Tetramethyl orthosilicate supplier

Name
Tetramethyl orthosilicate
EINECS 211-656-4
CAS No. 681-84-5
Article Data121
CAS DataBase
Density 0.977 g/cm³
Solubility hydrolysis in water
Melting Point -4 °C(lit.)
Formula C₄H₁₂O₄Si
Boiling Point 121.207 °C at 760 mmHg
Molecular Weight 152.222
Flash Point 28.889 °C
Transport Information UN 2606 6.1/PG 1
Appearance Colorless transparent liquid
Safety 16-26-36/37/39-45-28A
Risk Codes 10-26-37/38-41
Molecular Structure
Hazard Symbols T+
Synonyms Methylsilicate ((MeO)4Si) (6CI);Dynasil M;Methyl Silicate 28;Methyl Silicate 39;Methyl orthosilicate;Methyl silicate((CH3)4SiO4);Silane, tetramethoxy-;Siliconmethoxide (Si(OMe)4);Silicon tetramethoxide;Siluplex;Tetramethoxysilane;Tetramethyl silicate;Methyl silicate;
PSA 36.92000
LogP 0.00760

Synthetic route

: 67-56-1
methanol

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With amorphous silicon In hexane at 20℃; Temperature; Solvent; Inert atmosphere; Schlenk technique; Cooling with ice;	98%
With nickel(II) sulphate; tetrachlorosilane; trichlorosilane In tetrachloromethane at 55 - 60℃; for 3h; Large scale;	96.8%
Stage #1: methanol With iodine; silicon tetrafluoride; aluminium at 37℃; for 2.5h; Stage #2: at 40℃; for 2.5h; Reflux;	86%

: 67-56-1
methanol

: 7783-61-1
silicon tetrafluoride

: 7439-95-4
magnesium

A: magnesium fluoride

B: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
Stage #1: methanol; magnesium With iodine at 20℃; for 1.5h; Inert atmosphere; Reflux; Stage #2: silicon tetrafluoride Inert atmosphere; Stage #3: at 300℃; for 2h; Catalytic behavior; Reagent/catalyst; Temperature; Calcination;	A 98% B 85%
Stage #1: methanol; magnesium at 20℃; for 3h; Stage #2: silicon tetrafluoride at 20℃; for 0.5h; Temperature;

...Expand

: 7783-61-1
silicon tetrafluoride

A: ammonium hexafluorosilicate

B: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With CH3OH; NH3 In methanol introduction of NH3 into CH3OH in absence of air; introduction of SiF4;; filtration; distn. of the filtrate;;	A n/a B 95%
With methanol; ammonia In methanol introduction of NH3 into CH3OH in absence of air; introduction of SiF4;; filtration; distn. of the filtrate;;	A n/a B 95%

: 5625-96-7
(morpholinomethyl)hydrosilane

: 67-56-1
methanol

A: 109-02-4
4-methyl-morpholine

B: 681-84-5
tetramethylorthosilicate

C: 154206-90-3
α-morpholine methyltrimethoxysilane

Conditions

Conditions	Yield
In neat (no solvent) at 0 - 5℃; for 5h; Mechanism; Inert atmosphere;	A 5.5% B 5.5% C 90%

...Expand

: 10026-04-7, 53609-55-5
tetrachlorosilane

: 624-91-9
methyl nitrite

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
SiCl4 and a small excess of methylnitrite in absence of moisture under cooling; slow heating at about 120°C;;	80%

: 10026-04-7, 53609-55-5
tetrachlorosilane

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With methanol In methanol fast addn. of SiCl4 to a small excess of CH3OH (ice bath);; fractional distn.;;	80%
With CH3OH SiCl4 and CH3OH in presence of CH3COONa;;	80%
With CH3OH In methanol fast addn. of SiCl4 to a small excess of CH3OH (ice bath);; fractional distn.;;	80%

: 67-56-1
methanol

: 102-71-6
triethanolamine

A: 681-84-5
tetramethylorthosilicate

B: 2C6H15NO3*F6Si(2-)*2H(1+)

Conditions

Conditions	Yield
Stage #1: methanol With Hexafluoropropene oxide at 20℃; Stage #2: triethanolamine In methanol for 1h;	A n/a B 71%

...Expand

: 67-56-1
methanol

A: 681-84-5
tetramethylorthosilicate

B: 4371-91-9
hexamethoxydisiloxane

Conditions

Conditions	Yield
With copper(l) chloride; silicon at 250℃; under 159611 Torr; for 3h; Temperature; Pressure; Autoclave;	A 70% B n/a

