s-Trioxane supplier | CasNO.110-88-3

Name
1,3,5-trioxane
EINECS 203-812-5
CAS No. 110-88-3
Article Data46
CAS DataBase
Density 1.131 g/cm³
Solubility 221 g/L (25 °C) in water
Melting Point 59-62 °C(lit.)
Formula C₃H₆O₃
Boiling Point 114.5 °C at 760 mmHg
Molecular Weight 90.0788
Flash Point 45 °C
Transport Information UN 1325 4.1/PG 2
Appearance colourless transparent crystals
Safety 36/37-46
Risk Codes 11-37-63
Molecular Structure
Hazard Symbols F, Xn
Synonyms Trioxane(6CI,7CI);1,3,5-Trioxane;Formaldehyde, trimer;NSC 26347;Triformol;Trioxan;Trioxymethylene;sym-Trioxane;
PSA 27.69000
LogP -0.07770

Synthetic route

: 1670-46-8
2-acetylcyclopentanaone

A: 110-88-3
1,3,5-Trioxan

B: 96-48-0
4-butanolide

C: 108-55-4
glutaric anhydride,

D: 64-18-6
formic acid

E: 110-94-1
1,5-pentanedioic acid

F: 123-42-2
4-Hydroxy-4-methyl-2-pentanone

G: 26976-72-7
4-acetoxybutyric acid

H: 85951-55-9
5,6-dioxo-n-heptanoic acid

I: 1262892-77-2
2-acetyl-2-hydroxycyclopentanone

J: 52789-75-0
2-acetoxycyclopentanone

K: 1167443-17-5
2-acetyl-2-hydroxymethylcyclopentanone

L: 1426960-55-5
1,1'-diacetyl-1,1'-bicyclopentyl-2,2'-dione

M: 89540-15-8
2-acetyl-2,3-epoxycyclopentanone

N: 64-19-7
acetic acid

Conditions

Conditions	Yield
With oxygen; calcium chloride In acetone at 57℃; for 30h;	A 1% B 2% C 7% D n/a E 7% F 0.014 g G 2% H 13% I 38% J 2% K 5% L 11% M 2% N n/a

...Expand

: 1670-46-8
2-acetylcyclopentanaone

A: 110-88-3
1,3,5-Trioxan

B: 96-48-0
4-butanolide

C: 108-55-4
glutaric anhydride,

D: 110-94-1
1,5-pentanedioic acid

E: 1262892-77-2
2-acetyl-2-hydroxycyclopentanone

F: 52789-75-0
2-acetoxycyclopentanone

G: 1167443-17-5
2-acetyl-2-hydroxymethylcyclopentanone

H: 89540-15-8
2-acetyl-2,3-epoxycyclopentanone

Conditions

Conditions	Yield
With oxygen In acetone at 20℃; for 4h; Irradiation;	A 1% B 3% C 3% D 13% E 36% F 1% G 22% H 2%

...Expand

: 1670-46-8
2-acetylcyclopentanaone

A: 110-88-3
1,3,5-Trioxan

B: 96-48-0
4-butanolide

C: 108-55-4
glutaric anhydride,

D: 64-18-6
formic acid

E: 110-94-1
1,5-pentanedioic acid

F: 1262892-77-2
2-acetyl-2-hydroxycyclopentanone

G: 52789-75-0
2-acetoxycyclopentanone

H: 1167443-17-5
2-acetyl-2-hydroxymethylcyclopentanone

I: 89540-15-8
2-acetyl-2,3-epoxycyclopentanone

J: 64-19-7
acetic acid

Conditions

Conditions	Yield
With oxygen In acetone at 20℃; for 6h; Irradiation;	A 2% B 4% C 5% D n/a E 17% F 18% G 2% H 30% I 3% J n/a

...Expand

: 93-58-3
benzoic acid methyl ester

A: 110-88-3
1,3,5-Trioxan

B: 92-52-4
biphenyl

C: 16606-00-1
methyl 3-phenylbenzoate

D: 71-43-2
benzene

Conditions

Conditions	Yield
thermische Zersetzung an einem hellrotgluehenden Draht.Thermolysis;

