Tetramethylguanidine supplier

Name
Tetramethylguanidine
EINECS 201-302-7
CAS No. 80-70-6
Article Data15
CAS DataBase
Density 0.9 g/cm³
Solubility miscible with water
Melting Point -30 °C
Formula C₅H₁₃N₃
Boiling Point 163.2 °C at 760 mmHg
Molecular Weight 115.178
Flash Point 60 °C
Transport Information UN 2920 8/PG 2
Appearance liquid
Safety 26-27-36/37/39-45-16
Risk Codes 22-34-20/22-10
Molecular Structure
Hazard Symbols
Synonyms Guanidine,1,1,3,3-tetramethyl- (6CI,8CI);1,1,3,3-Tetramethylguanidine;
PSA 30.33000
LogP 0.14410

Synthetic route

: 506-78-5
cyanogen iodide

: 124-40-3
dimethyl amine

: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
With diethyl ether

: 126661-09-4
1-Nitro-4-nitromethyl-benzene; compound with N,N,N',N'-tetramethyl-guanidine

A: 1610-26-0
1-nitro-4-(nitromethyl)benzene

B: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
In 1,3,5-trimethyl-benzene at 30℃; Equilibrium constant; Irradiation; other solvents;

: 1-Ethoxy-2,2-bis-(4-nitro-phenyl)-ethenol; compound with N,N,N',N'-tetramethyl-guanidine

A: 40748-64-9
ethyl bis-(4-nitrophenyl)acetate

B: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
In tetrahydrofuran at 10.3 - 34.8℃; Kinetics; Equilibrium constant;

methyl iodide compound of tetramethylthiourea: methyl iodide compound of tetramethylthiourea

: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃;

pentamethylisothiuronium-iodide: pentamethylisothiuronium-iodide

: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
With ammonia; water

: 124-40-3
dimethyl amine

S.N.N-trimethyl-isothiourea: S.N.N-trimethyl-isothiourea

: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
With ethanol; mercury dichloride

: 1467-79-4
NCNMe2

: 124-40-3
dimethyl amine

: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
With N,N-dimethylammonium chloride at 100℃; for 12h;

: 325774-15-0
1,1,3,3-tetramethylgyanidine-gallane (1/1)

A: 7440-55-3
gallium

B: 1333-74-0
hydrogen

C: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
at 85 - 90℃; Thermodynamic data;

...Expand

: C2H5FO*C5H13N3

A: 371-62-0
2-fluoroethanol

B: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
In octanol at 24.84℃; Equilibrium constant;

: C4H4F6O*C5H13N3

A: 1515-14-6
1,1,1,3,3,3-hexafluoro-2-methylpropan-2-ol

B: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
In octanol at 24.84℃; Equilibrium constant;

: C3H2F6O*C5H13N3

A: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

B: 80-70-6
N,N,N',N'-tetramethylguanidine

Conditions

Conditions	Yield
In octanol at 24.84℃; Equilibrium constant;

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 108-95-2
phenol

: tetramethylguanidinum phenolate

Conditions

Conditions	Yield
at 4℃; for 20h;	100%
In tetrachloromethane at 25℃; Equilibrium constant; ΔH; other temp.: 40, 57, 75 deg C; other solvent: CHCl3 (25, 36, 50, 65 deg C);
In tetrachloromethane at 25℃; other temp.; solvent CHCl3;
at 20℃;

: 118786-28-0
benzyl 2-methylene-4-phenylbutanoate

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 153642-81-0
benzyl 2-((methoxyphosphinyl)methyl)-4-phenylbutanoate

Conditions

Conditions	Yield
With trimethyl orthoformate In ethyl acetate	100%

: C25H23NO6

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1729-17-5
1,1,3,3-tetramethylguanidine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; N,N,N',N'-tetramethylguanidine In acetonitrile at 0 - 5℃; for 0.5h; Stage #2: C25H23NO6 In acetonitrile for 12h;	100%

...Expand

: 54-12-6
Trp

: 80-70-6
N,N,N',N'-tetramethylguanidine

: bis(dimethylamino)methaniminium DL-2-amino-3-(1H-indol-3-yl)propanoate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 23h;	100%

: 63-91-2
L-phenylalanine

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 55378-77-3
bis(dimethylamino)methaniminium (L)-2-amino-3-phenylpropanoate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 75h;	100%

: 2314-97-8
iodotrifluoromethane

: 80-70-6
N,N,N',N'-tetramethylguanidine

: TMG•CF3I

Conditions

Conditions	Yield
at -78 - 23℃; Schlenk technique; Inert atmosphere;	100%
at -78 - 23℃; Inert atmosphere;	100%

