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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Quinidine Manufacturer/High quality/Best price/In stock

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Description A white, crystalline powder A white, crystalline powder solubility

High purity 56-54-2 Quinidine

Cas:56-54-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Kono Chem Co.,Ltd

Introduction An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skelet

CAS:56-54-2 Quinidine low price

Cas:56-54-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High purity raw material 99% Quinidine powder CAS:56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $759.0 / 800.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Quinidine

Cas:56-54-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Quinidine

Cas:56-54-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Quinidine 56-54-2 GMP Manufacturer

Cas:56-54-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(+)-Quinidine

Cas:56-54-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

56-54-2 Quinidine

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - Quinidine

Cas:56-54-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 56-54-2 with best quality

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Quinidine 99.0% Cas 56-54-2 Basic Information: Productname Quinidine CAS NO. 56-54-2 MF C20H25N2O2

GMP Manufacturer Quinidine 99% CAS:56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed conta

top quality Quinidine cas#56-54-2

Cas:56-54-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cinchonan-9-ol,6'-methoxy-, (9S)- 56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Quinidine

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $136.0 / 150.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Quinidine CAS 56-54-2 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

High quality Quinidine CAS 56-54-2

Cas:56-54-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

GMP Manufacturer Quinidine 99% CAS:56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cinchonan-9-ol,6'-methoxy-, (9S)-

Cas:56-54-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Quinidine

Cas:56-54-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

QUINIDINE

Cas:56-54-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Miheng Trading Co., Ltd.

Quinidine CAS 56-54-2 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Profes

Quinidine CAS 56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol

Cas:56-54-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cinchonan-9-ol,6'-methoxy-, (9S)-

Cas:56-54-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Quinidine CAS 56-54-2 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality con

Quinidine CAS 56-54-2

Cas:56-54-2

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Quinidine

Cas:56-54-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Quinidine

Cas:56-54-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Quinidine

Cas:56-54-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Quinidine

Cas:56-54-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Synthetic route

(3R,4S)-4-[(2S,3S)-3-(6-Methoxy-quinolin-4-yl)-oxiranylmethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
865853-19-6

(3R,4S)-4-[(2S,3S)-3-(6-Methoxy-quinolin-4-yl)-oxiranylmethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide; tert-butyl alcohol at 110℃; for 12h;98%
2-(trimethylsilyl)ethyl 6-methoxy-4-((2R,3R)-3-(((3R,4S)-1-((2-(trimethylsilyl)ethoxy)carbonyl)-3-vinylpiperidin-4-yl)methyl)oxiran-2-yl)quinoline-1(2H)-carboxylate
1207974-84-2

2-(trimethylsilyl)ethyl 6-methoxy-4-((2R,3R)-3-(((3R,4S)-1-((2-(trimethylsilyl)ethoxy)carbonyl)-3-vinylpiperidin-4-yl)methyl)oxiran-2-yl)quinoline-1(2H)-carboxylate

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
Stage #1: 2-(trimethylsilyl)ethyl 6-methoxy-4-((2R,3R)-3-(((3R,4S)-1-((2-(trimethylsilyl)ethoxy)carbonyl)-3-vinylpiperidin-4-yl)methyl)oxiran-2-yl)quinoline-1(2H)-carboxylate With cesium fluoride In N,N-dimethyl-formamide at 180℃; for 0.25h; Microwave irradiation;
Stage #2: With oxygen In N,N-dimethyl-formamide at 20℃; for 19h;
78%
Quinine
130-95-0

Quinine

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
With 9-fluorenone; 2-Heptanol; sodium compound of heptan-2-ol
6'-methoxy-cinchonan-9-one

6'-methoxy-cinchonan-9-one

A

quinidine
56-54-2

quinidine

B

Quinine
130-95-0

Quinine

Conditions
ConditionsYield
With sodium isopropylate; toluene
With 2-pentanol; sodium
sodium ethanolate
141-52-6

sodium ethanolate

6'-methoxy-cinchonan-9-one
569329-55-1

6'-methoxy-cinchonan-9-one

aluminium

aluminium

A

quinidine
56-54-2

quinidine

B

Quinine
130-95-0

Quinine

Conditions
ConditionsYield
quininone;
quininone

quininone

A

quinidine
56-54-2

quinidine

B

Quinine
130-95-0

Quinine

Conditions
ConditionsYield
With ethanol; sodium ethanolate; aluminium
isopropyl alcohol
67-63-0

isopropyl alcohol

6'-methoxycinchoninone
14528-53-1

6'-methoxycinchoninone

butan-1-ol
71-36-3

butan-1-ol

sodium alkylates

sodium alkylates

pentan-3-ol; compound 5:2,4-dimethyl-pentan-3-ol; compound 6:cyclohexanol

pentan-3-ol; compound 5:2,4-dimethyl-pentan-3-ol; compound 6:cyclohexanol

B

quinidine
56-54-2

quinidine

C

Quinine
130-95-0

Quinine

pyridine
110-86-1

pyridine

C59H60FeN7O6

C59H60FeN7O6

A

Fe(protoporphyrin-IX)(pyridine)2(1+)
25875-12-1

Fe(protoporphyrin-IX)(pyridine)2(1+)

