Product Name

  • Name

    Thiophene-2-ethylamine

  • EINECS 250-196-9
  • CAS No. 30433-91-1
  • Article Data38
  • CAS DataBase
  • Density 1.102 g/cm3
  • Solubility
  • Melting Point 202 °C
  • Formula C6H9NS
  • Boiling Point 199.7 °C at 760 mmHg
  • Molecular Weight 127.21
  • Flash Point 74.6 °C
  • Transport Information
  • Appearance colorless to yellow liquid
  • Safety 26-36-37/39
  • Risk Codes 20/21/22-36/37/38
  • Molecular Structure Molecular Structure of 30433-91-1 (Thiophene-2-ethylamine)
  • Hazard Symbols HarmfulXn,IrritantXi
  • Synonyms 2-thiophen-2-ylethylazanium;2-Thiophene ethylamine;2-thiophen-2-ylethanamine;2-Thiopheneethylamine;2-thiophene ethyl amine;thiophene-2-ethylamine / 2-Thiophene ethylamine;Clopidogrel 2-(2-Thienyl)Ethyl Amine;
  • PSA 54.26000
  • LogP 1.94960

Synthetic route

2-(2-nitroethenyl)thiophene
874-84-0, 34312-77-1

2-(2-nitroethenyl)thiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Cooling with ice; Reflux;92%
With lithium aluminium tetrahydride In tetrahydrofuran Reflux; Cooling with ice;92%
With lithium aluminium tetrahydride In tetrahydrofuran Cooling with ice; Reflux;92%
2-(2-azidoethyl)thiophene
149551-70-2

2-(2-azidoethyl)thiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 16h;100%
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tri-n-butyl-tin hydride In tetrahydrofuran at 0℃; for 0.5h; Reduction;89%
2-cyanomethylthiophene
20893-30-5

2-cyanomethylthiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With indium(III) chloride; sodium tetrahydroborate In tetrahydrofuran at 25℃; for 4h; Inert atmosphere;98%
With lithium aluminium tetrahydride In tetrahydrofuran71%
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether for 1h; Ambient temperature;56%
3-(thiophen-2-yl)-propionamide
26359-22-8

3-(thiophen-2-yl)-propionamide

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sodium hydroxide; sodium hypochlorite Zusatz von Kaliumhydroxid;
With bromine at 70℃; for 1h; Hofmann Rearrangement; Large scale;1110g
2-(thiophen-2-yl)acetamide
4461-29-4

2-(thiophen-2-yl)acetamide

4,5,6,7-tetrahydrothieno[3,2-c]pyridine
54903-50-3

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-(2-thienyl)ethylimide

2-(2-thienyl)ethylimide

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
In hydrogenchloride; sodium hydroxide74.5%
1-(2-thienyl)-2-nitroethene
34312-77-1

1-(2-thienyl)-2-nitroethene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With diborane
With hydrogenchloride; sodium borohydrid; trifluoroborane diethyl ether In tetrahydrofuran; water; toluene
acetylacetone
123-54-6

acetylacetone

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sodium carbonate In 2-methoxy-ethanol; water
C7H10N2OS

C7H10N2OS

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With bromine at 60℃; for 1h; Hofmann Rearrangement;
4-(thiophen-2-yl)butan-2-one
59594-93-3

4-(thiophen-2-yl)butan-2-one

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With hydrogen azide at 60 - 120℃;
2-(2-nitroethyl)thiophene
30807-46-6

2-(2-nitroethyl)thiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With hydrogen at 120℃; for 12h; Autoclave;1009 g
C19H17NS

C19H17NS

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sulfuric acid; water at 20℃;
2-thiophenethanol
5402-55-1

2-thiophenethanol

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With dmap; trifluoromethylsulfonic anhydride; ammonia 1.) CH2Cl2, from -30 deg C to RT, 2.) THF, from -30 deg C to RT; Multistep reaction;
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 12 h / -5 °C
2: 85 percent / dimethylformamide / 6 h / 60 °C
3: 89 percent / TBTH; Ni(diphenylphosphinoethane)Cl2 / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: chloroform; pyridine; phosphorus (III)-bromide
2: ammonia; ethanol
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0.5 h / 20 °C
2: sodium azide / dimethyl sulfoxide / 1 h / 80 °C
3: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C
View Scheme
1,3,5-tris-(2-(2-thienyl)ethyl)isocyanurate
150177-92-7

1,3,5-tris-(2-(2-thienyl)ethyl)isocyanurate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sodium hydroxide In butan-1-ol for 72h; Heating;83%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; ammonium acetate / 10 h / Heating
2: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux
View Scheme
Multi-step reaction with 2 steps
1: acetic acid; ammonium acetate / 10 h / 80 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: ammonium acetate / acetic acid / 10 h / 80 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux
View Scheme
Multi-step reaction with 2 steps
1: ammonium acetate / 2 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
2-(2-Bromoethyl)thiophene
26478-16-0

