Product Name

  • Name

    Amstat

  • EINECS 214-818-2
  • CAS No. 1197-18-8
  • Article Data33
  • CAS DataBase
  • Density 1.096 g/cm3
  • Solubility water: 1 g/6mL
  • Melting Point 300 °C
  • Formula C8H15NO2
  • Boiling Point 300.201 °C at 760 mmHg
  • Molecular Weight 157.213
  • Flash Point 135.357 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 26-36-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 1197-18-8 (Amstat)
  • Hazard Symbols IrritantXi
  • Synonyms trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;
  • PSA 63.32000
  • LogP 1.53640

Synthetic route

concentrated ammonia water

concentrated ammonia water

trans-4-cyanocyclohexane-1-ylcarboxylic acid
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
aluminum nickel In methanol; water; acetone92%
methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate
51782-10-6

methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
With barium hydroxide octahydrate; hydrogen In ethanol; water at 250℃; under 7500.75 - 30003 Torr; for 7.5h; Pressure; Temperature;85.11%
methyl trans-4-cyanocyclohexane-1-carboxylate
19145-95-0

methyl trans-4-cyanocyclohexane-1-carboxylate

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
With triethylamine In hydrous methanol
C12H17NO5
953817-12-4

C12H17NO5

A

maleic anhydride
108-31-6

maleic anhydride

B

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 1h; Kinetics;
4-cyanobenzoic acid methyl ester
1129-35-7

4-cyanobenzoic acid methyl ester

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; hydrogen; ruthenium-carbon composite / 7 h / 40 °C / 6750.68 - 7500.75 Torr
2: hydrogen; potassium acetate / toluene / 13 h / 150 °C / 7500.75 - 75007.5 Torr
3: hydrogen; barium hydroxide octahydrate / ethanol; water / 7.5 h / 250 °C / 7500.75 - 30003 Torr
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid

trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; sodium hydroxide100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid
27687-14-5

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 20℃; for 18h; Industrial scale;97%
With sodium hydrogencarbonate In 1,4-dioxane95%
With sodium hydroxide In water; tert-butyl alcohol for 18h; Ambient temperature;94%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
27687-12-3

(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h;97%
With sodium hydroxide
With sodium hydroxide for 1h;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Allyl chloroformate
2937-50-0

Allyl chloroformate

trans-4-allyloxycarbonylaminomethylcyclohexanecarboxylic acid
177583-51-6

trans-4-allyloxycarbonylaminomethylcyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane97%
ethanol
64-17-5

ethanol

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

ethyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride
19878-18-3

ethyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 70℃; for 1.16667h;96%
5-Phenylpentanoic acid
2270-20-4

5-Phenylpentanoic acid

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans--4-aminomethyl>-cyclohexanecarboxylic acid

trans--4-aminomethyl>-cyclohexanecarboxylic acid

Conditions
ConditionsYield
95%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid
167690-53-1

(1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid

Conditions
ConditionsYield
Stage #1: trans-4-aminomethyl-cyclohexyl-carboxylic acid With triethylamine In water at 20℃;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In water; acetonitrile at 20℃;		95%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
With sodium carbonate In N,N-dimethyl-formamide
Stage #1: trans-4-aminomethyl-cyclohexyl-carboxylic acid With potassium carbonate In acetonitrile for 0.333333h;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In acetonitrile for 2h; Cooling with ice;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

2,5-dichlorobenzenesulphonyl chloride
5402-73-3

2,5-dichlorobenzenesulphonyl chloride

4-({[(2,5-dichlorophenyl)sulfonyl]amino}methyl)cyclohexanecarboxylic acid

4-({[(2,5-dichlorophenyl)sulfonyl]amino}methyl)cyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; pH=8 - 9;94%
methanolic hydrochloric acid

methanolic hydrochloric acid

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans-4-(aminomethyl)cyclohexanemethanol hydrochloride
178972-33-3

trans-4-(aminomethyl)cyclohexanemethanol hydrochloride

Conditions
ConditionsYield
With borane In tetrahydrofuran; methanol93%
icewater-cooled methanol

icewater-cooled methanol

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans-(4-aminomethyl)cyclohexane-1-carboxylic acid methyl ester hydrochloride

trans-(4-aminomethyl)cyclohexane-1-carboxylic acid methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride92.1%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

ethylene glycol
107-21-1

ethylene glycol

2-hydroxyethyl-trans-4-(aminomethyl)cyclohexylcarboxylate hydrochloride
1034250-62-8

