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Dayang Chem (Hangzhou) Co.,Ltd.

img _fcksavedurl="/UserAppearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Phar

trans-Methyl crotonate

Cas:623-43-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl Crotonate supplier in China

Cas:623-43-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Methyl crotonate;Methyl-α-crotonate

Cas:623-43-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl crotonate

Cas:623-43-8

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Methyl crotonate

Cas:623-43-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good service Appearance:Powder Storage:Dry and cold condition Package:25KG, 500KG and1000KG, seaworthy and suitable for container transportation. Application:coatings, printing ink, rubber, glass, leather, cos

623-43-8 pharmaceutical chemical .Trans-Methyl crotonate,CAS;623-43-8

Cas:623-43-8

Min.Order:20 Metric Ton

FOB Price: $2100.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

623-43-8 trans-Methyl crotonate

Cas:623-43-8

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hefei TNJ chemical industry co.,ltd

Colourless liquid.The boiling point is 121 ℃, the refractive index is 1.4242, and the flash point 4 ℃. Soluble in alcohol and ether, insoluble in water. Used as intermediates in organic synthesis and spices. Appearance:Colourless liquid Storage:Sto

Trans-Methyl Crotonate

Cas:623-43-8

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

trans-Methyl crotonate 623-43-8

Cas:623-43-8

Min.Order:1 Kilogram

FOB Price: $60.0 / 80.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-Butenoic acid, methylester, (2E)-/ LIDE PHARMA- Factory supply / Best price

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

trans-Methyl crotonate CAS NO.623-43-8

Cas:623-43-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:623-43-8

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

trans-Methyl crotonate

Cas:623-43-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Butenoic acid, methylester, (2E)-

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

trans-Methyl crotonate

Cas:623-43-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2-Butenoic acid, methylester, (2E)-

Cas:623-43-8

Min.Order:0

Negotiable

Type:Other

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

trans-Methyl crotonate(E)

Cas:623-43-8

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(E)-Methyl but-2-enoate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Methyl Crotonate

Cas:623-43-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Methyl Crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

Trans-Methyl crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard

factory directly supply CAS 623-43-8 with best price

Cas:623-43-8

Min.Order:1 Kilogram

FOB Price: $112.0

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Methyl crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

Methyl crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

Methyl crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

trans-Methyl crotonate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

(E)-Methyl but-2-enoate

Cas:623-43-8

Min.Order:0

Negotiable

Type:Other

inquiry

Baoji Kano Phytochem Technology Co.,Ltd

Our Advantages 1>Professional quality control department 2>Strict inspection system for receiving inspection,in-process and finished products. 3>ISO quality system. 4>All of our service comply to CUSTOMER FIRST. Appearance:color

trans-Methyl crotonate Cas No.:623-43-8

Cas:623-43-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(E)-2-butenoic acid methyl ester

Cas:623-43-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

trans-Methylcrotonate

Cas:623-43-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methanol
67-56-1

methanol

(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid for 0.25h; Esterification; Irradiation;94%
With sulfuric acid for 12h; Heating;82%
With thionyl chloride
methanol
67-56-1

methanol

2-(diethylamino)ethyl crotonate
84115-05-9

2-(diethylamino)ethyl crotonate

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 4h; Heating;A 90%
B 82%
2-(diethylamino)ethyl crotonate
84115-05-9

2-(diethylamino)ethyl crotonate

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With methanol; toluene-4-sulfonic acid for 4h; Heating;A 90%
B 82%
2-ethylthio methyl ester
36056-36-7

2-ethylthio methyl ester

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With tetrabutylammomium bromide; ammonium chloride In ethanol electrolysis;90%
methanol
67-56-1

methanol

crotonaldehyde
123-73-9

crotonaldehyde

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With perchloric acid; sodium percarbonate; vanadia for 1h; Heating;90%
With tert.-butylhydroperoxide In decane at 25℃; for 8h; Inert atmosphere;72%
methyl 2,3-dibromobutyrate
5469-24-9

methyl 2,3-dibromobutyrate

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 20℃; for 0.583333h;90%
wt.-% NaOH

wt.-% NaOH

wt.-% sodium methylate

wt.-% sodium methylate

water
7732-18-5

water

3-chloroprop-1-ene
107-05-1

3-chloroprop-1-ene

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
Ni(CO)4 In methanol; aqueous KCl90%
sodium methylate
124-41-4

