The UV–vis absorption and steady state fluorescence spectra of phenyl salicylate (abbreviated as PS) have been recorded in a series of non-polar, polar protic and polar aprotic solvents at room temperature and the obtained spectral data are used to determine the solvatochromic behavior and the ...

A toxicologic and dermatologic review of phenyl salicylate when used as a fragrance ingredient is presented.

Photo-Fries rearrangement of phenyl salicylate was examined by real-time infrared (IR) monitoring in conjunction with density functional theory (DFT) calculation. Changes in the spectral features were readily captured during the photo-induced chemical reaction of the phenyl salicylate by means o...

BackgroundThere is no recent systematic review on the risk of cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients despite many new studies on the subject. All past reviews have several limitations such as not including any patient with a T-cell–mediated penicillin...

Magnetic Ni0.5Zn0.5Fe2O4@SiO2 nanocomposite was prepared via the rapid combustion process, and its surface was modified to obtain amino-functionalized magnetic Ni0.5Zn0.5Fe2O4@SiO2-NH2 nanocomposite. The modified nanocomposite was loaded on graphene oxide (GO), on which penicillin G acylase (PGA...

One of the most successful achievements of mankind is represented by the discovery and development of beta-lactam antibiotics. Ninety years after Fleming's fortuitous discovery of penicillin and the penicillin-producing fungus Penicillium notatum/Penicillium chrysogenum (recently re-identif...

There is an ever-increasing demand for the β-lactam bulk intermediate 6-aminopenicillanic acid (6-APA) that has wide applications in the synthesis of newer generations of semisynthetic penicillins. It is commercially synthesized by biocatalytic transformation using penicillin acylase. Since the...

Discovery, industrial production and clinical applications of penicillin, together with scientific findings on penicillin biosynthesis and its complex regulation, are model milestones of the historical evolution of the most recognized ‘magic bullet’ against microbial infections available in th...

BackgroundMost pregnant women who self-report penicillin allergy are not truly penicillin-allergic and this misunderstanding often leads to administration of inappropriate antibiotic therapy. Decision algorithms have been developed to guide antibiotic selection but major discrepancies have been ...

Antibiotic contamination to the environment is a global problem now a days, due to the prevalence of resistance. The antibiotic resistant Serratia sp. R1 was isolated from Yamuna river water to check its antibiotic degradation potential. Bacteria was characterized by 16s-rRNA gene sequencing, ba...

A new chemiluminescence (CL) flow-injection method is proposed for the determination of 1,3-dichloro-5,5-dimethylhydantoin (DDH). The method is based on the chemiluminescent reaction of DDH and luminol–H2O2 in an alkaline medium (pH 12.0–12.5). The concentration of the analyte shows a good lin...

1,3,5-Trisubstituted pyrazolines are rapidly and conveniently oxidized to their corresponding pyrazoles by 1,3-dichloro-5,5-dimethylhydantoin (DCH) in solution and solvent-free conditions under microwave irradiation. The presence of silica gel as a supporting agent is shown to be effective in re...

Simple and efficient synthetic procedures for the selective preparation of 3-bromo/3-chloroindoles and 2,3-dibromo/2,3-dichloroindoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) were developed. Using 1,4-dioxane as the solvent, a variety of ...

We have developed the chloramphenicol base urea-catalyzed intramolecular Michael addition of γ-hydroxy-α, β-unsaturated enones. The oxidation of the resulting products provided facile access to the corresponding α-hydroxy chiral alcohols with good efficiency and enantioselectivity, with the ...

α-Acyloxy-carboxamide azides 1, obtained from Passerini reaction of easily accessible o-azidobenzaldehyde with isocyanides and carboxylic acids, reacted with triphenylphosphine to give various 4-aminocarbonyl substituted 4H-1,3-benzoxazines 3 in moderate to high yields via sequential Staudinger...

Three series of Spiro [(2H,3H) quinazoline-2,1′-cyclohexan]-4(1H)-one derivatives have been synthesized. Some of the novel quinazolinone derivatives IIe, VIIIc, XIc, XIIb, XIIc, XVIb showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experim...

Reaction of 3-arylimino-2-indolinones 1 with m-chloroperbenzoic acid in CH2Cl2 or methanol at 0°C leads to the corresponding 3-aryl-2,4(1H,3H)-quinazolinediones 4 and (2-arylcarbamoyphenyl)carbamic acid methyl ester 5, respectively. These conversions proceed through 4-arylimino-(1H,4H)-3,1-benz...

To reveal an enzyme-like catalytic activity of metal-octabromo-tetrakis(sulfophenyl)porphines (M-OBPSs), their peroxidease-like catalytic activity on linoleate hydroperoxide (LOOH) were evaluated on the basis of dye-formation in the coloring reaction between N,N-diethylaniline and 4-aminoantipyr...

Pyrylium salts react exclusively with the ϵ-amino group of lysyl moieties and display a degree of selectivity exceeding all other known amino group reagents. This study represents the first use of a pyrylium salt in positively identifying the functional role of lysyl residues in a biologically a...

This work forms part of an investigation which seeks to determine metal complexes in a solid phase by photoacoustic spectrometry (PAS). Results of spectral determination of Co(II) complexes are introduced. The method is based on Co(II) colorimetric reaction with 3-(2-pyridyl)-5,6-bis(4-sulfophen...