: 7440-21-3
silicon

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With methanol In neat (no solvent) heating of Si at 1050°C in H2-atm. for 2 h in presence of Cu-oxide, Cu-halide or Cu-nitrate; dropwise addn. of CH3OH at 300°C;;	50%
With methanol; copper In neat (no solvent) heating of Cu and Si at 1050°C in H2-atm. for 2 h; dropwise addn. of CH3OH at 300°C;;	50%
With CH3OH; copper In neat (no solvent) heating of Cu and Si at 1050°C in H2-atm. for 2 h; dropwise addn. of CH3OH at 300°C;;	50%

: 67-56-1
methanol

: 29167-65-5
tris(silatranyloxyethyl)amine

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With hydrogenchloride	38%

: 67-56-1
methanol

A: 2487-90-3
trimethoxysilane

B: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With amorphous silicon In paraffin oil at 300℃; for 6h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique;	A 24% B 21%
With copper; silicon at 259.9℃; under 742.6 Torr; for 5h; Product distribution; preheating at 623 K for 3 h; other reaction times, temperatures, and partial pressures;
With copper(l) chloride; silicon at 219.9℃; under 442.5 Torr; Kinetics; temperature- and pressure dependence;

: 67-56-1
methanol

A: 2487-90-3
trimethoxysilane

B: 681-84-5
tetramethylorthosilicate

C: 5314-52-3
dimethoxysilane

D: 16881-77-9
(dimethoxy)methylsilane

Conditions

Conditions	Yield
With thiophene; silicon grains; copper(l) chloride at 379.85℃; under 315.025 Torr;	A n/a B n/a C n/a D 10%
With thiophene; silicon grains; copper(l) chloride at 379.85 - 449.85℃; under 315.025 Torr; for 3h;

...Expand

: 67-56-1
methanol

: 3410-77-3
tetraisocyanatosilane

A: 681-84-5
tetramethylorthosilicate

B: 18147-89-2
silicon dimethoxy diisocyanate

C: 18169-84-1
silicon trimethoxy isocyanate

D: 5578-37-0
silicon methoxy triisocyanate

Conditions

Conditions	Yield
at 25℃;

...Expand

: 624-91-9
methyl nitrite

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With tetrachlorosilane dann Erhitzen auf 120grad;

: 18135-11-0
phosphoric acid dimethyl ester-trimethoxysilanyl ester

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
beim Erwaermen im Hochvakuum;

: 67-56-1
methanol

: 562-90-3
tetraacetoxysilane

: 681-84-5
tetramethylorthosilicate

: 2768-02-7
(vinyl)trimethoxylsilane

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

A: 681-84-5
tetramethylorthosilicate

: trans-1-Methoxy-2-(trimethoxysilyl)-cyclopropan

: cis-1-Methoxy-2-(trimethoxysilyl)-cyclopropan

Conditions

Conditions	Yield
at 125℃;

...Expand

: 590-18-1
(Z)-2-Butene

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

A: 681-84-5
tetramethylorthosilicate

B: 2988-72-9
r-1-methoxy-c-2,c-3-dimethylcyclopropane

C: 2988-73-0
r-1-methoxy-t-2,-t-3-dimethylcyclopropane

Conditions

Conditions	Yield
at 125℃;

...Expand

: 563-79-1
2,3-Dimethyl-2-butene

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

A: 681-84-5
tetramethylorthosilicate

B: 22859-35-4
ether, methyl 2,2,3,3-tetramethylcyclopropyl

Conditions

Conditions	Yield
at 125℃;

...Expand

: 624-64-6
trans-2-Butene

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

A: 681-84-5
tetramethylorthosilicate

: 2799-30-6, 2988-72-9, 2988-73-0, 66791-94-4, 116405-11-9
r-1-methoxy-c-2,t-3-dimethylcyclopropane

Conditions

Conditions	Yield
at 125℃;

...Expand

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

A: 681-84-5
tetramethylorthosilicate

B: 22859-36-5
trimethoxy(methoxymethyl)silane

Conditions

Conditions	Yield
With trimethoxysilane at 125℃;

: 22859-33-2
(dimethoxymethyl)trimethoxysilane

: 110-83-8
cyclohexene

A: 681-84-5
tetramethylorthosilicate

B: 23865-95-4
exo-7-Methoxynorcaran

Conditions

Conditions	Yield
at 125℃;

