p-Toluenesulfonic acid supplier

Name
p-Toluenesulfonic acid
EINECS 203-180-0
CAS No. 104-15-4
Article Data298
CAS DataBase
Density 1.34 g/cm³
Solubility soluble
Melting Point 106~107 °C
Formula C₇H₈O₃S
Boiling Point 116 °C
Molecular Weight 172.205
Flash Point 41 °C
Transport Information UN 2585
Appearance clear colorless to light yellow solution
Safety 45-26-23
Risk Codes 34-10
Molecular Structure
Hazard Symbols C
Synonyms P-Toluene sulfonic acid monohydrate;2-Toluene Sulfonic Acid;4-Toluene sulfonic acid;P-Toluosulfonic Acid Monohydrate;Methylbenzenesulfonic acid;Toluene-p-sulfonate;4-methylbenzenesulfonic acid;Cyzac 4040;4-Toluenesulfonic acid;Cyclophil P T S A;Benzenesulfonic acid, methyl-;p-toluene sulfonic acid;Toluene-4-sulfonic acid;ar-Toluenesulfonic acid;Kyselina p-toluenesulfonova;p-Toluene-sulfonic acid;Toluene-4-sulfonate;Benzenesulfonic acid, 4-methyl-;Benzenesulfonic acid,4-methyl-;Eltesol;p-Tolylsulfonic acid;p-Methylbenzene sulfonic acid;toluene-4-sulphonic acid;o-toluenesulfonic Acid;
PSA 62.75000
LogP 2.32250

Synthetic route

: 98-59-9
p-toluenesulfonyl chloride

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; water; phenylzinc(II) bromide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
Stage #1: p-toluenesulfonyl chloride With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 22℃; Stage #2: With trifluoroacetic acid In dichloromethane Further stages.;	95%
With pyridine; dmap In dichloromethane	82%

: 106-45-6
para-thiocresol

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With dinitrogen tetraoxide In tetrachloromethane; diethyl ether for 2.5h; Ambient temperature;	100%
With dihydrogen peroxide; trichlorophosphate In water at 80℃; for 1.16667h; Micellar solution;	95%
With HOF* CH3CN In dichloromethane at 0℃;	90%
With dihydrogen peroxide; methyltrioxorhenium(VII) In acetonitrile at 20℃;	87%
Multi-step reaction with 2 steps 1: pyridine / acetonitrile / Heating 2: hydrogenchloride; water / 40 °C View Scheme

: 26177-05-9
1-(p-methylbenzenesulfonoyloxy)-2(1H)-quinolone

A: 104-15-4
toluene-4-sulfonic acid

B: 58-57-1
1-hydroxycarbostyril

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran for 2h; Product distribution; Ambient temperature;	A n/a B 98%

: 15404-00-9
triethylammonium toluene-p-sulfonate

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With sulfuric acid In water pH=3;	97.5%

: (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl 4-methylbenzenesulfonate

A: 1033736-87-6
C16H10O3S

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
In chloroform-d1 for 0.233333h; Photolysis; Inert atmosphere;	A n/a B 97%

: 103-19-5
di(p-tolyl) disulfide

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; trichlorophosphate In water at 80℃; for 1h; Micellar solution;	94%

: 108-88-3
toluene

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide at 35 - 65℃; Temperature; Inert atmosphere;	93.3%
With sodium hydrogensulfite; pyridinium chlorochromate In neat (no solvent) at 100℃; under 1500.15 Torr; for 0.0666667h; Reagent/catalyst; Microwave irradiation;	93%
With 1,3-disulfonic acid imidazolonium chloride In water at 50℃; for 0.05h; Green chemistry; regioselective reaction;	72%

: 84877-44-1
toluene-4-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With trifluoroacetic acid In water at 20℃; for 2h;	91%

: 64-04-0
phenethylamine

: 98-59-9
p-toluenesulfonyl chloride

A: 5450-75-9
4-methyl-N-(2-phenylethyl)benzenesulfonamide

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -50℃; for 2h; Product distribution; Mechanism; further amines;	A 90% B 10%
With n-butyllithium 1) THF, hexane, -10 deg C, 15 min, 2) THF, hexane, -50 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 478363-68-7
phenylmethyl 3,5,6,7,8,8a-hexahydro-5,5,8a-trimethyl-6-(trifluoroacetylamino)-(6β,8aβ)-2(1H)-isoquinolinecarboxylate

A: N-Trifluoroacetyl-1,2,3,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-(6β,8aβ)-6-isoquinolineamine 4-methylbenzenesulfonate

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
In ethanol; di-isopropyl ether; palladium	A n/a B 90%