sodium methylate

2-Chloro-2-(1-chloroethyl)oxirane
51107-31-4

2-Chloro-2-(1-chloroethyl)oxirane

A

Methyl β-methoxybutyrate
3136-17-2, 117745-43-4, 117745-47-8

Methyl β-methoxybutyrate

B

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

C

ethylglyoxal dimethylacetal
6342-57-0

ethylglyoxal dimethylacetal

Conditions
ConditionsYield
In methanolA 11%
B 3%
C 86%
In methanolA 11 % Chromat.
B 3 % Chromat.
C 86 % Chromat.
In methanol Product distribution; -50 deg C, then 3h, roomtemp.;A 11 % Chromat.
B 3 % Chromat.
C 86 % Chromat.
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With indium(III) chloride; sodium tetrahydroborate In acetonitrile at -10℃; for 3h;78%
methyl-4-bromo-2-butenoate
1117-71-1, 56699-18-4, 6000-00-6

methyl-4-bromo-2-butenoate

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

methyl but-3-enoate
3724-55-8

methyl but-3-enoate

C

5-Vinyl-trans-hexen-2-disaeuredimethylester
26474-34-0

5-Vinyl-trans-hexen-2-disaeuredimethylester

Conditions
ConditionsYield
With zinc In dimethyl sulfoxide for 4h; Yields of byproduct given;A n/a
B n/a
C 75%
dimethylsulfite
616-42-2

dimethylsulfite

(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
sulfuric acid In methanol for 2h; Heating;73%
methanol
67-56-1

methanol

2-piperidinoethyl trans-crotonate
84115-06-0

2-piperidinoethyl trans-crotonate

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 3.5h; Heating;72%
(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

Fe(ClO4)3(CH3OH)6/SiO2

Fe(ClO4)3(CH3OH)6/SiO2

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
for 2h; Solid phase reaction; esterification;66%
1-phenylmethylenecyclopropane
7555-67-1

1-phenylmethylenecyclopropane

pentacrbonyl[(1-methoxy-1-(2-methylethenyl)carbene]chromium(0)

pentacrbonyl[(1-methoxy-1-(2-methylethenyl)carbene]chromium(0)

A

2-Methoxy-3-[1-phenyl-meth-(E)-ylidene]-2-((E)-propenyl)-cyclopentanone

2-Methoxy-3-[1-phenyl-meth-(E)-ylidene]-2-((E)-propenyl)-cyclopentanone

B

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0) In N,N-dimethyl-formamide at 0℃; for 1h;A 55%
B n/a
sodium methylate
124-41-4

sodium methylate

1,3-dichlorobutan-2-one
16714-77-5

1,3-dichlorobutan-2-one

A

Methyl β-methoxybutyrate
3136-17-2, 117745-43-4, 117745-47-8

Methyl β-methoxybutyrate

B

(Z)-methyl but-2-enoate
4358-59-2

(Z)-methyl but-2-enoate

C

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

D

ethylglyoxal dimethylacetal
6342-57-0

ethylglyoxal dimethylacetal

Conditions
ConditionsYield
In methanol -50 deg C, then 3h, roomtemp.; Further byproducts given;A 13%
B 36%
C 16%
D 16%
sodium methylate
124-41-4

sodium methylate

1,3-dichlorobutan-2-one
16714-77-5

1,3-dichlorobutan-2-one

A

Methyl β-methoxybutyrate
3136-17-2, 117745-43-4, 117745-47-8

Methyl β-methoxybutyrate

B

(Z)-methyl but-2-enoate
4358-59-2

(Z)-methyl but-2-enoate

C

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

D

ethylglyoxal dimethylacetal
6342-57-0

ethylglyoxal dimethylacetal

E

methacrylic acid methyl ester
80-62-6

methacrylic acid methyl ester

Conditions
ConditionsYield
In methanol Product distribution; -50 deg C, then 3h, roomtemp.;A 13%
B 36%
C 16%
D 16%
E 13%
sodium methylate
124-41-4

sodium methylate

1,3-dichlorobutan-2-one
16714-77-5

1,3-dichlorobutan-2-one

A

(Z)-methyl but-2-enoate
4358-59-2

(Z)-methyl but-2-enoate

B

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

C

ethylglyoxal dimethylacetal
6342-57-0

ethylglyoxal dimethylacetal

D

methacrylic acid methyl ester
80-62-6

methacrylic acid methyl ester

Conditions
ConditionsYield
In methanol -50 deg C, then 3h, roomtemp.; Further byproducts given;A 36%
B 16%
C 16%
D 13%
allyl methyl carbonate
35466-83-2

