Trimethyl borate supplier | CasNO.121-43-7

Name
Trimethyl borate
EINECS 204-468-9
CAS No. 121-43-7
Article Data266
CAS DataBase
Density 0.932 g/mL at 20 °C(lit.)
Solubility decomposes in water
Melting Point -34 °C
Formula C₃H₉BO₃
Boiling Point 67.5 °C at 760 mmHg
Molecular Weight 103.914
Flash Point -8 °C
Transport Information UN 2416 3/PG 2
Appearance water-white liquid
Safety 16-27-36/37/39-45-25-23-2
Risk Codes 11-21-23/25-36/37/38-10
Molecular Structure
Hazard Symbols Xn,F
Synonyms NSC 777;Trimethoxyborane;Trimethoxyborine;Trimethoxyboron;Boricacid (H3BO3), trimethyl ester;Methylborate ((MeO)3B) (6CI);Borester O;Boric acid trimethyl ester;Borontrimethoxide;
PSA 27.69000
LogP -0.08950

Synthetic route

: 446822-71-5
(borane)diphenylphosphinomethanethiol acetate

: 67-56-1
methanol

A: 121-43-7
Trimethyl borate

B: 324753-11-9
thioacetic acid S-[(diphenylphosphanyl)methyl] ester

Conditions

Conditions	Yield
In toluene at 100℃; Inert atmosphere;	A n/a B 100%

...Expand

: 67-56-1
methanol

: 1186392-98-2
diphenyl(2-pyridyl)phosphane(P-B)borane(1:1)

A: 121-43-7
Trimethyl borate

B: 37943-90-1
2-(diphenylphosphino)pyridine

Conditions

Conditions	Yield
at 120℃; Inert atmosphere; Microwave irradiation;	A n/a B 100%

...Expand

: 67-56-1
methanol

: 24442-15-7
methylenebis(diphenylphosphane)-borane(1:2)

A: 121-43-7
Trimethyl borate

B: 2071-20-7
bis-diphenylphosphinomethane

Conditions

Conditions	Yield
In toluene at 100℃; Inert atmosphere;	A n/a B 100%

...Expand

: 155402-41-8
dimethoxyboryl trimethylsilyl ketene

A: 2916-76-9
methyl (trimethylsilyl)acetate

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With methanol In diethyl ether for 0.5h;	A 77% B 99%
With methanol In diethyl ether methanol in abs. ether added to a soln. of the ketene, warmed up, further methanol added, stirred for 30 min; distd.;	A 77% B 90%

: zirconium(IV) borohydride

A: 121-43-7
Trimethyl borate

B: zirconium tetramethoxide

Conditions

Conditions	Yield
With CH3OH In pentane byproducts: H2; (Ar (N2) or vac.); dropwise addn. of excess of MeOH to Zr-complex in pentane with stirring (60 min, room temp.), stirring (1 h), standing (12-17 h); volatiles and solvent distn. (vac.); elem. anal.;	A n/a B 99%

: 67-56-1
methanol

: 2049-55-0
triphenylphosphine borane

A: 121-43-7
Trimethyl borate

B: 603-35-0
triphenylphosphine

Conditions

Conditions	Yield
at 120℃; Inert atmosphere; Microwave irradiation;	A n/a B 99%

...Expand

: 67-56-1
methanol

: 100809-49-2
(propane-1,3-diyl)bis(diphenylphosphane)-borane(1:2)

A: 121-43-7
Trimethyl borate

B: 6737-42-4
1,3-bis-(diphenylphosphino)propane

Conditions

Conditions	Yield
In toluene at 100℃; Inert atmosphere;	A n/a B 98%

...Expand

: 124-38-9
carbon dioxide

: 13292-87-0
dimethylsulfide borane complex

A: boron trioxide

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With 1,3,5-Tri-tert-butylbenzene; bis-(phosphoranyl)methanido aluminum hydride In benzene-d6 at 110℃; for 1h; Solvent; Schlenk technique;	A n/a B 97.6%

...Expand

: 67-56-1
methanol

: C12H27BCl2O2Si

A: 121-43-7
Trimethyl borate

B: 103202-59-1
6-(tert-butyldimethylsilyl)oxyhexan-1-ol

Conditions

Conditions	Yield
methanolysis;	A n/a B 97%

...Expand

: 67-56-1
methanol

: 1186392-99-3
(2-biphenyl)dicyclohexylphosphane-borane(1:1)