: 26177-05-9
1-(p-methylbenzenesulfonoyloxy)-2(1H)-quinolone

A: 59-31-4, 70254-42-1
2-quinolone

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
In methanol; water Quantum yield; UV-irradiation; Photolysis;	A n/a B 90%

: 86108-37-4
Toluene-4-sulfonic acid 2-methyl-1,2-diphenyl-propyl ester

A: 781-33-9
2-methyl-1,1-diphenylpropene

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
at 115℃; Product distribution; Rate constant; Thermodynamic data; Ea(excit.), ΔS(excit.);	A 85% B n/a

: 4031-16-7
N'-2-butanylidene-4-methylbenzenesulfonohydrazine

A: 104-15-4
toluene-4-sulfonic acid

B: 78-93-3
butanone

Conditions

Conditions	Yield
With molecular sieve; dihydrogen peroxide In methanol for 4h; Mechanism; Heating; other solvent; tosylhydrazones of other ketones;	A n/a B 84%

: 3,4-dichloro-5-[(4-me thylphenyl)sulfanyl]-2(5H)-furanone

A: 766-40-5
Mucochloric acid

B: 1610693-10-1
3,4-dichloro-5-[(4-methyl phenyl)sulfonyl]-2(5H)-furanone

C: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetic acid at 20℃; for 96h;	A n/a B 83% C n/a

...Expand

: 624-31-7
4-tolyl iodide

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; Aminoiminomethanesulfinic acid In dimethyl sulfoxide at 100℃; for 14h;	80%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; Aminoiminomethanesulfinic acid In dimethyl sulfoxide at 100℃; for 14h; Reagent/catalyst; Solvent; Green chemistry;	78%

: 2943-42-2
di(4-methyl)phenylthiosulfonate

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 2h; Heating;	78%

: 824-79-3
sodium 4-methylbenzenesulfinate

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With 18O-labeled water In dimethyl sulfoxide at 100℃; for 14h; Reagent/catalyst;	75%
With hydrogenchloride; oxygen In d(4)-methanol at 20℃; for 0.166667h;

: 73706-60-2
1-tosyloxy-4-phenyl-2-butanone

A: 644-08-6
4-Methylbiphenyl

B: 2550-26-7
4-Phenyl-2-butanone

C: 37985-17-4
1,4-diphenyl-2-butanone

D: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
In benzene Irradiation;	A 13% B 7% C 10% D 74%

...Expand

: 86108-35-2
Toluene-4-sulfonic acid 2,2-dimethyl-3-oxo-1,3-diphenyl-propyl ester

A: 29689-80-3
3-methyl-1,2-diphenylbut-2-en-1-one

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
at 130℃; Product distribution; Rate constant; Thermodynamic data; Ea(excit.), ΔS(excit.);	A 74% B n/a

: 1577-18-0
(E)-3-hexenoic acid

A: 2407-43-4
5-ethyl-5H-furan-2-one

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With hydroxy(tosyloxy)iodobenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 5h; Ambient temperature;	A 32% B 71%

: 13668-61-6
(cyclopent-2-eneyl)acetic acid

A: 5650-67-9
3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With hydroxy(tosyloxy)iodobenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 4h; Ambient temperature;	A 56% B 70%

: 3695-77-0
triphenylmethanethiol

: 1950-69-2
toluene-p-sulfonyl bromide

A: 76-84-6
triphenylmethyl alcohol

B: 104-15-4
toluene-4-sulfonic acid

C: 118511-93-6
Toluene-4-thiosulfonic acid S-trityl ester

Conditions

Conditions	Yield
With triethylamine In tetrachloromethane at 0℃; for 0.5h; Yields of byproduct given;	A n/a B n/a C 70%

...Expand

: 56410-24-3
N,N'-bis(p-toluenesulfonyl)hydroxylamine

A: 62419-04-9
bis(4-methylphenylsulfonyl)amino 4-methylbenzenesulfonate

B: 104-15-4
toluene-4-sulfonic acid

C: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With air In chloroform for 12h; Product distribution; Mechanism; Ambient temperature; various reaction conditions;	A 20% B 70% C 5%

...Expand

: 657-84-1
sodium tosylate

: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; water for 0.5h;	69%
Stage #1: sodium tosylate In tert-butyl methyl ether; water for 0.166667h; Stage #2: With hydrogenchloride In tert-butyl methyl ether; water for 0.333333h;

: 27126-76-7
[hydroxy(tosyloxy)iodo]benzene

: 934-30-5, 1195-12-6, 20507-53-3, 58001-99-3, 67999-50-2, 67999-53-5, 74645-32-2, 108266-75-7, 120-74-1
5-norbornene-endo-2-carboxylic acid