allyl methyl carbonate

carbon monoxide
201230-82-2

carbon monoxide

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

methyl but-3-enoate
3724-55-8

methyl but-3-enoate

Conditions
ConditionsYield
With 1,10-Phenanthroline; dodecacarbonyl-triangulo-triruthenium at 120℃; under 30400 Torr; for 10h; Yields of byproduct given;A 18%
B n/a
allyl bromide
106-95-6

allyl bromide

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
4%
methanol
67-56-1

methanol

2-butenoic acid
3724-65-0

2-butenoic acid

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid
With hydrogenchloride
With sulfuric acid
2-butenoic acid
3724-65-0

2-butenoic acid

dimethylsulfite
616-42-2

dimethylsulfite

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With mineral acid
tetramethylorthosilicate
681-84-5

tetramethylorthosilicate

(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

1,1-dimethoxyethylene
922-69-0

1,1-dimethoxyethylene

acetaldehyde
75-07-0

acetaldehyde

A

Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

B

trans-Crotonaldehyde
123-73-9

trans-Crotonaldehyde

C

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

D

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
at 150℃;
methyl iodide
74-88-4

methyl iodide

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With 18-crown-6 ether; potassium naphthalenide 1) THF, 20 deg C, 10 min; Yield given. Multistep reaction;
methanol
67-56-1

methanol

trans-chrotonyl chloride
625-35-4, 3488-22-0, 10487-71-5

trans-chrotonyl chloride

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

methyl but-3-enoate
3724-55-8

methyl but-3-enoate

Conditions
ConditionsYield
With 2,4-dimethylaminopyridine; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.5h; Yield given. Yields of byproduct given;
methanol
67-56-1

methanol

4,4-bis-methylsulfanyl-but-3-en-2-ol
15081-72-8

4,4-bis-methylsulfanyl-but-3-en-2-ol

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate 1) room temp., 5 min, 2) reflux, 16 h; Yield given. Multistep reaction;
methanol
67-56-1

methanol

1-chloroethyl trans-crotonate
91488-52-7

1-chloroethyl trans-crotonate

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 9h; Heating;1.28 g
methanol
67-56-1

methanol

2-chloropropyl trans-crotonate

2-chloropropyl trans-crotonate

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

glutaric anhydride,
108-55-4

glutaric anhydride,

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

C

butanoic acid methyl ester
623-42-7

butanoic acid methyl ester

D

methyl but-3-enoate
3724-55-8

methyl but-3-enoate

E

methyl heptanoate
106-73-0

methyl heptanoate

F

dimethyl subarate
1732-09-8

dimethyl subarate

Conditions
ConditionsYield
With electrochemical reduction Product distribution; by-products;
nitromethane
75-52-5

nitromethane

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

methyl 3-methyl-4-nitro-butyrate
16507-06-5

methyl 3-methyl-4-nitro-butyrate

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine at 20℃; for 576h;100%
With DBN In methanol at 60℃; for 6h; Inert atmosphere;71.44%
With methanol; potassium carbonate
With N-benzyl-trimethylammonium hydroxide In methanol
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol Michael addition;
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

methyl 2,3-dibromobutyrate
5469-24-9

methyl 2,3-dibromobutyrate

Conditions
ConditionsYield
With bromine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With bromine In acetic acid at 30℃; Mechanism; Rate constant;
With bromine
With bromine In tetrachloromethane at 0℃; for 0.5h;
With bromine In n-heptane at 25 - 35℃; for 1.33333 - 1.5h;
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

butanoic acid methyl ester
623-42-7

butanoic acid methyl ester

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; methylcopper; diisobutylaluminium hydride In tetrahydrofuran; diethyl ether; hexane at -50℃; for 0.5h;100%
With hydrogen; Rhodium chloride tri(triphenylphosphine-meta-trisulfonate) In water for 16h; Ambient temperature;95%
With hydrogen; Pd(II) complex containing tridentate hydrazonic ligands In methanol at 40℃; for 24h; Hydrogenation;35%
With hydrogen; montmorillonite-(bipyridine)x In benzene at 75℃; under 31028.9 Torr; for 45h;91 % Spectr.
With hydrogen In methanol at 80℃; under 37503.8 Torr; for 20h; Autoclave;
piperidine
110-89-4