...Expand

: 50-00-0
formaldehyd

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
With water at 100℃; im Vakuum;
With sulfuric acid at 115℃; im evakuierten Rohr;
With sulfuric acid Destillieren des Reaktionsprodukts mit Kohlendioxyd in Eiswasser;

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 64-18-6
formic acid

Conditions

Conditions	Yield
With phosphotungstic acid; water at 96.5℃; Kinetics; Product distribution; other heteropolyacids;
C15H16N2O4(2+)*HO4P(2-) In methanol; water at 92 - 97℃; for 4h; Product distribution / selectivity;

: 67-56-1
methanol

A: 110-88-3
1,3,5-Trioxan

B: 50-00-0
formaldehyd

Conditions

Conditions	Yield
With [Ru3Ir(CO)13](1-)*[N(PPh3)2](1+) at 90℃; for 48h; Dehydrogenation; trimerization;

α-polyoxymethylene: α-polyoxymethylene

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
With water at 100℃; im Vakuum;

β-polyoxymethylene: β-polyoxymethylene

γ-polyoxymethylene: γ-polyoxymethylene

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
With water at 100℃; im Vakuum;

diluted formaldehyde: diluted formaldehyde

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
With nitrogen

polyoxymethylene: polyoxymethylene

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
With sulfuric acid at 115℃; im Rohr;

: 7664-93-9
sulfuric acid

: 99-94-5
p-Toluic acid

: 67-64-1
acetone

lead-anodes: lead-anodes

: 110-88-3
1,3,5-Trioxan

Conditions

Conditions	Yield
at 75℃; Oxydation;

...Expand

: 4382-76-7
methoxymethyl acetate

: 7732-18-5
water

A: 110-88-3
1,3,5-Trioxan

B: 67-56-1
methanol

C: 64-19-7
acetic acid

...Expand

: 4382-76-7
methoxymethyl acetate

alkali: alkali

A: 110-88-3
1,3,5-Trioxan

B: 67-56-1
methanol

C: 64-19-7
acetic acid

...Expand

: 2-hydroxymethoxy-2-methyl-butyraldehyde

: 108-24-7
acetic anhydride

A: 110-88-3
1,3,5-Trioxan

B dimer(ic) 2-hydroxy-2-methyl-butyraldehyde: dimer(ic) 2-hydroxy-2-methyl-butyraldehyde

...Expand

: 80653-57-2
N,O-Dimesyl-N-methylhydroxylamin

A: 110-88-3
1,3,5-Trioxan

B: 50-00-0
formaldehyd

C: 593-77-1
N-Methylhydroxylamine

D: 4229-44-1
N-methylhydroxyamine hydrochloride

E: 2386-57-4
methanesulfonic acid sodium salt

F NH3: NH3

Conditions

Conditions	Yield
With sodium hydroxide In water Mechanism; Product distribution; hydrolysis with basic, neutral and acidic aqu. solutions;	A 5 % Spectr. B n/a C 1 % Spectr. D n/a E 33 % Spectr. F n/a

...Expand

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 67-56-1
methanol

C: 534-15-6
1,1-dimethoxyethane

D: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With water under 75.0075 - 7500.75 Torr; Gas phase; Acidic conditions;

...Expand

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 109-87-5
Dimethoxymethane

C: 107-31-3
Methyl formate

Conditions

Conditions	Yield
silicotungstic acid In water at 100℃; Product distribution; Further Variations:; Catalysts; Temperatures; Cyclization; Cannizzaro reaction; Etherification;

...Expand

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
C7H7O3S(1-)*C10H19O3S(1+) In methanol; water at 92 - 96.5℃; for 3h; Product distribution / selectivity; Heating / reflux;
1-(4-sulfonylbutyl)pyridinium trifluoromethanesulfonate In methanol; water at 92 - 97℃; for 3h; Product distribution / selectivity; Heating / reflux;
CF3O3S(1-)*C8H12NO3S(1+) In methanol; water at 93 - 97℃; for 3h; Product distribution / selectivity; Heating / reflux;

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 64-18-6
formic acid

C: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
CF3O3S(1-)*C10H19O3S(1+) In methanol; water at 94 - 96.5℃; for 4h; Product distribution / selectivity; Heating / reflux;