A: 121-43-7
Trimethyl borate

B: 247940-06-3
CyJohnPhos

Conditions

Conditions	Yield
In toluene at 100℃; Inert atmosphere;	A n/a B 97%

...Expand

: 15277-97-1
1-aza-4,6,11-trioxa-5-boratricyclo[3.3.3.0(1,5)]undecane

: 2996-92-1
phenyl trimethylsiloxane

A: 121-43-7
Trimethyl borate

B: 1-phenyl-2,8,9-trioxa-5-aza-1-silatricyclo<3.3.3.01.5>undecane(phenylsilatrane)

Conditions

Conditions	Yield
With aluminum (III) chloride In 5,5-dimethyl-1,3-cyclohexadiene for 12h; Reflux;	A n/a B 97%

...Expand

: 67-56-1
methanol

: 11113-50-1
boric acid

: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 129 - 130℃; under 750.075 Torr;	96%
In methanol byproducts: H2O; removal of product by azeotropic distn.;; separation of azeotrope by distn. through Raschig-rings (coated with H2SO4), purity of product:99.6%;;	96.5%
In methanol byproducts: H2O; removal of product by azeotropic distn.;; separation of azeotrope by treatment with LiCl (reuse of upper layer), purity of product:99.6%;;	96%

: 868-81-5
chlorodimethoxyborane

: 74348-94-0
<β-Methyl-allyl>-triethyl-zinn

A: 121-43-7
Trimethyl borate

B: 54857-24-8
methallyl-dimethoxyborane

C: 74349-03-4
dimethallylmethoxyborane

D: 994-31-0
chlorotriethylstannane

Conditions

Conditions	Yield
In dichloromethane (N2); into soln. of B compd. was dropped soln. of Sn compd. within 20 min at -10°C; mixt. was sepd. by fractionated distn. in vac., yielding mixt. of B compds. and sepd. Et3SnCl;	A n/a B n/a C n/a D 92%

...Expand

: 67-56-1
methanol

: 1341221-68-8
(1S,6R)-diethyl 5-oxo-3-oxabicyclo[4.1.0]heptane-7,7-dicarboxylate

A: 121-43-7
Trimethyl borate

B: 1341221-72-4
((1S,5S,6R)-5-hydroxy-3-oxabicyclo[4.1.0]heptane-7,7-diyl)dimethanol

Conditions

Conditions	Yield
Stage #1: (1S,6R)-diethyl 5-oxo-3-oxabicyclo[4.1.0]heptane-7,7-dicarboxylate With sodium tetrahydroborate In tetrahydrofuran at 20 - 60℃; for 6h; Inert atmosphere; Stage #2: methanol In tetrahydrofuran at 60℃; for 1.16667h; Inert atmosphere; Stage #3: With acetic acid In tetrahydrofuran; methanol at 0℃; Inert atmosphere;	A n/a B 84%

...Expand

: 67-56-1
methanol

: lithium bis(1,2-dicarba-closo-dodecaborane-1,2-diselena)borate diethyl ether disolvate

A: 16872-09-6
1,2-dicarba-closo-dodecaborane(12)

B: 121-43-7
Trimethyl borate

C: 325820-04-0
1,2-di(hydroseleno)-1,2-dicarba-closo-dodecaborane(12)

Conditions

Conditions	Yield
In dichloromethane-d2 air- and moisture excluded; soln. of carborane cooled to 0 °C, CH3OH added, stand for 2 h at 60 °C; monitored by (11)B, (13)C, (1)H NMR;	A 80% B n/a C 20%
In dichloromethane-d2 air- and moisture excluded; soln. of carborane cooled to 0 °C, CH3OH added, stand for 24 h at room temp.; monitored by (11)B NMR;	A 20% B n/a C 30%

...Expand

: 5926-26-1
(chloromethyl)trimethoxysilane

: 15277-97-1
1-aza-4,6,11-trioxa-5-boratricyclo[3.3.3.0(1,5)]undecane

A: 121-43-7
Trimethyl borate

B: 1-(chloromethyl)silatrane

Conditions

Conditions	Yield
With aluminum (III) chloride In 5,5-dimethyl-1,3-cyclohexadiene for 12h; Reflux;	A n/a B 76%

