-
Name
Trifluoromethanesulfonic anhydride
- EINECS 206-616-8
- CAS No. 358-23-6
- Article Data47
- CAS DataBase
- Density 1.976 g/cm3
- Solubility reacts violently with water
- Melting Point -80 °C
- Formula C2F6O5S2
- Boiling Point 82.6 °C at 760 mmHg
- Molecular Weight 282.141
- Flash Point 81-83°C
- Transport Information UN 3265 8/PG 2
- Appearance clear colorless to light brown liquid
- Safety 26-36/37/39-43-45-8
- Risk Codes 14-21/22-34-35
-
Molecular Structure
-
Hazard Symbols
C
- Synonyms Methanesulfonicacid, trifluoro-, anhydride (6CI,7CI,8CI,9CI);Perfluoromethanesulfonicanhydride;Tirflic anhydride;Triflate anhydride;Triflic acid anhydride;Triflic anhydride;Trifluoromethanesulfonic acid anhydride;Trifluoromethylsulfonic acid anhydride;Trifluoromethylsulfonic anhydride;
- PSA 94.27000
- LogP 2.86380
Synthetic route
| Conditions | Yield |
|---|---|
| With phosphorus pentoxide at 40 - 90℃; Concentration; Temperature; Industrial scale; | 96.1% |
| With phosphorus pentoxide at 90℃; Temperature; Large scale; | 96.1% |
| With α,α,α-trichloro-o-toluic chloride at 115 - 140℃; for 3.08h; Product distribution / selectivity; | 91.4% |
-
-
67-66-3
chloroform
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
1493-13-6
trifluorormethanesulfonic acid
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| at 22℃; for 1h; | A n/a B 92% |
-
-
81715-08-4, 81715-17-5
methyl 3,5-di-O-benzoyl-2,6-dideoxy-2-iodo-β-D-altrofuranoside
-
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| With azobisisobutyronitrile; tri-n-butyl-tin hydride In toluene for 4h; Heating; | 90% |
-
-
2923-28-6
silver trifluoromethanesulfonate
-
A
-
2314-97-8
iodotrifluoromethane
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| at higher temp.; | A 0.5% B n/a |
-
-
75-69-4
trichlorofluoromethane
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
74501-97-6
Trifluoro-methanesulfonic acid dichloro-fluoro-methyl ester
| Conditions | Yield |
|---|---|
| at -78 - 22℃; for 15h; | A 0.2% B 4.4 mmol |
-
-
75-71-8
Dichlorodifluoromethane
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
353-50-4
Carbonyl fluoride
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
C
-
74501-96-5
perfluorochloromethyl trifluoromethanesulfonate
-
D
-
74512-41-7
difluoromethyl bis(trifluoromethanesulfonate)
| Conditions | Yield |
|---|---|
| at -60 - 22℃; for 15h; Further byproducts given; | A 0.8 mmol B 0.8 mmol C 1.0 mmol D 0.1 mmol |
-
-
75-71-8
Dichlorodifluoromethane
-
-
70142-16-4
Bromine(I) trifluoromethanesulfonate
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
3582-05-6
trifluoromethyl trifluoromethanesulfonate
-
C
-
74501-96-5
perfluorochloromethyl trifluoromethanesulfonate
-
D
-
74512-41-7
difluoromethyl bis(trifluoromethanesulfonate)
| Conditions | Yield |
|---|---|
| at -111 - -50℃; for 15h; Further byproducts given; | A 0.6 mmol B 0.7 mmol C 0.6 mmol D 0.12 mmol |
-
-
75-69-4
trichlorofluoromethane
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
74501-99-8
fluoroformyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| at -78 - 22℃; for 24h; |
-
-
75-61-6
dibromodifluoromethane
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
353-50-4
Carbonyl fluoride
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
C
-
74501-92-1
perfluorobromomethyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| In Dichlorodifluoromethane at -160℃; for 1h; | A 1.2 mmol B 0.6 mmol C 2.0 mmol |
-
-
75-61-6
dibromodifluoromethane
-
-
70142-16-4
Bromine(I) trifluoromethanesulfonate
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
3582-05-6
trifluoromethyl trifluoromethanesulfonate
-
C
-
74501-92-1