B

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
In acetonitrile Equilibrium constant;
C54H55FeN6O6

C54H55FeN6O6

ferriprotoporphyrin IX hydroxide
15489-90-4

ferriprotoporphyrin IX hydroxide

B

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
In acetonitrile Equilibrium constant;
C26H36N2O3Si

C26H36N2O3Si

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanesulfonamide; AD-mix-α / water; tert-butyl alcohol / 17 h / 20 °C
2.1: Trimethyl orthoacetate; pyridinium p-toluenesulfonate / dichloromethane / 12 h / 20 °C / Inert atmosphere
2.2: 6 h / 0 - 20 °C / Inert atmosphere
2.3: 0.5 h / 20 °C / Inert atmosphere
3.1: cesium fluoride / N,N-dimethyl-formamide; tert-butyl alcohol / 12 h / 110 °C
View Scheme
(3R,4S)-4-[(2S,3S)-2,3-Dihydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
946491-91-4

(3R,4S)-4-[(2S,3S)-2,3-Dihydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

quinidine
56-54-2

quinidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Trimethyl orthoacetate; pyridinium p-toluenesulfonate / dichloromethane / 12 h / 20 °C / Inert atmosphere
1.2: 6 h / 0 - 20 °C / Inert atmosphere
1.3: 0.5 h / 20 °C / Inert atmosphere
2.1: cesium fluoride / N,N-dimethyl-formamide; tert-butyl alcohol / 12 h / 110 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

quinidine
56-54-2

quinidine

9-O-benzylquinidine
345217-88-1

9-O-benzylquinidine

Conditions
ConditionsYield
Stage #1: quinidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: benzyl chloride In N,N-dimethyl-formamide at 20℃; for 20h; Inert atmosphere;
100%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere;96%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 20h;
4-chlorobenzoylmethyl bromide
536-38-9

4-chlorobenzoylmethyl bromide

quinidine
56-54-2

quinidine

C28H30ClN2O3(1+)*Br(1-)

C28H30ClN2O3(1+)*Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran Inert atmosphere;100%
4-(bromoacetyl)toluene
619-41-0

4-(bromoacetyl)toluene

quinidine
56-54-2

quinidine

C29H33N2O3(1+)*Br(1-)

C29H33N2O3(1+)*Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran Inert atmosphere;99%
2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

quinidine
56-54-2

quinidine

C29H33N2O4(1+)*Br(1-)

C29H33N2O4(1+)*Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran Inert atmosphere;99%
benzyl bromide
100-39-0

benzyl bromide

quinidine
56-54-2

quinidine

(1S,2R,4S,5R)-1-benzyl-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide
131042-95-0

(1S,2R,4S,5R)-1-benzyl-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide

Conditions
ConditionsYield
In acetone at 60℃; for 4h;98%
α-bromoacetophenone
70-11-1

α-bromoacetophenone

quinidine
56-54-2

quinidine

C28H31N2O3(1+)*Br(1-)

C28H31N2O3(1+)*Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran for 72h;98%
In tetrahydrofuran Inert atmosphere;89%
3,5-bis(trifluoromethyl)benzyl bromide
32247-96-4

3,5-bis(trifluoromethyl)benzyl bromide

quinidine
56-54-2

quinidine

N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide
945732-76-3

N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide

Conditions
ConditionsYield
In acetone at 60℃; for 4h;97%
In toluene at 80℃; Inert atmosphere;85%
In toluene at 80℃; for 12h;85%
In toluene at 80℃;
In toluene at 80℃;
2-[3,5-bis(4-tert-butylphenyl)phenyl]-4,6-dichloro-5-phenylpyrimidine

2-[3,5-bis(4-tert-butylphenyl)phenyl]-4,6-dichloro-5-phenylpyrimidine

quinidine
56-54-2

quinidine

C76H80N6O4

C76H80N6O4

Conditions
ConditionsYield
With potassium hydroxide In toluene for 2h; Dean-Stark; Reflux;97%
3,5-di-tert-butylbenzyl bromide
62938-08-3

3,5-di-tert-butylbenzyl bromide

quinidine
56-54-2

quinidine

C35H47N2O2(1+)*Br(1-)

