2-(2-nitroethenyl)thiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Cooling with ice; Reflux; | 92% |
With lithium aluminium tetrahydride In tetrahydrofuran Reflux; Cooling with ice; | 92% |
With lithium aluminium tetrahydride In tetrahydrofuran Cooling with ice; Reflux; | 92% |
2-(2-azidoethyl)thiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 16h; | 100% |
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tri-n-butyl-tin hydride In tetrahydrofuran at 0℃; for 0.5h; Reduction; | 89% |
2-cyanomethylthiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With indium(III) chloride; sodium tetrahydroborate In tetrahydrofuran at 25℃; for 4h; Inert atmosphere; | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran | 71% |
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether for 1h; Ambient temperature; | 56% |
3-(thiophen-2-yl)-propionamide
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hypochlorite Zusatz von Kaliumhydroxid; | |
With bromine at 70℃; for 1h; Hofmann Rearrangement; Large scale; | 1110g |
2-(thiophen-2-yl)acetamide
4,5,6,7-tetrahydrothieno[3,2-c]pyridine
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
In hydrogenchloride; sodium hydroxide | 74.5% |
1-(2-thienyl)-2-nitroethene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With diborane | |
With hydrogenchloride; sodium borohydrid; trifluoroborane diethyl ether In tetrahydrofuran; water; toluene |
acetylacetone
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sodium carbonate In 2-methoxy-ethanol; water |
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With bromine at 60℃; for 1h; Hofmann Rearrangement; |
4-(thiophen-2-yl)butan-2-one
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With hydrogen azide at 60 - 120℃; |
2-(2-nitroethyl)thiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With hydrogen at 120℃; for 12h; Autoclave; | 1009 g |
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sulfuric acid; water at 20℃; |
2-thiophenethanol
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With dmap; trifluoromethylsulfonic anhydride; ammonia 1.) CH2Cl2, from -30 deg C to RT, 2.) THF, from -30 deg C to RT; Multistep reaction; | |
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 12 h / -5 °C 2: 85 percent / dimethylformamide / 6 h / 60 °C 3: 89 percent / TBTH; Ni(diphenylphosphinoethane)Cl2 / tetrahydrofuran / 0.5 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: chloroform; pyridine; phosphorus (III)-bromide 2: ammonia; ethanol View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 20 °C 2: sodium azide / dimethyl sulfoxide / 1 h / 80 °C 3: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C View Scheme |
1,3,5-tris-(2-(2-thienyl)ethyl)isocyanurate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sodium hydroxide In butan-1-ol for 72h; Heating; | 83% |
thiophene-2-carbaldehyde
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; ammonium acetate / 10 h / Heating 2: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; ammonium acetate / 10 h / 80 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: ammonium acetate / acetic acid / 10 h / 80 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice; Reflux View Scheme | |
Multi-step reaction with 2 steps 1: ammonium acetate / 2 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme |
2-(2-Bromoethyl)thiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With ethanol; ammonia |
2-(thiophen-2-yl)acetamide
[2-(2-thyenyl)ethyl]amine
N-(2-(thien-2-yl)ethyl)-phthalimide
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With hydrazine In ethanol; water for 14h; Reflux; |
N-<2-(2-Thienyl)ethyl>benzolsulfonamid
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 72h; Heating; | 25% |
4-methyl-N-(2-(thiophen-2-yl)ethyl)benzenesulfonamide
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 24h; Heating; | 6% |
diethyl N-[2-(thien-2-yl)-ethyl]-phosphoramidate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given; |
isopropyl N-[2-(thien-2-yl)-ethyl]-amino-phenylphosphinate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given; |
2-(thiophen-2-yl)ethyl methanesulfonate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / dimethylformamide / 6 h / 60 °C 2: 89 percent / TBTH; Ni(diphenylphosphinoethane)Cl2 / tetrahydrofuran / 0.5 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium azide / dimethyl sulfoxide / 1 h / 80 °C 2: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C View Scheme |
Diethyl N-[β-(thien-2-yl)-vinyl]-phosphoramidate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaBH4 / ethanol / 1 h / 50 °C 2: aq. HCl / 1.5 h / 80 - 85 °C View Scheme |