perfluorobromomethyl trifluoromethanesulfonate
-
D
-
74512-41-7
difluoromethyl bis(trifluoromethanesulfonate)
| Conditions | Yield |
|---|---|
| at -111 - -60℃; for 24h; Further byproducts given; | A 0.35 mmol B 0.4 mmol C 0.7 mmol D 0.7 mmol |
-
-
353-54-8
tribromofluoromethane
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
74501-99-8
fluoroformyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| In Dichlorodifluoromethane at -111℃; for 15h; | A 1.8 mmol B 1.6 mmol |
-
-
1493-13-6
trifluorormethanesulfonic acid
-
A
-
354-34-7
trifluoroacetyl fluoride
-
B
-
354-88-1
perfluoroethanesulfonic acid
-
C
-
358-23-6
trifluoromethylsulfonic anhydride
-
D
-
3582-05-6
trifluoromethyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| at 45℃; for 14h; Product distribution; |
-
-
64371-01-3
tris(trifluoromethanesulfonyloxy)boron
-
A
-
353-50-4
Carbonyl fluoride
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
C
-
3582-05-6
trifluoromethyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| In neat (no solvent) at 200℃; for 1h; |
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
-
74501-92-1
perfluorobromomethyl trifluoromethanesulfonate
-
A
-
353-50-4
Carbonyl fluoride
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
C
-
74512-41-7
difluoromethyl bis(trifluoromethanesulfonate)
| Conditions | Yield |
|---|---|
| In Dichlorodifluoromethane at -111 - 22℃; for 24h; | A 0.8 mmol B 0.8 mmol C 0.6 mmol |
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
A
-
75-72-9
chlorotrifluoromethane
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| With difluorophosphinic bromide at -111 - -20℃; |
-
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| With trifluorophosphane at -130 - 0℃; |
-
-
144125-08-6
(S)-Formyloxy-phenyl-acetic acid methyl ester
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
21210-43-5
(S)-Methyl mandelate
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid In methanol for 1h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
-
-
120049-36-7
(R)-Phenyl-trifluoromethanesulfonyloxy-acetic acid methyl ester
-
-
68-12-2, 33513-42-7
N,N-dimethyl-formamide
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
21210-43-5
(S)-Methyl mandelate
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid 2.) MeOH, 1 h, room temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
-
-
372-64-5
Bis(trifluoromethyl)disulfid
-
A
-
358-15-6
Trifluoro-methanethiosulfonic acid S-trifluoromethyl ester
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
C
-
63548-94-7
Bis(trifluormethyl)disulfanoxid
| Conditions | Yield |
|---|---|
| With fluoro alcohol In [D3]acetonitrile; acetonitrile at -50℃; for 1h; Product distribution; other temperatures, other exposition, other products; |
-
-
51567-94-3
trifluoromethanesulphonic-p-toluenesulphonic acid anhydride
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
4124-41-8
p-toluenesulfonylanhydride
| Conditions | Yield |
|---|---|
| With decalin In nitromethane at 0℃; for 3h; | A 0.54 g B 0.95 g |
-
-
1493-13-6
trifluorormethanesulfonic acid
-
-
55865-38-8
bis(trifluoromethyl)diethylaminophosphane
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
359-65-9
bis(trifluoromethyl)phosphinous acid
-
C
-
2728-67-8
Tetrakis(trifluormethyl)disphosphoxan
-
-
879545-43-4
(5-bromo-2-chlorophenyl)(4-ethylphenyl)methanone
-
-
879545-44-5
(5-bromo-2-chlorophenyl)(2-ethylphenyl)methanone
-
A
-
879545-41-2
4-bromo-1-chloro-2-(4-ethylbenzyl)benzene
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| With triethylsilane; trifluorormethanesulfonic acid In trifluoroacetic acid at 30 - 70℃; Heating / reflux; |
-
-
