Trimecaine supplier | CasNO.616-68-2

Name
Trimecaine
EINECS 210-487-3
CAS No. 616-68-2
Density 1.015 g/cm³
Solubility soluble in water and ethanol
Melting Point 44°
Formula C₁₅H₂₄N₂O
Boiling Point 360.298 °C at 760 mmHg
Molecular Weight 248.368
Flash Point 171.702 °C
Transport Information
Appearance white crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Acetanilide,2-(diethylamino)-2',4',6'-trimethyl- (6CI,8CI);2-(Diethylamino)-2',4',6'-trimethylacetanilide;Diethylglycinemesidide;Justecaina;Mesdicain;Mesidicaine;Mesokain;N-(Diethylaminoacetyl)-2,4,6-trimethylaniline;w-Diethylaminoacetylaminomesitylene;N2,N2-Diethyl-N-mesitylglycinamide;
PSA 32.34000
LogP 2.96510

Synthetic route

: 3910-51-8
N-(chloroacetyl)-2,4,6-trimethylaniline

: 109-89-7
diethylamine

: 616-68-2
trimecaine

Conditions

Conditions	Yield
With benzene

: 603-71-4
nitromesitylene

: 616-68-2
trimecaine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq.-ethanolic sulfuric acid / bei der elektrochemischen Reduktion 2: sodium acetate; aqueous acetic acid 3: benzene View Scheme

: 88-05-1
2,4,6-trimethylaniline

: 616-68-2
trimecaine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium acetate; aqueous acetic acid 2: benzene View Scheme

: 616-68-2
trimecaine

: 106-95-6
allyl bromide

: 79143-64-9
Allyl-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 9h;	94%

: 616-68-2
trimecaine

: 74-88-4
methyl iodide

: 68638-18-6
Diethyl-methyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; iodide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 6h;	94%

: 616-68-2
trimecaine

: 100-44-7
benzyl chloride

: 79143-66-1
Benzyl-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 14h;	93%

: 616-68-2
trimecaine

: 624-65-7
2-propynyl chloride

: 79143-65-0
Diethyl-prop-2-ynyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 10h;	92%

: 616-68-2
trimecaine

: 75-03-6
ethyl iodide

: 68638-19-7
Triethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; iodide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 10h;	90%

: 616-68-2
trimecaine

: 611-17-6
1-bromomethyl-2-chlorobenzene

: 79154-29-3
(2-Chloro-benzyl)-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 15h;	88%

: 616-68-2
trimecaine

: 99-73-0
para-bromophenacyl bromide

: 79143-69-4
[2-(4-Bromo-phenyl)-2-oxo-ethyl]-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 10h;	87%

: 616-68-2
trimecaine

: 824-55-5
2,4-dimethyl-benzyl chloride

: 79143-67-2
(2,4-Dimethyl-benzyl)-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 9h;	87%

: 616-68-2
trimecaine

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 79154-28-2
(2-Bromo-benzyl)-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 9h;	85%

: 616-68-2
trimecaine

: 105-36-2
ethyl bromoacetate

: 79143-70-7
Ethoxycarbonylmethyl-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 20h;	76%

: 616-68-2
trimecaine

: 2315-36-8
2-Chloro-N,N-diethylacetamide

: 79143-73-0
Diethylcarbamoylmethyl-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 8h;	75%

: 616-68-2
trimecaine

: 79-07-2
Chloroacetamide

: 79143-72-9
Carbamoylmethyl-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 20h;	74.5%

: 616-68-2
trimecaine

: 540-51-2
2-bromoethanol

: 79143-68-3
Diethyl-(2-hydroxy-ethyl)-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 12h;	74%

: 75-30-9
2-iodo-propane

: 616-68-2
trimecaine

: 68638-21-1
Diethyl-isopropyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; iodide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 14h;	72%

: 616-68-2
trimecaine

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 79143-71-8
(1-Ethoxycarbonyl-ethyl)-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; bromide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 20h;	71%

: 55860-22-5
2-chloro-N-(2-methoxyphenyl)acetamide

: 616-68-2
trimecaine

: 79143-75-2
Diethyl-[(2-methoxy-phenylcarbamoyl)-methyl]-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 16h;	70%

: 616-68-2
trimecaine

: 107-08-4
1-iodo-propane

: 68638-20-0
Diethyl-propyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; iodide

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 13h;	68%

: 3910-51-8
N-(chloroacetyl)-2,4,6-trimethylaniline

: 616-68-2
trimecaine

: 79143-74-1
Diethyl-bis-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 15h;	62%

: 2653-14-7
N-benzyl-N-phenylchloroacetamide

: 616-68-2
trimecaine

: 79143-76-3
[(Benzyl-phenyl-carbamoyl)-methyl]-diethyl-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-ammonium; chloride

Conditions

Conditions	Yield
In acetone at 70 - 90℃; for 14h;	53%

: 616-68-2
trimecaine

: 101261-52-3
N,N-diethyl-thioglycine-(2,4,6-trimethyl-anilide)

Conditions

Conditions	Yield
With tetraphosphorus decasulfide

Trimecaine Specification

The (Z)-Capsaicin, with the CAS registry number 616-68-2, is also known as 2-(Diethylamino)-N-mesitylacetamide. Its EINECS number is 210-487-3. This chemical's molecular formula is C₁₅H₂₄N₂O and molecular weight is 248.36. What's more, its IUPAC name is 2-Diethylamino-N-(2,4,6-trimethylphenyl)acetamide. Its classification codes are: (1)Anesthetics; (2)Anesthetics, local; (3)Central Nervous System Agents; (4)Central Nervous System Depressants; (5)Drug / Therapeutic Agent; (6)Peripheral Nervous System Agents; (7)Sensory System Agents. This chemical is acetanilide derivative used as a local anesthetic. It is white crystalline powder readily soluble in water and ethanol. It is an active ingredient in products available under trademarks Mesdicain, Mesocain, Mesokain and others.

Physical properties of (Z)-Capsaicin are: (1)ACD/LogP: 2.7; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.48; (4)ACD/LogD (pH 7.4): 2.17; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 19.62; (7)ACD/KOC (pH 5.5): 4.23; (8)ACD/KOC (pH 7.4): 207.32; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 32.34 Å²; (13)Index of Refraction: 1.544; (14)Molar Refractivity: 77.252 cm³; (15)Molar Volume: 244.622 cm³; (16)Polarizability: 30.625×10^-24cm³; (17)Surface Tension: 38.36 dyne/cm; (18)Density: 1.015 g/cm³; (19)Flash Point: 171.702 °C; (20)Enthalpy of Vaporization: 60.6 kJ/mol; (21)Boiling Point: 360.298 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Nc1c(cc(cc1C)C)C)CN(CC)CC
(2)Std. InChI: InChI=1S/C15H24N2O/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5/h8-9H,6-7,10H2,1-5H3,(H,16,18)
(3)Std. InChIKey: GOZBHBFUQHMKQB-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
cat	LDLo	intravenous	129mg/kg (129mg/kg)	Farmakologiya i Toksikologiya Vol. 39, Pg. 426, 1976.
mouse	LD50	intraperitoneal	180mg/kg (180mg/kg)	Pharmaceutical Chemistry Journal Vol. 23, Pg. 222, 1989.
mouse	LD50	intravenous	187mg/kg (187mg/kg)	Russian Pharmacology and Toxicology Vol. 50, Pg. 112, 1987.
mouse	LD50	subcutaneous	295mg/kg (295mg/kg)	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 402, 1959.

Product Name

Trimecaine

Synthetic route

Trimecaine Specification

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