...Expand

: 94363-48-1
(dibromoboryl)(trimethylsily)ketene

A: 2916-76-9
methyl (trimethylsilyl)acetate

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With methanol; triethylamine In diethyl ether byproducts: Et3N.HBr; argon atmosphere; methanol and triethylamine soln. addn. to B-compd. soln. cooled to -30°C (stirring); ppt. filtration off, washing (ether), fractionation; elem. anal.;	A 74% B 32%

: 67-56-1
methanol

: 617-86-7
triethylsilane

: 74-85-1
ethene

: 10294-34-5
boron trichloride

A: 121-43-7
Trimethyl borate

B: 7318-82-3
ethylboronic acid dimethyl ester

C: 7397-46-8
diethyl methoxy borane

Conditions

Conditions	Yield
In methanol; xylene byproducts: Et3SiCl; Ar-atmosphere; mixing BCl3, Et3SiH and C2H4, distillation of EtBCl2, addn. of MeOH; collection (distillation); NMR spectroscopy;	A n/a B 72% C n/a
In methanol; dichloromethane byproducts: Et3SiCl, HCl; Ar-atmosphere; mixing BCl3 and Et3SiH at -78°C, bubling of C2H4, distillation of EtBCl2 and Et2BCl, addn. of MeOH at -78°C, warming to 0°C; collection (distillation); NMR spectroscopy;
In neat (no solvent) byproducts: Et3SiCl; Ar-atmosphere; mixing BCl3, Et3SiH and C2H4, addn. of MeOH; collection (distillation); NMR spectroscopy;

...Expand

: 12075-02-4
1,1'-bis(o-carborane)

A: Cs(1+)*{(C2B10H11)C2B9H11}(1-)=Cs{(C2B10H11)C2B9H11}

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With KOH,; caesium chloride In ethanol byproducts: H2; by 2.5 fold molar quant. KOH in boiling ethanolic soln., 1.5 h; recrystm. (water);	A 69% B n/a

: 1825-61-2
Methoxytrimethylsilane

: 369-57-3
benzenediazonium tetrafluoroborate

A: 121-43-7
Trimethyl borate

B: 420-56-4
trimethylsilyl fluoride

C: 100-66-3
methoxybenzene

Conditions

Conditions	Yield
In 1,1,2-Trichloro-1,2,2-trifluoroethane 1.) 0 to 55 deg C very slowly, 2.) sonication, reflux, 16 h;	A 66% B n/a C 51%
In 1,1,2-Trichloro-1,2,2-trifluoroethane 1.) 0 to 55 deg C very slowly, 2.) sonication, reflux, 16 h; other alkyl(acyl)oxytrimethylsilanes;	A 66% B n/a C 51%

...Expand

: 67-56-1
methanol

: sodium metaborate

: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With carbon monoxide In methanol byproducts: H2O; generation of Na-formate by treatment of NaBO2 in methanol with CO at 100°C, distn. of the soln.;;	64.6%
In methanol

: lithium pentafluorophenyltrimethoxyborate

A: 848609-02-9
dimethyl pentafluorophenylboronate

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
In neat (no solvent) byproducts: C6F5H; under Ar, teflon-perfluoropropylene block copolymer vessel evacuated at 3E-2 hPa, 150-170 °C for 3 h; distn., yields were determined by (19)F and (11)B NMR;	A 2.5% B 56%

: 1-(dichloroboryl)pentaborane

A: pentaborane(9)

B: 1-(dimethoxyboryl)pentaborane

C: 121-43-7
Trimethyl borate

D: 867-46-9
(methoxy)dichloroborane

E: 868-81-5
chlorodimethoxyborane

Conditions

Conditions	Yield
With methanol In dichloromethane Teflon-valve-equipped standard vacuum line or a nitrogen-filled glovebox; solvent, BCl2B5H8, CH3OH condensed into reactor, vessel warmed to room temp. over 4 h,; contents were fractionated, boron NMR data indicated presence of B(OMe)2B5H8 and BCl(OMe)B5H8 in the molar ratio 3:2;addn. of additional methanol, stirred for 5 min at -60 and -20 ° C, sepn., B(OMe)2B5H8 isolated;by-products:other boron compds.,;	A n/a B 46% C n/a D n/a E n/a