1493-13-6
trifluorormethanesulfonic acid
-
A
-
353-50-4
Carbonyl fluoride
-
B
-
76-16-4
Hexafluoroethane
-
C
-
358-23-6
trifluoromethylsulfonic anhydride
-
D
-
3582-05-6
trifluoromethyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| byproducts: SO3, SOF2; at 10°C; |
| Conditions | Yield |
|---|---|
| With iodine heating above 300°C; |
-
-
594-22-9
trichloroiodomethane
-
-
49539-99-3, 49540-00-3
mercuric triflate
-
A
-
75-44-5
phosgene
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
1493-13-6
trifluorormethanesulfonic acid
-
-
10026-13-8, 874483-75-7
phosphorus pentachloride
-
A
-
358-23-6
trifluoromethylsulfonic anhydride
-
B
-
65597-24-2
Chlorine(I) trifluoromethanesulfonate
-
-
558-13-4
carbon tetrabromide
-
-
49539-99-3, 49540-00-3
mercuric triflate
-
A
-
593-95-3
carbonyl dibromide
-
B
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| With phosphorus pentoxide |
-
-
7664-41-7
ammonia
-
A
-
38542-94-8
ammonium triflate
-
B
-
421-85-2
Trifluoromethanesulfonamide
-
C
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| In ammonia | |
| In ammonia aq. ammonia=NH3; |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
10472-24-9
methyl 2-oxocyclopentane-1-carboxylate
-
-
65832-21-5
methyl 2-(trifluoromethylsulfonyloxy)cyclopent-1-enecarboxylate
| Conditions | Yield |
|---|---|
| Stage #1: methyl 2-oxocyclopentane-1-carboxylate With N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at -78 - 20℃; Inert atmosphere; | 100% |
| With sodium hydride In diethyl ether; pentane at 20℃; for 1h; | 99% |
| With sodium hydride In diethyl ether | 99% |
-
-
20880-92-6
2,3;4,5-di-O-isopropylidene-β-D-fructopyranose
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
74925-15-8
2,3:4,5-di-O-isopropylidene-1-O-(trifluoromethanesulfonyl)-β-D-fructopyranose
| Conditions | Yield |
|---|---|
| With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane at -10℃; for 0.666667h; | 100% |
| With pyridine In dichloromethane at -15℃; for 1.5h; | 95% |
| With pyridine In dichloromethane at -20℃; for 2h; | 92% |
-
-
148-24-3
8-quinolinol
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
108530-08-1
quinolin-8-yl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0 - 20℃; for 12h; Schlenk technique; Inert atmosphere; | 100% |
| With pyridine In dichloromethane at 0 - 20℃; | 99% |
| With pyridine In dichloromethane at 0 - 20℃; | 97% |
-
-
23276-32-6
benzyl 2,3-O-isopropylidene-D-ribofuranoside
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
70209-12-0
benzyl 2,3-O-isopropylidene-5-O-triflyl-β-D-ribofuranoside
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at -5℃; for 0.5h; | 100% |
| With pyridine In dichloromethane at -20℃; for 0.5h; Inert atmosphere; |
-
-
620630-82-2
1,2 5,6-O-di(isopropylidene)-α-D-allofuranose
-
-
358-23-6
trifluoromethylsulfonic anhydride
| Conditions | Yield |
|---|---|
| Stage #1: 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose; trifluoromethylsulfonic anhydride With pyridine In dichloromethane at -5℃; for 1h; Stage #2: With water In dichloromethane at 20℃; | 100% |
| With pyridine In dichloromethane at 20℃; | 80% |
| With pyridine In dichloromethane for 0.166667h; | |
| With pyridine In dichloromethane at 0℃; | |
| In dichloromethane at 0℃; for 5h; Inert atmosphere; |
-
-
100713-03-9
2-hydroxy-7,8,9,10-tetrahydrophenanthridine
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
144127-49-1
2-<<(trifluoromethyl)sulfonyl>oxy>-7,8,9,10-tetrahydrophenanthridine
| Conditions | Yield |
|---|---|
| With pyridine at 0℃; for 24h; | 100% |
-
-
1806-29-7
2,2'-dihydroxybiphenyl
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