piperidine

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

(+/-)-3-(1-piperidinyl)butyric acid methyl ester
122958-11-6

(+/-)-3-(1-piperidinyl)butyric acid methyl ester

Conditions
ConditionsYield
[(dppf)Pd(NCMe)(H2O)](OTf)2 In toluene at 20℃; for 18h;100%
In methanol at 20℃; for 168h; Addition;85%
With 3-butyl-1-methylimidazolium hydroxide at 25℃; for 1.5h; aza-Michael addition;85%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

para-thiocresol
106-45-6

para-thiocresol

4-(4-mercapto-phenyl)-3-methyl-butyric acid methyl ester

4-(4-mercapto-phenyl)-3-methyl-butyric acid methyl ester

Conditions
ConditionsYield
With magnesium oxide In toluene at 20℃; for 0.5h; Michael addition;100%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

5-methyl-pyrazolidin-3-one
10234-76-1

5-methyl-pyrazolidin-3-one

Conditions
ConditionsYield
With hydrazine hydrate100%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

methyl 3-(N-benzyl-N-methylamino)-3-methylpropionate
40871-09-8

methyl 3-(N-benzyl-N-methylamino)-3-methylpropionate

Conditions
ConditionsYield
100%
100%
100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 14h; aza-Michael addition;77%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

methyl nonyl ketone
112-12-9

methyl nonyl ketone

4,5-Dimethyl-5-nonyl-dihydro-furan-2-one
111748-84-6, 111748-88-0

4,5-Dimethyl-5-nonyl-dihydro-furan-2-one

Conditions
ConditionsYield
With samarium diiodide; isopropyl alcohol In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 0℃; for 0.0166667h;99%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

2-(Trimethylsilyl)benzenethiol
33356-45-5

2-(Trimethylsilyl)benzenethiol

(S)-3-(2-Trimethylsilanyl-phenylsulfanyl)-butyric acid methyl ester

(S)-3-(2-Trimethylsilanyl-phenylsulfanyl)-butyric acid methyl ester

Conditions
ConditionsYield
With 2-TMSC6H4SLi; (-)-(1R,2R)-1-dimethylamino-2-(2-methoxyphenoxy)-1,2-diphenylethane In hexane; toluene at -78℃; for 120h; Addition;99%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

benzylamine
100-46-9

benzylamine

methyl 3-(benzylamino)butanoate
507444-65-7

methyl 3-(benzylamino)butanoate

Conditions
ConditionsYield
In ethanol for 16h; Heating;99%
In methanol at 150℃; under 5688.78 Torr; for 3h; Michael addition; microwave irradiation;98%
In methanol at 20℃; for 2h;96%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

2-tert-butyl 4-methyl 3-methyl-5,5-diphenylpyrrolidine-2,4-dicarboxylate

2-tert-butyl 4-methyl 3-methyl-5,5-diphenylpyrrolidine-2,4-dicarboxylate

Conditions
ConditionsYield
With 4 A molecular sieve; calcium bis-iso-propoxide; 2,2'-methylene bis((4S)-4-phenyl-2-oxazoline) In tetrahydrofuran at -30℃; for 12h; Michael addition;99%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

1H-4(5)-nitroimidazole
3034-38-6

1H-4(5)-nitroimidazole

3-(4-nitroimidazol-1-yl)-butyric acid methyl ester

3-(4-nitroimidazol-1-yl)-butyric acid methyl ester

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In dimethyl sulfoxide at 70℃; for 12h; Michael addition;99%
With acylase Amano from Aspergillus oryzae In dimethyl sulfoxide at 50℃; for 24h; Michael addition reaction;37%
1-thiopropane
107-03-9

1-thiopropane

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

A

C8H16O2S

C8H16O2S

B

C8H16O2S

C8H16O2S

Conditions
ConditionsYield
With C49H53N4O4PS In toluene at 20℃; for 3h; Reagent/catalyst; enantioselective reaction;A n/a
B 99%
2-methylimidazole
693-98-1

2-methylimidazole

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

methyl 3-(2-methyl-1H-imidazol-1-yl)butanoate

methyl 3-(2-methyl-1H-imidazol-1-yl)butanoate

Conditions
ConditionsYield
In neat (no solvent) at 80℃; for 24h; Michael Addition; Schlenk technique; Sealed tube;98.5%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

