydrazide

: C23H18N4O4S

Conditions

Conditions	Yield
In ethanol; water for 6h; Reflux;	100%

: 727-80-0
3-acetylbenzo[f]coumarin

: 2231-57-4
Thiocarbohydrazide

: C31H22N4O4S

Conditions

Conditions	Yield
In ethanol; water for 6h; Reflux;	100%

: 2231-57-4
Thiocarbohydrazide

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 78382-05-5
1-(4-methoxyphenyl)ethylidenethiocarbonohydrazide

Conditions

Conditions	Yield
In methanol; water at 20℃; for 12h;	99.1%
With acetic acid In ethanol at 50 - 80℃; for 3h;	75%

: 64-19-7
acetic acid

: 2231-57-4
Thiocarbohydrazide

: 20939-15-5
3-methyl-4-amino-5-mercapto-1,2,4-triazole

Conditions

Conditions	Yield
Reflux; Dean-Stark; Inert atmosphere;	99%
at 160 - 170℃; for 0.25h;	91%
at 118℃; for 4h;	81%

: 10025-91-9
antimony(III) chloride

: 2231-57-4
Thiocarbohydrazide

: 90981-52-5
trichloro-thiocarbohydrazide-antimony

Conditions

Conditions	Yield
In benzene ligand soln. added to SbCl3 soln. in molar ratio 1/1, refluxed for 10 h; filtered, washed with anhyd. alc., dried (vac.) at 35°C; elem. anal.;	98%

: 2231-57-4
Thiocarbohydrazide

: 2-oxo-4-(2-thienyl)but-3-enoic acid

: 649573-14-8
4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one

Conditions

Conditions	Yield
With silica gel In methanol; dichloromethane Microwave irradiation;	98%
With silica gel Microwave irradiation;	98%

: 51751-34-9
4-hydroxycoumarin-3-carboxaldehyde

: 2231-57-4
Thiocarbohydrazide

: 1334670-55-1
4-hydroxycoumarin-3-thiocarbohydrazone

Conditions

Conditions	Yield
In ethanol; water for 1h; Heating;	98%

: 2231-57-4
Thiocarbohydrazide

: 1676-63-7
4'-ethoxyacetophenone

: 78382-06-6
C11H16N4OS

Conditions

Conditions	Yield
In methanol; water at 20℃; for 12h;	97.6%

: 1122-62-9
2-acetylpyridine

: 2231-57-4
Thiocarbohydrazide

: 96699-87-5
methyl 2-pyridyl ketone thiocarbonohydrazone

Conditions

Conditions	Yield
In methanol Heating;	97%
With acetic acid In methanol for 2h; Heating;	80%

: 64-19-7
acetic acid

: 2231-57-4
Thiocarbohydrazide

: 20939-15-5
4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione

Conditions

Conditions	Yield
Heating;	97%
at 120℃;	91%
In ethanol for 4h; Reflux;	85%

: 123-11-5
4-methoxy-benzaldehyde

: 2231-57-4
Thiocarbohydrazide

: 7147-50-4
N,N-bis[(4-methoxyphenyl)methylidene]carbothioic dihydrazide

Conditions

Conditions	Yield
In ethanol; water at 70 - 80℃; for 3h;	97%
With acetic acid In ethanol Reflux;	83%
In ethanol Heating;

: 141-78-6
ethyl acetate

: 2231-57-4
Thiocarbohydrazide

: 20939-15-5
4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione

Conditions

Conditions	Yield
With iron oxide In ethanol; water Reflux; Green chemistry;	97%
With sodium methylate In methanol for 24h; Heating;	77%

: 10025-91-9
antimony(III) chloride

: 2231-57-4
Thiocarbohydrazide

: dichloro-bis(thiocarbohydrazide)-antimony chloride

Conditions

Conditions	Yield
In benzene ligand soln. added to SbCl3 soln. in molar ratio 2/1, refluxed for 10 h; filtered, washed with anhyd. alc., dried (vac.) at 35°C; elem. anal.;	97%

: 100-52-7
benzaldehyde

: 2231-57-4
Thiocarbohydrazide

: 6956-33-8
dibenzylidenethiocarbohydrazide

Conditions

Conditions	Yield
In ethanol 1a) reflux, 3 h, 1b) glacial acetic acid, room temp., overnight;	96%
With acetic acid In ethanol Reflux;	74%
In ethanol 1. 30 min, reflux 2. 2 h, room temperature;	70%

