Product Name

  • Name

    4-Chlorobenzophenone

  • EINECS 205-160-7
  • CAS No. 134-85-0
  • Article Data537
  • CAS DataBase
  • Density 1.207 g/cm3
  • Solubility 20.706mg/L at 29℃
  • Melting Point 93-96 °C(lit.)
  • Formula C13H9ClO
  • Boiling Point 333 °C at 760 mmHg
  • Molecular Weight 216.667
  • Flash Point 176.1 °C
  • Transport Information UN 3261 8/PG 2
  • Appearance white to off-white crystalline powder
  • Safety 26-36/37/39-45-24/25-22
  • Risk Codes 34-36/37/38-20/21/22
  • Molecular Structure Molecular Structure of 134-85-0 (4-Chlorobenzophenone)
  • Hazard Symbols CorrosiveC,IrritantXi,HarmfulXn
  • Synonyms Benzophenone, 4-chloro- (8CI);para-Chlorobenzophenone;(4-chlorophenyl)-phenyl-methanone;Benzophenone, 4-chloro-;p-CBP;Methanone, (4-chlorophenyl)phenyl-;4-Chloro-benzophenone;Methanone;
  • PSA 17.07000
  • LogP 3.57100

Synthetic route

(4-chlorophenyl)phenylmethanol
119-56-2

(4-chlorophenyl)phenylmethanol

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With butyltriphenylphosphonium chlorochromate In acetonitrile for 0.75h; Heating;100%
With diisopropyl-carbodiimide In toluene at 120℃; for 24h; Inert atmosphere; Sealed tube;100%
With Montmorillonite K10; ferric nitrate In hexane at 60℃; for 4h;99%
2-(4-chlorophenyl)-2-phenyl-1,3-dithiolane
6008-75-9

2-(4-chlorophenyl)-2-phenyl-1,3-dithiolane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With t-butyl bromide; dimethyl sulfoxide at 70 - 75℃; for 24h;100%
With trimethylsilyl iodide; dimethyl sulfoxide In tetrachloromethane at 75 - 80℃; for 6h;99%
With trichloroisocyanuric acid; silver nitrate In water; acetonitrile Ambient temperature;94%
4-cholorobenzophenone oxime
2998-98-3, 2998-99-4, 38032-14-3

4-cholorobenzophenone oxime

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With tert.-butylhydroperoxide In tetrachloromethane for 2h; Product distribution; Heating; other oxidants, various solvents, various times, other temperature;100%
With tert.-butylhydroperoxide In tetrachloromethane for 4h; Heating;98%
With aluminum(III) nitrate nonahydrate; sodium bromide In dichloromethane at 20℃; for 1.75h;97%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With potassium phosphate; 3,3-dimethyl-butan-2-one; C14H10Cl2N2O2Ru; tri tert-butylphosphoniumtetrafluoroborate In water; toluene at 100℃; for 24h;100%
With C35H26NO2PPd; caesium carbonate In toluene for 18h; Reagent/catalyst; Reflux;97%
With [Pd(2-((1-naphthalenyl)methylene)-N-phenylhydrazinecarbothioamide)Cl(PPh3)]; caesium carbonate In toluene at 110℃; for 12h;94%
4-chlorophenyl(phenyl)methane
831-81-2

4-chlorophenyl(phenyl)methane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With pyridine; tert.-butylhydroperoxide; iodine In water at 80℃; chemoselective reaction;99%
With N-Bromosuccinimide; water In chloroform for 3h; Reflux;98%
With pyridine; tert.-butylhydroperoxide; air; K(1+)*AuCl4(1-)*0.5H2O=K[AuCl4]*0.5H2O In decane at 90℃; for 24h;96%
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With water; sodium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; palladium diacetate at 60℃; for 2h; Suzuki reaction;99%
With C35H35ClFeN3O2PPd; sodium hydrogencarbonate In water; toluene at 50℃; Inert atmosphere;99%
With C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate In water; toluene at 50℃; for 1h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;99%
bromochlorobenzene
106-39-8

bromochlorobenzene

benzaldehyde
100-52-7

benzaldehyde

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With palladium diacetate; N-picolinoylcyclohexylamine; potassium hydrogencarbonate In tert-Amyl alcohol at 150℃; for 24h;99%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