17763-95-0
2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0℃; Inert atmosphere; | 100% |
| With triethylamine In dichloromethane at 0 - 23℃; for 14h; | 99% |
| With pyridine | 97% |
-
-
27871-49-4
(S)-Methyl lactate
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
99208-98-7
methyl (S)-2-[(trifluoromethanesulfonyl)oxy]propionate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 15℃; for 2h; Inert atmosphere; | 100% |
| With 2,6-dimethylpyridine In dichloromethane at -78℃; | 91% |
| In pyridine; dichloromethane at -22 - 20℃; | 74.4% |
-
-
687-47-8
(S)-Ethyl lactate
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
84028-88-6
ethyl (S)-lactate triflate
| Conditions | Yield |
|---|---|
| With 2,6-dimethylpyridine In dichloromethane at -78 - 20℃; for 1.66667h; | 100% |
| With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; | 98% |
| With N,N-diisobutyl-2,4-dimethyl-3-pentylamine In tetrachloromethane for 0.5h; 0 deg C to RT; | 96% |
-
-
112-30-1
1-Decanol
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
53059-89-5
1-(tert-butyldimethylsilyl)oxydecane
| Conditions | Yield |
|---|---|
| With 2,6-dimethylpyridine In dichloromethane at 0℃; for 0.25h; Inert atmosphere; | 100% |
| With triethylamine In toluene for 0.25h; Ambient temperature; | 77% |
| With pyridine In dichloromethane at -5 - 5℃; for 3h; | 62% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
540-38-5
4-Iodophenol
-
-
109586-39-2
4-iodophenyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| With pyridine at 0 - 20℃; for 12h; Inert atmosphere; | 100% |
| With pyridine In dichloromethane at 0℃; | 95% |
| Stage #1: p-Iodophenol With 2,6-dimethylpyridine In dichloromethane at -30℃; for 0.25h; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at 20℃; for 4.5h; | 90% |
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
| With pyridine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere; | 100% |
| With triethylamine In dichloromethane at 0℃; for 1h; | 99% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
3470-50-6
6-Hydroxy-1-tetralone
-
-
144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane | 100% |
| With pyridine at 20℃; | 100% |
| With pyridine In dichloromethane | 99% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
35216-79-6, 73572-12-0, 86631-63-2
1-naphthyl-2-naphthol
-
-
187522-58-3, 126613-04-5, 405877-72-7
(S)-(-)-2-trifluoromethanesulfonyloxy-1,1'-binaphthyl
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 2h; | 100% |
| With pyridine In dichloromethane for 2h; | 92% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester
-
-
112766-18-4
methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0 - 5℃; for 2.5h; | 100% |
| With 2,6-dimethylpyridine In dichloromethane at 0℃; | 99% |
| With 4-methyl-morpholine In dichloromethane at -15 - -5℃; for 2.16667h; | 98% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate
-
-
88767-98-0
ethyl (R)-4-phenyl-2-<<(trifluoromethyl)sulfonyl>oxy>butyrate
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0℃; for 0.5h; | 100% |
| In pyridine; dichloromethane at 10℃; for 2h; | 85% |
| With pyridine In dichloromethane at 4℃; for 3h; | 57% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol
-
-
126613-06-7, 128544-05-8, 128575-34-8, 141807-44-5
(S)-2,2'-bis((trifluoromethanesulfonyl)oxy)-1,1'-binaphthyl
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at -78 - 20℃; for 2h; Inert atmosphere; | 100% |
| With 2,6-dimethylpyridine; dmap In dichloromethane at -78 - 20℃; | 100% |
| With pyridine In dichloromethane at 0 - 20℃; for 5h; Schlenk technique; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