C35H47N2O2(1+)*Br(1-)

Conditions
ConditionsYield
In acetone at 60℃; for 4h;97%
4,6-dichloro-2-(2-methoxyphenyl)-5-phenylpyrimidine

4,6-dichloro-2-(2-methoxyphenyl)-5-phenylpyrimidine

quinidine
56-54-2

quinidine

C57H58N6O5

C57H58N6O5

Conditions
ConditionsYield
With potassium hydroxide In toluene for 2h; Dean-Stark; Reflux;96%
2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

quinidine
56-54-2

quinidine

C28H30N3O2(1+)*Br(1-)

C28H30N3O2(1+)*Br(1-)

Conditions
ConditionsYield
In acetone at 60℃; for 4h;96%
With sodium iodide In tetrahydrofuran at 20℃; Reflux;
quinidine
56-54-2

quinidine

dihydroquinidine
1435-55-8

dihydroquinidine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol under 2280.15 Torr; for 5h;95%
With palladium 10% on activated carbon; hydrogen In methanol under 2280.15 Torr; for 5h;92%
With hydrogenchloride; hydrogen; palladium dichloride
2-methoxybenzyl bromide
52289-93-7

2-methoxybenzyl bromide

quinidine
56-54-2

quinidine

Br(1-)*C28H33N2O3(1+)

Br(1-)*C28H33N2O3(1+)

Conditions
ConditionsYield
In acetone at 60℃; for 4h;95%
With sodium iodide In tetrahydrofuran at 20℃; Reflux;
1-chloro-4-(9-O-dihydroquinidinyl)phthalazine
151955-32-7

1-chloro-4-(9-O-dihydroquinidinyl)phthalazine

quinidine
56-54-2

quinidine

1-(9-O-quinidinyl)-4-(9-O-dihydroquinidinyl)phthalazine
188816-43-5

1-(9-O-quinidinyl)-4-(9-O-dihydroquinidinyl)phthalazine

Conditions
ConditionsYield
With potassium hydroxide; potassium carbonate In toluene for 10h; 32;93%
quinidine
56-54-2

quinidine

4-((S)-hydroxy((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-ol

4-((S)-hydroxy((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-ol

Conditions
ConditionsYield
Stage #1: quinidine With boron tribromide In dichloromethane at -78 - 40℃; Inert atmosphere;
Stage #2: With ammonium hydroxide; water In dichloromethane at 0℃;
93%
With sodium thioethylate In N,N-dimethyl-formamide at 110℃; for 6h; Inert atmosphere;79%
With boron tribromide In dichloromethane at -78℃; Inert atmosphere; Reflux;78%
quinidine
56-54-2

quinidine

methyl iodide
74-88-4

methyl iodide

(1S,4S,5R)-2-((S)-methoxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine
577782-70-8

(1S,4S,5R)-2-((S)-methoxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

Conditions
ConditionsYield
Stage #1: quinidine With potassium hydride In N,N-dimethyl-formamide; mineral oil; pentane at 0℃; for 1h; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil; pentane at 0 - 20℃; for 2h; Inert atmosphere;
93%
Stage #1: quinidine With potassium hydride In tetrahydrofuran at 0 - 50℃; for 1h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
86%
Stage #1: quinidine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃;
56%
Stage #1: quinidine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Schlenk technique; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; Schlenk technique; Inert atmosphere;
41%
Stage #1: quinidine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 50℃; for 2.5h; Inert atmosphere; Schlenk technique;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 24h; Inert atmosphere; Schlenk technique;
32%
4,6-dichloro-2-(3,5-diphenylphenyl)-5-phenylpyrimidine

4,6-dichloro-2-(3,5-diphenylphenyl)-5-phenylpyrimidine

quinidine
56-54-2

quinidine

C68H64N6O4

C68H64N6O4

Conditions
ConditionsYield
With potassium hydroxide In toluene for 2h; Dean-Stark; Reflux;92%
3,5-ditrifluoromethylisocyanate
16588-74-2

3,5-ditrifluoromethylisocyanate

quinidine
56-54-2

quinidine

9-O-(3,5-bis(trifluoromethyl)phenylcarbamate)quinidine

9-O-(3,5-bis(trifluoromethyl)phenylcarbamate)quinidine

Conditions
ConditionsYield
In dichloromethane at 0℃; for 2h; Inert atmosphere;92%
3,5-di-tert-butyl-2-hydroxybenzaldehyde
37942-07-7

3,5-di-tert-butyl-2-hydroxybenzaldehyde

quinidine
56-54-2

quinidine

C35H45N3O2

C35H45N3O2

Conditions
ConditionsYield
With magnesium sulfate In ethanol for 5h; Reflux;90%
quinidine
56-54-2

quinidine

(S)-4-((1S,2R,4S,5Z/E)-5-ethylidene-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-methoxyquinoline
139237-97-1

