Trimethyl orthoacetate supplier

Name
Trimethyl orthoacetate
EINECS 215-892-9
CAS No. 1445-45-0
Article Data18
CAS DataBase
Density 0.922 g/cm³
Solubility hydrolysis in water
Melting Point -58oC
Formula C₅H₁₂O₃
Boiling Point 108 °C at 760 mmHg
Molecular Weight 120.148
Flash Point 16.7 °C
Transport Information UN 3272 3/PG 2
Appearance Colorless transparent liquid
Safety 16-37/39-24-33-26-7/9
Risk Codes 11-43-38-36/37/38
Molecular Structure
Hazard Symbols F,Xi
Synonyms Orthoacetic acid, trimethyl ester;Ethane, 1,1,1-trimethoxy-;
PSA 27.69000
LogP 0.59930

Synthetic route

: 67-56-1
methanol

: 75-05-8
acetonitrile

: 1445-45-0
Trimethyl orthoacetate

Conditions

Conditions	Yield
Stage #1: methanol; acetonitrile With hydrogenchloride; cetyltrimethylammonium chloride In hexane at -10℃; for 6h; Large scale; Stage #2: methanol at 40℃; for 4h; pH=5-6; Reagent/catalyst; Temperature; Large scale;	95.16%
Stage #1: methanol; acetonitrile With hydrogenchloride In 1,3,5-trimethyl-benzene at 0 - 25℃; for 8h; Large scale; Stage #2: With ammonia at 0 - 39℃; for 8h; pH=5 - 6; Solvent; Large scale;	87%
Stage #1: methanol; acetonitrile With hydrogenchloride In 1,3,5-trimethyl-benzene at 0 - 25℃; Large scale; Stage #2: With ammonia at 37 - 39℃; for 8h; pH=5-6; Solvent; Large scale;	87%

: 67-56-1
methanol

: 14777-27-6
methyl acetimidate hydrochloride

: 1445-45-0
Trimethyl orthoacetate

Conditions

Conditions	Yield
With ammonia at 0 - 40℃; pH=5.6;	80%

: 67-56-1
methanol

: 594-72-9
1,1-dichloro-1-nitroethane

: 124-41-4
sodium methylate

: 1445-45-0
Trimethyl orthoacetate

Conditions

Conditions	Yield
Irradiation;	56%

...Expand

: 922-69-0
1,1-dimethoxyethylene

: 75-07-0
acetaldehyde

A: 1445-45-0
Trimethyl orthoacetate

B: 123-73-9
trans-Crotonaldehyde

C: 623-43-8
crotonic acid methyl ester

D: 79-20-9
acetic acid methyl ester

Conditions

Conditions	Yield
at 150℃;

...Expand

: 67-56-1
methanol

: 60-29-7
diethyl ether

: 82190-86-1
1-((2-chloroethyl)oxy)ethanimine hydrochloride

A: 1445-45-0
Trimethyl orthoacetate

B: 82190-84-9
1,1-divinyloxy-1-methoxyethane

Conditions

Conditions	Yield
With potassium tert-butylate Yield given. Yields of byproduct given;

...Expand

: 67-56-1
methanol

: 79-20-9
acetic acid methyl ester

: 1445-45-0
Trimethyl orthoacetate

Conditions

Conditions	Yield
With triethylamine at 37℃; Irradiation; gas phase alcoholysis; Yield given;

: 1445-45-0
Trimethyl orthoacetate

: 87-91-2
diethyl (2R,3R)-tartrate

: 134745-01-0
diethyl (4R)-trans-2-methoxy-2-methyl-1,3-dioxolan-4,5-dicarboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 12h;	100%
With sulfuric acid In benzene at 80℃;	98%

: 1445-45-0
Trimethyl orthoacetate

: 69097-20-7
tris(trimethylsilyloxy)ethylene

: 108009-58-1
3,3-Dimethoxy-2-(trimethylsiloxy)butansaeure-trimethylsilylester

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 16h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 122517-81-1
(2R,3S)-methyl 2,3-dihydroxy-3-(4-methoxyphenyl)propanoate

: 106146-95-6
(4R,5S)-2-Methoxy-5-(4-methoxy-phenyl)-2-methyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	100%

: 1445-45-0
Trimethyl orthoacetate

: 82204-15-7
4-methoxy-2-(trimethylsilyloxy)furan

: 82204-19-1
methyl 5-(1,1-dimethoxyethyl)tetronate

Conditions

Conditions	Yield
With titanium tetrachloride In dichloromethane -95 deg C, 1 h, RT., 2 days;	100%

: 1445-45-0
Trimethyl orthoacetate

: 89821-78-3
allyl 4-O-benzyl-α-L-rhamnopyranoside

: 134136-22-4
allyl 2-O-acetyl-4-O-benzyl-α-L-rhamnopyranoside

Conditions

Conditions	Yield
Stage #1: Trimethyl orthoacetate; allyl 4-O-benzyl-α-L-rhamnopyranoside With toluene-4-sulfonic acid In acetonitrile Stage #2: With acetic acid In water; acetonitrile	100%
Stage #1: Trimethyl orthoacetate; allyl 4-O-benzyl-α-L-rhamnopyranoside With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Stage #2: With acetic acid In water; acetonitrile at 20℃; for 1h; Cooling with ice;	98%
With toluene-4-sulfonic acid In acetonitrile 1a) 50 deg C, b) 12 h, r. t.;	85%

