Since its discovery in Tanganyika, Africa in 1952, chikungunya virus (CHIKV) outbreaks have occurred in Africa, Asia, Europe, and America. Till now chikungunya fever has spread in nearly 40 countries. Because of lack of effective vaccines and antiviral drugs to intervene this disease, 21 new con...

Guanosine (GUO) is a guanine-based purine that has been extensively described in the literature as an endogenous nucleoside with participation in brain cell signalling pathways. Here, we evaluated whether chronic treatment with exogenous guanosine during brain development altered behavioral and ...

Glutamatergic neurotransmission is present in most mammalian excitatory synapses and plays a key role in central nervous system homeostasis. When over-activated, it can induce excitotoxicity, which is present in several neuropathologies. The nucleoside guanosine (GUO) is a guanine-based purine k...

The ketamine's potential for the treatment of refractory depression and anxiety has been considered one the most important discoveries in the last years, however, repeated use of ketamine is limited due to its side/adverse effects. Therefore, the search for effective augmentation strategies...

Reactions of Sr(II) and Ba(II) chlorides with 2-hydroxybenzophenone and salicylaldehyde, hydroxyaromatic ketones or β-diketones in 1:1:1 molar ratios have resulted in the formation of mixed ligand complexes of the type [MLL′(H2O)2] (M = Sr(II) or Ba(II); HL = 2-hydroxybenzophenone and HL′ = s...

The gas-phase Proton Affinity (PA) and Basicity (GB) of 2-, 3- and 4-hydroxybenzophenone isomers have been experimentally determined by the Extended Kinetic Cooks Method (EKCM), using ESI-TQ Mass Spectrometry. Our results show that 4-hydroxybenzophenone isomer (PA = 912.6 ± 8.4 kJ·mol−1) is in...

Phenol derivatives containing 2,2,6,6-tetramethylpiperidine group were successfully benzoylated with both benzoyl chloride in the presence of aluminium chloride and benzotrichloride in aqueous sodium hydroxide solution. The 2-hydroxybenzophenone UV-absorbers bearing light stabilizing fragment —...

The synthesis of new stabilizer type compounds (a combination between 2,2,6,6-tetramethylpiperidine and 2-hydroxybenzophenone in one molecule) under phase transfer catalysis (PTC) conditions is reported. The most favorable reaction conditions (the type of two-phase system, solvent, catalyst) wer...

The reactions of di-2-pyridyl ketone (dpk), 2-benzoylpyridine (zpy) and 2-hydroxybenzophenone (Hbp) with [Re(CO)5Cl] (A) and trans-[ReOX3(PPh3)2] (B, X = Cl, Br) were studied. The complex fac-[Re(CO)3(dpk·OCH3)] was isolated from the reaction of A with dpk in methanol. The monoanionic tridentat...

2-Hydroxy-4-[(2,4,4,5,5-pentamethylimidazolidin-2-yl)methoxy]benzophenone (4)-2-hydroxybenzophenone UV-absorber containing 4,4,5,5-tetramethylimidazolidine fragment was obtained in the reaction of 4-(2-oxopropoxy)-2-hydroxybenzophenone (3) with 2,3-diamino-2,3-dimethylbutane (2).

Two 2-hydroxy-4-alkoxy-3′-nitrobenzophenones were synthesized in a facile way. Their structures were characterized with the aid of mass spectra and 1H NMR spectra analysis, as well as X-ray diffraction analysis. The 1H NMR spectra showed an intramolecular hydrogen bond formation in their struct...

A variety of 2-hydroxybenzophenones on reaction with Corey–Chaykovsky reagent underwent unprecedented rearrangements leading to 3-substituted benzofurans 8 and one-carbon homologated compounds 9 and 12. Compounds 9 could further be quantitatively transformed to 2-substituted benzofuran derivati...

Two diketone complexes of Cu(II) and Co(II) were easily synthesized in reaction of M(CH3COO)2 with 2-Hydroxybenzophenone (bpoH). The complexes of M(bpo)2 were characterized by UV–vis, IR spectroscopy, and elemental analysis. The complexes are active catalysts for the oxidation of styrene using ...

Enneanuclear lanthanide(III) hydroxo coordination clusters with an “hourglass”- or “sandglass”-like topology have been synthesized via 2-hydroxybenzophenone-controlled hydrolysis of the metal ions in ethanol; the EuIII9 complex displays an intense red, metal-centered emission in the solid st...

Publisher SummaryThis chapter discusses the diatrizoic acid. Diatrizoic Acid is 3,5- diacetamido - 2,4,6 triiodbenzoic acid. Chemical abstracts listings are under the heading benzoic acid, 3,5 – diacetamido – 2,4,6 – triido. Among the generic and trivial names for this compound are urografin ...

Recent studies have confirmed that the aquatic ecosystem is being polluted with an unknown cocktail of pharmaceuticals, their metabolites and/or their transformation products (TPs). Although individual chemicals are typically present at low concentrations, they can interact with each other resul...

Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such ...

Diatrizoic acid (DIA) is an iodinated X-ray contrast media commonly used in hospitals. It is persistent and recalcitrant in aquatic environments and difficult to biodegrade. Thus, we studied its removal from aquatic medium by two electrochemical advanced oxidation processes: anodic oxidation and...

The series of bidentate N^N iron(II) and cobalt(II) complexes containing 8-(1-aryliminoethylidene) quinaldine derived ligands, 8-[2,6-(R1)2-4-R2-C6H2NC (Me)]-2-Me-C10H5N, were synthesized and characterized by elemental and spectroscopic techniques. The molecular structures of Co1 (R1 = Me, R2 = ...

Tricaine, quinaldine sulfate, and metomidate were compared as anesthetics for larvae of two species of fish, red drum (Sciaenops ocellatus) and goldfish (Carassius auratus). Larvae were exposed to various concentrations of each anesthetic and the percentages of fish reaching stage 4 of anesthesi...