A novel quinaldine–indole based spiropyran (QSP) with stabilized merocyanine form has been developed for colorimetric detection of Cu2+ ions. Chemosensor QSP shows high sensitivity and selectivity for Cu2+ ions amongst other metal ions (Na+, Mg2+, K+, Ca2+, Al3+, Co2+, Ni2+, Zn2+, Cd2+, Ba2+, L...

A series of 5-[1-(arylimino)methyl]quinaldine-8-ol derivatives L1–L5 and their trinuclear zinc(II) complexes (C1–C5) were synthesized. The compounds L1–L5 were fully characterized by the FT-IR spectra, NMR measurement and elemental analysis, meanwhile the zinc complexes C1–C5 were characteri...

A “naked-eye” detection of health hazardous bisulfite (HSO3−) and hypochlorite (ClO−) using an indicator dye (Quinaldine Red, QR) in a wide range of pH is demonstrated. The molecule contains a quinoline moiety linked to an N,N-dimethylaniline moiety with a conjugated double bond. Treatment of ...

We investigated the effect of the calmodulin inhibitor and antipsychotic drug trifluoperazine on voltage-dependent K+ (Kv) channels. Kv currents were recorded by whole-cell configuration of patch clamp in freshly isolated rabbit coronary arterial smooth muscle cells. The amplitudes of Kv current...

A reverse phase HPLC method is developed for the simultaneous analysis of Trifluoperazine (TFP) and prochlorperazine (PCP) in pharmaceutical preparations. HPLC was carried out on a C18 column using acetonitrile as a mobile phase at 1 mL min−1 flow rate and the effluent was monitored at 250 nm. C...

Two sensitive, selective and precise stability indicating methods for the determination of isopropamide iodide (ISO), trifluoperazine hydrochloride (TPZ) and trifluoperazine oxidative degradate (DEG) were developed and validated. Method A is a successive derivative ratio spectrophotometric one, ...

Trifluoperazine is a phenothiazine derivative which is mainly used in the management of schizophrenia and also acts as a calmodulin inhibitor. We used the whole-cell patch-clamp technique to study the effects of trifluoperazine on human Nav1.5 (hNav1.5) currents expressed in HEK293 cells. The 50...

Trifluoperazine, a trifluoro-methyl phenothiazine derivative, is widely used in the management of schizophrenia and related psychotic disorders. We studied the effects of trifluoperazine on Kv4.3 currents expressed in CHO cells using the whole-cell patch-clamp technique. Trifluoperazine blocked ...

Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-b...

Glioblastoma (GBM) is regarded as the most common malignant brain tumor but treatment options are limited. Thus, there is an unmet clinical need for compounds and corresponding targets that could inhibit GBM growth. We screened a library of 80 dopaminergic ligands with the aim of identifying com...

Glioblastoma (GBM) is regarded as the most common malignant brain tumor but treatment options are limited. Thus, there is an unmet clinical need for compounds and corresponding targets that could inhibit GBM growth. We screened a library of 80 dopaminergic ligands with the aim of identifying com...

Repositioning of the antipsychotic drug trifluoperazine for treatment of glioblastoma, an aggressive brain tumor, has been previously suggested. However, trifluoperazine did not increase the survival time in mice models of glioblastoma. In attempt to identify an effective trifluoperazine analog,...

Maleic anhydride was reported illegally adulterated into starch to prepare traditional foods for decades in Taiwan. Maleic acid (MA), hydrolyzed from maleic anhydride, could cause kidney damages to animals. The potential health effects due to long-term MA exposures through food consumption have ...

Mammalian aminoacylase-1 (Acy1) participates in the breakdown of N-acetylated amino acids during intracellular protein catabolism. Acy1 is most abundantly expressed in the kidney tubular epithelium. Lately, Acy1 deficiency was identified in children with increased urinary excretion of several N-...

The occurrence and fate of nine phthalate esters (PAEs), including dimethyl phthalate (DMP), diethyl phthalate (DEP), di‑n‑butyl phthalate (DBP), di-isobutyl phthalate (DIBP), benzyl butyl phthalate (BzBP), di (2‑ethylhexyl) phthalate (DEHP), di‑n‑hexyl phthalate (DNHP), dicyclohexyl phthalate (...

Phthalates are mainly used as binders and plasticizers in various industrial products including detergents, surfactants, waxes, paints, pharmaceuticals, food products, and cosmetics. However, they have been reported to be endocrine disruptors, which are chemicals that can mimic or disturb endocr...

Wide utilization of phthalates-containing products results in the significant exposure of humans to these compounds. Many adverse effects of phthalates have been documented in rodent models, but their effects in humans exposed to these chemicals remain unclear until more mechanistic studies on p...

Phthalates (phthalic acid esters) have been widely applied as plasticizers. They are ubiquitous contaminants in soils, thereby posing a threat to human health. In this study, ecotoxicological effects of three typical PAEs (dimethyl phthalate-DMP, di-n-octyl phthalate-DOP and butyl benzyl phthala...

Phthalate esters (PAEs) have been used in large quantities all over the world for decades, leading to ubiquitous occurrence in the indoor environment. Indoor dust samples were collected from six geographical regions in China (n = 120) and the concentrations, profiles and human exposure to nine p...

Two bacterial strains were isolated from activated sludge using mixtures of phthalic acid esters (PAEs) as the sole source of carbon and energy. One of the isolates was identified as Gordonia sp. strain JDC-2 and the other as Arthrobacter sp. strain JDC-32, mainly through 16S rRNA gene sequence ...