The highly regioselective fluorination of 1-hydroxyisoquinoline is described using Selectfluor™ (F–TEDA–BF4) under a variety of conditions.

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition ...

Cathodic reduction of phthalimide anion in methanol was studied. The novel product, N-hydroxymethyl-3-hydroxyphthalimidine, was found. Full characterization of this new compound was carried out by means of NMR, FT-IR, MS, and X-ray crystallography. The mechanism of electrolytic formation of N-hy...

Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure–activity relationship studies indicated th...

The conversion of N-(hydroxymethyl) phthalimide (NHPH) to phthalimide could not be detected within 300 s at pH 9.0 whereas in 0.18 M NaOH complete conversion of NHPH to phthalimide was observed within 50 s. In the presence of 0.2–0.4 M 1,4-diazabicyclo[2.2.2]octane buffer solutions (pH 9.30–9....

1.1. From a study of 34 normal individuals and some 296 patients treated with Ambodryl (β-[4-bromobenzhydryloxy]-ethyldimethylamine hydrochloride), the following pharmacologic actions were demonstrated in human beings: (a) suppression of the “wheal and flare” reaction which normally follows t...

The efficiency of AA5754 aluminium alloy corrosion inhibition achieved with maleic, malic, succinic, tartaric, citric, tricarballylic acids and serine in alkaline environment (pH 11) was examined. Selected corrosion inhibitors are characterized by different numbers and distribution of carbonyl a...

Quinone organic materials are promising candidates to construct supercapacitor electrodes as they are entirely nontoxic, nonflammable, and safe for use. However, their wide adoption in supercapacitor applications is restricted by the inadequate electrical conductivity, which results in low mass ...

A sensitive and selective spectrophotometric method was studied for the determination of erbium (Er) with kojic acid dye (koj) and cetylpyridinium chloride (CPC) as a cationic surfactant from Egyptian monazite and xenotime concentrates using third derivative spectrophotometry. The calibration cu...

This work is aimed to improve protection function of an epoxy ester coating by embedding inhibitor loaded halloysite nanotubes (HNTs). At first step, in the solution phase, corrosion inhibition of imidazole dicarboxcylic acid (IDC) released from loaded HNTs was assessed by using electrochemical ...

In past years, terpyridine-containing substances have been found useful in polynucleotide chemistry and enzymatic engineering applications. Therefore, the construction of a noncanonical amino acid with a terpyridine side chain may offer promising features for in vitro and in vivo applications, s...

The solvothermal reactions of Cd(NO3)2∙ 6H2O with 2-hydroxyquinoline-4-carboxylic acid (H2hqc) and 4,4′-bipyridine (bpy) or trans-1,2-bi(4-pyridyl)ethylene (bpe) afforded two coordination polymers [Cd(H-hqc)2(bpy)(H2O)2]n (1) and [Cd(H-hqc)2(bpe)0.5]n (2), respectively. The bipyridine based aux...

The synthesis of several fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould–Jacobs reaction is presented. These quinolines are important intermediates for the preparation of antibacterial fluoroquinolones.

The enantioselective hydrogenation of (E)-N-acetyl dehydrophenylalanine methyl ester (NADPME) to N-acetyl phenylalanine methyl ester was investigated using cinchonine-modified Pd/Al2O3 catalysts. The catalysts were evaluated for this reaction using methanol as solvent with various cinchonine:NAD...

The different fluorescence lifetime profiles of the optical isomers (+)-cinchonine (CN) and (−)-cinchonidine (CD) have been used to resolve their mixtures, on the basis of phase and modulation fluorescence lifetime measurements. To resolve mixtures of these compounds two distinct approaches have...

Cinchonine was employed as backbone for the synthesis of novel phosphite compounds with diol substituents. These monophosphinites were provided in one pot with the yields ranged from 63% to 75%. Their structures were confirmed by NMR spectroscopy and HRMS.

The tandem enantioselective Michael addition/cyclisation reaction of malononitrile and nitrovinylphenols was catalysed by a recoverable C3-symmetric cinchonine-squaramide organocatalyst 1a to afford the 2-amino-4H-chromene-3-carbonitrile derivatives in excellent yields (up to 95%) and with excel...

Absorption and fluorescence spectra of dications of cinchonine (C2 +) and cinchonidine (Cd2 +) have been measured at room temperature in solvents of different polarities. Ground and excited state electric dipole moments are determined experimentally using solvatochromic shift method based on bul...

The cinchonine-catalyzed in situ generation of unstable and gaseous trifluoroacetaldehyde from its hemiacetal and successive direct aldol reaction with 2-methoxy-1-phenylethanone proceeded smoothly to give 4,4,4-trifluoro-3-hydroxy-2-methoxy-1-phenylbutan-1-one in good yield with low diastereose...

Photophysical properties of cinchonine dication (C++) have been studied in protic and aprotic polymers by monitoring steady state and time resolved measurements. It is found to be sensitive towards the microenvironment of polymers. Edge excitation red shifted emission (EERS) is observed in all p...