N,N-bis(methanesulfonyl)benzamide
120622-90-4

N,N-bis(methanesulfonyl)benzamide

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In toluene at 65℃; for 4h; Inert atmosphere;99%
4-chloro-N,N-bis(methanesulfonyl)benzamide
1441987-15-0

4-chloro-N,N-bis(methanesulfonyl)benzamide

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In toluene at 65℃; for 0.333333h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere;99%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

trimethyl(phenyl)stannane
934-56-5

trimethyl(phenyl)stannane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
bis(η3-allyl-μ-chloropalladium(II)) In N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 12h;98%
...Expand
sodium tetraphenyl borate
143-66-8

sodium tetraphenyl borate

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride In acetone for 0.15h; microwave irradiation (525 W);98%
With aluminum oxide; bis-triphenylphosphine-palladium(II) chloride; potassium fluoride In acetone for 0.0833333h; MW-irradiation;95%
With silica-supported diphenylphosphine palladium(0) In tetrahydrofuran at 40℃; for 48h;80%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

benzoic acid anhydride
93-97-0

benzoic acid anhydride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
Stage #1: 4-Chlorophenylboronic acid; benzoic acid anhydride With sodium hydrogencarbonate In water at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With C19H25Br2N5Pd In water at 20℃; for 36h; Inert atmosphere;		98%
With [Pd(η(5)-C5H5)Fe(η(5)-C5H3-C(CH3)=N-C6H4-4-CH3)Cl(P(C6H5)3)]; potassium carbonate In 1,4-dioxane at 110℃; for 12h; Inert atmosphere;81%
With NHC-Pd(II)-Im; sodium hydrogencarbonate In water at 20℃; for 12h; Inert atmosphere;52%
1-(4-bromophenyl)-3-((4-chlorophenyl)(phenyl)methyl)urea

1-(4-bromophenyl)-3-((4-chlorophenyl)(phenyl)methyl)urea

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With 2,4,6-triphenylpyrylium tetrafluoroborate at 35℃; for 10h; Irradiation;98%
1-(4-chlorophenyl)-1-phenylethene
18218-20-7

1-(4-chlorophenyl)-1-phenylethene

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With oxygen at 110℃; for 8h; Sealed tube;97.2%
With oxygen at 110℃; for 8h; Schlenk technique; Green chemistry;97%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at -78 - 20℃; for 1.33333h; Inert atmosphere;83%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

phenyl(diisobutyl)aluminium
62673-29-4

phenyl(diisobutyl)aluminium

A

benzophenone
119-61-9

benzophenone

B

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
dichloro bis(acetonitrile) palladium(II) In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 40℃; for 2h; Product distribution;A 16%
B 97%
...Expand
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

phenyllithium
591-51-5

phenyllithium

A

benzophenone
119-61-9

benzophenone

B

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With diisobutylaluminum chloride; dichloro bis(acetonitrile) palladium(II) In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 40℃; under 760 Torr; for 2h;A 16%
B 97%
...Expand
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

benzoic acid
65-85-0

benzoic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); water; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In N,N-dimethyl-formamide at 60℃; for 15h; Inert atmosphere;97%
With P(p-CH3OC6H4)3; water; dimethyl dicarbonate; palladium diacetate In tetrahydrofuran at 50℃; for 16h;71%
1-((4-chlorophenyl)(phenyl)methylene)-2-phenylhydrazine

1-((4-chlorophenyl)(phenyl)methylene)-2-phenylhydrazine

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.133333h; Heating;97%
With quinolinium monofluorochromate(VI) In dichloromethane at 20℃; for 1h;95%
With cetyltrimethylammonium peroxodisulphate In acetonitrile for 0.416667h; Reflux;95%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With potassium carbonate under 7500.75 Torr; for 1h; Autoclave; Reflux;97%
With potassium carbonate under 11251.1 Torr; for 0.5h; Suzuki-Miyaura Coupling; Autoclave; Reflux;96%
With potassium phosphate; palladium diacetate at 20℃; under 760.051 Torr; for 20h;95%
...Expand
bromobenzene
108-86-1

bromobenzene

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
Stage #1: bromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: 4-chlorobenzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
Stage #3: With iodine; potassium carbonate In tert-butyl alcohol for 3h; Reflux;		97%
With palladium diacetate; N-picolinoylcyclohexylamine; potassium hydrogencarbonate In tert-Amyl alcohol at 150℃; for 24h;82%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

