Dibenzo[b,d]pyran-6-one, hydroxylated and methoxylated derivatives of this ring system, and some other analogues of the natural product ellagic acid have been synthesized and examined as inhibitors of benzo[a]pyrene dihydrodiol epoxide (BPDE) mutagenicity in Salmonella typhimurium strain TA100. ...

A series of phenothiazinyl- and 4-diethylaminophenyl-substituted diethylenes were synthesized and characterised; their thermal, optical and photoelectrical properties were investigated. TGA showed that the compounds display high thermal stability, achieving 5% mass loss at temperatures up to 385...

The enantiomers of benzyl-(2-chloroethyl)-[2-(2-methoxyphenoxy)-1-methylethyl]amine hydrochloride (1, CM18) were synthesized and studied pharmacologically for their irreversible antagonism at rat vas deferens α-adrenoceptors. In addition, assignment of the absolute configuration of the two enan...

Plants are sessile organisms, hence to face environmental constrains they developed strategies that rely on the activation of stress-response genes under the control of specific transcription factors. The plant hormone ethylene mediates physiological, developmental and stress responses through t...

Regulation of tomato fruit ripening may help extend fruit shelf life and prevent losses due to spoilage. Here, tomato fruit were investigated whether sound treatment could delay their ripening. Harvested fruit were treated with low-frequency sound waves (1 kHz) for 6 h, and then monitored variou...

MADS-box genes encode important transcription factors that are involved in many biological processes of plants, including fruit ripening. In our research, a MADS-box gene, SlMBP8, was identified, and its tissue-specific expression profiles were analysed. SlMBP8 was highly expressed in fruits of ...

In tomato, Verticillium resistance is determined by the Ve gene locus encoding two leucine-rich repeat-receptor-like proteins (Ve1, Ve2). The resistance function usually is attributed to Ve1 alone, with two known alleles: Ve1, encoding a resistance protein, and ve1, with a premature stop codon e...

ERF proteins are plant-specific transcription factors that play significant roles in plant defense against various stresses. However, only little information regarding stress-related ERF genes is available in tomato (Solanum lycopersicum, Sl). In this study, a tomato ERF gene, SlERF84, was clone...

Ethylene signaling converges on the ETHYLENE-INSENSITIVE3 (EIN3)/EIN3-like (EIL) transcription factors to regulate a wide range of developmental processes in plants. EBF1/2 (EIN3-binding F-box protein 1 and 2) negatively regulate the ethylene signaling pathway by mediating the degradation of EIN...

The acetylation levels of histones on lysine residues are regulated by histone acetyltransferases and histone deacetylases, which play an important but understudied role in the control of gene expression in plants. There is an increasing research focus on histone deacetylation in crops, but to d...

The regulatory protein CONSTITUTIVE PHOTOMORPHOGENIC (COP) 1 is a key repressor of photomorphogenesis; it regulates numerous developmental processes and responds to biotic and abiotic stress in plants. Here, we report the role of a novel and uncharacterized Solanum melongena COP1 (SmCOP1) gene i...

The objective of this work was to evaluate the production of fatty acid methyl esters using macauba oil and methyl acetate under pressurized conditions, using heterogeneous γ-alumina catalyst in a continuous system. The catalytic reaction kinetics were evaluated at temperatures between 225 and ...

One of the attempts to reduce the consumption of fossil fuels is to replace them with renewable and clean fuels. Among these fuels, biodiesel has been considered as a promising alternative to petroleum diesel fuel. Thermal conductivity of biodiesel is a very important thermophysical property for...

Up to 35% of (R)-methyl 2-methylbutanoate (M2MB) was observed in a beverage fermented with shiitake. As M2MB naturally occurs typically in high excesses of the (S)-enantiomer, the origin of the (R)-ester was elucidated by stable isotope labeled precursor-feeding studies. (R)-2-Methylbutanoic aci...

The title compound was obtained with high regioisomeric and enantiomeric purity starting from the tartrate salt of (1S,2S)-1-hydroxy-2-methylaminocyclohexane. The determination of the enantiomeric excess both of the title compound and of its precursor (2S)-2-(N-methyl-N-benzyloxycarbonylamino)cy...

The first total synthesis of a new enantiopure polyhydroxylated cyclopentyl β-amino acid [methyl (1S,2R,3S,4R,5S)-2-benzyloxy-5-benzyloxycarbonylamino-3-hydroxy-4-methoxycyclopentanecarboxylate] was achieved according to our recent novel strategy for the transformation of nitrohexofuranoses int...

Nine aryl 4-guanidinobenzoates were synthesized as inhibitors of the sperm enzyme acrosin. These esters were prepared from 4-guanidinobenzoic acid and a number of phenols which had been approved by the FDA for clinical use. The vaginal contraceptive activity of the inhibitors was evaluated in th...

A series of five 3,5-bisarylidene-4-piperidones designed as analogs of curcumin and their twenty five fatty acid conjugates were synthesized as candidate anticancer agents. The fatty acid conjugates were designed for efficient delivery of these compounds at the targeted cancer sites. The cytosta...

New light-sensitive polymer, poly(1-(4-carboethoxyphenyl)-2-propen-1-one), Mw = 1·3 × 106 Dalton, MwMn = 2·6, was prepared. On the basis of fractions prepared by photolysis, Mark-Houwink coefficients (α=0·79 ± 0·02 and K=(2·41 ± 1·4) × 10−3) were determined in chlorobenzene at 25°C e...

Precise determination of hydrazine has gained a great importance for the environmental ecology and health risk assessment owing to the significant biotoxicity of hydrazine. However, most existing fluorescent hydrazine probes, whose selectivity relies on the nucleophilicity of one −NH2 group on h...