We report here the synthesis and spectroscopic properties of two enantiomeric chiral tridentate ligands (TPyCCD and TPyCCN) composed of terpyridine (TPy) and cinchonidine (CCD) or cinchonine (CCN) substituent, as well as their metal complexes with Zn2+, Fe2+, Eu3+, and Tb3+ ions. For the pure li...

Chitosan-supported succinic anhydride-cinchonine (CTS-SA-CN) was synthesized via a two-step route with succinic anhydride as the linker. The catalyst was used to promote the direct asymmetric aldol reaction between cyclohexanone and a variety of aromatic aldehydes in aqueous medium. Aldol adduct...

Herein, we have carried out a structural optimization campaign to discover the novel anti-tumor agents with our previously screened YQY-26 as the hit compound. A library of thirty-seven 6-amide-2-aryl benzoxazole/benzimidazole derivatives has been designed and synthesized based on the highly con...

Glycine conjugation of a series of benzoic acid derivatives was investigated in bovine liver mitochondria. Benzoic acids with chlorine, methyl, methoxy, or ethoxy substituents in the para- or metapositions of the benzene ring showed a high degree of glycine conjugation. In contrast, the acids wi...

The complexes of Sm(III) and Tb(III) with 2-aminobenzoic acid (anthranilic acid, AA) and 2-amino-5-chlorobenzoic acid (5-chloroanthranilic acid, AACl) were synthesized and characterized based on elemental analysis, IR and mass spectroscopy. The data are in accordance with 1:3 [Metal]:[Ligand] ra...

A series of benzoic acid hydrazones and its nicotinyl derivatives (1–10) were prepared and evaluated for their antitubercular activity towards a strain of Mycobacterium tuberculosis (MTB). The structures of newly synthesized compounds were confirmed by infrared (IR) and 1H-nuclear magnetic reso...

An unprecedented method for the conversion of (Z)-3-chloro-3-arylacrylic acids to corresponding benzoic acids by stirring in POCl3 at 80 °C is reported. The benzoic acids formed in situ undergo condensation with 4-amino-5-aryl-3-mercapto-1,2,4-triazoles to yield s-triazolo[3,4-b][1,3,4]thiadiaz...

The effect of 2,3-seco-5α-cholestan-2,3-dioic acid on the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine is markedly dependent on pH. Above pH 6.56, the 2,3-seco-5α-cholestan-2,3-dioic acid raises the temperature of this transition, i.e., it stabilizes ...

Six amino naphthalene sulfonic acids including mono-, di- and tri-sulfonic acid compounds were studied to find the relationship between the reactivity of this kind of compounds in Fenton oxidation process and energies of the frontier molecular orbital. It was found that the initial rates of TOC ...

The colored complexes formed by the reaction of dinitrosoresorcinol with Cu(II) and Fe(III) is utilized for the microdetermination of both metal ions either alone or in a binary mixtures. Satisfactory results are obtained when the proper media are utilized in the presence of an excess of the org...

Summary2,4-Dinitrosoresorcinol (DNR) is polarographically reduced in aqueous buffered solutions along two equal, diffusion-controlled waves each involving the transfer of 2e−/molecule. Comparison with studied cases supports the conclusion that each of the two nitroso grous in DNR reduces indepen...

Hydrated Ni(II) chloride reacts with new substituted phenylazo-2,4-dinitrosoresorcinol ligands to give complexes with stoichiometry [NiClnL(H2O)](n = 0 or 1, and L is the anion of the ligand). These complexes have room-temperature μcff in the 1.77–2.66BM/Ni range. The planar ⇌ tetrahedral equi...

The electrochemical behaviour of 2,4-dinitrosoresorcinol (DNR) on Pt and Au electrodes modified by underpotentially-deposited heavy metal monolayers was studied in aqueous HClO4 solutions. At these modified electrodes, DNR is reduced to 2,4-diaminoresorcinol. The reduction wave of this eight-ele...

The thermal and spectral properties of chelates of 2,4-dinitrosoresorcinol with copper, cobalt, nickel, zinc, lead, cadmium, and mercury have been investigated. The properties of these chelates are compared with the previously studied chelates of N,N′-dinitroso-p-phenylenedihydroxylamine (dicup...

Electrical conductivity measurements of 2,4-dinitrosoresorcinol (DNR) and its complexes were measured in the temperature range 20–115°C to give faint semiconducting behaviour for these systems. The conductivity values of the bis Co, Ni, Cu and Zn systems indicated that the metal ion forms a br...

Mitochondria play an important role in cell life and in the regulation of cell death. In addition, mitochondrial dysfunction contributes to a wide range of neuropathologies. The nucleoside Guanosine (GUO) is an endogenous molecule, presenting antioxidant properties, possibly due to its direct sc...

Cyclic guanosine monophosphate (cGMP) influences intrarenal hemodynamics in animal models, but the relationship between cGMP and renal function in adults with type 1 diabetes (T1D) remains unclear. In this study, plasma cGMP correlated with efferent arteriolar resistance, effective renal plasma ...

In this work, the thermotropic liquid crystals (LCs) composed of a biological molecule, guanosine 5′-monophosphate disodium salt (GMP), with different cationic surfactants were reported. When GMP interacted with the surfactants, the length of the surfactant alkyl chains was found to be of great...

Metal-organic coordination polymers have emerged as attractive functional materials due to their tunable structures and unique properties. In this work, by the self-assembly of citrate (Cit) and lanthanide ions, we developed lanthanide coordination polymer nanoparticles (LCPNPs), Cit/Tb, for flu...

BackgroundGuanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to inv...