: 2457-50-3
2-acetylpyridine N-oxide

: 2231-57-4
Thiocarbohydrazide

: 140835-37-6
2-acetylpyridine thiocarbonohydrazone 1-oxide

Conditions

Conditions	Yield
In methanol for 3h; Heating;	96%

: 82645-25-8
1,8-bis(2-formylphenoxy)3,6-dioxaoctane

: 2231-57-4
Thiocarbohydrazide

: 96323-70-5
11,12:20,21-dibenzo-1,4,7,10-tetraoxa-14,15,17,18-tetra-azacycloheneicosa-13,18-diene-16-thione

Conditions

Conditions	Yield
With aluminium trichloride In ethanol; water at 20℃;	96%
With aluminium trichloride In ethanol; water at 20 - 25℃;	96%

: 55-22-1
pyridine-4-carboxylic acid

: 2231-57-4
Thiocarbohydrazide

: 36209-51-5
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

Conditions

Conditions	Yield
Heating;	96%

: 2231-57-4
Thiocarbohydrazide

: 67-64-1
acetone

: 879-18-5
naphthalene-1-carbonic acid chloride

: 1234360-54-3
C15H16N4OS

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 20℃; for 3.58333h; Reflux;	96%

...Expand

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 2231-57-4
Thiocarbohydrazide

: C11H16N4O3S

Conditions

Conditions	Yield
With acetic acid In ethanol; water for 4h; Reflux;	96%

: 623-27-8
terephthalaldehyde,

: 2231-57-4
Thiocarbohydrazide

: C10H14N8S2

Conditions

Conditions	Yield
With acetic acid In ethanol for 5h; Reflux;	96%

: 104-88-1
4-chlorobenzaldehyde

: 2231-57-4
Thiocarbohydrazide

: 6340-16-5
N1,N5-di(p-chlorobenzylidene)thiocarbohydrazide

Conditions

Conditions	Yield
In ethanol 1a) reflux, 3 h, 1b) glacial acetic acid, room temp., overnight;	95%
With ethanol
With acetic acid In ethanol; water for 1h; Heating;

: 90-02-8
salicylaldehyde

: 2231-57-4
Thiocarbohydrazide

: 6327-27-1
N′,2-bis((E)-2- hydroxybenzylidene)hydrazine-1-carbothiohydrazide

Conditions

Conditions	Yield
In ethanol 1a) reflux, 3 h, 1b) glacial acetic acid, room temp., overnight;	95%
In ethanol for 3h; Reflux;	65%
With ethanol

: 82645-24-7
1,5-bis(benzaldehydeoxy)-3-oxopentane

: 2231-57-4
Thiocarbohydrazide

: 102821-95-4
8,9:17,18-dibenzo-1,4,7-trioxa-11,12,14,15-tetraazacyclooctadecane-10,15-diene-13-thione

Conditions

Conditions	Yield
With aluminium trichloride In ethanol; water at 20 - 25℃;	95%
In ethanol; water 1.) 45 deg C to 50 deg C, 0.5 h, 2.) 20 deg C, 1 h;	72%

: 2231-57-4
Thiocarbohydrazide

: 502-42-1
cycloheptanone

: 106659-18-1
8,9,11,12-Tetraazaspiro<5.6>dodecane-10-thione

Conditions

Conditions	Yield
In ethanol; water for 0.0138889h; Microwave irradiation;	95%
In ethanol; water Heating;	85%
In ethanol; water	80%

: 503-74-2
3-methylbutyric acid

: 2231-57-4
Thiocarbohydrazide

: 31821-71-3
4-amino-5-isobutyl-2,4-dihydro-[1,2,4]triazole-3-thione

Conditions

Conditions	Yield
at 160 - 170℃; for 0.25h;	95%
at 160 - 170℃; for 0.25h;	85%
Reflux;

: 2231-57-4
Thiocarbohydrazide

: 99-94-5
p-Toluic acid

: 13229-01-1
3-(4-methylphenyl)-4-amino-5-mercapto-1,2,4-triazole

Conditions

Conditions	Yield
at 160 - 170℃; for 0.25h;	95%

: 2231-57-4
Thiocarbohydrazide

: 1821-12-1
4-Phenylbutyric acid

: 193743-96-3
4-Amino-5-(3-phenyl-propyl)-4H-[1,2,4]triazole-3-thiol

Conditions

Conditions	Yield
at 160 - 170℃; for 0.25h;	95%
at 160 - 170℃; for 0.25h;	89%

: 2231-57-4
Thiocarbohydrazide

: 23442-14-0
4-aminophenacyl bromide

: 2-hydrazino-5-(p-aminophenyl)-1,3,4-thiadiazine

Conditions

Conditions	Yield
With potassium carbonate In methanol for 0.0444444h; pH=11; microwave irradiation;	95%

