1,1,3,3-Tetramethylurea supplier

Name
1,1,3,3-Tetramethylurea
EINECS 211-173-9
CAS No. 632-22-4
Article Data66
CAS DataBase
Density 0.9879 g/cm³
Solubility miscible with water
Melting Point -1 °C(lit.)
Formula C₅H₁₂N₂O
Boiling Point 175.2 °C at 760 mmHg
Molecular Weight 116.163
Flash Point 53.9 °C
Transport Information
Appearance Clear colorless to pale yellow liquid
Safety 53-45
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Urea,1,1,3,3-tetramethyl- (6CI);Urea, tetramethyl- (8CI,9CI);NSC 91488;TMU;Temur;Tetramethylcarbamide;
PSA 23.55000
LogP 0.22960

Synthetic route

: 32315-10-9
bis(trichloromethyl) carbonate

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In dichloromethane; water at 15 - 20℃; Large scale;	92%

: 201230-82-2
carbon monoxide

: 506-59-2
N,N-dimethylammonium chloride

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With 2C7H9N4Au(1+)Cu(1+)*2I(1-); sodium carbonate In toluene at 60℃; Autoclave;	86%

: 2782-91-4
1,1,3,3-tetramethyl-2-thiourea

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With hydrogenchloride; N-nitrosopiperidine; potassium iodide In dichloromethane; water at 22℃; for 48h;	85%
With manganese(IV) oxide In chloroform Ambient temperature;	79%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 5h; Ambient temperature;	75%

: 138767-93-8
C16H27N3O4Si

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In chloroform-d1 at 90℃; for 20h;	81%

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 109-77-3
malononitrile

A: 31774-36-4
(bis-dimethylamino-methylene)-malononitrile

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 25℃; for 24h;	A 70% B n/a

...Expand

: 18424-76-5
dimethyl malonate sodium salt

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

A: 31774-43-3
malonsaeure-dimethylester

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile at 25℃; for 0.25h;	A 55% B n/a

...Expand

: 555-21-5
4-Nitrophenylacetonitrile

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

A: 22703-65-7
α--4-nitrophenylacetonitrile

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 81℃; for 20h;	A 52% B n/a

...Expand

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 105-56-6
ethyl 2-cyanoacetate

A: 72834-60-7
2-Cyan-3,3-bis-(dimethylamino)-acrylsaeure-ethylester

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dimethylaminomethyl-polystyrene In acetonitrile at 81℃; for 20h;	A 51% B n/a

...Expand

: 63442-64-8
bis(dimethylamino)malononitrile

: 141-52-6
sodium ethanolate

A: 67751-11-5
N,N,N',N'-Tetramethylharnstoff-diethylacetal

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile for 12h;	A 42% B 14 % Spectr.

...Expand

: 78581-29-0
Bis(N,N,N',N'-tetramethylformamidinium)ether-bis(trifluormethansulfonat)

: 5353-66-2
diphenylphosphorylazide

Et3N: Et3N

A: 97513-13-8
<2-<2,2-Bis(dimethylamino)-1-(diphenylphosphoryl)vinyl>-2H-tetrazol-5-yl>diphenylphosphanoxid

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile -20 deg C to r.t. 30 min;	A 42% B 39%

...Expand

: 67-66-3
chloroform

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With 4-methylmorpholine N-oxide; sodium hydroxide In water at 50℃; for 1h;	40%

: 124-38-9
carbon dioxide

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
tetraphosphorus decasulfide; triphenyl antimony oxide In benzene at 120℃; under 36752.9 Torr; for 3h;	33%

: 151-50-8
potassium cyanide

: N,N,N,N-tetramethyldiamino ethoxycarbonium tetrafluoroborate

A: 71023-22-8
2,2-Bis(dimethylamino)-2-ethoxyacetonitril

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With sodium cyanide In acetonitrile for 40h; Ambient temperature;	A 30.2% B n/a

...Expand

: 88470-22-8
N-Methoxy-N-chloro-N',N'-dimethylurea

: 124-40-3
dimethyl amine

A: 51-80-9
bis-(dimethylamino)methane

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
at 0℃; for 1h;	A 26.4% B 9.1%

...Expand

: 88470-22-8
N-Methoxy-N-chloro-N',N'-dimethylurea

A: 17696-89-8
1,2-bis(N,N-dimethylcarbamoyl)hydrazine

B: 68692-39-7
N-methoxy-N′,N′-dimethylurea

C: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With triethylamine In benzene at 7℃;	A 17.4% B 7.2% C 22.7%

...Expand

: 93280-56-9
N-(n-butyl)-N',N'-dimethyl-N-nitrourea

A: 52696-91-0
N-(n-butyl)-N',N'-dimethylurea

B: 7304-97-4
1-butyl N,N-dimethylcarbamate

C: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In tetrachloromethane at 110℃; Mechanism;	A 10% B 7% C 19%
In tetrachloromethane at 110℃;	A 10 % Spectr. B 7 % Spectr. C 19 % Spectr.