benzoyl chloride
98-88-4

benzoyl chloride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With [Ph2P(ferrocene-1,1′-diyl)ONHCH2CH2NHC(NH2)NH2]Cl*0.4chloroform; palladium diacetate; sodium carbonate In water; toluene at 50℃; for 1h; Schlenk technique; Inert atmosphere;97%
With trans-(Et3NH)2[PdCl2(Ph2Pferrocene-1,1′-diylSO3-κP)2]; sodium phosphate In water; toluene at 50℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;95%
With palladium 10% on activated carbon; sodium carbonate In water; acetone at 60℃; Suzuki Coupling; Green chemistry;93%
1-chloro-4-(chloro(phenyl)methyl)benzene
134-83-8

1-chloro-4-(chloro(phenyl)methyl)benzene

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With N-Bromosuccinimide; water In chloroform for 3h; Time; Reflux;97%
4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine In water at 60℃; for 7h;97%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

chromium(0) hexacarbonyl
199620-14-9, 13007-92-6

chromium(0) hexacarbonyl

phenylboronic acid
98-80-6

phenylboronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With sodium t-butanolate In N,N-dimethyl acetamide at 80℃; for 0.25h; Suzuki Coupling;97%
...Expand
4-chloro-thiobenzophenone
2484-99-3

4-chloro-thiobenzophenone

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With 3-carboxypyridinium chlorochromate In acetonitrile for 0.0333333h; Product distribution; Further Variations:; Reagents; Temperatures; without microwave irradiation; solvent-free; microwave irradiation;96%
With clay supported ferric nitrate In dichloromethane for 1h; Ambient temperature;95%
With 4-nitrobenzaldehdye; trimethylsilyl trifluoromethanesulfonate In dichloromethane for 3h; Ambient temperature;74%
With bismuth(III) nitrate In acetonitrile for 1h; Heating;18%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

benzaldehyde
100-52-7

benzaldehyde

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With C35H26NO2PPd; caesium carbonate In toluene for 18h; Reagent/catalyst; Reflux;96%
With [Pd(2-((1-naphthalenyl)methylene)-N-phenylhydrazinecarbothioamide)Cl(PPh3)]; caesium carbonate In toluene at 110℃; for 12h;94%
With potassium phosphate; 3,3-dimethyl-butan-2-one; C14H10Cl2N2O2Ru; tri tert-butylphosphoniumtetrafluoroborate In water; toluene at 100℃; for 24h;82%
1-(4-chlorobenzoyl)piperidine-2,6-dione

1-(4-chlorobenzoyl)piperidine-2,6-dione

triethoxyphenylsilane
780-69-8

triethoxyphenylsilane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With lithium acetate; palladium diacetate; triethylamine tris(hydrogen fluoride); tricyclohexylphosphine In 1,4-dioxane; water at 90℃; for 6h; Hiyama Coupling;96%
C14H12ClN3O

C14H12ClN3O

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.133333h; Heating;95%
With manganese triacetate In acetic acid at 28℃; Mechanism; Rate constant;
2-(4-chlorophenyl)-2-phenyl-1,3-dioxolane
374589-65-8

2-(4-chlorophenyl)-2-phenyl-1,3-dioxolane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With 2,6-dicarboxypyridinium chlorochromate In acetonitrile at 20℃; for 0.25h;95%
With caro's acid; silica gel In acetonitrile at 20℃; for 1h;93%
potassium ferrate(VI); montmorillonite K-10 In dichloromethane for 0.25h; Heating;88%
With K5 In acetone for 1.25h; Heating;80%
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4-chlorophenyl)phenylmethanol
119-56-2

(4-chlorophenyl)phenylmethanol

Conditions
ConditionsYield
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran for 0.666667h; Heating;100%
With [(OC-6-13)-RuCl2[P(p-CH3C6H5)3]2(en)]; potassium tert-butylate; hydrogen In isopropyl alcohol at 35℃; under 6080.41 Torr; for 8h; Catalytic hydrogenation;99.8%
Stage #1: 4-chlorobenzophenone With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; polymethylhydrosiloxane; copper(l) chloride; sodium t-butanolate In toluene at 0℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium hydroxide; water In ethyl acetate; toluene for 1h; Inert atmosphere;		99%
ethane-1,2-dithiol
540-63-6