THIOCARBOHYDRAZIDE Chemical Properties

IUPAC Name:1,3-Diaminothiourea (2231-57-4)
Synonyms: Aurora 1561 ; Carbonothioic dihydrazide ; Tch ; Thiocarbonohydrazide ; Thiocarbonyldihydrazide ;Tthiocarbazide ;Thiocarbohydrazide ;Thiocarbohydrazide, for electron microsc opy .
CAS: 2231-57-4
MF: CH₆N₄S
MW: 106.15
EINECS: 218-769-8
MS:
Mol File: 2231-57-4.mol
Surface Tension: 92.2 dyne/cm
Density: 1.415 g/cm³
Flash Point: 93 °C
Melting point: 171-174 °C (dec.)(lit.)
Enthalpy of Vaporization: 46.67 kJ/mol
Boiling Point: 230.1 °C at 760 mmHg
Vapour Pressure: 0.067 mmHg at 25°C
Storage temp: Poison room
Sensitive: Light Sensitive
BRN : 506657

THIOCARBOHYDRAZIDE Uses

Thiocarbohydrazide (2231-57-4) is widely used in organic synthesis and important raw materials of Metribuzin of highly efficient broad-spectrum herbicide .

THIOCARBOHYDRAZIDE Production

Preparation method of Thiocarbohydrazide (2231-57-4):add carbon disulfide into the reactor,then with cooling and stirring, add hydrazine hydrate dropwisly, and then warming up to remove off hydrogen sulfide gas. hydrogen sulfide with absorption of alkali to form sodium sulfide, after cooling of reaction solution then derive crystallization.by the way of filtration, washing, filtrate can be used as mother liquor cycle to apply. Then get Thiocarbohydrazide (2231-57-4) by washing the filter cake.

THIOCARBOHYDRAZIDE Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	8200ug/kg (8.2mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994.
mouse	LD50	intraperitoneal	5mg/kg (5mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	6mg/kg (6mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994.
rat	LC50	inhalation	50mg/m3/4H (50mg/m3)	peripheral nerve and sensation: fasciculations behavioral: somnolence (general depressed activity) behavioral: muscle contraction or spasticity)	National Technical Information Service. Vol. OTS0555465,
rat	LD50	oral	21600ug/kg (21.6mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994.
rat	LD50	skin	> 500mg/kg (500mg/kg)	behavioral: somnolence (general depressed activity)	National Technical Information Service. Vol. OTS0555465,

THIOCARBOHYDRAZIDE Safety Profile

Hazard Codes: T+
Risk Statements : 5-21-26/28-36/38
5: Heating may cause an explosion
21: Harmful in contact with skin
26/28: Very Toxic by inhalation and if swallowed
36/38: Irritating to eyes and skin
Safety Statements: 36/37/39-45-38-28A-1
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
38: In case of insufficient ventilation, wear suitable respiratory equipment
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
1: Keep locked up
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS : FF2975000
F: 4.4-8
HazardClass: 6.1
PackingGroup: I

THIOCARBOHYDRAZIDE Specification

1.Chemical Properties:Thiocarbohydrazide (2231-57-4) is white to grey-beige crystalline powder
2.General Description: Crystalline needles and plates. Used in electron microscopy to produce electron-opaque deposits for ultra structural analysis.
3.Reactivity Profile :Thiocarbohydrazide is a thioamide, which may behave as a weak base and therefore will react with acids forming salts with production of heat. Thiocarbohydrazide may react with acids and reducing agents to form toxic hydrogen sulfide gas. This may be vigorous depending on the nature of the reducing agent. Organic amides/imides react with azo and diazo compounds to generate toxic gases. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
4.Health Hazard :High oral toxicity.
5.Fire Hazard: When heated to decomposition Thiocarbohydrazide emits very toxic fumes of nitrogen oxides and sulfur oxides.

Product Name

Thiocarbohydrazide

Synthetic route

THIOCARBOHYDRAZIDE Chemical Properties

THIOCARBOHYDRAZIDE Uses

THIOCARBOHYDRAZIDE Production

THIOCARBOHYDRAZIDE Toxicity Data With Reference

THIOCARBOHYDRAZIDE Safety Profile

THIOCARBOHYDRAZIDE Specification

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