The synthesis of 2,4-bis(bromomethyl)estrone methyl ether was accomplished by reacting estrone methyl ether with formaldehyde and hydrogen bromide in s-tetrachloroethane. The compound readily reacts with cysteine, tryptophan and histidine in 0.05 M phosphate buffer pH 7.0. It also reacts with co...

Three biphenanthrenes, blestrianol A, B and C and one dibenzylphenanthrene were isolated from tubers of Bletilla striata. The structures were elucidated as 4,4′-dimethoxy-9,9′,10,10′-tetrahydro-[1′,3-biphenanthrene]-2,2′,7,7′-tetraol, 4′,5-dimethoxy-8-(4-hydroxybenzyl)-9,9′,10,10′-tetra...

Recently, the in-capillary electrophoresis assay has been applied to variety kinds of analyses owing to its multiple functional integrating features, including mixing of samples, reaction process of the mixtures, and the separation and detection in one capillary system. However, the micro-reacto...

Iron supplementation presents several challenges, such as low bioavailability, high reactivity and a metallic taste. Iron absorption is enhanced by complexing with organic compounds such as peptides, while microencapsulation is an alternative to protect the mineral and mask undesirable flavors. ...

The detection of adulteration and mislabeling of food products, including intensively processed meat, is a challenge which needs urgent solutions to protect consumers’ rights. The aim of the study was to demonstrate the feasibility of species-specific peptide-based LC–MS methods for monitoring...

Unregulated disinfection byproducts (DBPs), including nitrogenous disinfection byproducts (N-DBPs), originating from chlorination of the precursor amino acid phenylalanine in aqueous systems, were identified in laboratory reactions and distributed tap. The major N-DBP identified was phenylaceton...

Imidazo[1,2a]pyridines have gained much interest in the field of medicinal chemistry research. In the aim of accessing new privileged structure, we decided to design and synthesize 8-aminated-imidazo[1,2a]pyridines substituted on positions 2 and 6. This scaffold, rarely found in the literature, ...

The molecular orbital (MO) reactivity indices of a new potent reversible anticholinesterase (anti-ChE) agent, Suberogorgin (S), and its derivatives (S-E; S-OH, α and β forms; S-H, α and β forms also) were calculated using the MNDO method; and their anti-ChE activities against Torpediniforms ...

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments are associated with poor tolerability and insufficient therapeutic efficacy, prompting the need for alternative therapeutic approaches. Recent advances suggest ...

Publisher SummaryPhenylephrine Hydrochloride is 1-m-Hydroxy -α-[ ( methyl amino) methyl] benzyl alcohol hydrochloride. It is also known as 1-α- hydroxy -β-methyl amino-3-hydroxy-1-ethyl benzene hydrochloride. It appear as a white or nearly white, odorless crystals having a bitter taste. Leger...

A novel series of N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinolines (14–33) containing triazole moiety were designed and synthesized through rational cycloadditions using the modified Pictet–Spengler reaction and the Click chemistry. Antiproliferative activity against four cancer cell lines (e...

A series of 1,4-disubstituted-1,2,3-triazoles (13–35) containing sulfonamide moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity (IC50 = 1.3–9.4 μM). Interestingly, the meta a...

The title reaction in the absence of catalysts has been investigated both with the racemic and with the optically active cycloolefins. Both title olefins form [2 + 2] dimers of the trans double bonds with complete retention of configuration (trans-syn-trans 2 by R + S and trans-anti-trans 3 by R...

Background. Ursodeoxycholic acid has been widely used as a therapeutic agent in cholesterol gallstones and liver disease patients, but its mechanism of action is still under investigation.Aims. The protective effect of ursodeoxycholic acid, both free, taurine and glycine conjugated, against hepa...

Various taurine-conjugated bile acids were fed to rats at the 1%-level in the diet for 3 or 7 days and the effect on several hydroxylations involved in the biosynthesis and metabolism of bile acids was studied. The hydroxylations studied were all catalyzed by the microsomal fraction of liver hom...

Background and AimsApproximately 95% of bile acids (BAs) excreted into bile are reabsorbed in the gut and circulate back to the liver for further biliary secretion. Therefore, pharmacological inhibition of the ileal apical sodium-dependent BA transporter (ASBT/SLC10A2) may protect against BA-med...

Background. The pathogenesis of inflammatory bowel disease is still unknown. However, it is possible that faecal bile acids influence the clinical course.Aims. To evaluate the eliminating effects of faecal bile acids by the oral adsorbent on dextran sulphate sodium-induced rat colitis.Methods. R...

Five strains of bifidobacteria were screened for their bile salt deconjugation ability, bile salt hydrolase (BSH) activity and co-precipitation of cholesterol with deconjugated bile. Bile salt deconjugation was determined by the release of cholic acid. All strains exhibited deconjugation of both...

Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50 years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a variety of confounding or contributing facto...

BackgroundBile acids (BAs) participate in lipid absorption and serve as metabolic regulatory factors in gut-liver communication. To date, there are no studies on the systemic patterns of BAs in the serum, liver, and gut in the same non-alcoholic fatty liver disease (NAFLD) model.