: 1445-45-0
Trimethyl orthoacetate

: 69556-70-3
4-methoxy-5H-furan-2-one

: 82204-19-1
methyl 5-(1,1-dimethoxyethyl)tetronate

Conditions

Conditions	Yield
zinc dibromide	100%
With n-butyllithium; boron trifluoride diethyl etherate 1.) ether, hexane, -78 deg C, 2.) ether:THF=10:1, -78 deg C; Yield given. Multistep reaction;

: 1445-45-0
Trimethyl orthoacetate

: 104-15-4
toluene-4-sulfonic acid

: 80-48-8
methyl p-toluene sulfonate

Conditions

Conditions	Yield
at 20℃; for 0.5h;	100%
In dichloromethane for 0.5h; Ambient temperature;	96%

: 1445-45-0
Trimethyl orthoacetate

: 475672-28-7
methyl (4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside

: 475672-29-8
methyl (2-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside

Conditions

Conditions	Yield
Stage #1: Trimethyl orthoacetate; methyl (4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Stage #2: With water; acetic acid at 20℃; for 0.5h; Further stages.;	100%

: 1445-45-0
Trimethyl orthoacetate

: 37111-91-4
allyl 2,6-di-O-benzyl-α-D-galactopyranoside

: 525585-38-0
allyl 4-O-acetyl-2,6-di-O-benzyl-α-D-galactopyranoside

Conditions

Conditions	Yield
Stage #1: Trimethyl orthoacetate; allyl 2,6-di-O-benzyl-α-D-galactopyranoside With pyridinium p-toluenesulfonate In acetonitrile for 0.166667h; Stage #2: With acetic acid In water; acetonitrile for 1.5h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 2374-03-0
4-aminosalicylic acid

: 13452-14-7
2-methyl-6-benzoxazole carboxylic acid

Conditions

Conditions	Yield
at 100℃; for 0.0833333h; Microwave irradiation;	100%
at 100℃; for 0.0833333h; Microwave irradiation;	95%
	46%

: 1445-45-0
Trimethyl orthoacetate

: 96-22-0
pentan-3-one

: 25636-49-1
3,3-dimethoxypentane

Conditions

Conditions	Yield
With p-toluenesulfonic acid monohydrate; sodium methylate In methanol	100%
With p-toluenesulfonic acid monohydrate In methanol at 5 - 20℃; for 3.5h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 320-94-5
2-nitro-4-trifluoromethylbenzoic acid

: 228418-45-9
methyl 2-nitro-4-trifluoromethylbenzoate

Conditions

Conditions	Yield
In toluene at 80℃; for 16h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 407-25-0
trifluoroacetic anhydride

: 1071146-39-8
1,1,1-trifluoro-4,4-dimethoxy-but-3-en-2-one

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h;	100%
With pyridine In chloroform at 20℃; Cooling with ice;	92%
With pyridine In chloroform at 20℃; for 12h;	75%
With pyridine In chloroform at 20℃; for 12h; Inert atmosphere;	75%

: 1445-45-0
Trimethyl orthoacetate

: 1198109-76-0
N-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2-methylpyrimidine-4,5-diamine

: 1198109-77-1
9-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2,8-dimethyl-9H-purine

Conditions

Conditions	Yield
With acetic acid In acetonitrile for 18h; Reflux;	100%

: 1445-45-0
Trimethyl orthoacetate

: C12H10F2N2O3S2*0.6ClH

: methyl (1E)-N-({6-[(3,4-difluorophenyl)thio]-5-(hydroxymethyl)pyridin-3-yl}sulfonyl)ethanimidoate

Conditions

Conditions	Yield
In acetonitrile at 85℃; for 18h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 1410973-85-1
2-amino-6-bromo-N-methylbenzamide

: 1410974-43-4
5-bromo-2,3-dimethyl-3H-quinazolin-4-one

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; 1-methyl-pyrrolidin-2-one at 110℃; for 9h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 107-21-1
ethylene glycol

: 2-(1-methoxy-ethoxy)-ethanol

Conditions

Conditions	Yield
With trifluoroacetic acid In chloroform-d1 at 20℃; for 1h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 120-80-9
benzene-1,2-diol

: 51487-87-7
o-(1-methoxyethoxy)-phenol

Conditions

Conditions	Yield
With trifluoroacetic acid In dimethylsulfoxide-d6 at 20℃; for 1h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 77-85-0
2-(hydroxymethyl)-2-methylpropane-1,3-diol

: C7H16O3

Conditions

Conditions	Yield
With trifluoroacetic acid In dimethylsulfoxide-d6 at 20℃; for 1h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 16429-44-0
3-chloro-5-bromo-1,2-diaminobenzene

: 16429-40-6
5-bromo-7-chloro-2-methyl-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With ytterbium(III) triflate at 90℃; for 1h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 556-82-1
3-methyl-2-buten-1-ol