2-hydroxyethyl-trans-4-(aminomethyl)cyclohexylcarboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 75℃; for 1h;92%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

trans-4-[(4-bromobenzenesulfonyl)aminomethyl]cyclohexanecarboxylic acid
674819-27-3

trans-4-[(4-bromobenzenesulfonyl)aminomethyl]cyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; pH=8 - 9;91%
With sodium hydroxide In water at 20℃; for 24h;21%
With sodium hydroxide at 20℃; for 48h;
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

2-methoxyethyl-trans-4-(aminomethyl)cyclohexylcarboxylate hydrochloride
1034250-63-9

2-methoxyethyl-trans-4-(aminomethyl)cyclohexylcarboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 75℃; for 1h;90%
p-fluorobenzoic acid succinimidyl ester
66134-67-6

p-fluorobenzoic acid succinimidyl ester

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans-4-(4-fluorobenzamidomethyl)cyclohexanecarboxylic acid

trans-4-(4-fluorobenzamidomethyl)cyclohexanecarboxylic acid

Conditions
ConditionsYield
In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;89%
maleic anhydride
108-31-6

maleic anhydride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

C12H17NO5
953817-12-4

C12H17NO5

Conditions
ConditionsYield
Stage #1: trans-4-aminomethyl-cyclohexyl-carboxylic acid With sodium hydroxide In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #2: maleic anhydride In tetrahydrofuran for 12h; Inert atmosphere; Reflux;		87%
In 1,4-dioxane at 20℃; for 48h;
Stage #1: maleic anhydride; trans-4-aminomethyl-cyclohexyl-carboxylic acid In N,N-dimethyl-formamide at 15 - 25℃;
Stage #2: With 2,4,6-trimethyl-pyridine In N,N-dimethyl-formamide at -5 - 5℃; for 0.333333h;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

p-acetylaminobenzenesulfonyl chloride
121-60-8

p-acetylaminobenzenesulfonyl chloride

4-[(4-acetylaminobenzenesulfonylamino)methyl]cyclohexane carboxylic acid

4-[(4-acetylaminobenzenesulfonylamino)methyl]cyclohexane carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; pH=8 - 9;87%
maleic anhydride
108-31-6

maleic anhydride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans-4-([(2Z)-3-carboxyprop-2-enoyl]aminolmethyl)cyclohexanecarboxylic acid
69907-68-2

trans-4-([(2Z)-3-carboxyprop-2-enoyl]aminolmethyl)cyclohexanecarboxylic acid

Conditions
ConditionsYield
In acetonitrile at 20℃; for 6h; Inert atmosphere;86%
With acetic acid at 20℃;
With acetic acid at 20℃;
phthalic anhydride
85-44-9

phthalic anhydride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

(1R*,4R*)-4-((1,3-dioxoisoindolin-2-yl)methyl)cyclohexane-1-carboxylic acid
80191-01-1

(1R*,4R*)-4-((1,3-dioxoisoindolin-2-yl)methyl)cyclohexane-1-carboxylic acid

Conditions
ConditionsYield
With acetic acid for 3h; Reflux;85%
In acetic acid for 16h; Heating;80%
at 150℃; for 0.75h; Yield given;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-[(toluene-4-sulfonylamino)methyl]cyclohexanecarboxylic acid
38697-79-9

4-[(toluene-4-sulfonylamino)methyl]cyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; pH=8 - 9;84%
With sodium hydroxide at 20℃; for 48h;
With sodium hydroxide In chloroform; water at 20℃; for 48h;
With sodium hydroxide In chloroform; water at 20℃; for 72h;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

methyl carbamimidothioate bis(sulfate)
867-44-7, 2260-00-6, 14527-26-5

methyl carbamimidothioate bis(sulfate)

4-guanidinomethylcyclohexanecarboxylic acid
38697-86-8

4-guanidinomethylcyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water Ambient temperature;83%
L-arginine
74-79-3

L-arginine

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

6-((S)-1-{[(E)-Allyloxycarbonylimino]-amino-methyl}-3-tert-butoxycarbonylamino-piperidin-2-yloxy)-hexanoic acid
241146-47-4

6-((S)-1-{[(E)-Allyloxycarbonylimino]-amino-methyl}-3-tert-butoxycarbonylamino-piperidin-2-yloxy)-hexanoic acid

4-[((S)-2-Amino-5-guanidino-pentanoylamino)-methyl]-cyclohexanecarboxylic acid ((S)-1-carbamimidoyl-2-hydroxy-piperidin-3-yl)-amide; compound with trifluoro-acetic acid

4-[((S)-2-Amino-5-guanidino-pentanoylamino)-methyl]-cyclohexanecarboxylic acid ((S)-1-carbamimidoyl-2-hydroxy-piperidin-3-yl)-amide; compound with trifluoro-acetic acid

