Quinine and chloroquine are the most common antimalarial drugs encountered in acute poisoning. Their severe toxicity in overdose results from cardiotoxicity secondary to membrane-stabilizing effects.

Ingestion of aspirin is the most common form of salicylate poisoning. Salicylate poisoning may also result from percutaneous absorption of salicylic acid (used in keratolytic agents) and ingestion of methyl salicylate (oil of wintergreen).

Salicylate and quinine, alone and in combination, were added to suspensions of sensitized mouse spleen cells and analyzed for hemolysin plaque forming cells according to the Jerne localized hemolysin-in-gel technique. The in vitro results of this study indicated a suppression of hemolysin plaque...

Quinine, a cinchona alkaloid, is the levorotatory isomer of …

This study presents firing rates for simultaneously recorded spontaneous and stimulus driven multi-unit activity in primary auditory cortex (AI), anterior auditory field (AAF) and secondary auditory cortex (AII) in cats before and after application of salicylate or quinine. From 21 cats, in thre...

Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulat...

Three different S, N and Se-modified methyl salicylate derivatives, methyl 2-hydroxy-4-(pyridin-2-yl)benzoate (MHPB), methyl 2-hydroxy-4-(thiophen-2-yl)benzoate (MHTB) and methyl 2-hydroxy-4-(selenophen-2-yl)benzoate (MHSB) have been synthesized and their photophysical properties are examined in...

Mobilization of the ribose moiety and of the amino group of guanosine may be realized in rat liver extract by the concerted action of purine nucleoside phosphorylase and guanase. Ribose 1-phosphate formed from guanosine through the action of purine nucleoside phosphorylase acts as ribose donor i...

An efficient and convergent method for the synthesis of mannose-1-phosphate prodrugs is described as a potential therapy for congenital disorders of glycosylation-Ia (CDG-Ia). The key feature of the proposed approach is the silver assisted nucleophilic substitution of 2,3,4,6-tetra-O-protected-α...

Publisher SummaryIn the presence of inorganic phosphate, guanosine is converted to guanine and ribose-1-phosphate by nucleoside phosphorylase. Guanase converts guanine to xanthine, and xanthine oxidase converts xanthine to uric acid; the extinction at 293 nm increases. After the addition of uric...

Excess phosphate levels in water can lead to increased algal growth, eutrophication and reduced water quality. Phosphate levels in water are regulated by the EU through the Urban Waste Water Treatment Directive (annual mean total phosphorus concentrations of 1–2 mg/l) and the Water Framework Di...

Excitatory amino acids (EAAs) and their receptors play a central role in the mechanisms underlying pain transmission. NMDA-receptor antagonists such as MK-801 produce antinociceptive effects against experimental models of chronic pain, but results in acute pain models are conflicting, perhaps du...

The intracellular alarmone guanosine 3′,5′-bis(diphosphate) (ppGpp) has been thoroughly investigated over the past 40 years and has become one of the best-known effectors in bacterial physiology. ppGpp is also of great importance for biotechnological applications. Systems biology research, inv...

Publisher SummaryThis chapter discusses the selective phosphorylation of ribonucleosides. Various methods have been proposed for the preparation of ribonucleoside 5'-phosphate. Among them are chemical or enzymic hydrolysis of ribonucleic acid, enzymic phosphorylation of ribonucleosides, and...

The reaction of guanosine with glucose, glucose 6-phosphate or ribose in the presence of propylamine leads to the formation of several guanosine derivatives. During this process sugar degradation products are attached to the amino group of the guanosine residue. N2-(1-Carboxy-3,4-dihydroxybutyl)...

In order to solve the toxic and hazardous issues of the agents in the chemical reduction process of graphene oxide (GO), disodium guanosine 5′-monophosphate (GMP-2Na) was used as an ideal reducing agent for the synthesis of functionalized GO (FGO) for lipase immobilization. At the condition of ...

This work describes the development of a ternary hexafluoroisopropylidene- dianiline/Cyclophosphazene/benzidinedisulfonic acid-carbon nanotubes (HFPA/CP/BZD-CNT) composite as a novel support for the electrooxidation of ethylene glycol. Pt and Pt-Sn nanoparticles were coated on HFPA/CP/BZD-CNT co...

Hydrolytically stable, proton conductive membranes were prepared from cross-linked poly(arylene ether ketone). The reduction of proton conduction caused by cross-linking was compensated for using a proton conductive cross-linker, 2,2′-benzidinedisulfonic acid. Sulfonation was achieved at pendan...

Thin film composite (TFC) polyamide membranes for reverse osmosis (RO) were successfully prepared via interfacial polymerization of m-phenylenediamine (MPD), 2,2′-benzidinedisulfonic acid (BDSA) and trimesoyl chloride (TMC) on a polysulfone support. The physico-chemical characteristics of the m...

Starting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51 Å for the edge O–O distance), and the knowledge that this value also corresponds to the O7–O12 distance of the skeleton of cholic acid, it is ...