A series of novel 2′-modified nucleoside 5′-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were use...
Recombinant Lactobacillus leichmannii ribonucleosidetriphosphate reductase has been purified and evaluated as a biocatalyst for the preparative synthesis of 2′-deoxyribonucleoside-5′-triphosphates. The addition of expensive 2′-deoxyribonucleoside-5′-triphosphates as allosteric effectors of r...
An overview is given of the chemistry of tris(azolyl)phosphines with focus on their preparation and application in coordination- and organometallic chemistry and catalysis. These systems share with the more abundant tris(pyrazolyl)borates and -methanes the ability to function as tridentate nitro...
Uridine adenosine tetraphosphate (Up4A) has been recently identified as a novel and potent endothelium-derived contracting factor and contains both purine and pyrimidine moieties, which activate purinergic P2X and P2Y receptors. The present study was designed to compare contractile responses to ...
Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2′-SeCH3-uridine and 2′-SeCH3-cytidine derivatized RNAs for applications in RNA crystallography, using...
Extracellular nucleotides such as adenosine 5′-triphospate (ATP) and uridine 5′-triphosphate (UTP) interact with P2 purinergic receptors on the surface of phagocytic cells and induce various physiological reactions. In this study, the production of antibody in mice immunized with an inactivate...
We investigated actions of uridine 5′-triphosphate (UTP) in rat aorta, cerebral and mesenteric arteries, and their single myocytes. UTP (≥10 μM) elicited an inward-rectifying current strongly reminiscent of activation of P2X1 receptor, and a similar current was also induced by α,β-methylene...
The first synthesis of highly fluorescent acridine-1,8-dione dye labeled aminoallyl-uridine-5′-triphosphate is described. The coupling reaction of acridine-1,8-dione benzoic acid succinimidyl ester with aminoallyl-uridine-5′-triphosphate, followed by anion exchange purification results in the ...
Several functional group exchange reactions were discussed in second and third chapters, but these reactions primarily focused on molecules that contained sp3 hybridized carbon atoms, or sp and sp2 hybridized carbon atoms bonded to other carbon atoms. The chemistry of carbonyl compounds, with a ...
Oleic and ricinoleic acids or their trans isomers, elaidic and ricinelaidic acids, wereadministered intraduodenally and evaluated for their effects on the digestive motor activity of the canine small and large bowel. Four dogs of mixed breed were implanted with duodenal cannulas and extraluminal...
When mono-unsaturated fatty acids are heated in air, they form hemagglutinins. When the double bond is Δ-6,7 or Δ-9,10, the titer is higher than for Δ-11,12. Stearic acid does not become a hemagglutinin on heating. Hydroxy-monounsaturated fatty acids, ricinoleic (cis-12-OH-Δ-9) and ricinelai...
A series of essential fatty acids and fatty acid derivatives were evaluated for their ability to inhibit [3H] leukotriene B4 (LTB4) binding to pig neutrophil membranes. The fatty acids varied in chain length, extent of unsaturation, position of unsaturation, and isomerization. Generally, fatty a...
1.1. d-3-Phosphoglycerate: NAD oxidoreductase (d-3-phosphoglycerate dehydrogenase) has been partially purified from chicken liver.2.2. The distribution of this enzyme has been compared to that of d-glycerate dehydrogenase (d-glycerate:NAD(P) oxidoreductase). A marked variation in the ratio of ph...
1.1.AMP deaminase (AMP aminohydrolase, EC 3.5.4.6) activities of dialyzed and undialyzed hemolyzates of human erythrocytes in the presence of optimal concentrations of K+ were measured. Whereas the activity of the dialyzed hemolyzate was a linear function of the hemolyzate concentration, that of...
1.1. In addition to its primary role as regulator of hemoglobin oxygenation, 2,3-diphosphoglyceric acid has been cited as an inhibitor of several enzymes in the erythrocyte. In this paper four enzymes of glycolysis [hexokinase (ATP:d:hexose 6-phosphotransferase, EC 2.7.1.1), phosphofructokinase ...
A chiral titanium complex, formed in situ from Ti(Oi-Pr)4, (S,S)-N,N′-dibenzyl tartramide and water was found to serve as an efficient catalyst for the asymmetric oxidations of 1H-benzimidazolyl pyridinylmethyl sulfides with cumene hydroperoxide (CHP) in the absence of a base. Several proton pu...
The aminoglycoside, geneticin (G418), was recently shown to have antiviral activity against bovine viral diarrhea virus (BVDV). Since BVDV, dengue virus (DENV) and yellow fever virus (YFV) all belong to the Flaviviridae family, it seemed possible that a common step in their life cycle might be a...
We have recently characterized the central components of the three MAP kinase cascades present in Cryphonectria parasitica : the MEK genes cpkk1, cpkk2 and cpkk3. When we attempted to infect through anastomosis the three knock out strains with Cryphonectria hypovirus 1 (CHV1), only the deletion ...
Geneticin is a 2-deoxystreptamine antibiotic that is structurally related to …
SummaryThe glycan ligands recognized by Siglecs, influenza viruses, and galectins, as well as many plant lectins, are not well defined. To explore their binding to asparagine (Asn)-linked N-glycans, we synthesized a library of isomeric multiantennary N-glycans that vary in terminal non-reducing ...
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