...Expand

: 67-56-1
methanol

: 149-73-5
trimethyl orthoformate

A: 681-84-5
tetramethylorthosilicate

B: 22859-33-2
(dimethoxymethyl)trimethoxysilane

C: 22859-34-3
Bis--methoxy-methan

Conditions

Conditions	Yield
With hexachlorodisilane

...Expand

: 13170-06-4
(acetoxy)tri(methoxy)silane

A: 681-84-5
tetramethylorthosilicate

B: 13170-07-5
(diacetoxy)(dimethoxy)silane

Conditions

Conditions	Yield
Product distribution; Ambient temperature; prolonged storage; also heating;

: C16H30O4Si

A: 681-84-5
tetramethylorthosilicate

B: 17283-81-7
4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on

Conditions

Conditions	Yield
With methanol; sodium hydroxide for 12h; Ambient temperature; Yield given;

: 616-38-6
carbonic acid dimethyl ester

: 681-84-5
tetramethylorthosilicate

Conditions

Conditions	Yield
With potassium hydroxide; silica gel at 226.9 - 326.9℃; under 720.06 Torr; Mechanism;
With potassium hydroxide; silica gel at 426.9℃; under 720.06 Torr; for 4.5h;

: 124-41-4
sodium methylate

: 2530-87-2
3-Chloropropyltrimethoxysilan

A: 681-84-5
tetramethylorthosilicate

B: 2551-83-9
allyltrimethoxysilane

C: (3-methoxypropyl)trimethoxysilane

D: propenyltrimethoxysilane

Conditions

Conditions	Yield
at 190℃; Product distribution; other methoxides, var. temperature; substitution versus elimination products;

...Expand

: 67-56-1
methanol

: 74-85-1
ethene

A: 2487-90-3
trimethoxysilane

B: 681-84-5
tetramethylorthosilicate

C: 5314-55-6
ethyltrimethoxysilane

D: 19753-84-5
ethyl dimethoxy silane

Conditions

Conditions	Yield
With copper(l) chloride; silicon In toluene at 159.9℃; under 3040 Torr; for 3h; Product distribution; Mechanism; also ethanol; other solvents; effect of the amount of methanol on the silicon conversion and selectivity for organomethoxysilanes; var. pressures, times and temperatures;

...Expand

: 67-56-1
methanol

sis2: sis2

: 681-84-5
tetramethylorthosilicate

: 7783-81-5
uranium hexafluoride

: 681-84-5
tetramethylorthosilicate

: uranium hexamethoxide

Conditions

Conditions	Yield
byproducts: SiF(OCH3)3;	100%

: 28384-96-5
L-enterobactin

: 681-84-5
tetramethylorthosilicate

: potassium hydroxide

: C30H21N3O15Si(2-)*2K(1+)

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%

...Expand

: 681-84-5
tetramethylorthosilicate

: 108-44-1
1-amino-3-methylbenzene

: 65-85-0
benzoic acid

A: 93-58-3
benzoic acid methyl ester

B: 582-77-4
3'-methylbenzanilide

Conditions

Conditions	Yield
In toluene at 110℃; for 24h; Molecular sieve; Inert atmosphere;	A 27% B 100%

...Expand

: 681-84-5
tetramethylorthosilicate

: 1309672-95-4
C30H27N3O14

: potassium hydroxide

: C30H22N3O14Si(1-)*K(1+)

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%

...Expand

: 681-84-5
tetramethylorthosilicate

: C30H27N3O14

: potassium hydroxide

: C30H22N3O14Si(1-)*K(1+)

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%

...Expand

: 681-84-5
tetramethylorthosilicate

: 350-46-9
4-Fluoronitrobenzene

: 100-17-4
para-methoxynitrobenzene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride at 80℃; for 0.5h;	99%

: 271-63-6
7-Azaindole

: 681-84-5
tetramethylorthosilicate

: bis(7-azaindoledimethoxy)silane

Conditions

Conditions	Yield
Stage #1: 7-Azaindole With n-butyllithium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Cooling with ice; Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 8h; Inert atmosphere;	98%

: 681-84-5
tetramethylorthosilicate

: 124-38-9
carbon dioxide

: 62-53-3
aniline

: 2603-10-3
N-phenyl methyl carbamate

Conditions

Conditions	Yield
With di(n-butyl)tin oxide In toluene at 135℃; under 52505.3 Torr; for 5.1h; Reagent/catalyst; Glovebox; Autoclave;	98%
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Catalytic behavior; Mechanism; Reagent/catalyst; Temperature; Pressure; Autoclave; Inert atmosphere; Ionic liquid; Green chemistry; chemoselective reaction;	92%
With 1,10-Phenanthroline; zinc diacetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere; Autoclave; Green chemistry; chemoselective reaction;	84 %Chromat.
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Reagent/catalyst; Temperature; Pressure; Solvent; Autoclave; Sealed tube;	96 %Chromat.