128143-88-4
2,2':6',2''-Terpyridin-4'(1'H)-one
-
-
134653-69-3
4'-{[(Trifluoromethyl)sulfonyl]oxy}-2,2':6',2''-terpyridine
| Conditions | Yield |
|---|---|
| With pyridine at 0 - 20℃; Inert atmosphere; | 100% |
| In pyridine Inert atmosphere; | 94% |
| With pyridine 1) 0 deg C, 30 min, 2) 25 deg C, 48h; | 70% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
17392-84-6
methyl (2S)-2-hydroxy-4-methylpentanoate
-
-
120049-34-5
(S)-methyl 4-methyl-2-{[(trifluoromethyl)sulfonyl]oxy}pentanoate
| Conditions | Yield |
|---|---|
| Stage #1: trifluoromethylsulfonic anhydride; methyl (2S)-2-hydroxy-4-methylpentanoate In dichloromethane at -30℃; for 0.166667h; Stage #2: With 2,6-dimethylpyridine In dichloromethane at 20℃; for 16h; | 100% |
| With 2,6-dimethylpyridine In dichloromethane at -78℃; | 91% |
| With lutidine In dichloromethane at 0℃; | |
| With 2,6-dimethylpyridine In dichloromethane at 0℃; for 0.25h; Inert atmosphere; |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
132454-70-7
3-Deoxy-3-C-methyl-D-ribonolactone
-
-
132454-69-4
Trifluoro-methanesulfonic acid (3R,4R,5S)-5-benzyloxymethyl-4-methyl-2-oxo-tetrahydro-furan-3-yl ester
| Conditions | Yield |
|---|---|
| 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
134645-97-9
methyl 2,3-di-O-benzoyl-6-deoxy-β-D-galactopyranoside
-
-
134659-74-8
methyl 2,3-di-O-benzoyl-6-deoxy-4-O-trifluoromethanesulfonyl-β-D-galactopyranoside
| Conditions | Yield |
|---|---|
| With pyridine | 100% |
| With pyridine In dichloromethane at 0℃; for 0.333333h; | 87% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
73697-07-1, 106758-95-6
3α,18-pivalyldioxy-17-noraphidicolan-16-one
-
-
135405-00-4
3α,18-(2,2-dimethylpropylidenedioxy)-16-(trifluoromethylsulphonyloxy)-17-noraphidicol-15-ene
| Conditions | Yield |
|---|---|
| With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane Ambient temperature; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
71695-52-8
methyl 4-O-benzoyl-2,6-dideoxy-β-D-arabino-hexopyranoside
-
-
102650-55-5
Benzoic acid (2R,3R,4R,6R)-6-methoxy-2-methyl-4-trifluoromethanesulfonyloxy-tetrahydro-pyran-3-yl ester
| Conditions | Yield |
|---|---|
| With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane at 23℃; for 0.166667h; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
112298-15-4
5-(4-chlorophenyl)-1,1,1-trifluoropentan-2-ol
-
-
112298-11-0
5-(p-chlorophenyl)-1,1,1-trifluoropentan-2-ol triflate
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 0℃; for 4h; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
145411-92-3, 145411-94-5
(4aS,5R)-5-Methyl-2-propyl-4a,5,6,7,8,8a-hexahydro-1H-quinolin-4-one
-
-
145585-44-0
Trifluoro-methanesulfonic acid (4aR,5S,8aS)-5-methyl-2-propyl-4a,5,6,7,8,8a-hexahydro-quinolin-4-yl ester; compound with trifluoro-methanesulfonic acid
| Conditions | Yield |
|---|---|
| In dichloromethane at 40℃; for 18h; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
110418-88-7
methyl 3-O-benzoyl-2,6-dideoxy-α-D-arabino-hexopyranoside
-
-
110418-89-8
methyl 3-O-benzoyl-2,6-dideoxy-4-O-<(trifluoromethyl)sulfonyl>-α-D-arabino-hexopyranoside
| Conditions | Yield |
|---|---|
| With 2,6-di-tert-butyl-4-methylpyridine In chloroform-d1 at 20℃; for 0.25h; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
143444-50-2
(4S,5R)-2,2-dimethyl-4-(hydroxymethyl)-5-(2'-methylpropyl)-1,3-dioxolane
-
-
143427-04-7
(4S,5R)-2,2-dimethyl-4-(trifluoromethanesulfonyloxymethyl)-5-(2'-methylpropyl)-1,3-dioxolane
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at -15℃; for 0.333333h; | 100% |
| With pyridine at -15℃; for 0.25h; |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