Yield

With methanol In dichloromethane Teflon-valve-equipped standard vacuum line or a nitrogen-filled glovebox; solvent, BCl2B5H8, CH3OH condensed into reactor, vessel warmed to room temp. over 4 h,; contents were fractionated, boron NMR data indicated presence of B(OMe)2B5H8 and BCl(OMe)B5H8 in the molar ratio 3:2;addn. of additional methanol, stirred for 5 min at -60 and -20 ° C, sepn., B(OMe)2B5H8 isolated;by-products:other boron compds.,;

A n/a
B 46%
C n/a
D n/a
E n/a

...Expand

: 81175-91-9
bis(dimethylamino)[tris(trimethylsilyl)silyl]borane

A: 121-43-7
Trimethyl borate

B: 7318-74-3
(dimethylamino)dimethoxy borane

C: 4375-83-1
tris(dimethylamino)borane

Conditions

Conditions	Yield
With methanol In hexane (under Ar); the borane is dissolved in hexane and treated with MeOH, mixt. is heated to 45°C; monitored by (11)B-NMR;	A 44% B 8% C 6%

...Expand

: 67-56-1
methanol

: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With aluminum oxide; sodium borate; carbon dioxide at 80℃; under 1034.32 Torr; for 4h;	43%
With sodium borate; molecular sieve; carbon dioxide at 80℃; under 1034.32 Torr; for 4h;	38%
With sodium borate; carbon dioxide at 80℃; under 1034.32 Torr; for 4h;	28%

: arachno-9-Et2S-6-SB9H11

: 75-57-0
tetramethlyammonium chloride

A: (CH3)4N(1+)*SB8H11(1-)=(CH3)4N{SB8H11}

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With methanol; potassium hydroxide In methanol; water byproducts: C2H6; N2 atmosphere, refluxing (overnight), evapn. of solvent, dissolving (water), pptn. on addn. of aq. soln. of Me4NCl; recrystn. (acetonitrile/acetone), drying (vac.);	A 32.3% B n/a

...Expand

: 94318-00-0
{bis(dimethylamino)boryl}ethoxyacetylene

A: 126686-31-5
{(dimethylamino)methoxyboryl}ethoxyacetylene

B: 121-43-7
Trimethyl borate

C: 927-80-0
1-ethoxyacetylene

Conditions

Conditions	Yield
With methanol In neat (no solvent) Ar atmospher; addn. of MeOH to (Me2N)2BCCOEt (dropwise, water-cooling), heating (50-60°C, 1 h); fractionation (trap, solid carbon dioxide-cooling); NMR- and IR-spectroscopy;	A 32% B n/a C n/a

...Expand

: arachno-9-Et3N-6-SB9H11

: 75-57-0
tetramethlyammonium chloride

A: (CH3)4N(1+)*SB8H11(1-)=(CH3)4N{SB8H11}

B: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With methanol; potassium hydroxide In methanol; water byproducts: C2H6, H2; N2 atmosphere, refluxing (overnight), evapn. of volatiles, dissolving (water), pptn. on addn. of aq. soln. of Me4NCl; recrystn. (acetonitrile/acetone), drying (vac.);	A 30% B n/a

...Expand

: 30624-33-0
1-I-B5H8

A: 19624-22-7
pentaborane(9)

B: 23556-01-6
2-methoxypentaborane(9)

C: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With (CH3)2O In Dimethyl ether byproducts: CH3I, HB(OCH3)2, H2; at -12°C, 15h;;	A n/a B 25% C n/a

...Expand

: 81175-92-0
bis{tris(trimethylsilyl)silyl} (dimethylamino)borane

: 121-43-7
Trimethyl borate

Conditions

Conditions	Yield
With methanol In chloroform-d1 (under Ar); the borane is dissolved in CDCl3 and treated with MeOH, mixt. is heated to 80°C for 0,5 h; monitored by (11)B-NMR;	6%

: 121-43-7
Trimethyl borate

: C19H31BN2O4

Conditions

Conditions	Yield
Stage #1: 1,1-dimethylethyl (2S)-4-[(3-bromophenyl)methyl]-2-methyl-1-piperazine carboxylate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 2h;	100%

: 3-Bromothioanisole

: 121-43-7
Trimethyl borate

: 128312-11-8
3-methylthiophenylboronic acid

Conditions

Conditions	Yield
With sodium hydroxide; iodine; magnesium In tetrahydrofuran	100%