ethane-1,2-dithiol

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

2-(4-chlorophenyl)-2-phenyl-1,3-dithiolane
6008-75-9

2-(4-chlorophenyl)-2-phenyl-1,3-dithiolane

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;99%
With silica gel-supported phosphorus pentoxide at 20℃; Neat (no solvent);98%
Nafion-H In benzene Heating;80%
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

phenylboronic acid
98-80-6

phenylboronic acid

biphenyl-4-yl-phenyl-methanone
2128-93-0

biphenyl-4-yl-phenyl-methanone

Conditions
ConditionsYield
With potassium phosphate monohydrate; 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; palladium diacetate In 1,4-dioxane at 135℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere;99%
With 2-chloro-1,3-[di-(2,6-diisopropyl)phenyl]-1,3,2-diazaphospholidine; tris-(dibenzylideneacetone)dipalladium(0); cesium fluoride In 1,4-dioxane at 80℃; for 19h; Suzuki-Miyaura cross-coupling; Inert atmosphere;98%
With {N,N-bis((3,5-dimethylpyrazol-1-yl)methyl)benzylamine}PdCl2; tetrabutylammomium bromide; caesium carbonate In water; N,N-dimethyl-formamide at 120℃; for 5h; Suzuki-Miyaura cross-coupling;93%
morpholine
110-91-8

morpholine

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4-morpholinophenyl)phenylmethanone
24758-49-4

(4-morpholinophenyl)phenylmethanone

Conditions
ConditionsYield
With sodium hydride; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; tert-butyl alcohol; bis(acetylacetonate)nickel(II) In tetrahydrofuran at 65℃;99%
With (IPr)Ni(π-allyl)Cl; sodium t-butanolate In tetrahydrofuran at 25℃; for 24h; Buchwald-Hartwig reaction; Inert atmosphere;98%
With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methoxyphenyl]imidazol-2-ylidene)(allyl)Cl]; sodium t-butanolate In tetrahydrofuran at 60℃; for 2h; Buchwald-Hartwig Coupling; Glovebox;97%
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

N-methylaniline
100-61-8

N-methylaniline

(4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone
20349-66-0

(4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With sodium hydride; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; tert-butyl alcohol; bis(acetylacetonate)nickel(II) In 1,4-dioxane at 100℃;99%
With polymethylhydrosiloxane; sodium t-butanolate; bis(acetylacetonate)nickel(II) In 1,2-dimethoxyethane; toluene at 130℃; for 18h;94%
With 2‐(di‐tert‐butylphosphino)‐N,N‐diisopropyl‐5,6‐dimethyl‐1H‐benzo[d]imidazole‐1‐carboxamide; palladium diacetate; potassium carbonate In toluene at 110℃; for 24h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; Sealed tube;92%
ethylene glycol
107-21-1

ethylene glycol

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

2-(4-chlorophenyl)-2-phenyl-1,3-dioxolane
374589-65-8

2-(4-chlorophenyl)-2-phenyl-1,3-dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 40h; Heating;99%
phenyl trimethylsiloxane
2996-92-1

phenyl trimethylsiloxane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

biphenyl-4-yl-phenyl-methanone
2128-93-0

biphenyl-4-yl-phenyl-methanone

Conditions
ConditionsYield
With 3-(dicyclohexylphosphino)-2-(2-methoxyphenyl)-1-methyl-1-H-indole; tetrabutyl ammonium fluoride; palladium diacetate In toluene at 110℃; for 3h; Hiyama Coupling; Schlenk technique; Inert atmosphere; Sealed tube;99%
With tetrabutyl ammonium fluoride; [Pd(dibenzylideneacetone)2] In 1,4-dioxane at 80℃; for 17h; Hiyama cross-coupling;65%
4-bromo-N,N-dimethylaniline
586-77-6

4-bromo-N,N-dimethylaniline

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)(phenyl)methanone
94869-73-5

(4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)(phenyl)methanone

Conditions
ConditionsYield
Stage #1: 4-bromo-N,N-dimethylaniline With lithium
Stage #2: With zinc(II) chloride
Stage #3: 4-chlorobenzophenone; nickel phosphine amido pincer complex In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 70℃; for 8h; Negishi cross-coupling; Further stages.;		99%
furan
110-00-9

furan

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4-(furan-2-yl)phenyl)(phenyl)methanone