: 354-64-3
Pentafluoroethyl iodide

: 80-70-6
N,N,N',N'-tetramethylguanidine

: TMG•CF3CF2I

Conditions

Conditions	Yield
at -78 - 23℃; Schlenk technique; Inert atmosphere;	100%
at -78 - 23℃; Inert atmosphere;	100%

: 1-cyclohexyl-3-(4-nitrophenyl)carbodiimide

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1-cyclohexyl-2-(4-nitrophenyl)-4,4,5,5-tetramethylbiguanide

Conditions

Conditions	Yield
In toluene at 25℃; for 1h;	100%

: 85721-33-1
ciprofloxacin

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C17H18FN3O3*C5H13N3

Conditions

Conditions	Yield
In methanol; water at 20℃; for 3h;	100%

: 55577-80-5
D-6-methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C14H14O3*C5H13N3

Conditions

Conditions	Yield
Stage #1: D-6-methoxy-α-methyl-2-naphthaleneacetic acid sodium salt With Amberlyst 15 hydrogen In methanol Stage #2: N,N,N',N'-tetramethylguanidine In methanol at 20℃; for 1h;	100%

: 3-imidazolyl-3-(4-methoxyphenyl)propionic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C13H14N2O3*C5H13N3

Conditions

Conditions	Yield
In methanol at 60℃; for 0.5h; Inert atmosphere;	100%
In methanol at 60℃; for 0.5h; Inert atmosphere;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: bis(dimethylamino)methaniminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: bis(bis(dimethylamino)methaniminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 54207-61-3
3,3,4,4,5,5,6,6,7,7,8,8,8,9,10,10,10,10-heptadecafluoro-1-decathioacetic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C12H7F17O2S*C5H13N3

Conditions

Conditions	Yield
In methanol for 2h; Reflux;	100%

: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,9,10,10,10-heptadecafluoro-1-decane-6-thiohexanoic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C16H15F17O2S*C5H13N3

Conditions

Conditions	Yield
In methanol for 2h; Reflux;	100%

: 135130-97-1
2,4,6-tris(trifluoromethyl)benzoyl chloride

: 80-70-6
N,N,N',N'-tetramethylguanidine

: N,N,N',N'-tetramethyl-N''-(2,4,6-tris-trifluoromethyl-benzoyl)-guanidine

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 0.5h;	99%

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 321709-95-9
4-methylbenzenesulfonic acid 1,1,3,3-tetramethylguanidine salt

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol at 20℃;	99%

: 551-16-6
6-Aminopenicillanic Acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C8H12N2O3S*C5H13N3

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1.5h;	99%

: 1H,1H,2H,2H-perfluoro-1-decyl succinic acid monoester

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C14H9F17O4*C5H13N3

Conditions

Conditions	Yield
In methanol Heating;	99%

: 1147550-11-5
ammonium thiocyanate

: 80-70-6
N,N,N',N'-tetramethylguanidine

: N,N,N',N'-tetramethylguanidinium thiocyanate

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	99%

: 14243-64-2
(triphenylphosphine)gold(I) chloride

: 2923-28-6
silver trifluoromethanesulfonate

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 197569-91-8
(tetramethylguanidine)(triphenylphosphane)gold(I) triflate

Conditions

Conditions	Yield
In tetrahydrofuran (N2); stirring the Au complex and AgO3SCF3 in THF at 0°C for 30 min, filtration, addn. of tetramethylguanidine, reacting 1 h; solvent removal, addn. of CH2Cl2, crystn. upon layering with pentane; elem. anal.;	98%

...Expand

: 2432-11-3
(1,1';3',1''-terphenyl)-2'-ol

: 557-20-0
diethylzinc

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1228276-48-9
[zinc(2,6-(C6H5)2-C6H3O)2(1,1,3,3-tetramethylquanidine)2]

Conditions

Conditions	Yield
In hexane byproducts: C2H6; (Et)2Zn (1.0 mmol) added to soln. of HNC(N(CH3)2)2 (2.0 mmol) and HOC6H3(C6H5)2 (2.0 mmol); ppt. dissolved in THF, volatiles evapd. over 24 h; elem. anal.;	98%

...Expand

: 1633-83-6
1,4-butane sultone

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1294516-89-4
4-(1,1,3,3-tetramethylguanidine-2-yl)butylsulfonic acid

Conditions

Conditions	Yield
In toluene at 80 - 85℃; for 4h;	98%

: 905707-78-0
3-methyl-1-sulphonic acid imidazolium chloride

: 80-70-6
N,N,N',N'-tetramethylguanidine

: [1,1,3,3-tetramethylguanidinium chloride][1-methylimidazolium-3-sulfonate]