: 121-43-7
Trimethyl borate

: CH2CHC(O)(OCH2CH2)4OB(OC6H4)2

Conditions

Conditions	Yield
With 2,2'-biphenyldiol; tetraethylene glycol monoacrylate In acetonitrile soln. of B(OCH3)3 and 2,2'-biphenyldiol stirred at 60°C for 1 h; tetraethylene glycol monoacrylate added, stirred at 60°C for 1.5 h; cooled; solvent evapd.; residue dissolved (toluene); insolubles filtered; solvent removed by evapn.;	100%

: 121-43-7
Trimethyl borate

: 92-44-4
2,3-naphthalenediol

: 19812-60-3
tetraethylene glycol monoacrylate

: CH2CHC(O)(OCH2CH2)4O(BO2C10H6)

Conditions

Conditions	Yield
In acetonitrile naphthalene diol reacted with soln. of B(OCH3)3 at 60°C for 1 h; tetraethylene glycol monoacrylate added, stirred for 2 h; cooled; solvent evapd. at 40°C for 24 h;	100%

...Expand

: 121-43-7
Trimethyl borate

: 120-80-9
benzene-1,2-diol

: 19812-60-3
tetraethylene glycol monoacrylate

: CH2CHC(O)(OCH2CH2)4OB(O2C6H4)

Conditions

Conditions	Yield
In acetonitrile stirring of catechol and B(OMe)3 at 60 °C for 1h, addn of tetraethylene glycol monoacrylate, 2 h stirring; cooling, vac. evapn. at 40 °C for 24 h;	100%

...Expand

: 474688-76-1
2-bromo-9,10-di(2-naphthyl)anthracene

: 121-43-7
Trimethyl borate

: 867044-28-8
(9,10-di (naphthalene-2-yl) anthracene-2-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 2-bromo-9,10-di(2-naphthyl)anthracene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 17h; Inert atmosphere;	100%
Stage #1: 2-bromo-9,10-di(2-naphthyl)anthracene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 1h; Stage #3: With hydrogenchloride; water In tetrahydrofuran	70%
Stage #1: 2-bromo-9,10-di(2-naphthyl)anthracene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 1h; Stage #3: With hydrogenchloride; water In tetrahydrofuran at 20℃; for 3h;	70%
Stage #1: 2-bromo-9,10-di(2-naphthyl)anthracene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 1h; Stage #3: With hydrogenchloride; water In tetrahydrofuran for 3h;	70%
Stage #1: 2-bromo-9,10-di(2-naphthyl)anthracene With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran for 3h;

: 121-43-7
Trimethyl borate

: 1073633-62-1
1,1-dimethylethyl (7-bromo-1-methyl-2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)carbamate

: 1073633-63-2
[7-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-methyl-6-oxo-5,6,7,8-tetrahydro-1,5-naphthyridin-3-yl]boronic acid

Conditions

Conditions	Yield
Stage #1: 1,1-dimethylethyl (7-bromo-1-methyl-2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)carbamate With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 3h;	100%

: 872548-85-1
2-bromo-6-methoxy-1-(methoxymethoxy)-3-methylnaphthalene

: 121-43-7
Trimethyl borate

: 872550-84-0
(3-methyl-6-(methyloxy)-1-{[(methyloxy)methyl]oxy}-2-naphthalenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: 2-bromo-6-methoxy-1-(methoxymethoxy)-3-methylnaphthalene With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran; hexanes at -78 - 20℃; for 20.5h; Stage #3: With water; ammonium chloride In tetrahydrofuran; hexanes	100%

: 871114-85-1
4-bromo-2,5-dimethyl-4'-(trimethylsilyl)-1,1'-biphenyl

: 121-43-7
Trimethyl borate

: 1256293-81-8
2,5-dimethyl-p-(4'-trimethylsilylphenyl)phenylboronic acid

Conditions

Conditions	Yield
Stage #1: 4-bromo-2,5-dimethyl-4'-(trimethylsilyl)-1,1'-biphenyl; Trimethyl borate With n-butyllithium In tetrahydrofuran Stage #2: With hydrogenchloride In tetrahydrofuran; water	100%

: 121-43-7
Trimethyl borate

: 10097-02-6
2,2-bis(hydroxymethyl)butanoic acid

: 1188369-89-2
C6H9BO4

Conditions

Conditions	Yield
In methanol	100%

: 121-43-7
Trimethyl borate

: 107658-18-4
3-iodo-4-methylfuran

: 1358063-54-3
4-methylfuran-3-ylboronic acid

Conditions

Conditions	Yield
Stage #1: 3-iodo-4-methylfuran With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; pentane at -78 - 20℃; for 1h; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; pentane for 0.75h; Inert atmosphere;	100%