2-(2-Bromoethyl)thiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With ethanol; ammonia
2-(thiophen-2-yl)acetamide
4461-29-4

2-(thiophen-2-yl)acetamide

2-(2-thienyl)ethylimide

2-(2-thienyl)ethylimide

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

N-(2-(thien-2-yl)ethyl)-phthalimide
60555-55-7

N-(2-(thien-2-yl)ethyl)-phthalimide

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With hydrazine In ethanol; water for 14h; Reflux;
N-<2-(2-Thienyl)ethyl>benzolsulfonamid
115328-17-1

N-<2-(2-Thienyl)ethyl>benzolsulfonamid

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 72h; Heating;25%
4-methyl-N-(2-(thiophen-2-yl)ethyl)benzenesulfonamide
102996-95-2

4-methyl-N-(2-(thiophen-2-yl)ethyl)benzenesulfonamide

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 24h; Heating;6%
diethyl N-[2-(thien-2-yl)-ethyl]-phosphoramidate
86052-66-6

diethyl N-[2-(thien-2-yl)-ethyl]-phosphoramidate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given;
isopropyl N-[2-(thien-2-yl)-ethyl]-amino-phenylphosphinate
111512-35-7

isopropyl N-[2-(thien-2-yl)-ethyl]-amino-phenylphosphinate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given;
2-(thiophen-2-yl)ethyl methanesulfonate
61380-07-2

2-(thiophen-2-yl)ethyl methanesulfonate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / dimethylformamide / 6 h / 60 °C
2: 89 percent / TBTH; Ni(diphenylphosphinoethane)Cl2 / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium azide / dimethyl sulfoxide / 1 h / 80 °C
2: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C
View Scheme
Diethyl N-[β-(thien-2-yl)-vinyl]-phosphoramidate
86052-65-5

Diethyl N-[β-(thien-2-yl)-vinyl]-phosphoramidate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / ethanol / 1 h / 50 °C
2: aq. HCl / 1.5 h / 80 - 85 °C
View Scheme
Isopropyl N-[β-(thien-2-yl)-vinyl]-amino-phenylphosphinate
86423-62-3

Isopropyl N-[β-(thien-2-yl)-vinyl]-amino-phenylphosphinate

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / ethanol / 1 h / 50 °C
2: aq. HCl / 1.5 h / 80 - 85 °C
View Scheme
2-Chloromethylthiophene
765-50-4

2-Chloromethylthiophene

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-benzyl-N,N,N-triethylammonium chloride / water-d2
2: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 20 °C
2: triethylamine / dichloromethane / 0.5 h / 20 °C
3: sodium azide / dimethyl sulfoxide / 1 h / 80 °C
4: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C
View Scheme
3-thiophen-2-yl-2-thioxo-propionic acid
89677-36-1

3-thiophen-2-yl-2-thioxo-propionic acid

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol; hydroxylamine
2: acetic acid anhydride
3: lithium alanate; diethyl ether
View Scheme
5-(2'-thiophenemethylene)rhodamine
6319-47-7, 98800-08-9, 98800-09-0

5-(2'-thiophenemethylene)rhodamine

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aq. NaOH solution
2: ethanol; hydroxylamine
3: acetic acid anhydride
4: lithium alanate; diethyl ether
View Scheme
2-hydroxyimino-3-[2]thienyl-propionic acid
139109-61-8

2-hydroxyimino-3-[2]thienyl-propionic acid

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid anhydride
2: lithium alanate; diethyl ether
View Scheme
3-(2-thienyl)propanoic acid
5928-51-8

3-(2-thienyl)propanoic acid

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chloroform; thionyl chloride / Behandeln des Reaktionsgemisches mit wss. Ammoniak und wss. Natronlauge
2: aqueous sodium hypochlorite solution; aq. NaOH solution / Zusatz von Kaliumhydroxid
View Scheme
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-N-(2-(thiophen-2-yl)ethyl)acetamide
135709-69-2

2-chloro-N-(2-(thiophen-2-yl)ethyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane Ambient temperature;100%
With triethylamine In dichloromethane at 0℃;82%
In benzene at 0℃; Reflux;
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)iminodiacetic acid monoamide
188625-17-4

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)iminodiacetic acid monoamide

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(2-(2'-thienyl)ethyl)iminodiacetic acid diamide
211745-31-2

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(2-(2'-thienyl)ethyl)iminodiacetic acid diamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;100%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; Acylation;93%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h;
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