5-cyclohexyl-4-methyl-dihydrofuran-2(3H)-one

5-cyclohexyl-4-methyl-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With samarium diiodide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; isopropyl alcohol for 0.0166667h;98%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

malononitrile
109-77-3

malononitrile

2,4-diamino-5,6-dihydro-5-methylpyrido<2,3-d>pyrimidin-7(8H)-one
97934-10-6

2,4-diamino-5,6-dihydro-5-methylpyrido<2,3-d>pyrimidin-7(8H)-one

Conditions
ConditionsYield
Stage #1: guanidine hydrogen carbonate With sodium methylate In methanol for 0.25h; Heating;
Stage #2: crotonic acid methyl ester; malononitrile In methanol at 140℃; for 0.166667h; Irradiation;
98%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

2-amino-4-hydroxy-5-methyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one

2-amino-4-hydroxy-5-methyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one

Conditions
ConditionsYield
Stage #1: guanidine hydrogen carbonate With sodium methylate In methanol for 0.25h; Heating;
Stage #2: crotonic acid methyl ester; methyl 2-cyanoacetate In methanol at 140℃; for 0.166667h; Irradiation;
98%
(6-oxo-4-oxy-3,6-dihydro-2H-pyrazin-1-yl)-acetic acid methyl ester
930122-16-0

(6-oxo-4-oxy-3,6-dihydro-2H-pyrazin-1-yl)-acetic acid methyl ester

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

5-methoxycarbonylmethyl-2-methyl-4-oxo-hexahydro-isoxazolo[2,3-a]pyrazine-3-carboxylic acid methyl ester

5-methoxycarbonylmethyl-2-methyl-4-oxo-hexahydro-isoxazolo[2,3-a]pyrazine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With ytterbium(III) triflate In tetrahydrofuran for 14h; Heating;98%
1-(N,N‑dimethylcarbamoyl)indole
70957-05-0

1-(N,N‑dimethylcarbamoyl)indole

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

(E)-methyl 3-(1-(dimethylcarbamoyl)-1H-indol-2-yl)but-2-enoate
1454704-66-5

(E)-methyl 3-(1-(dimethylcarbamoyl)-1H-indol-2-yl)but-2-enoate

Conditions
ConditionsYield
With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; copper(II) acetate monohydrate In tetrahydrofuran at 100℃; for 24h; Heck Reaction; Inert atmosphere; stereoselective reaction;98%
With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate In 1,4-dioxane at 100℃; for 30h; Schlenk technique; Inert atmosphere; regioselective reaction;90%
tert-butyl (S,E)-4-methyl-2-((thiazol-2-ylmethylene)amino)pentanoate

tert-butyl (S,E)-4-methyl-2-((thiazol-2-ylmethylene)amino)pentanoate

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

2-tert-butoxycarbonyl-2-isobutyl-4-methoxycarbonyl-3-methyl-5-thiazol-2-ylpyrrolidine

2-tert-butoxycarbonyl-2-isobutyl-4-methoxycarbonyl-3-methyl-5-thiazol-2-ylpyrrolidine

Conditions
ConditionsYield
With C34H43N4O6Zn(1+)*CF3O3S(1-) In acetonitrile at 50℃; for 24h; Schlenk technique; Inert atmosphere; enantioselective reaction;98%
1H-imidazole
288-32-4

1H-imidazole

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

3-imidazol-1-yl-butyric acid methyl ester
1153450-51-1

3-imidazol-1-yl-butyric acid methyl ester

Conditions
ConditionsYield
In neat (no solvent) at 80℃; for 24h; Michael Addition; Schlenk technique; Sealed tube;97.5%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

benzaldehyde
100-52-7

benzaldehyde

5-hydroxy-5-phenyl-pent-2-enoic acid methyl ester
72853-47-5

5-hydroxy-5-phenyl-pent-2-enoic acid methyl ester

Conditions
ConditionsYield
Stage #1: crotonic acid methyl ester; benzaldehyde With aluminium tris(2,6-diphenylphenoxide) In toluene at -78℃; for 0.333333h; Complexation;
Stage #2: With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane; toluene at -78℃; for 0.5h; Crossed aldol condensation;
97%
Stage #1: crotonic acid methyl ester; benzaldehyde With aluminium tris(2,6-diphenylphenoxide) In toluene at -78℃; for 0.0833333h;
Stage #2: With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane; toluene at -78℃; for 0.5h;
97%
Stage #1: crotonic acid methyl ester; benzaldehyde With aluminum tris(2,6-di-2-naphthylphenoxide) In toluene at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; toluene at -78℃; for 3h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; toluene at -78 - 20℃; for 0.5h; Inert atmosphere;
97%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