: 75759-33-0, 108033-20-1
Toluene-4-sulfonic acid (1S,3S,6S,7R)-4-oxo-5-oxa-tricyclo[4.3.0.03,7]non-9-yl ester

B: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
In dichloromethane at 0℃;	A 28% B 60%

...Expand

: 81699-64-1
2,2-Dimethyl-3-phenyl-3-(toluene-4-sulfonyloxy)-propionic acid ethyl ester

A: 6335-78-0
ethyl isopropylidenephenylacetic carboxylate

B: 81699-67-4
ethyl 2-methylene-3-phenylbutanoate

C: 104-15-4
toluene-4-sulfonic acid

D: 81699-66-3
Ethyl 1-methyl-2-phenylcyclopropane-1-carboxylate

Conditions

Conditions	Yield
at 145 - 160℃; Product distribution; Kinetics; Thermodynamic data; Ea(excit.), ΔS(excit.);	A 58% B 6% C n/a D 5%

...Expand

: 14062-05-6
N,N'-ditosylhydrazine

A: 10409-07-1
bis(4-methylphenyl)disulfone

B: 1950-69-2
toluene-p-sulfonyl bromide

C: 104-15-4
toluene-4-sulfonic acid

Conditions

Conditions	Yield
With bromine In water; acetonitrile at 20℃;	A 10% B 57% C 20%

...Expand

: 98435-42-8
3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

: 104-15-4
toluene-4-sulfonic acid

: 135625-83-1
3-methoxy-1-methyl-1,2,5,6-tetrahydropyridinium toluene-p-sulphonate

Conditions

Conditions	Yield
In acetone for 0.25h; educt toluene-p-sulphonic acid: anhydrous;	100%

: 10133-06-9, 10133-07-0, 10133-45-6, 50468-20-7, 59123-20-5, 83057-88-9, 121252-25-3, 129311-57-5, 136889-92-4, 2980-48-5
methyl (+/-)-trans-(2,3)-epoxy butanoate

: 104-15-4
toluene-4-sulfonic acid

: methyl 2-hydroxy-3-(p-tolylsulfonyloxy)butanoate

Conditions

Conditions	Yield
	100%

: 1445-45-0
Trimethyl orthoacetate

: 104-15-4
toluene-4-sulfonic acid

: 80-48-8
methyl p-toluene sulfonate

Conditions

Conditions	Yield
at 20℃; for 0.5h;	100%
In dichloromethane for 0.5h; Ambient temperature;	96%

: 64-17-5
ethanol

: 63-91-2
L-phenylalanine

: 104-15-4
toluene-4-sulfonic acid

: 5002-64-2
Phe-OEt * TosOH

Conditions

Conditions	Yield
for 24h; Heating;	100%

...Expand

: 72-18-4
L-valine

: 78-83-1
2-methyl-propan-1-ol

: 104-15-4
toluene-4-sulfonic acid

: 13018-45-6
(S)-1-isobutoxy-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
In water; toluene for 24h; Reflux; Dean-Stark;	100%
In benzene Heating;	84%
In benzene Heating;

...Expand

: 3240-34-4
[bis(acetoxy)iodo]benzene

: 104-15-4
toluene-4-sulfonic acid

: 27126-76-7
[hydroxy(tosyloxy)iodo]benzene

Conditions

Conditions	Yield
In acetonitrile	100%
for 0.166667h;	97%
In acetonitrile at 20℃;	94%

: 89121-14-2
(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

: 104-15-4
toluene-4-sulfonic acid

: 89106-04-7
Nε-(Benzyloxycarbonyl)-L-lysine 2-(Trimethylsilyl)ethyl Ester p-Toluenesulfonate

Conditions

Conditions	Yield
In benzene for 1h; Heating;	100%

: 104-15-4
toluene-4-sulfonic acid

: 125376-21-8
(S)-2-tert-Butoxycarbonylamino-propionic acid 6-((S)-2-tert-butoxycarbonylamino-propionyloxy)-hexa-2,4-diynyl ester

: 125376-29-6
(S)-2-Amino-propionic acid 6-((S)-2-amino-propionyloxy)-hexa-2,4-diynyl ester; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
With acetic acid at 50℃;	100%

: 104-15-4
toluene-4-sulfonic acid

: 136185-16-5
Z-L-Leu-L-Lys(Boc)-L-Lys(Boc)-OPh

: (S)-2-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-6-tert-butoxycarbonylamino-hexanoic acid phenyl ester; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal for 1.33333h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 136185-19-8
Z-L-Ser(tBu)-L-Lys(Boc)-L-Leu-L-Lys(Boc)-L-Lys(Boc)-OPh