...Expand

: 1585-74-6
dimethylchloroamine

: 151-50-8
potassium cyanide

A: 1467-79-4
NCNMe2

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With ethanol

...Expand

: 56387-81-6
1,μ-dithio-dicarbonic acid bis-dimethylamide

A: 463-58-1
carbon oxide sulfide

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
at 25℃;
at 210℃;

: 124-40-3
dimethyl amine

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 71-43-2
benzene

: 632-22-4
tetramethylurea

...Expand

: 75-44-5
phosgene

: 124-40-3
dimethyl amine

: 71-43-2
benzene

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
je nach Bedingungen;

...Expand

: 36284-91-0
N-(1-norbornyl)-N',N'-dimethyl-N-nitrosourea

A: 52696-91-0
N-(n-butyl)-N',N'-dimethylurea

B: 7304-97-4
1-butyl N,N-dimethylcarbamate

C: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In tetrachloromethane at 110℃;	A 10 % Spectr. B 7 % Spectr. C 19 % Spectr.

...Expand

: 1186-70-5
bis(dimethylamino)methoxymethane

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With dibenzoyl peroxide In chlorobenzene at 100℃; for 3h;	25 % Turnov.
With dibenzoyl peroxide In chlorobenzene at 100℃; for 3h; Product distribution; Kinetics;	25 % Turnov.

: 56654-53-6
N-(n-butyl)-N',N'-dimethyl-N-nitrosourea

A: 7304-97-4
1-butyl N,N-dimethylcarbamate

B: n-butyl 2-(dimethylamino)pentanoate

C: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In tetrachloromethane at 60℃;	A 37 % Spectr. B 12 % Spectr. C 26 % Spectr.
at 83℃;	A 45 % Spectr. B 32 % Spectr. C 23 % Spectr.
In tetrachloromethane at 60℃; for 163h; Product distribution; Mechanism; other temperature; without solvent; other reaction time;

...Expand

: 63812-19-1
N,N,N,N-tetramethyldiamino methoxycarbonium methylsulfonate

A: 62-75-9
N-Nitrosodimethylamine

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With sodium nitrite In water at 69.9℃; for 2h;	A 20 % Spectr. B 80 % Spectr.

: 56-23-5
tetrachloromethane

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

: 201230-82-2
carbon monoxide

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With iodine; potassium carbonate; palladium diacetate In acetonitrile at 95℃; under 2052 Torr; for 3h;	40 % Chromat.
With oxygen

: 124-40-3
dimethyl amine

: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
With tetrachloromethane for 48h;

: 2782-91-4
1,1,3,3-tetramethyl-2-thiourea

: 684-16-2
Hexafluoroacetone

A: 791-50-4
2,2,4,4-Tetrakis(trifluoromethyl)-1,3-dithietane

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
In acetonitrile 1) 24h, r.t., 2) 24h, 40 deg C; Yield given. Yields of byproduct given;
In acetonitrile for 24h; Ambient temperature; Yield given. Yields of byproduct given;

...Expand

: (Dimethylamino-m-tolylsulfanyl-methylene)-dimethyl-ammonium; iodide

A: 108-40-7
toluene-3-thiol

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
at 20℃; Rate constant; pH=11;

: (Dimethylamino-p-tolylsulfanyl-methylene)-dimethyl-ammonium; iodide

A: 106-45-6
para-thiocresol

B: 632-22-4
tetramethylurea

Conditions

Conditions	Yield
at 20℃; Rate constant; pH=11;

: 632-22-4
tetramethylurea

: 56043-45-9, 13829-06-6
N,N,N',N'-tetramethylchlorformamidinium chloride

Conditions

Conditions	Yield
With oxalyl dichloride In chloroform at 105℃; for 18h; Inert atmosphere; Schlenk technique;	100%
With oxalyl dichloride In chloroform at 85℃; for 16h; Inert atmosphere;	99.5%
With COCl2	98%

: 632-22-4
tetramethylurea

: N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate

Conditions

Conditions	Yield
Stage #1: tetramethylurea With phosgene In toluene at 20 - 60℃; for 0.416667h; Stage #2: With ammonium hexafluorophosphate In dichloromethane; water at 20℃;	100%
Stage #1: tetramethylurea With oxalyl dichloride In toluene at 20℃; for 18h; Cooling with ice; Stage #2: With potassium hexafluorophosphate In water at 20℃;	76%
With potassium hexafluorophosphate 1) toluene, 0 deg C; Yield given. Multistep reaction;