...Expand

: 681-84-5
tetramethylorthosilicate

: 1-isopropyldecahydro quinoxaline

: bis(decahydroquinoxalinedimethoxy)silane

Conditions

Conditions	Yield
Stage #1: 1-isopropyldecahydro quinoxaline With n-butyllithium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Cooling with ice; Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 8h; Inert atmosphere;	97.7%

: 681-84-5
tetramethylorthosilicate

: C15H28N2

: bis(5-isopropyltetradecahydrophenazinedimethoxy)silane

Conditions

Conditions	Yield
Stage #1: C15H28N2 With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;	97.5%

: 681-84-5
tetramethylorthosilicate

: C15H16N2

: bis(5-isopropylphenazine)dimethoxysilane

Conditions

Conditions	Yield
Stage #1: C15H16N2 With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;	97.1%

: 681-84-5
tetramethylorthosilicate

: 555-16-8
4-nitrobenzaldehdye

: 619-50-1
4-nitrobenzoic acid methyl ester

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; (t-Bu2POH)2PdCl2 In acetonitrile at 50℃; for 24h;	97%

: 681-84-5
tetramethylorthosilicate

: 100-52-7
benzaldehyde

: 93-58-3
benzoic acid methyl ester

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; (t-Bu2POH)2PdCl2 In acetonitrile at 50℃; for 24h;	97%

: 681-84-5
tetramethylorthosilicate

: 124-38-9
carbon dioxide

: 108-91-8
cyclohexylamine

: 5817-68-5
cyclohexyl-carbamic acid methyl ester

Conditions

Conditions	Yield
With di(n-butyl)tin oxide In toluene at 135℃; under 52505.3 Torr; Glovebox; Autoclave;	97%
With 1,10-Phenanthroline; zinc diacetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Inert atmosphere; Autoclave; Green chemistry; chemoselective reaction;	80%
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere; Ionic liquid; Green chemistry; chemoselective reaction;	76%

...Expand

: 681-84-5
tetramethylorthosilicate

: 124-38-9
carbon dioxide

: 104-94-9
4-methoxy-aniline

: 14803-72-6
methyl N-(4-methoxyphenyl)carbamate

Conditions

Conditions	Yield
With 1,10-Phenanthroline; zinc diacetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Inert atmosphere; Autoclave; Green chemistry; chemoselective reaction;	96%
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere; Ionic liquid; Green chemistry; chemoselective reaction;	96%
With potassium carbonate In acetonitrile at 150℃; under 37503.8 Torr; for 24h; Autoclave; Sealed tube;	91%
With di(n-butyl)tin oxide In toluene at 135℃; under 52505.3 Torr; for 5.1h; Glovebox; Autoclave;	71%

...Expand

: 681-84-5
tetramethylorthosilicate

: 107-46-0
Hexamethyldisiloxane

A: 17477-97-3
1,1,1,5,5,5-hexamethyl-3-trimethylsiloxy-3-hydroxytrisiloxane

B: 3555-47-3
1,1,1,5,5,5-hexamethyl-3,3-bis(trimethylsiloxy)trisiloxane

C: 56120-91-3
1,1,1,5,5,5-hexamethyl-3-trimethylsiloxy-3-methoxytrisiloxane

Conditions

Conditions	Yield
Stage #1: Hexamethyldisiloxane With methanol; sulfuric acid at 5 - 10℃; for 1h; Stage #2: tetramethylorthosilicate at 5 - 10℃; for 1.5h; Stage #3: With sulfuric acid; water more than 3 stages;	A n/a B 94.5% C n/a

...Expand

: 681-84-5
tetramethylorthosilicate

: 66-25-1
hexanal

: 762-72-1
allyl-trimethyl-silane

: 90246-13-2
4-methoxy-1-nonene

Conditions

Conditions	Yield
trimethylsilyl iodide In dichloromethane 1.) -78 deg C, 15 min, 2.) 0 deg C, 3 h;	94%

...Expand

: 681-84-5
tetramethylorthosilicate

: 1194-02-1
4-fluorobenzonitrile

: 874-90-8
4-methoxybenzonitrile

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride at 80℃; for 2h;	94%

: 681-84-5
tetramethylorthosilicate

: 446-35-5
2,4-Difluoronitrobenzene

: 4920-84-7
2,4-dimethoxynitrobenzene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride at 80℃; for 2h;	94%