C14H22N2O2S

C14H22N2O2S

2-tert-butoxycarbonyl-2-isobutyl-4-methoxycarbonyl-3-methyl-5-thiazol-2-ylpyrrolidine

2-tert-butoxycarbonyl-2-isobutyl-4-methoxycarbonyl-3-methyl-5-thiazol-2-ylpyrrolidine

Conditions
ConditionsYield
With CF3O3S(1-)*C32H40N4O4*Zn(2+)*C2H3O2(1-) In acetonitrile at 80℃; for 60h; enantioselective reaction;97%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

2-methylpropan-1,1,3-tricarboxylic acid trimethyl ester
65844-74-8

2-methylpropan-1,1,3-tricarboxylic acid trimethyl ester

Conditions
ConditionsYield
Stage #1: malonic acid dimethyl ester With sodium methylate In tetrahydrofuran; methanol at 23℃; for 0.166667h;
Stage #2: crotonic acid methyl ester In tetrahydrofuran; methanol at 45 - 50℃; for 4.16667h;
96%
With sodium methylate In methanol Heating;84%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

cis-(RS,SR)-γ-cyclohexyl-γ-hydroxy-β-methylbutanoic acid lactone
111748-83-5, 111748-87-9, 133101-54-9, 133101-64-1

cis-(RS,SR)-γ-cyclohexyl-γ-hydroxy-β-methylbutanoic acid lactone

Conditions
ConditionsYield
With samarium diiodide; isopropyl alcohol In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 0℃; for 0.0166667h; Product distribution; without HMPA, further reaction time;96%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

(Z) methyl 2-chloro-2-butenoate
22038-57-9, 60753-84-6, 22038-58-0

(Z) methyl 2-chloro-2-butenoate

Conditions
ConditionsYield
With aluminium trichloride; benzeneseleninyl chloride In dichloromethane at 40℃; for 23h;96%
With chlorine In dichloromethane for 0.666667h;34%
Multi-step reaction with 2 steps
1: Cl2 / CCl4 / 48 h / 0 °C
2: triethylamine / 72 h
View Scheme
Multi-step reaction with 2 steps
1: Cl2, Br2 / CCl4 / 48 h / 0 °C
2: triethylamine / 72 h
View Scheme
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

(S)-1-(4-benzyl-2-oxazolidin-3-yl)propan-1-one

(S)-1-(4-benzyl-2-oxazolidin-3-yl)propan-1-one

(S)-4-benzyl-3-(4-methoxycarbonyl-2,3-dimethylbutanoyl)oxazolidine

(S)-4-benzyl-3-(4-methoxycarbonyl-2,3-dimethylbutanoyl)oxazolidine

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h;96%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

(5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide
182316-01-4

(5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide

(2R,6R,7R,8S)-2-phenyl-8-methyl-1-aza-4,9-dioxa[4.3.0]bicyclononan-5-one-7-carboxylic acid, methyl ester

(2R,6R,7R,8S)-2-phenyl-8-methyl-1-aza-4,9-dioxa[4.3.0]bicyclononan-5-one-7-carboxylic acid, methyl ester

Conditions
ConditionsYield
In chloroform for 3h; Ambient temperature;96%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

(E)-methyl 5-cyclohexyl-5-hydroxypent-2-enoate

(E)-methyl 5-cyclohexyl-5-hydroxypent-2-enoate

Conditions
ConditionsYield
Stage #1: crotonic acid methyl ester; cyclohexanecarbaldehyde With aluminum tris(2,6-di-2-naphthylphenoxide) In toluene at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; toluene at -78℃; for 3h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; toluene at -78 - 20℃; for 0.5h; Inert atmosphere;
96%
Stage #1: crotonic acid methyl ester; cyclohexanecarbaldehyde With aluminium tris(2,6-diphenylphenoxide) In toluene at -78℃; for 0.333333h; Complexation;
Stage #2: With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane; toluene at -78℃; for 0.5h; Crossed aldol condensation;
90%
crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

benzaldehyde
100-52-7

benzaldehyde

Methyl 4-benzoylbutanoate
1501-04-8

Methyl 4-benzoylbutanoate

Conditions
ConditionsYield
With 3-methylpyridin-2-ylamine; benzoic acid; Wilkinson's catalyst In toluene at 150℃; for 72h;96%

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