4-biphenyl-carboxylic acid chloride
14002-51-8

4-biphenyl-carboxylic acid chloride

4-phenylbenzoyl chloride

4-phenylbenzoyl chloride

Conditions
ConditionsYield
With sodium hydroxide In water at 0℃;100%
With triethylamine In tetrahydrofuran for 0.5h;96%
With sodium hydroxide In water for 12h; Cooling with ice;82%
With triethylamine In tetrahydrofuran at 20℃;55%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

formaldehyd
50-00-0

formaldehyd

benzotriazol-1-ylmethyl-(2-thiophen-2-yl-ethyl)-amine
1201693-98-2

benzotriazol-1-ylmethyl-(2-thiophen-2-yl-ethyl)-amine

Conditions
ConditionsYield
In diethyl ether; water at 20℃;100%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid
73991-95-4, 114458-03-6, 119618-59-6, 113278-68-5

2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid

C13H17NO4S
1218950-25-4

C13H17NO4S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide100%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-((thiophen-2-yl)ethylamino)naphthalene-1,4-dione

2-((thiophen-2-yl)ethylamino)naphthalene-1,4-dione

Conditions
ConditionsYield
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; Further stages;100%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea
59311-69-2

1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h; Addition;99%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Cyclohexanecarboxylic acid
98-89-5

Cyclohexanecarboxylic acid

cyclohexanecarboxylic acid (2-thiophen-2-ylethyl)amide
308287-68-5

cyclohexanecarboxylic acid (2-thiophen-2-ylethyl)amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 15h; Substitution;99%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

formaldehyd
50-00-0

formaldehyd

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In dichloromethane at 40 - 45℃;
Stage #2: With hydrogenchloride In dichloromethane; water; N,N-dimethyl-formamide at 20 - 70℃;
99%
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In toluene for 1.5h; Reflux; Inert atmosphere; Dean-Stark;
Stage #2: With hydrogenchloride In 1,4-dioxane; toluene at 60℃; for 0.5h; Inert atmosphere;
98%
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In 1,2-dichloro-ethane for 4h; Heating / reflux;
Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 70℃; for 4h;
90%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Diethyl maleate
141-05-9

Diethyl maleate

1,4-diethyl 2-{[2-(thiophen-2-yl)ethyl]amino}butanedioate

1,4-diethyl 2-{[2-(thiophen-2-yl)ethyl]amino}butanedioate

Conditions
ConditionsYield
In acetonitrile at 20℃; for 16h;99%
In acetonitrile at 20℃; for 16h;99%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

p-tert-butyl benzoyl chloride
1710-98-1

p-tert-butyl benzoyl chloride

C17H21NOS

C17H21NOS

Conditions
ConditionsYield
With sodium hydroxide In water for 12h; Cooling with ice;99%
With sodium hydroxide In water at 0℃;98%
With sodium hydroxide In water for 12h;80%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl (2-(thiophen-2-yl)ethyl)carbamate
381666-12-2

tert-butyl (2-(thiophen-2-yl)ethyl)carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 72h; Inert atmosphere;98%
With triethylamine In dichloromethane at 20℃; Schlenk technique; Inert atmosphere;98%
In chloroform for 6h; Heating;
In dichloromethane at 20℃; Inert atmosphere;
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

5-methoxy-2-tetralone
32940-15-1

5-methoxy-2-tetralone

5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine
102120-95-6

5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine

Conditions
ConditionsYield
Stage #1: [2-(2-thyenyl)ethyl]amine; 5-methoxy-2-tetralone With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; Inert atmosphere; Industry scale;
Stage #2: With acetic acid In dichloromethane at 20℃;
Stage #3: With sodium hydroxide In dichloromethane; water Product distribution / selectivity; cooling with ice-water; Alkaline conditions;
98%
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Solvent; Reagent/catalyst; Temperature; Time; Inert atmosphere;98%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

C19H22O7

C19H22O7

C25H29NO6S

C25H29NO6S

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;98%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

m-Toluic acid
99-04-7

m-Toluic acid

[2-(2-thienyl)ethylamino](m-tolyl)formaldehyde

[2-(2-thienyl)ethylamino](m-tolyl)formaldehyde

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;98%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

carbon disulfide
75-15-0

carbon disulfide

1,3-di(2-(thiophen-2-yl)ethyl)thiourea
336804-80-9

1,3-di(2-(thiophen-2-yl)ethyl)thiourea

Conditions
ConditionsYield
In water at 20℃; for 0.166667h; Green chemistry;98%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

formaldehyd
50-00-0

formaldehyd

N-(thiophen-2-ylethyl)methyleneamine
111954-31-5

N-(thiophen-2-ylethyl)methyleneamine

Conditions
ConditionsYield
In ethanol at 49 - 53℃; for 3h; Temperature; Solvent; Eschweiler-Clarke Methylation;97.69%
In water Heating;
In water at 20 - 90℃; for 18h;
With titanium(IV) isopropylate at 80℃; for 2h; Inert atmosphere;
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

benzoyl chloride
98-88-4

benzoyl chloride

N-<2-(2-thienyl)ethyl>benzamide
76356-24-6

N-<2-(2-thienyl)ethyl>benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.25h;97%
With sodium hydroxide In water for 12h; Cooling with ice;95%
With sodium hydroxide In water for 12h;80%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

formic acid ethyl ester
109-94-4

formic acid ethyl ester

N-(2-(thien-2-yl)ethyl)formamide
28783-49-5

N-(2-(thien-2-yl)ethyl)formamide

Conditions
ConditionsYield
With sodium hydrogencarbonate at 20℃;97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