: 681-84-5
tetramethylorthosilicate

: 107-05-1
3-chloroprop-1-ene

: di(2-propenyl)dimethoxysilane

Conditions

Conditions	Yield
With 1-bromo-butane; magnesium for 5h; Inert atmosphere; Reflux;	93.43%

Tetramethyl orthosilicate Chemical Properties

IUPAC Name: Tetramethyl silicate
Empirical Formula: C₄H₁₂O₄Si
Molecular Weight: 152.2212
Canonical SMILES: CO[Si](OC)(OC)OC
InChI: InChI=1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3
InChIKey: LFQCEHFDDXELDD-UHFFFAOYSA-N
EINECS: 211-656-4
Product Categories: Silicate; Organics; Si (Classes of Silicon Compounds); Si-O Compounds; Tetraalkoxysilanes; Crosslinkers; Crosslinking Agents; Orthosilicate
Appearance: colourless liquid
Melting point: 4-5 °C
Solubility in water: organic solvents
storage temp.: Flammables area
Sensitive: Moisture Sensitive
Index of Refraction: 1.382
Molar Refractivity: 36.27 cm³
Molar Volume: 155.7 cm³Surface Tension: 19.9 dyne/cm
Density: 0.977 g/cm³
Flash Point: 28.9 °C
Enthalpy of Vaporization: 34.44 kJ/mol
Boiling Point: 121.2 °C at 760 mmHg
Vapour Pressure of Methyl silicate (CAS NO.681-84-5): 17.7 mmHg at 25 °C

Tetramethyl orthosilicate Uses

In organic synthesis, Methyl silicate (CAS NO.681-84-5) has been used to convert ketones and aldehydes to the corresponding ketals and acetals, respectively.

Tetramethyl orthosilicate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	1gm/kg (1000mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse	LCLo	inhalation	1gm/m3/10M (1000mg/m3)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE MUSCULOSKELETAL: OTHER CHANGES	National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. MAY1942,
mouse	LD50	intraperitoneal	250mg/kg (250mg/kg)		"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 2, Pg. 56, 1950.
rabbit	LD50	skin	17mL/kg (17mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rabbit	LDLo	intravenous	100mg/kg (100mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	"Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980Vol. 3, Pg. 935, 1968.
rat	LCLo	inhalation	250ppm/4H (250ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1222, 1986.
rat	LDLo	oral	700mg/kg (700mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	"Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980Vol. 3, Pg. 935, 1968.

Tetramethyl orthosilicate Consensus Reports

Reported in EPA TSCA Inventory.

Tetramethyl orthosilicate Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation. Mildly toxic by skin contact. A severe eye irritant. This material can cause extensive necrosis (experimentally), keratoconus, and opaque cornea. It also causes severe human eye injuries, as well as necrosis of corneal cells, which progresses long after exposure has ceased. It is destructive and its effects resist treatment. Permanent blindness is possible from exposure to it. The kidney seems to be most subject to injury regardless of the mode of exposure. Pulmonary edema has also occurred. This material is more toxic than either ethyl silicate or silicic acid, although it has been thought that the injury caused is largely due to the action of the silicic acid. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. Potentially violent reaction with metal hexafluorides (e.g., rhenium, molybdenum, tungsten). When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Very T+
Risk Statements: 10-26-37/38-41
R10:Flammable.
R26:Very toxic by inhalation.
R37/38:Irritating to respiratory system and skin.
R41:Risk of serious damage to the eyes.
Safety Statements: 16-26-36/37/39-45-28A
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2606 6.1/PG 1
WGK Germany: 3
RTECS: VV9800000
F: 10-21
TSCA: Yes
HazardClass: 6.1
PackingGroup: I

Tetramethyl orthosilicate Standards and Recommendations

OSHA PEL: TWA 1 ppm
ACGIH TLV: TWA 1 ppm
DOT Classification: 3; Label: Flammable Liquid, Poison

Tetramethyl orthosilicate Specification

Methyl silicate (CAS NO.681-84-5), its Synonyms are Tetramethoxysilane ; Tetramethyl silicate ; Methyl Silicate 39 ; Methyl orthosilicate ; Silane, tetramethoxy- ; Silicic acid, methyl ester of ortho- ; Silicic acid, tetramethyl ester ; Tetra-methyl orthosilicate .

Product Name

Tetramethyl orthosilicate

Synthetic route

Tetramethyl orthosilicate Chemical Properties

Tetramethyl orthosilicate Uses

Tetramethyl orthosilicate Toxicity Data With Reference

Tetramethyl orthosilicate Consensus Reports

Tetramethyl orthosilicate Safety Profile

Tetramethyl orthosilicate Standards and Recommendations

Tetramethyl orthosilicate Specification

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