...Expand

: 67-56-1
methanol

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
2CF3O3S(1-)*C11H18N4O3S(2+) In water at 92 - 97℃; for 7h; Product distribution / selectivity; Heating / reflux;
1-butyl-3-methylimidazolium hydrogen sulfate In water at 92 - 97℃; for 7h; Product distribution / selectivity; Heating / reflux;
tetrabutylammonium bis[(trifluoromethane)sulfonyl]imide In water at 93 - 97℃; for 7h; Product distribution / selectivity; Heating / reflux;

...Expand

: 67-56-1
methanol

: 50-00-0
formaldehyd

A: 110-88-3
1,3,5-Trioxan

B: 64-18-6
formic acid

C: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
2C7H7O3S(1-)*C15H26N4O6S2(2+) In water at 94 - 96.5℃; for 4h; Product distribution / selectivity;

...Expand

: 50-00-0
formaldehyd

: 109-87-5
Dimethoxymethane

A: 110-88-3
1,3,5-Trioxan

B: C11H24O10

C: C13H28O12

D: 13353-03-2
bis-methoxymethoxy-methane

E: 628-90-0
bis(methoxymethyl)ether

F: 13352-75-5
POMM4

G: 13352-78-8
CH3-(OCH2)8-OCH3

H: 54261-86-8
Methoxymethoxymethoxymethoxymethoxy-methoxymethoxymethoxymethoxymethoxymethoxy-methane

I: 13353-04-3
CH3-(OCH2)7-OCH3

J: C14H30O13

K: C15H32O14

L: 13352-77-7
CH3-(OCH2)6-OCH3

Conditions

Conditions	Yield
With sulfuric acid at 55 - 115℃; Inert atmosphere;

...Expand

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 105-57-7
diethyl acetal

C: 60-29-7
diethyl ether

D: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With silicon carbide at 250℃; under 750.075 Torr; for 3h; Temperature;

...Expand

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 105-57-7
diethyl acetal

C: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With silicon carbide at 225℃; under 750.075 Torr; for 3h;

...Expand

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 105-57-7
diethyl acetal

C: 75-07-0
acetaldehyde

D: 64-19-7
acetic acid

Conditions

Conditions	Yield
With silicon carbide; hydrotalcite at 150℃; under 750.075 Torr; for 3h;

...Expand

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With silicon carbide at 150℃; under 750.075 Torr; for 3h;

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 75-07-0
acetaldehyde

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With silicon carbide at 150℃; under 750.075 Torr; for 3h;

...Expand

: 64-17-5
ethanol

A: 110-88-3
1,3,5-Trioxan

B: 105-57-7
diethyl acetal

Conditions

Conditions	Yield
With silicon carbide at 200℃; under 750.075 Torr; for 3h;

: 110-88-3
1,3,5-Trioxan

: 19299-41-3
N-methyl-1-phenylmethanesulfonamide

: 61199-72-2
3-methyl-3,4-dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide

Conditions

Conditions	Yield
With Amberlyst 15 In 1,2-dichloro-ethane at 35℃; for 3h;	100%
With methanesulfonic acid; trifluoroacetic acid at 35℃; for 0.5h;	78%
With silica-supported molybdophosphoric heteropolyacid In toluene at 110℃; for 4.5h;	68%
With methanesulfonic acid In trifluoroacetic acid

: 110-88-3
1,3,5-Trioxan

: 4563-33-1
phenyl-methanesulfonic acid amide

: 33183-87-8
3,4-dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide

Conditions

Conditions	Yield
With Amberlyst 15 In 1,2-dichloro-ethane at 80℃; for 3h;	100%
With sulfated zirconia at 115℃; for 6h;	82%
With amberlyst 15H+ resin In 1,2-dichloro-ethane at 80℃;	79%
With methanesulfonic acid; acetic anhydride In 1,2-dichloro-ethane at 35℃; for 4h;	68%
With silica-supported molybdophosphoric heteropolyacid In toluene at 110℃; for 4.5h;	62%

: 110-88-3
1,3,5-Trioxan

: 85952-14-3
N-ethyl-benzylsulfonamide

: 33050-15-6
3-ethyl-3,4-dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide

Conditions

Conditions	Yield
With Amberlyst 15 In 1,2-dichloro-ethane at 35℃; for 3h;	100%
With sulfated zirconia at 115℃; for 3h;	96%
With methanesulfonic acid; trifluoroacetic acid at 35℃; for 0.5h;	88%
With silica-supported molybdophosphoric heteropolyacid In toluene at 110℃; for 4.5h;	88%

: 110-88-3
1,3,5-Trioxan

: 85952-15-4
N-isopropyl-1-phenyl methanesulfonamide

: 110654-43-8
3-Isopropyl-3,4-dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide

Conditions

Conditions	Yield
With Amberlyst 15 In 1,2-dichloro-ethane at 35℃; for 3h;	100%
With methanesulfonic acid; trifluoroacetic acid at 35℃; for 0.5h;	90%
With silica-supported molybdophosphoric heteropolyacid In toluene at 110℃; for 4.5h;	87%
With sulfated zirconia at 115℃; for 6h;	57%

: 110-88-3
1,3,5-Trioxan

: 64-19-7
acetic acid

: 153528-91-7
4,5-dimethoxy-N-(3-hydroxypropyl) salicylamide

: 153528-89-3
2,3-dihydro-6,7-dimethoxy-3-(3-acetoxypropyl)-4H-1,3-benzoxazin-4-one

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate for 16h; Ambient temperature;	100%

...Expand

: 110-88-3
1,3,5-Trioxan

: 878672-60-7
tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

: 1033265-31-4
tert-butyl 2-(5-bromo-2-nitrophenyl)propenoate

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 48h; Knoevenagel-type condensation; Heating;	100%

: 110-88-3
1,3,5-Trioxan

: 81327-28-8
tert-butyl 2-(5-chloro-2-nitrophenyl)ethanoate

: 1033265-33-6
tert-butyl 2-(5-chloro-2-nitrophenyl)propenoate

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 120h; Knoevenagel-type condensation; Heating;	100%

: 110-88-3
1,3,5-Trioxan

: 1350837-04-5
C17H27ClO2Si

: 1350837-05-6
C18H29ClO3Si

Conditions

Conditions	Yield
Stage #1: 1,3,5-Trioxan; C17H27ClO2Si With zirconium(IV) chloride In dichloromethane for 2h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In dichloromethane	100%

: 110-88-3
1,3,5-Trioxan

: (2S,3R,4S,5S)-tert-butyl 4-nitro-3,5-diphenylpyrrolidine-2-carboxylate

: C22H26N2O4

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; for 48h; Inert atmosphere;	100%

: 110-88-3
1,3,5-Trioxan

: 108-24-7
acetic anhydride

: 4082-91-1
bis(acetoxymethyl)ether

Conditions

Conditions	Yield
With perchloric acid at 65 - 110℃; Inert atmosphere;	99.7%

: 110-88-3
1,3,5-Trioxan

A: 60833-52-5
iodo(iodomethoxy)methane

B: 107-46-0
Hexamethyldisiloxane

Conditions

Conditions	Yield
With trimethylsilyl iodide at 40℃; for 10h;	A 99.5% B 98%

: 110-88-3
1,3,5-Trioxan

: 2388-68-3
o-bis(mercaptomethyl)benzene

: 7216-19-5
1,5-dihydrobenzo[e]-1,3-dithiepine

Conditions

Conditions	Yield
With Montmorillonite KSF In benzene for 1.5h; Heating;	99%

: 110-88-3
1,3,5-Trioxan

: 93624-87-4
α-p-methoxy phenoxymethyl β-N-carbomethoxy aminoxyethanol

: 93625-07-1
carbomethoxy-3 p-methoxy phenoxymethyl-5 tetrahydrodioxazine-1,4,2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 4h; Heating;	99%

: 110-88-3
1,3,5-Trioxan

: 527-60-6
Mesitol

: 194211-77-3
3,5-bis(bromomethyl)-2,4,6-trimethylphenol

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid for 2h; Heating;	99%
With hydrogen bromide; acetic acid for 3h; Reflux;	95%
With hydrogen bromide; acetic acid for 2h; Heating;	90%
With hydrogen bromide In acetic acid