: 121-43-7
Trimethyl borate

: 1599475-25-8
C8H9N3S

: 1599475-26-9
C8H10BN3O2S

Conditions

Conditions	Yield
Stage #1: C8H9N3S With n-butyllithium In tetrahydrofuran at -78℃; for 6h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran for 0.5h;	100%

: 121-43-7
Trimethyl borate

: 1599475-34-9
C8H7N3S

: 1599475-35-0
C8H8BN3O2S

Conditions

Conditions	Yield
Stage #1: C8H7N3S With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran for 0.5h;	100%

: 121-43-7
Trimethyl borate

: 12-(4-bromophenyl)-N,N-dimethyldodecan-1-amine

: C20H36BNO2

Conditions

Conditions	Yield
Stage #1: 12-(4-bromophenyl)-N,N-dimethyldodecan-1-amine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 12h; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 0.333333h; pH=9; Inert atmosphere;	100%

: 121-43-7
Trimethyl borate

: (15-(4-bromophenyl)pentadecyloxy)(tert-butyl)dimethylsilane

: C27H51BO3Si

Conditions

Conditions	Yield
Stage #1: (15-(4-bromophenyl)pentadecyloxy)(tert-butyl)dimethylsilane With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 12h; Inert atmosphere;	100%

: 174913-19-0
1-bromo-2,3-dichloro-5-methoxybenzene

: 121-43-7
Trimethyl borate

: (2,3-dichloro-5-methoxyphenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-2,3-dichloro-5-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane at 20℃; for 1h;	100%

: 121-43-7
Trimethyl borate

: 130225-27-3, 164297-25-0, 238753-24-7
(SS)-ferrocenyl p-tolylsulfoxide

: (Sp,SS)-2-(p-tolylsulfinyl)ferrocenyl boronic acid

Conditions

Conditions	Yield
Stage #1: (SS)-ferrocenyl p-tolylsulfoxide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;	100%

: 121-43-7
Trimethyl borate

: (RS)-ferrocenyl p-tolylsulfoxide

: (Rp,RS)-2-(p-tolylsulfinyl)ferrocenyl boronic acid

Conditions

Conditions	Yield
Stage #1: (RS)-ferrocenyl p-tolylsulfoxide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;	100%

: 847490-69-1
4-iodoisoxazole

: 121-43-7
Trimethyl borate

: (isoxazol-4-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 4-iodoisoxazole With TurboGrignard In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran at 0℃; for 4.5h; Inert atmosphere;	100%

: 121-43-7
Trimethyl borate

: 3-bromo-10-mesityl-10H-phenothiazine

: (10-mesityl-10H-phenothiazin-3-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 3-bromo-10-mesityl-10H-phenothiazine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere; Schlenk technique; Stage #3: With hydrogenchloride	100%

: 121-43-7
Trimethyl borate

: 4984-62-7
2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridine

: (2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-4-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridine With n-butyllithium In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: Trimethyl borate In diethyl ether at 20℃; for 1h;	100%

: 121-43-7
Trimethyl borate

: 4-bromo-2-(tert-butoxycarbonylamino)-6-chlorobenzo[d]thiazole

: (2-((tert-butoxycarbonyl)amino)-6-chlorobenzo[d]thiazol-4-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 4-bromo-2-(tert-butoxycarbonylamino)-6-chlorobenzo[d]thiazole With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -10 - 20℃; for 2h; Stage #2: Trimethyl borate at -78℃; for 0.5h;	100%

: 121-43-7
Trimethyl borate

: 134364-69-5
2.3-difluoroanisole

: (2,3-difluoro-4-methoxyphenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: 2.3-difluoroanisole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane for 2h; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at -30℃; for 2h; Inert atmosphere;	100%
Stage #1: 2.3-difluoroanisole With n-butyllithium In tetrahydrofuran; hexane at -85 - -75℃; for 2h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -85 - -75℃;

: 121-43-7
Trimethyl borate

: 7732-18-5
water

: 4984-62-7
2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridine

: (2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-4-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: 2,6-bis(2,5-dimethyl-1H-pyrrol-1-yl)pyridine With n-butyllithium In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: Trimethyl borate In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Stage #3: water With hydrogenchloride at 0℃; for 0.166667h;	100%