Conditions

Conditions	Yield
In dichloromethane at 20℃;	98%

: 15687-27-1
ibuprofen

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C13H18O2*C5H13N3

Conditions

Conditions	Yield
In methanol at 20℃; for 3h;	98%

: [Et3N-SO3H]ClSO3

: 80-70-6
N,N,N',N'-tetramethylguanidine

: [TMG-H][TEA-H][(HCl)(HSO4)2]

Conditions

Conditions	Yield
In dichloromethane at 20℃;	98%

: 107-66-4
dibutyl phosphate

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C8H19O4P*C5H13N3

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 12h; Inert atmosphere;	98%

: 80-70-6
N,N,N',N'-tetramethylguanidine

: tris(tetramethylguanido)sulfonium chloride

Conditions

Conditions	Yield
With sulfur tetrachloride In dichloromethane	97%

: 557-20-0
diethylzinc

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1000401-32-0
[Zn3(μ-1,1,3,3-tetramethylguanidinate))4(Et)2]

Conditions

Conditions	Yield
In hexane byproducts: ethane; (Ar); addn. dropwise of Zn(Et)2 (3 equiv.) to soln. of 1,1,3,3-tetramethylguanidine (4 equiv.) in hexane; stirring for 30 min; evapn. of solvent, crystn., recrystn. from concd. hexanes soln. at -37°C; elem. anal.;	97%

: 542-85-8
Ethyl isothiocyanate

: 536-38-9
4-chlorobenzoylmethyl bromide

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1264379-59-0
(4-chlorophenyl)(4-(dimethylamino)-2-(ethylamino)thiazol-5-yl)methanone

Conditions

Conditions	Yield
Stage #1: Ethyl isothiocyanate; N,N,N',N'-tetramethylguanidine In acetone at 20℃; for 0.5h; Stage #2: 4-chlorobenzoylmethyl bromide In acetone at 20℃;	97%

...Expand

Tetramethylguanidine Chemical Properties

Molecular formula: C₅H₁₃N₃
Molecular Weight: 115.18 g/mol
Molecular Structure of Tetramethylguanidine (CAS NO.80-70-6):

EINECS: 201-302-7
Appearance: liquid
Melting Point: -30 °C
Boiling Point: 163.2 °C at 760 mmHg
Flash Point: 60 °C
Density: 0.918 g/mL at 25 °C(lit.)
Storage Temp.: 2-8 °C
Water Solubility: miscible
Index of Refraction: 1.455
Molar Refractivity: 34.66 cm³
Molar Volume: 127.5 cm³
Surface Tension: 27.7 dyne/cm
XLogP3: 0.4
H-Bond Donor: 1
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Exact Mass: 115.110947
MonoIsotopic Mass: 115.110947
Topological Polar Surface Area: 30.3
Heavy Atom Count: 8
Canonical SMILES: CN(C)C(=N)N(C)C
InChI: InChI=1S/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
InChIKey: KYVBNYUBXIEUFW-UHFFFAOYSA-N
EINECS: 201-302-7
Product Categories: Various hydrocyanic acid derivatives; Hydrocyanic acid derivatives

Tetramethylguanidine Uses

Tetramethylguanidine (80-70-6) is used as as accelerator for the syntheses of polysulfured rubber, polyurethane foam catalyst, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries.

Tetramethylguanidine Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 22-34-20/22-10
R22:Harmful if swallowed.
R34:Causes burns.
R20/22:Harmful by inhalation and if swallowed.
R10:Flammable.
Safety Statements: 26-27-36/37/39-45-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S16:Keep away from sources of ignition.
RIDADR: UN 2920 8/PG 2
WGK Germany: 1
F: 9-23
Hazard Note: Harmful/Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29252000

Tetramethylguanidine Specification

Tetramethylguanidine (CAS NO.80-70-6) is also named as AI3-51030 ; CCRIS 6689 ; N,N,N',N'-Tetramethylguanidine ; NSC 148309 ; Guanidine, 1,1,3,3-tetramethyl- (8CI) ; Guanidine, N,N,N',N'-tetramethyl- . Tetramethylguanidine (CAS NO.80-70-6) is a strong amine base with a higher pKa than typical amines. It is highly water soluble so easily removed from other chemicals in a chemical process.

Product Name

Tetramethylguanidine

Synthetic route

Tetramethylguanidine Chemical Properties

Tetramethylguanidine Uses

Tetramethylguanidine Safety Profile

Tetramethylguanidine Specification

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