(4-(furan-2-yl)phenyl)(phenyl)methanone

Conditions
ConditionsYield
Stage #1: furan With n-butyllithium In diethyl ether
Stage #2: With zinc(II) chloride
Stage #3: 4-chlorobenzophenone; nickel amido phosphine pincer complex In tetrahydrofuran; diethyl ether at 70℃; for 10h; Negishi cross-coupling; Further stages.;		99%
With potassium phosphate; palladium diacetate; CyJohnPhos In 1-methyl-pyrrolidin-2-one at 15 - 100℃; for 24.25h; Inert atmosphere;80%
bromobenzene
108-86-1

bromobenzene

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

biphenyl-4-yl-phenyl-methanone
2128-93-0

biphenyl-4-yl-phenyl-methanone

Conditions
ConditionsYield
Stage #1: bromobenzene With lithium
Stage #2: With zinc(II) chloride
Stage #3: 4-chlorobenzophenone; nickel phosphine amido pincer complex In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 70℃; for 6h; Negishi cross-coupling; Further stages.;		99%
p-tolylzinc(II) chloride
90252-89-4

p-tolylzinc(II) chloride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

4-benzoyl-4'-methylbiphenyl
63283-56-7

4-benzoyl-4'-methylbiphenyl

Conditions
ConditionsYield
With C26H24ClN2NiP*0.1C7H8 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Negishi Coupling; Schlenk technique; Inert atmosphere;99%
With C38H34Br2N4Ni2P2 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 40℃; for 12h; Reagent/catalyst; Negishi Coupling; Inert atmosphere; Schlenk technique;99%
With C27H22Cl2N3NiP In tetrahydrofuran; 1-methyl-pyrrolidin-2-one for 2h; Schlenk technique; Inert atmosphere; Heating;99%
With Ni(Cl){2-(Ph2P)C6H4NCH(Ph)P(O)Ph2} In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 25℃; for 24h; Negishi coupling reaction; Inert atmosphere;98%
With C21H18N8Ni2O(2+)*2F6P(1-) In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20 - 80℃; Negishi coupling reaction;95%
1.3-propanedithiol
109-80-8

1.3-propanedithiol

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

2-(4-chlorophenyl)-2-phenyl-1,3-dithiane
139021-94-6

2-(4-chlorophenyl)-2-phenyl-1,3-dithiane

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;99%
With silica gel-supported phosphorus pentoxide at 20℃; Neat (no solvent);96%
With ferric hydrogen sulphate In acetonitrile at 20℃; for 0.133333h;91%
With boron trifluoride diethyl etherate; sodium sulfate In chloroform at 0 - 20℃; Inert atmosphere;
ethyl acetoacetate
141-97-9

ethyl acetoacetate

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

malononitrile
109-77-3

malononitrile

6-amino-4-(4-chorophenyl)-2,4-dihydro-3-methyl-4-phenylpyrano[2,3-c]pyrazole-5-carbonitrile
1235990-69-8

6-amino-4-(4-chorophenyl)-2,4-dihydro-3-methyl-4-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Conditions
ConditionsYield
With hydrazine hydrate; heptakis(6-amino-6-deoxy)-β-cyclodextrin at 20℃; for 0.0166667h; Neat (no solvent);99%
...Expand
2,6-dimethylbenzene boronic acid
100379-00-8

2,6-dimethylbenzene boronic acid

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(2',6'-dimethylbiphenyl-4-yl)phenyl-methanone
1067883-66-2

(2',6'-dimethylbiphenyl-4-yl)phenyl-methanone

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate monohydrate; 2-(2-methoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole In 1,4-dioxane at 90℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere;99%
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

potassium o-tolyltrifluoroborate

potassium o-tolyltrifluoroborate

(2'-methylbiphenyl-4-yl)(phenyl)methanone

(2'-methylbiphenyl-4-yl)(phenyl)methanone

Conditions
ConditionsYield
With potassium phosphate monohydrate; 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; bis(dibenzylideneacetone)-palladium(0) In toluene; tert-butyl alcohol at 135℃; for 24h; Suzuki coupling; Inert atmosphere;99%
2-furylzinc chloride
81745-86-0

2-furylzinc chloride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4-(furan-2-yl)phenyl)(phenyl)methanone

