In our previous study, we reported a series of 1-hydroxy-2-phenyl-1H-imidazole-5-carboxylic acid derivatives that presented excellent in vitro xanthine oxidase inhibitory potency. As a continuation study, a series of 1-hydroxy-2-phenyl-1H-imidazole derivatives containing a pyridine moiety (4a-g ...

To establish an in vitro model of drug incorporation into hair and to elucidate the potential roles of hair cell selectivity and hair color in the incorporation of certain drugs into hair, the basic drug amphetamine and its nonbasic analog N‐acetylamphetamine (N‐AcAp) were analyzed for influx ...

Zearalenone (ZEN) and its metabolites are commonly found in many food commodities and are known to cause reproductive disorders and genotoxic effects. The major ZEN metabolites are α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL). Although many studies have demonstrated the cytotoxic effects of...

The sparingly soluble complex formed between vanadium(V) and 4-(2-thiazolylazo)resorcinol (5) requires extraction with chloroform, whereas maximum color development for the complex with 4-(2-pyridylazo)resorcinol (4) takes place after 60 min. Heating of reactants is required in the methods with ...

A membrane optode was developed utilizing the 8-hydroxyquinaldine (HQ) facilitated preconcentration of UO22+ ions and subsequent colored complex formation of UO22+ with 4-(2-thiazolylazo)-resorcinol (TAR) in optode matrix. The composition of the membrane optode was optimized by scanning several ...

A sensitive and simple separation-enrichment technique for the determination of trace amounts of some metal ions was described. By the passage of aqueous samples including Fe(III), Cu(II), Ni(II) and Co(II) ions–4-(2-thiazolylazo) resorcinol (TAR) chelates through Diaion SP-850 column, metal ch...

The most common problems in spectrophotometric determination of various complex species originate from the background spectral interference. Thus, the present study aimed to overcome the spectral matrix interference for the precise analysis and speciation of mercury(II) in water by dual-waveleng...

Reaction of 1,8-dichloroanthracene with ferrocene and AlCl3Al at 81 or 101 °C affords [η6-(1,8-dichloro-9,10-dihydroantracene)FeCp](PF6) (I) and [η6:η6-(1,8-dichloro-9,10-dihydroanthracene)(FeCp)2](PF6)2 (II). NMR spectral analysis of I and II, isolation of 1,8-dichloro-9,10-dihydroanthrac...

The title compound, 9,10-dihydro-9,10-etheno-1,8-dichloro-11-diphenylphosphinyl-12-(diphenylphosphinylethynyl)anthracene (1), has been synthesized and its crystal structure has been determined. The compound 1 crystallized into the triclinic space group P-1 with a=11.881(3)Å,b=13.769(3)Å,c=14.0...

Chlamydocin–hydroxamic acid analogues were designed and synthesized as histone deacetylase (HDAC) inhibitors based on the structure and HDAC inhibitory activity of chlamydocin and trichostatin A. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone moiety in the side chain that makes ...

Hypobromous acid (HOBr) is formed by eosinophil peroxidase and myeloperoxidase in the presence of H2O2, Cl−, and Br− in the host defense system of humans, protecting against invading bacteria. However, the formed HOBr may cause damage to DNA and its components in the host. When a guanine nucleos...

Peroxidasin is a heme peroxidase that catalyses the oxidation of bromide by hydrogen peroxide to form an essential sulfilimine cross-link between methionine and hydroxylysine residues in collagen IV. We investigated cross-linking by peroxidasin embedded in extracellular matrix isolated from cult...

Hypobromous acid (HOBr) is an important reactive oxygen species and has been recently found to be associated with a variety of diseases. However, owing to a lack of effective analytical tools, there is still limited understanding of its roles in living systems. Here, we present a new type of nea...

Hypobromous acid (HOBr) is an inorganic acid produced by the oxidation of the bromide anion (Br−). The blood plasma level of Br− is more than 1,000-fold lower than that of chloride anion (Cl−). Consequently, the endogenous production of HOBr is also lower compared to hypochlorous acid (HOCl). Ne...

It is found that hypobromous acid (HOBr) can affect the activity of type IV collagen. Herein, we synthesized a lysosome-targeted fluorescence probe NA-lyso based on Suzuki coupling reaction with naphthalimide as a fluorescent group. HOBr can oxidize the amino group and methylthio group, which in...

Due to the importance of hypochlorous acid (HClO) in biological and industrial, development of fluorescent probes for HClO has been an active research area. Here, a new red-emitting ratiometric fluorescent probe (P) was synthesized and well defined characterization via NMR, HR-MS, and fluorescen...

New phenothiazine appended BODIPY derivative has been synthesized and characterized for the determination of hypochlorite in live cells. The fluorescent probe has exhibited 72 fold fluorescence enhancement upon addition of hypochlorite over other reactive oxygen species. Further, the studies pro...

The biochemistry of hypochlorite (ClO−) play important role in the operation of life system. In this work, the water-soluble red-emitting fluorescent probe (probe 1) was prepared for sensing ClO−. Probe 1 which replies excellent sensitivity with the limit of detection (LOD) of 2.41 nM, rapid res...

A novel indolium-based fluorescent probe (probe 1) for the recognition and detection of hypochlorite (OCl−) has been explored via a double oxidation reaction mechanism. Probe 1 exhibited excellent selectivity and sensitivity for OCl− over other analytes, and with a detection limit of 0.11 μM. M...

Since hypochlorite (ClO−) possesses the ability that oxidizes electron-rich objects with accompanying variations in spectroscopic features, we present here an effective strategy for generating new molecular-level probe that will be compatible for application in ClO− detection. This optical senso...