: 110-88-3
1,3,5-Trioxan

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 183017-88-1
3-tert-butyl-5-(chloromethyl)-2-hydroxybenzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride at 40℃; for 72h;	99%
With hydrogenchloride In water at 60℃; for 72h;	97%
With hydrogenchloride In water at 40℃; for 72h;	90%
With hydrogenchloride In water at 45 - 50℃; for 48h;	90%

: 110-88-3
1,3,5-Trioxan

: 1-[(4S)-4-benzyl-2-thioxo(1,3-thiazolidin-3-yl)]butan-1-one

: 1101186-75-7
C15H19NO2S2

Conditions

Conditions	Yield
With titanium tetrachloride; triethylamine optical yield given as %de;	99%
Stage #1: 1-[(4S)-4-benzyl-2-thioxo(1,3-thiazolidin-3-yl)]butan-1-one With titanium tetrachloride In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 0℃; for 0.55h; Stage #3: 1,3,5-Trioxan With titanium tetrachloride In dichloromethane at 0℃; for 2h; optical yield given as %de; diastereoselective reaction;	81%

: 110-88-3
1,3,5-Trioxan

: 700-12-9
pentamethylbenzene,

: 53442-65-2
2,3,4,5,6,-pentamethylbenzyl bromide

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid for 2.5h; Inert atmosphere; Reflux;	99%

: 110-88-3
1,3,5-Trioxan

: 100-01-6
4-nitro-aniline

: 100-23-2
N,N-Dimethyl-4-nitroaniline

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; for 48h; Inert atmosphere; chemoselective reaction;	99%

: 110-88-3
1,3,5-Trioxan

: 135-67-1
phenoxazine

: 25782-99-4
10-Methyl-10H-phenoxazine

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; for 24h; Inert atmosphere; chemoselective reaction;	99%

: 110-88-3
1,3,5-Trioxan

: 100-47-0
benzonitrile

: 5434-82-2
1,3,5-tribenzoylhexahydro-1,3,5-triazine

Conditions

Conditions	Yield
With phenylsulfonic acid functionalized mesoporous silica In 1,2-dichloro-ethane Reflux;	98.1%
With sulfuric acid

: 110-88-3
1,3,5-Trioxan

: 110654-41-6
4-Sulfamoylmethyl-benzoic acid

: 110654-57-4
C27H27N3O12S3

Conditions

Conditions	Yield
With methanesulfonic acid; trifluoroacetic acid at 35℃; for 0.5h;	98%

: 110-88-3
1,3,5-Trioxan

: ruthenium trichloride hydrate

: dicarbonyldichlororuthenium

Conditions

Conditions	Yield
In formic acid aq. formic acid; Ru-contg. compd. (20.5 mmol) and paraformaldehyde were added to a soln. of formic acid; the soln. was heated at reflux for 5 h; then orange soln. was cooled in an ice bath and stored in the freezer overnight (-4°C); the solvent was removed by rotary evapn.; the solid was washed with hexane and dried in vac.;	98%

: 110-88-3
1,3,5-Trioxan

: 69688-96-6
N-butyl-1-phenylmethanesulfonamide

: 1254217-19-0
N-butyl-3,4-dihydro-1H-2,3-benzothiazine 2,2-dioxide

Conditions

Conditions	Yield
With sulfated zirconia at 115℃; for 3h;	98%

: 110-88-3
1,3,5-Trioxan

: N-propyl-2-naphthylmethanesulfonamide

: 2-propyl-1,4-dihydro-2H-naphtho[1,2-d]3,2-thiazine 3,3-dioxide

Conditions

Conditions	Yield
With Amberlyst XN-1010 In 1,2-dichloro-ethane at 80℃; for 3h;	98%

: 110-88-3
1,3,5-Trioxan

: 60833-52-5
iodo(iodomethoxy)methane

Conditions

Conditions	Yield
With trimethylsilyl iodide at 40℃; for 15h;	98%
With trimethylsilyl iodide at 40℃; Darkness;	88.2%