(4-(furan-2-yl)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With C27H22Cl2N3NiP In tetrahydrofuran; 1-methyl-pyrrolidin-2-one for 1.5h; Inert atmosphere; Schlenk technique; Heating;99%
With C26H24ClN2NiP*0.1C7H8 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 90℃; for 24h; Negishi Coupling; Schlenk technique; Inert atmosphere;84%
p-toluidine
106-49-0

p-toluidine

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

{4-[(4-methylphenyl)amino]phenyl}(phenyl)methanone
42872-23-1

{4-[(4-methylphenyl)amino]phenyl}(phenyl)methanone

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; [1,1′-bis(diphenylphosphino)ferrocene]bis(triphenylphosphite)nickel(0); sodium t-butanolate In toluene at 100℃; for 18h; Schlenk technique; Inert atmosphere;99%
9H-carbazole
86-74-8

9H-carbazole

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

[4-(9H-carbazol-9-yl)phenyl](phenyl)methanone
204066-02-4

[4-(9H-carbazol-9-yl)phenyl](phenyl)methanone

Conditions
ConditionsYield
Stage #1: 9H-carbazole With methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 5 - 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 4-chlorobenzophenone With PdCl(π-allyl)(cyclohexyl-(1-methyl-2,2-diphenylcyclopropylphophine)) In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 108 - 112℃; for 0.25h; Inert atmosphere;		99%
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

phenyl(phenyl-4-d)methanone

phenyl(phenyl-4-d)methanone

Conditions
ConditionsYield
With C60H48BP3Pd; potassium deuteroformate; [2.2.2]cryptande In tetrahydrofuran at 60℃; for 72h; Schlenk technique; Inert atmosphere;99%
With potassium phosphate; d(4)-methanol; palladium diacetate; catacxium A In toluene at 80℃; for 10.5h;96%
With 5%-palladium/activated carbon; triethylamine; deuterium In tetrahydrofuran at 20℃; for 6h; Time; Sealed tube; regiospecific reaction;
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

4-Methylbenzophenone
134-84-9

4-Methylbenzophenone

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 3-(dicyclohexylphosphino)-2-(2,6-dimethoxyphenyl)-1-methyl-1H-indole In 1,4-dioxane at 100℃; for 6h; Suzuki-Miyaura Coupling; Schlenk technique; Sealed tube; Inert atmosphere;99%
diethoxymethylane
2031-62-1

diethoxymethylane

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

C18H23ClO3Si

C18H23ClO3Si

Conditions
ConditionsYield
With (S,E)-3-methyl-N-phenyl-2-((pyridin-2-ylmethylene)amino)butanamide-UiO-Fe metal-organic framework In tetrahydrofuran at 25℃; for 2h; Inert atmosphere; Glovebox; enantioselective reaction;99%

4-Chlorobenzophenone Specification

4-Chlorobenzophenone, its cas register number is 134-85-0. It also can be called 4-Chlorobenzophenone; AI3-00705;
 Benzophenone, 4-chloro-; HSDB 2740; Methanone, (4-chlorophenyl)phenyl-; NSC 2872; p-CBP; para-Chlorobenzophenone. 4-Chlorobenzophenone is a white to off-white powder. It belongs to the Product Categories of Aromatic Benzophenones & Derivatives (substituted);Functional Materials; Photopolymerization Initiators; C13 to C14; Carbonyl Compounds; Ketones.

Physical properties about 4-Chlorobenzophenone are: (1)ACD/LogP: 4.33; (2)ACD/LogD (pH 5.5): 4.33; (3)ACD/LogD (pH 7.4): 4.33; (4)ACD/BCF (pH 5.5): 1150.74; (5)ACD/BCF (pH 7.4): 1150.74; (6)ACD/KOC (pH 5.5): 5403.14; (7)ACD/KOC (pH 7.4): 5403.14; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.594; (11)Molar Refractivity: 60.941 cm3; (12)Molar Volume: 179.499 cm3; (13)Polarizability: 24.159 10-24cm3; (14)Surface Tension: 44.181999206543 dyne/cm; (15)Density: 1.207 g/cm3; (16)Flash Point: 176.084 °C; (17)Enthalpy of Vaporization: 57.587 kJ/mol; (18)Boiling Point: 333.041 °C at 760 mmHg

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing, gloves and eye/face protection;
3. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
4. Avoid contact with skin and eyes;
5.Do not breathe dust;
6. Wear suitable protective clothing;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C13H9ClO/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9H;
(2)InChIKey=UGVRJVHOJNYEHR-UHFFFAOYSA-N;
(3)Smilesc1(C(c2ccccc2)=O)ccc(Cl)cc1

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