(S)-4-((1S,2R,4S,5Z/E)-5-ethylidene-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-methoxyquinoline

Conditions
ConditionsYield
Stage #1: quinidine With sulfuric acid In ethanol at 20℃; for 0.166667h;
Stage #2: With rhodium(III) chloride trihydrate In ethanol Reflux;
88%
4-bromomethyltrifluoromethylbenzene
402-49-3

4-bromomethyltrifluoromethylbenzene

quinidine
56-54-2

quinidine

N-(4-trifluoromethylbenzyl)quinidinium bromide

N-(4-trifluoromethylbenzyl)quinidinium bromide

Conditions
ConditionsYield
In toluene at 80℃; Inert atmosphere;87%
In toluene at 80℃; for 12h;87%
In tetrahydrofuran Heating;
allyl bromide
106-95-6

allyl bromide

quinidine
56-54-2

quinidine

C23H28N2O2

C23H28N2O2

Conditions
ConditionsYield
Stage #1: quinidine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 20h; Inert atmosphere;
87%
chloro-diphenylphosphine
1079-66-9

chloro-diphenylphosphine

quinidine
56-54-2

quinidine

A

(9S)-6'-methoxycinchonan-9-yl diphenylphosphinite

(9S)-6'-methoxycinchonan-9-yl diphenylphosphinite

B

Diphenyl-phosphinic acid (S)-(6-methoxy-quinolin-4-yl)-((1S,2R,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester

Diphenyl-phosphinic acid (S)-(6-methoxy-quinolin-4-yl)-((1S,2R,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 1.5h;A 86%
B n/a
2-[(tert-butoxycarbonyl)amino]-1-ethanethiol
67385-09-5

2-[(tert-butoxycarbonyl)amino]-1-ethanethiol

quinidine
56-54-2

quinidine

tert‐butyl N‐[2‐({3‐[(1S,3R,4S,6R)‐6‐[(S)‐hydroxy(6‐methoxyquinolin‐4‐yl)methyl]‐1‐azabicyclo[2.2.2]octan‐3‐yl]propyl}sulfanyl)ethyl]carbamate

tert‐butyl N‐[2‐({3‐[(1S,3R,4S,6R)‐6‐[(S)‐hydroxy(6‐methoxyquinolin‐4‐yl)methyl]‐1‐azabicyclo[2.2.2]octan‐3‐yl]propyl}sulfanyl)ethyl]carbamate

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In chloroform for 0.166667h; Irradiation;86%
In neat (no solvent) at 80℃; for 60h; Sealed tube; Inert atmosphere;25%
carbon monoxide
201230-82-2

carbon monoxide

quinidine
56-54-2

quinidine

10,11-dihydroquinidine-11-carbaldehyde

10,11-dihydroquinidine-11-carbaldehyde

Conditions
ConditionsYield
With [(2,4-di-t-Bu-C6H3-O)2POCH2]4C; hydrogen; acetylacetonatodicarbonylrhodium(l) In toluene at 90℃; under 15001.5 Torr;85%
(bromomethyl)pentafluorobenzene
1765-40-8

(bromomethyl)pentafluorobenzene

quinidine
56-54-2

quinidine

N-(2,3,4,5,6-pentafluorobenzyl)quinidinium bromide
231303-52-9

N-(2,3,4,5,6-pentafluorobenzyl)quinidinium bromide

Conditions
ConditionsYield
In toluene at 80℃; for 12h;83%
quinidine
56-54-2

quinidine

quinidine 1'-oxide

quinidine 1'-oxide

Conditions
ConditionsYield
Stage #1: quinidine With 3-chloro-benzenecarboperoxoic acid In chloroform at 0 - 20℃; for 3h; pH=10; Inert atmosphere;
Stage #2: With sulphurous acid In acetone at 0 - 20℃; pH=8; Inert atmosphere;
83%
With 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 3.5h; Cooling with ice;83%
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 3 h / 0 - 20 °C
2: sodium hydrogensulfite; hydrogenchloride / water; acetone / 12 h / 0 - 20 °C
View Scheme
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

quinidine
56-54-2

quinidine

O-tosylquinidine
112661-57-1

O-tosylquinidine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 9h; Heating;82%
With tributyl-amine; potassium hydroxide In dichloromethane; water at 20℃;76%
With sodium hydroxide; benzene
p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

quinidine
56-54-2

quinidine

C28H29ClN2O3

C28H29ClN2O3

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; acetonitrile at 20℃; for 16h;82%

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