...Expand

: 121-43-7
Trimethyl borate

: C11H5BrFN

: C11H7BFNO2

Conditions

Conditions	Yield
Stage #1: C11H5BrFN With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at 20℃; for 16h;	100%

: 121-43-7
Trimethyl borate

: C25H25BrClN

: 7732-18-5
water

: C25H27BClNO2

Conditions

Conditions	Yield
Stage #1: C25H25BrClN With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -65 - 20℃; Inert atmosphere; Stage #3: water With hydrogenchloride In tetrahydrofuran; hexane at 0℃;	100%

...Expand

: 121-43-7
Trimethyl borate

: 6-(2-bromo-3-(di([1,1′-biphenyl]-4-yl)amino)phenoxy)-9,9-dimethyl-N,N-diphenyl-9H-fluoren-2-amine

: dimethyl (2-(di([1,1′-biphenyl]-4-yl)amino)-6-((7-(diphenylamino)-9,9-dimethyl-9H-fluoren-3-yl)oxy)phenyl)boronate

Conditions

Conditions	Yield
Stage #1: 6-(2-bromo-3-(di([1,1′-biphenyl]-4-yl)amino)phenoxy)-9,9-dimethyl-N,N-diphenyl-9H-fluoren-2-amine With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at 20℃; for 2h;	100%
Stage #1: 6-(2-bromo-3-(di([1,1′-biphenyl]-4-yl)amino)phenoxy)-9,9-dimethyl-N,N-diphenyl-9H-fluoren-2-amine With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere;	100%

Trimethyl borate Chemical Properties

IUPAC Name: Trimethyl borate
Molecular Formula: C₃H₉BO₃
EINECS: 204-468-9
Molecular Weight: 103.912760 g/mol
Appearance: Colorless clear liquid
Melting Point: -34 °C
Boiling Point: 68-69 °C(lit.)
Flash Point: 8 °F
Density: 0.932 g/mL at 20 °C(lit.)
Vapor density: 3.59 (vs air)
Refractive index: n20/D 1.358(lit.)
Sensitive: Moisture
Solubility: Ether, methanol, tetrahydrofuran, isopropylamine, and hexane
Structure of Trimethyl borate (CAS NO.121-43-7):

Product Category of Trimethyl borate (CAS NO.121-43-7): Boron Compounds;Organometallics;Boric Acid Esters;Boric Acid Triesters

Trimethyl borate Uses

Trimethyl borate (121-43-7) is primarily used as a precursor to boronic esters and boronic acids for Suzuki couplings.
Other uses include :
1.Anti-oxidant in Brazing and Solder Flux
2.Catalyst of olefin polymerisation
3.Wood preservative
4.raw material in the production of specialty glasses using sol-gel technology
5.raw material in the production of borophosphosilicate glass film by chemical vapor deposition
6.component of some flame retardants in textile industry
7.component of some welding fluxes
8.in green fire compositions for special effects (as a solution of boric acid in methanol, where it forms in small amounts)

Trimethyl borate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	oral	1290mg/kg (1290mg/kg)	"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
mouse	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit	LD50	skin	1980uL/kg (1.98mL/kg)	American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rabbit	LDLo	intraperitoneal	1600mg/kg (1600mg/kg)	"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rat	LD50	oral	6140mg/kg (6140mg/kg)	"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rat	LDLo	intraperitoneal	1600mg/kg (1600mg/kg)	"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.

Trimethyl borate Safety Profile

Hazard Codes: Harmful Xn,F
Risk Statements: 11-21-23/25-36/37/38-10
R10:Flammable.
R11:Highly flammable.
R21:Harmful in contact with skin.
R23/25:Toxic by inhalation and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-27-36/37/39-45-25-23-2
S16:Keep away from sources of ignition.
S23:Do not breathe vapour.
S25:Avoid contact with eyes.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Trimethyl borate Specification

Trimethyl borate , its cas register number is 121-43-7. It also can be called Boric acid trimethyl ester ; Methyl borate ; and Boron methoxide .

Product Name

Trimethyl borate

Synthetic route

Trimethyl borate Chemical Properties

Trimethyl borate Uses

Trimethyl borate Toxicity Data With Reference

Trimethyl borate Safety Profile

Trimethyl borate Specification

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