: 110-88-3
1,3,5-Trioxan

: 5279-03-8
2-methyl-6,7-dihydrobenzo[b]thiophene-4(5H)-one

: 95526-48-0
2-Methyl-5-methylene-6,7-dihydro-5H-benzo[b]thiophen-4-one

Conditions

Conditions	Yield
With N-methylanilinium trifluoroacetate In tetrahydrofuran	97%

: 110-88-3
1,3,5-Trioxan

: N-isopropyl-2-naphthylmethanesulfonamide

: 2-isopropyl-1,4-dihydro-2H-naphtho[1,2-d]3,2-thiazine 3,3-dioxide

Conditions

Conditions	Yield
With Amberlyst XN-1010 In 1,2-dichloro-ethane at 80℃; for 3h;	97%

: 110-88-3
1,3,5-Trioxan

: 34451-26-8
2-perfluorohexylethanethiol

: 114857-05-5
(F-hexyl-2 ethylthio) methanol

Conditions

Conditions	Yield
With triethylamine at 0℃; Mechanism;	96%
With triethylamine at 0℃;	96%

: 110-88-3
1,3,5-Trioxan

: 1078725-44-6
C22H23F4NO4

: 1078725-45-7
C23H23F4NO4

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In ethyl acetate at 80℃;	96%

: 110-88-3
1,3,5-Trioxan

: N-butyl-2-naphthylmethanesulfonamide

: 2-butyl-1,4-dihydro-2H-naphtho[1,2-d]3,2-thiazine 3,3-dioxide

Conditions

Conditions	Yield
With Amberlyst XN-1010 In 1,2-dichloro-ethane at 80℃; for 3h;	96%

s-Trioxane Consensus Reports

Reported in EPA TSCA Inventory.

s-Trioxane Specification

The s-Trioxane with CAS registry number of 110-88-3 is also known as Trioxymethylene. The IUPAC name is 1,3,5-Trioxane. Its EINECS registry number is 203-812-5. In addition, the formula is C₃H₆O₃ and the molecular weight is 90.08. This chemical is a white crystal that may cause damage to health and may catch fire in contact with air, only need brief contact with an ignition source. What's more, it can be used as chemical intermediate and disinfectant that should be sealed in ventilated, cool place away from oxidants, acids.

Physical properties about s-Trioxane are: (1)ACD/LogP: -0.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.62; (4)ACD/LogD (pH 7.4): -0.62; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 10.98; (8)ACD/KOC (pH 7.4): 10.98; (9)#H bond acceptors: 3; (10)Index of Refraction: 1.385; (11)Molar Refractivity: 18.65 cm³; (12)Molar Volume: 79.5 cm³; (13)Surface Tension: 35.2 dyne/cm; (14)Density: 1.131 g/cm³; (15)Flash Point: 45 °C; (16)Enthalpy of Vaporization: 33.83 kJ/mol; (17)Boiling Point: 114.5 °C at 760 mmHg; (18)Vapour Pressure: 23.5 mmHg at 25 °C.

Preparation of s-Trioxane. 60 % Formaldehyde solution containing 2 % to 5 % sulfuric acid is distilled continuously. Then the residue is extracted with benzene and distilled to obtain the prodcut.

Uses of s-Trioxane: it is used to produce 3,5-bis-bromomethyl-2,4,6-trimethyl-phenol by reaction with 2,4,6-trimethyl-phenol. The reaction occurs with reagents HBr, AcOH and other condition of heating. The yield is about 99 %.

s-Trioxane is used to produce 3,5-bis-bromomethyl-2,4,6-trimethyl-phenol by reaction with 2,4,6-trimethyl-phenol.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to respiratory system and highly flammable. There is possible risk of harm to the unborn child. During using it, wear suitable protective clothing and gloves. If swallowed, seek medical advice immediately and show this container or label.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1OCOCO1
2. InChI: InChI=1S/C3H6O3/c1-4-2-6-3-5-1/h1-3H2
3. InChIKey: BGJSXRVXTHVRSN-UHFFFAOYSA-N

Product Name

1,3,5-trioxane

Synthetic route

s-Trioxane Consensus Reports

s-Trioxane Specification

Related Products

Hot Products