Isopropyl N-[β-(thien-2-yl)-vinyl]-amino-phenylphosphinate
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaBH4 / ethanol / 1 h / 50 °C 2: aq. HCl / 1.5 h / 80 - 85 °C View Scheme |
2-Chloromethylthiophene
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-benzyl-N,N,N-triethylammonium chloride / water-d2 2: lithium aluminium tetrahydride / tetrahydrofuran View Scheme |
Thiophene-2-acetic acid
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 20 °C 2: triethylamine / dichloromethane / 0.5 h / 20 °C 3: sodium azide / dimethyl sulfoxide / 1 h / 80 °C 4: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C View Scheme |
3-thiophen-2-yl-2-thioxo-propionic acid
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol; hydroxylamine 2: acetic acid anhydride 3: lithium alanate; diethyl ether View Scheme |
5-(2'-thiophenemethylene)rhodamine
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aq. NaOH solution 2: ethanol; hydroxylamine 3: acetic acid anhydride 4: lithium alanate; diethyl ether View Scheme |
2-hydroxyimino-3-[2]thienyl-propionic acid
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid anhydride 2: lithium alanate; diethyl ether View Scheme |
3-(2-thienyl)propanoic acid
[2-(2-thyenyl)ethyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: chloroform; thionyl chloride / Behandeln des Reaktionsgemisches mit wss. Ammoniak und wss. Natronlauge 2: aqueous sodium hypochlorite solution; aq. NaOH solution / Zusatz von Kaliumhydroxid View Scheme |
[2-(2-thyenyl)ethyl]amine
chloroacetyl chloride
2-chloro-N-(2-(thiophen-2-yl)ethyl)acetamide
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane Ambient temperature; | 100% |
With triethylamine In dichloromethane at 0℃; | 82% |
In benzene at 0℃; Reflux; |
[2-(2-thyenyl)ethyl]amine
N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)iminodiacetic acid monoamide
N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(2-(2'-thienyl)ethyl)iminodiacetic acid diamide
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution; | 100% |
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; Acylation; | 93% |
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; |
[2-(2-thyenyl)ethyl]amine
4-biphenyl-carboxylic acid chloride
Conditions | Yield |
---|---|
With sodium hydroxide In water at 0℃; | 100% |
With triethylamine In tetrahydrofuran for 0.5h; | 96% |
With sodium hydroxide In water for 12h; Cooling with ice; | 82% |
With triethylamine In tetrahydrofuran at 20℃; | 55% |
[2-(2-thyenyl)ethyl]amine
1,2,3-Benzotriazole
formaldehyd
benzotriazol-1-ylmethyl-(2-thiophen-2-yl-ethyl)-amine
Conditions | Yield |
---|---|
In diethyl ether; water at 20℃; | 100% |
[2-(2-thyenyl)ethyl]amine
2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid
C13H17NO4S
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide | 100% |
[2-(2-thyenyl)ethyl]amine
1,4-Dihydroxynaphthalene
Conditions | Yield |
---|---|
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; Further stages; | 100% |
[2-(2-thyenyl)ethyl]amine
phenyl isothiocyanate
1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; Addition; | 99% |
[2-(2-thyenyl)ethyl]amine
Cyclohexanecarboxylic acid
cyclohexanecarboxylic acid (2-thiophen-2-ylethyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 15h; Substitution; | 99% |
[2-(2-thyenyl)ethyl]amine
formaldehyd
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
Conditions | Yield |
---|---|
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In dichloromethane at 40 - 45℃; Stage #2: With hydrogenchloride In dichloromethane; water; N,N-dimethyl-formamide at 20 - 70℃; | 99% |
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In toluene for 1.5h; Reflux; Inert atmosphere; Dean-Stark; Stage #2: With hydrogenchloride In 1,4-dioxane; toluene at 60℃; for 0.5h; Inert atmosphere; | 98% |
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In 1,2-dichloro-ethane for 4h; Heating / reflux; Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 70℃; for 4h; | 90% |
[2-(2-thyenyl)ethyl]amine
Diethyl maleate
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 16h; | 99% |
In acetonitrile at 20℃; for 16h; | 99% |
Conditions | Yield |
---|---|
With sodium hydroxide In water for 12h; Cooling with ice; | 99% |
With sodium hydroxide In water at 0℃; | 98% |
With sodium hydroxide In water for 12h; | 80% |
[2-(2-thyenyl)ethyl]amine
di-tert-butyl dicarbonate
tert-butyl (2-(thiophen-2-yl)ethyl)carbamate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 72h; Inert atmosphere; | 98% |