: 136185-33-6
H-L-Ser(tBu)-L-Lys(Boc)-L-Leu-L-Lys(Boc)-L-Lys(Boc)-OPh*TosOH

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide for 1h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 138541-14-7
Z-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh

: 138541-36-3
H-L-Glu(OtBu)-L-Lys(Boc)-L-Asn-L-Pro-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide for 4h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 138541-04-5
Z-L-Leu-L-Pro-L-Ser(tBu)-OPh

: 138541-24-9
H-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide for 1.5h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 138541-08-9
Z-L-Thr(tBu)-L-Gln-L-Glu(OtBu)-L-Lys(Boc)-OPh

: 138541-11-4
H-L-Thr(tBu)-L-Gln-L-Glu(OtBu)-L-Lys(Boc)-OPh*TosOH

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide for 1h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 88887-52-9
α-<2-(trimethylsilyl)ethyl> γ-n-hexadecyl N-(tert-butyloxycarbonyl)-L-glutamate

: 88887-54-1
α-<2-(trimethylsilyl)ethyl> γ-n-hexadecyl L-glutamate tosylate

Conditions

Conditions	Yield
In benzene for 1h; Heating;	100%

: 104-15-4
toluene-4-sulfonic acid

: 2,4-Dioxabicyclo[3.3.1]nonane-1,5-diethanol

: C25H32O8S2

Conditions

Conditions	Yield
	100%

: 104-15-4
toluene-4-sulfonic acid

: 90934-12-6
nonafluorobutyliodine(III) bis(trifluoroacetate)

: 155819-09-3
perfluorobutane

Conditions

Conditions	Yield
In acetonitrile at 0 - 20℃;	100%
In acetonitrile Ambient temperature;	91%
In acetonitrile at -20 - 20℃; for 1h;	91%

: 61-90-5
L-leucine

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

Conditions

Conditions	Yield
In cyclohexane; water for 4h; Dean-Stark; Reflux;	100%
In toluene for 20h; Reflux;	85%
In toluene for 4h; Reflux; Inert atmosphere;	82%

...Expand

: 2481-09-6
S-tert-Butyl-N-acetyl-L-cysteine hydrochloride

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 76499-06-4
p-Toluenesulfonate of S-tert-Butyl-L-cysteine Benzyl Ester

Conditions

Conditions	Yield
In chloroform for 6h; Heating;	100%

...Expand

: 104-15-4
toluene-4-sulfonic acid

: (+/-)-(3R*,4R*,5S*)-5-((1'S*)-azidopropyl)-3-methyl-4-(phenyldimethylsilyl)-dihydrofuran-2-one

: (+/-)-(3R*,4R*,5S*)-5-((1'S*)-aminopropyl)-3-methyl-4-(phenyldimethylsilyl)-dihydrofuran-2-one, p-toluenesulphonic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In tetrahydrofuran for 8h;	100%

: 56-41-7
L-alanin

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 42854-62-6
L-alanine benzyl ester p-toluenesulfonate

Conditions

Conditions	Yield
In benzene for 10h; Reflux; Inert atmosphere;	100%
at 50 - 62℃; under 15.0015 Torr; for 5.5h;	98.6%
In cyclohexane; water for 4h; Dean-Stark; Reflux;	92%

...Expand

: 104-15-4
toluene-4-sulfonic acid

: 4-[3-oxo-3-thiazol-2-yl-2-(2,2,2-trichloro-ethoxycarbonylamino)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

: (2-oxo-1-piperidin-4-ylmethyl-2-thiazol-2-yl-ethyl)-carbamic acid 2,2,2-trichloro-ethyl ester; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
In diethyl ether at 35℃; for 2h;	100%

: 56-89-3
L-cystine

: 104-15-4
toluene-4-sulfonic acid

: 107-18-6
allyl alcohol

: L-cystine-bis-allyl ester bis-(toluene-4-sulfonate)

Conditions

Conditions	Yield
In benzene at 90℃; for 16h;	100%
In benzene for 12h; Esterification; Heating;	95%

...Expand

: 2432-99-7
11-aminoundecanoic acid

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 11-Aminoundecanoic acid benzyl ester p-toluenesulfonate

Conditions

Conditions	Yield
In toluene for 5h; Inert atmosphere; Heating;	100%
In benzene for 24h; Reflux;	96%
In benzene Esterification;