Glyoxilic acid
298-12-4

Glyoxilic acid

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-4-carboxylic acid
77307-66-5

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-4-carboxylic acid

Conditions
ConditionsYield
In water for 0.5h; Ambient temperature;97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

aniline
62-53-3

aniline

N-(2-(thiophen-2-yl)ethyl)aniline
1120351-34-9

N-(2-(thiophen-2-yl)ethyl)aniline

Conditions
ConditionsYield
Shvo complex In tert-Amyl alcohol at 150℃; for 24h;97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine
1018481-30-5

4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine

C18H16F3N3O2S2
1018480-66-4

C18H16F3N3O2S2

Conditions
ConditionsYield
With triethylamine97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

3-fluoro-5-(trifluoromethyl)benzoic acid
161622-05-5

3-fluoro-5-(trifluoromethyl)benzoic acid

C14H11F4NOS
1370339-91-5

C14H11F4NOS

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In dichloromethane; acetonitrile at 20℃;97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

trans-Crotonaldehyde
123-73-9

trans-Crotonaldehyde

C10H15NS

C10H15NS

Conditions
ConditionsYield
Stage #1: [2-(2-thyenyl)ethyl]amine; trans-Crotonaldehyde With magnesium sulfate In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 16h; Inert atmosphere;
97%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

9-chloro-2-methoxyacridine
16492-13-0

9-chloro-2-methoxyacridine

2-methoxy-N-(2-(thiophen-2-yl)ethyl)acridin-9-amine
1217181-64-0

2-methoxy-N-(2-(thiophen-2-yl)ethyl)acridin-9-amine

Conditions
ConditionsYield
In methanol for 14h; Reflux;96%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

5-bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine
951626-91-8

5-bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine

3-chloro-N-(2-(thiophen-2-yl)ethyl)-1H-pyrrolo[2,3-b]pyridin-5-amine
1248587-77-0

3-chloro-N-(2-(thiophen-2-yl)ethyl)-1H-pyrrolo[2,3-b]pyridin-5-amine

Conditions
ConditionsYield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial;96%

Thiophene-2-ethylamine Chemical Properties

The Molecular Structure of Thiophene-2-ethylamine (CAS NO.30433-91-1):

Empirical Formula: C6H9NS
Molecular Weight: 127.2074 
IUPAC Name:  2-thiophen-2-ylethanamine 
Appearance: colorless to yellow liquid
Nominal Mass: 127 Da
Average Mass: 127.2074 Da
Monoisotopic Mass: 127.045569 Da 
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 °C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 °C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25°C 
Storage temp: Refrigerator (+4°C)
Sensitive: Air Sensitive
InChI
InChI=1/C6H9NS/c7-4-3-6-2-1-5-8-6/h1-2,5H,3-4,7H2
Smiles
s1c(ccc1)CCN 
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Thiophene&Benzothiophene;Amines;Heterocyclic Compounds;Ticlopidine Clopidogrel;Building Blocks;Heterocyclic Building Blocks;Thiophenes

Thiophene-2-ethylamine Uses

 Thiophene-2-ethylamine (CAS NO.30433-91-1) can be used for intermediates of the drug CLOPIDOGREL and General organic synthesis.

Thiophene-2-ethylamine Safety Profile

Hazard Codes: IrritantXiHarmfulXn
Risk Statements 
  R20/21/22-36/37/38 ( Harmful by inhalation, in contact with skin and if swallowed ;Irritating to eyes, respiratory system and skin )
Safety Statements 
  S26-36-37/39 (In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice;Wear suitable protective clothing;Wear suitable gloves and eye/face protection)
WGK Germany: 3
HazardClass: IRRITANT

Thiophene-2-ethylamine Specification

 Thiophene-2-ethylamine (CAS NO.30433-91-1) is also called as Thiophene ethylamine ; Thiophene-2-ethylamine hcl salt ; 2-(2-Aminoethyl)thiophene ; 2-(2'-Thienyl)ethyl amine ; 2-(2-Thienyl)ethylamine ; 2-(2-Thienyl)-1-ethanamine .

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