: 7796-72-7
ethyl 3,3-dimethylpent-4-enoate

Conditions

Conditions	Yield
With phenol at 130 - 160℃; for 16h; Johnson-Claisen Rearrangement; Inert atmosphere;	100%

: 1445-45-0
Trimethyl orthoacetate

: 593-51-1
methylamine hydrochloride

: 79-16-3
N-methyl-acetamide

Conditions

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

: 1445-45-0
Trimethyl orthoacetate

: 3287-99-8, 39110-74-2
benzylamine hydrochloride

: 588-46-5
N-(phenylmethyl)acetamide

Conditions

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

: 1445-45-0
Trimethyl orthoacetate

: 30684-05-0
3-phenylpropylamine hydrochloride

: 34059-10-4
N-acetyl-3-phenylpropylamine

Conditions

Conditions	Yield
for 2h; Reflux;	100%

: 1445-45-0
Trimethyl orthoacetate

: 665-66-7
amantadine hydrochloride

: 880-52-4
N-(1-adamantyl)acetamide

Conditions

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

: 1445-45-0
Trimethyl orthoacetate

: 73366-72-0
benzyl 4,6-O-benzylidene-α-D-mannopyranoside

: benzyl 2-O-acetyl-4,6-O-benzylidene-α-D-glucopyranoside

Conditions

Conditions	Yield
With (R)-10-camphorsulfonic acid In acetonitrile at 0 - 20℃; for 2h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

: 7-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-methoxy-2-methyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-fluoro-3H-pyrrolo[2,3-d]pyrimidin-4-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 1h;	100%

: 1445-45-0
Trimethyl orthoacetate

: 4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose

: 64-19-7
acetic acid

: 1-O-acetyl-4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose

Conditions

Conditions	Yield
Stage #1: Trimethyl orthoacetate; 4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Inert atmosphere; Stage #2: acetic acid In water; acetonitrile for 1h; Inert atmosphere;	100%

...Expand

: 1445-45-0
Trimethyl orthoacetate

: 3391-86-4
1-octen-3-ol

: 93979-14-7
methyl (4E)-dec-4-enoate

Conditions

Conditions	Yield
With propionic acid at 125℃; for 2h; Temperature; Claisen Rearrangement;	99.5%
With propionic acid at 105℃; for 4.5h;	87%
With propionic acid at 100 - 105℃;

: 1445-45-0
Trimethyl orthoacetate

: 67313-36-4
1,6-anhydro-2-azido-2-deoxy-β-D-galactopyranose

: 79705-76-3
1,6-Anhydro-2-azido-2-desoxy-3,4-O-(methyl-orthoacetyl)-β-D-galactopyranose

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 0.666667h;	99%

Trimethyl orthoacetate Chemical Properties

Molecular Structure of Trimethyl orthoacetate (CAS No.1445-45-0):

Molecular Formula: C₅H₁₂O₃
Molecular Weight: 120.14698
IUPAC Name: 1,1,1-Trimethoxyethane
CAS No: 1445-45-0
EINECS: 215-892-9
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 27.69 Å²
Index of Refraction: 1.383
Molar Refractivity: 30.41 cm³
Molar Volume: 130.2 cm³
Surface Tension: 23 dyne/cm
Density: 0.922 g/cm³
Flash Point: 16.7 °C
Enthalpy of Vaporization: 33.25 kJ/mol
Boiling Point: 108 °C at 760 mmHg
Vapour Pressure: 30.9 mmHg at 25°C
Solubility: Hydrolysis in water
Storage Temp.: Flammables area
Appearance: Clear colourless to slightly brown liquid
Canonical SMILES: CC(OC)(OC)OC
InChI: InChI=1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3
InChIKey: HDPNBNXLBDFELL-UHFFFAOYSA-N
Product Categories: Orthoesters

Trimethyl orthoacetate Safety Profile

Safety Information of Trimethyl orthoacetate (CAS No.1445-45-0):
Hazard Codes: F, Irritant Xi
Risk Statements: 11-43-38-36/37/38
R11:Highly flammable.
R43:May cause sensitization by skin contact.
R38:Irritating to skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-37/39-24-33-26-7/9
S16:Keep away from sources of ignition.
S37/39:Wear suitable gloves and eye/face protection.
S24:Avoid contact with skin.
S33:Take precautionary measures against static discharges.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S7:Keep container tightly closed.
S9:Keep container in a well-ventilated place.
RIDADR: UN 3272 3/PG 2
WGK Germany: 1
HazardClass: 3
PackingGroup: II
HS Code: 29159080

Trimethyl orthoacetate Specification

Trimethyl orthoacetate (CAS No.1445-45-0), it also can be called 1,1,1-Trimethoxyethane ; Orthoacetic acid, trimethyl ester ; Ethane, 1,1,1-trimethoxy- .

Product Name

Trimethyl orthoacetate

Synthetic route

Trimethyl orthoacetate Chemical Properties

Trimethyl orthoacetate Safety Profile

Trimethyl orthoacetate Specification

Related Products

Hot Products