...Expand

: 632-20-2
D-Threonine

: 104-15-4
toluene-4-sulfonic acid

: 107-18-6
allyl alcohol

: H-D-Thr-Oallyl p-tolunenesulfonate

Conditions

Conditions	Yield
In toluene at 140℃; for 24h; Dean-Stark; Schlenk technique; Inert atmosphere;	100%
In benzene for 42h; Heating;

...Expand

: 104-15-4
toluene-4-sulfonic acid

: 322407-87-4
2-(2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]oct-3-yl)-2-[(O-t-butylcarbonyl)(N-benzyloxycarbonyl)tyrosylamino]acetic acid n-butyl ester

: 2-(4-hydroxymethyl-1,3,4,5-tetrahydroxy-2-piperidinyl)-2-[(O-t-butylcarbonyl)tyrosylamino]acetic acid n-butyl ester p-toluenesulfonate salt

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 2h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 207612-91-7
{tert-butoxycarbonylmethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid tert-butyl ester

: {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
In dichloromethane for 24h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 445390-52-3
{tert-butoxycarbonylmethyl-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl]-amino}-acetic acid tert-butyl ester

: {carboxymethyl-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
In dichloromethane for 24h;	100%

: 104-15-4
toluene-4-sulfonic acid

: 207612-91-7
{tert-butoxycarbonylmethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid tert-butyl ester

: {carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

Conditions

Conditions	Yield
In dichloromethane	100%

p-Toluenesulfonic acid Chemical Properties

The Molecular Structure of p-Toluenesulfonic acid (CAS NO.104-15-4):

Empirical Formula: C₇H₈O₃S
Molecular Weight: 172.2016
IUPAC Name: 4-methylbenzenesulfonic acid
Appearance: Clear colorless to light yellow solution
Product Categories: FINE Chemical & INTERMEDIATES;Organics
Nominal Mass: 172 Da
Average Mass: 172.2016 Da
Monoisotopic Mass: 172.019414 Da
Index of Refraction: 1.562
Molar Refractivity: 41.72 cm³
Molar Volume: 128.4 cm³
Surface Tension: 48.2 dyne/cm
Density: 1.34 g/cm³
Boiling point: 116 ºC
Refractive index: 1.3825-1.3845
Flash point: 41 ºC
Storage temp: Flammables area
Water Solubility: soluble
InChI
InChI=1/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)
Smiles
S(c1ccc(C)cc1)(O)(=O)=O
It is abbreviated as TsOH,it is white solid , soluble in water, alcohols, and other polar organic solvents. Most often, TsOH refers to the monohydrate, TsOH.H₂O.

p-Toluenesulfonic acid Uses

p-Toluenesulfonic acid (CAS NO.104-15-4) is used for pharmaceutical, pesticide, dyestuff, also used in plastics and detergent and printing coatings.

p-Toluenesulfonic acid Production

p-Toluenesulfonic acid (CAS NO.104-15-4) is prepared on an industrial scale by the sulfonation of toluene. Common impurities include benzenesulfonic acid and sulfuric acid. Impurities can be removed by recrystallization from concentrated hydrochloric acid followed by azeotropic drying.

p-Toluenesulfonic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
quail	LD50	oral	> 316mg/kg (316mg/kg)		Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rat	LD50	oral	2480mg/kg (2480mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1055, 1986

p-Toluenesulfonic acid Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34-10
R34: Causes burns
R10: Flammable
Safety Statements: 45-26-23
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S23: Do not breathe vapour
RIDADR: 2585
HazardClass: 8
PackingGroup: III

p-Toluenesulfonic acid Specification

p-Toluenesulfonic acid (CAS NO.104-15-4) is also called as 4-Methylbenzenesulfonic acid ; 4-Toluenesulfonic acid ; Benzenesulfonic acid, 4-methyl- ; Toluene sulfonic acid ; 4-Methylbenzenesulfonic acid ; 4-Toluenesulfonic acid ; Benzenesulfonic acid, 4-methyl- ; Eltesol ; Kyselina p-toluenesulfonova ; Methylbenzenesulfonic acid ; Toluenesulfonic acid ; Toluenesulfonic acid (VAN) ; p-Toluene sulfonate ; p-Toluenesulphonic acid ; p-Toluolenesulfonic acid ; Toluene-4-sulphonic acid ; Benzenesulfonic acid, 4-methyl- ; Toluenesulfonic acid ; p-Toluenesulfonic acid .

Product Name

p-Toluenesulfonic acid

Synthetic route

p-Toluenesulfonic acid Chemical Properties

p-Toluenesulfonic acid Uses

p-Toluenesulfonic acid Production

p-Toluenesulfonic acid Toxicity Data With Reference

p-Toluenesulfonic acid Safety Profile

p-Toluenesulfonic acid Specification

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