112403-53-9
3-amino>-1-propanol
-
-
112403-59-5
1-methyl-1-<(E)-4-phenyl-3-butenyl>azetidinium trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| With potassium carbonate In dichloromethane at -78 - 23℃; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
112403-56-2
1-{2-[(3-Hydroxy-propyl)-methyl-amino]-ethyl}-3-phenyl-urea
-
-
112403-65-3
Trifluoro-methanesulfonate1-methyl-1-[2-(3-phenyl-ureido)-ethyl]-azetidinium;
| Conditions | Yield |
|---|---|
| With potassium carbonate In dichloromethane at -78 - 23℃; | 100% |
-
-
358-23-6
trifluoromethylsulfonic anhydride
-
-
107599-46-2
methyl 4-O-(tert-butyldimethylsilyl)-6-deoxy-α-D-allopyranoside 2-acetate
-
-
107599-47-3
methyl 4-O-(tert-butyldimethylsilyl)-6-deoxy-α-D-allopyranoside 2-acetate 3-(trifluormethanesulfonate)
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 25℃; for 2h; | 100% |
| With pyridine In dichloromethane at -10 - 25℃; for 2h; | 100% |
Trifluoromethanesulfonic anhydride Specification
The Trifluoromethanesulfonic anhydride, with its CAS registry number 358-23-6, has its IUPAC name of trifluoromethylsulfonyl trifluoromethanesulfonate. For being a kind of clear colorless to light brown liquid, it is sensitive to moisture and it could react violently with water. Besides, its product categories are including pharmacetical; Organic Fluorides. As to its usage, it is known to one of the strongest organic acids, which is widely used in pharmaceutical, chemical and other industries.
The physical properties of this chemical are as below: (1)ACD/LogP: 2.12; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.12; (4)ACD/LogD (pH 7.4): 2.12; (5)ACD/BCF (pH 5.5): 24.01; (6)ACD/BCF (pH 7.4): 24.01; (7)ACD/KOC (pH 5.5): 338.59; (8)ACD/KOC (pH 7.4): 338.59; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 94.27; (13)Index of Refraction: 1.358; (14)Molar Refractivity: 31.41 cm3; (15)Molar Volume: 142.7 cm3; (16)Polarizability: 12.45×10-24 cm3; (17)Surface Tension: 34.1 dyne/cm; (18)Density: 1.976 g/cm3; (19)Enthalpy of Vaporization: 30.98 kJ/mol; (20)Boiling Point: 82.6 °C at 760 mmHg; (21)Vapour Pressure: 86.8 mmHg at 25°C; (22)Exact Mass: 281.909134; (23)MonoIsotopic Mass: 281.909134; (24)Topological Polar Surface Area: 94.3; (25)Heavy Atom Count: 15; (26)Complexity: 370.
Use of this chemical: trifluoro-methanesulfonic acid could react to produce trifluoromethanesulfonic anhydride. This reaction could happen in the presence of the reagent of P2O5.
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Production method of this chemical: tetrahydrofuran could react with trifluoromethanesulfonic anhydride to produce 1,4-bis-trifluoromethanesulfonyloxy-butane. This reaction could react in the presence of the solvent of CH2Cl2.
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When you are dealing with this chemical, you should be very careful. For being corrosive, this chemical may destroy living tissue on contact and it will be very dangerous if by inhalation and in contact with skin. Besides, it may causes severe burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice, and if in case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add - Never use water). And then if in case of accident or if you feel unwell seek medical advice immediately (show the label where possible). When you need to store it, keep this container dry.
In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C(F)(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F
(2)InChI: InChI=1S/C2F6O5S2/c3-1(4,5)14(9,10)13-15(11,12)2(6,7)8
(3)InChIKey: WJKHJLXJJJATHN-UHFFFAOYSA-N
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