With triethylamine In dichloromethane at 20℃; Schlenk technique; Inert atmosphere; | 98% |
In chloroform for 6h; Heating; | |
In dichloromethane at 20℃; Inert atmosphere; |
[2-(2-thyenyl)ethyl]amine
5-methoxy-2-tetralone
5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine
Conditions | Yield |
---|---|
Stage #1: [2-(2-thyenyl)ethyl]amine; 5-methoxy-2-tetralone With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; Inert atmosphere; Industry scale; Stage #2: With acetic acid In dichloromethane at 20℃; Stage #3: With sodium hydroxide In dichloromethane; water Product distribution / selectivity; cooling with ice-water; Alkaline conditions; | 98% |
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Solvent; Reagent/catalyst; Temperature; Time; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 98% |
[2-(2-thyenyl)ethyl]amine
m-Toluic acid
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 98% |
[2-(2-thyenyl)ethyl]amine
carbon disulfide
1,3-di(2-(thiophen-2-yl)ethyl)thiourea
Conditions | Yield |
---|---|
In water at 20℃; for 0.166667h; Green chemistry; | 98% |
[2-(2-thyenyl)ethyl]amine
formaldehyd
N-(thiophen-2-ylethyl)methyleneamine
Conditions | Yield |
---|---|
In ethanol at 49 - 53℃; for 3h; Temperature; Solvent; Eschweiler-Clarke Methylation; | 97.69% |
In water Heating; | |
In water at 20 - 90℃; for 18h; | |
With titanium(IV) isopropylate at 80℃; for 2h; Inert atmosphere; |
[2-(2-thyenyl)ethyl]amine
benzoyl chloride
N-<2-(2-thienyl)ethyl>benzamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.25h; | 97% |
With sodium hydroxide In water for 12h; Cooling with ice; | 95% |
With sodium hydroxide In water for 12h; | 80% |
[2-(2-thyenyl)ethyl]amine
formic acid ethyl ester
N-(2-(thien-2-yl)ethyl)formamide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate at 20℃; | 97% |
[2-(2-thyenyl)ethyl]amine
Glyoxilic acid
4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-4-carboxylic acid
Conditions | Yield |
---|---|
In water for 0.5h; Ambient temperature; | 97% |
Conditions | Yield |
---|---|
Shvo complex In tert-Amyl alcohol at 150℃; for 24h; | 97% |
[2-(2-thyenyl)ethyl]amine
4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine
C18H16F3N3O2S2
Conditions | Yield |
---|---|
With triethylamine | 97% |
[2-(2-thyenyl)ethyl]amine
3-fluoro-5-(trifluoromethyl)benzoic acid
C14H11F4NOS
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In dichloromethane; acetonitrile at 20℃; | 97% |
Conditions | Yield |
---|---|
Stage #1: [2-(2-thyenyl)ethyl]amine; trans-Crotonaldehyde With magnesium sulfate In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 16h; Inert atmosphere; | 97% |
[2-(2-thyenyl)ethyl]amine
9-chloro-2-methoxyacridine
2-methoxy-N-(2-(thiophen-2-yl)ethyl)acridin-9-amine
Conditions | Yield |
---|---|
In methanol for 14h; Reflux; | 96% |
[2-(2-thyenyl)ethyl]amine
5-bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine
3-chloro-N-(2-(thiophen-2-yl)ethyl)-1H-pyrrolo[2,3-b]pyridin-5-amine
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 96% |
The Molecular Structure of Thiophene-2-ethylamine (CAS NO.30433-91-1):
Empirical Formula: C6H9NS
Molecular Weight: 127.2074
IUPAC Name: 2-thiophen-2-ylethanamine
Appearance: colorless to yellow liquid
Nominal Mass: 127 Da
Average Mass: 127.2074 Da
Monoisotopic Mass: 127.045569 Da
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 °C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 °C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25°C
Storage temp: Refrigerator (+4°C)
Sensitive: Air Sensitive
InChI
InChI=1/C6H9NS/c7-4-3-6-2-1-5-8-6/h1-2,5H,3-4,7H2
Smiles
s1c(ccc1)CCN
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Thiophene&Benzothiophene;Amines;Heterocyclic Compounds;Ticlopidine Clopidogrel;Building Blocks;Heterocyclic Building Blocks;Thiophenes
Thiophene-2-ethylamine (CAS NO.30433-91-1) can be used for intermediates of the drug CLOPIDOGREL and General organic synthesis.
Hazard Codes: XiXn
Risk Statements
R20/21/22-36/37/38 ( Harmful by inhalation, in contact with skin and if swallowed ;Irritating to eyes, respiratory system and skin )
Safety Statements
S26-36-37/39 (In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice;Wear suitable protective clothing;Wear suitable gloves and eye/face protection)
WGK Germany: 3
HazardClass: IRRITANT
Thiophene-2-ethylamine (CAS NO.30433-91-1) is also called as Thiophene ethylamine ; Thiophene-2-ethylamine hcl salt ; 2-(2-Aminoethyl)thiophene ; 2-(2'-Thienyl)ethyl amine ; 2-(2-Thienyl)ethylamine ; 2-(2-Thienyl)-1-ethanamine .
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