Conditions
ConditionsYield
With aminomethylated polystyrene resin Solid phase reaction;83%
...Expand
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

trans-4-[N-(3',4'-dihydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid
81519-03-1

trans-4-[N-(3',4'-dihydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid

Conditions
ConditionsYield
In methanol82.7%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

allyl alcohol
107-18-6

allyl alcohol

allyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

allyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 75℃; for 1h;82%
With thionyl chloride at 0 - 75℃; for 1.16667h;82%
1-Naphthalenesulfonyl chloride
85-46-1

1-Naphthalenesulfonyl chloride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

4-[(naphthalene-1-sulfonylamino)-methyl]-cyclohexanecarboxylic acid
192322-99-9

4-[(naphthalene-1-sulfonylamino)-methyl]-cyclohexanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide at 20℃; sulfonylation;80%
With sodium hydroxide In chloroform at 20℃; for 48h;
With sodium hydroxide In chloroform; water at 20℃; for 72h;
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

{[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetic acid

{[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetic acid

trans-4-{[({[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetyl)amino]methyl}cyclohexanecarboxylic acid

trans-4-{[({[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetyl)amino]methyl}cyclohexanecarboxylic acid

Conditions
ConditionsYield
Stage #1: {[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetic acid With 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide In 1,4-dioxane at 20℃; for 2h;
Stage #2: trans-4-aminomethyl-cyclohexyl-carboxylic acid With sodium hydrogencarbonate In 1,4-dioxane; water		79%
1,8-Naphthalic anhydride
81-84-5

1,8-Naphthalic anhydride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

4-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)cyclohexanecarboxylic acid
1361130-80-4

4-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)cyclohexanecarboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Reflux;78%
trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

2-[(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl)oxy]acetic acid
325737-63-1

2-[(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl)oxy]acetic acid

N-[2-[(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl)oxy]acetyl]-trans-4-aminomethylcyclohexanecarboxylic acid

N-[2-[(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl)oxy]acetyl]-trans-4-aminomethylcyclohexanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-[(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl)oxy]acetic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In 1,4-dioxane for 2h;
Stage #2: trans-4-aminomethyl-cyclohexyl-carboxylic acid With sodium hydroxide In 1,4-dioxane; water		71%

Tranexamic acid Chemical Properties

Product Name: Tranexamic acid (CAS NO.1197-18-8)

Molecular Formula: C8H15NO2
Molecular Weight: 157.21g/mol
EINECS: 214-818-2 
Melting point: 300 °C
Water solubility: 1g/6ml
Storage temp.: Store at 0 °C
Index of Refraction: 1.497 
Molar Refractivity: 42.007 cm3 
Molar Volume: 143.445 cm3 
Surface Tension: 43.639 dyne/cm 
Density: 1.096 g/cm3 
Flash Point: 135.357 °C 
Enthalpy of Vaporization: 59.426 kJ/mol 
Boiling Point: 300.201 °C at 760 mmHg
XLogP3-AA: -2
H-Bond Donor: 2
H-Bond Acceptor: 2
Structure Descriptors of Tranexamic acid (CAS NO.1197-18-8):
  IUPAC Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
  Canonical SMILES: C1CC(CCC1CN)C(=O)O
  InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11) 
  InChIKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
Product Categories: 4-Substituted Cyclohexanecarboxylic Acids; API's

Tranexamic acid Toxicity Data With Reference

1.    

orl-mus TDLo:9 mg/kg (female 7-12D post):REP

     OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),415.
2.    

orl-rat TDLo:9 mg/kg (female 9-14D post):TER

     OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),415.
3.    

orl-rat LD50:3000 mg/kg

     APTOA6    Acta Pharmacologica et Toxicologica. 22 (1965),340.
4.    

ipr-rat LD50:4200 mg/kg

     MEIEDD    Merck Index. 10 (1983),1269.
5.    

scu-rat LD50:4620 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512.
6.    

ivn-rat LD50:1200 mg/kg

     APTOA6    Acta Pharmacologica et Toxicologica. 22 (1965),340.
7.    

scu-mus LD50:5310 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512.
8.    

ivn-mus LD50:1350 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512.
9.    

ivn-dog LD50:1110 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512.

Tranexamic acid Safety Profile

Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes such as NOx. A hemostatic agent.
The Hazard Codes of  Tranexamic acid (CAS NO.1197-18-8)  Xi:;
The Risk Statements R36/37/38 : Irritating to eyes, respiratory system and skin.
The Safety Statements S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.S37/39 : Wear suitable gloves and eye/face protection.

Tranexamic acid Specification

 Tranexamic acid , its CAS NO. is 1197-18-8, the synonyms are trans-4-Aminomethylcyclohexane-1-carboxylate ; trans-4-(Aminomethyl)cyclohexanecarboxylic acid ; Amstat . 

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