: 632-22-4
tetramethylurea

: 333-27-7
methyl trifluoromethanesulfonate

: N,N,N',N'-tetramethyl-O-methylisouronium trifluoromethanesulfonate

Conditions

Conditions	Yield
at 20 - 25℃; for 21h;	100%
In pentane at 0 - 20℃; for 0.666667h;	98.1%

: 852616-02-5
methyl ester of bis(pentafluoroethyl)phosphinic acid

: 632-22-4
tetramethylurea

: N,N,N’,N’,O-pentamethylisouroniumbis(pentafluoro-ethyl)phosphinate

Conditions

Conditions	Yield
at 0 - 20℃; for 22.5h;	100%

: 425-75-2
trifluoromethanesulfonic acid ethyl ester

: 632-22-4
tetramethylurea

: O-ethyl-N,N,N',N'-tetramethylisouronium trifluoromethanesulfonate

Conditions

Conditions	Yield
In pentane at 0 - 20℃; for 0.666667h;	99.8%

: (bicyclopentadienyl)Yb*(tetrahydrofuran)2

: 632-22-4
tetramethylurea

: 170168-69-1
bis(cyclopentadienyl)bis(1,1,3,3-tetramethylurea)ytterbium(II)

Conditions

Conditions	Yield
In hexane addn. of tetramethylurea to soln. of complex; suspn. decantation, solid washing (hexane), drying (vac.); elem. anal.;	97%

: 94138-28-0
samarium diiodide bis(tetrahydrofuran)

: 632-22-4
tetramethylurea

: 237735-22-7
[SmI2(tetrahydrofuran)2(tetramethylurea)2]

Conditions

Conditions	Yield
In tetrahydrofuran ligand added to equimolecular amt. of Sm complex in THF at room temp. under Ar; left to stand for 2 h; filtered through a frit, evapd.; elem. anal.; X-ray detn.;	96%

: 75-44-5
phosgene

: 632-22-4
tetramethylurea

: 56043-45-9, 13829-06-6
N,N,N',N'-tetramethylchlorformamidinium chloride

Conditions

Conditions	Yield
In toluene at 0 - 20℃; for 26h;	95%

: 4083-64-1
Tosyl isocyanate

: 632-22-4
tetramethylurea

: 1823-69-4
N-bis(dimethylamino)methylene-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Reflux;	93.6%
In toluene for 48h; Reflux;	93.6%

: benzyldiphenylsulfonium tetrafluoroborate

: 632-22-4
tetramethylurea

: C12H19N2O(1+)*BF4(1-)

Conditions

Conditions	Yield
In acetonitrile for 24h; Ambient temperature;	93%

: 10604-59-8
N-Ethylindole

: 632-22-4
tetramethylurea

: bis(1-ethyl-1H-indol-3-yl)methane

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; ruthenium(III) chloride trihydrate In decane at 110℃; for 0.166667h; Microwave irradiation;	93%

: 632-22-4
tetramethylurea

: 108-46-3
recorcinol

: 87448-51-9
Tetramethyl-urea; compound with benzene-1,3-diol

Conditions

Conditions	Yield
	92%

: 111-86-4
n-Octylamine

: 632-22-4
tetramethylurea

: 89610-36-6
1,1,3,3-tetramethyl-2-(1-octyl)guanidine

Conditions

Conditions	Yield
Stage #1: tetramethylurea With oxalyl dichloride In dichloromethane at 60℃; for 18h; Stage #2: n-Octylamine In acetonitrile at 60℃; for 4h; Stage #3: With potassium carbonate; sodium hydroxide In diethyl ether; water at 0℃;	92%
With oxalyl dichloride 1.) DME, 60 deg C, 12 h, 2.) MeCN, reflux, 24 h; Multistep reaction;

: 632-22-4
tetramethylurea

: Trifluoro-methanesulfonatetriphenyl-trifluoromethanesulfonyloxymethyl-arsonium;

: Oxo(bis(dimethylamino)carbenio)(triphenylarsonio)methan-bis(trifluormethansulfonat)

Conditions

Conditions	Yield
In acetonitrile for 24h; Heating;	92%

: 75-44-5
phosgene

: 10361-92-9
yttrium(III) chloride

: 632-22-4
tetramethylurea

: (N(CH3)2)2CCl(1+)*YCl4(1-) = [(N(CH3)2)2CCl](YCl4)

Conditions

Conditions	Yield
In toluene (N2); stirring (0°C); ppt. washing (CHCl3, Et2O), drying (vac.); elem. anal.;	92%

...Expand

: 2700-22-3
Benzylidenemalononitrile

: 632-22-4
tetramethylurea

: C15H18N4O

Conditions

Conditions	Yield
With [Ir(3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl]phenyl)2(4,4'-bis(trifluoromethyl)bipyridine)]PF6; C16H14N4O In 1,2-dichloro-ethane at 25℃; Irradiation;	92%

: 67-56-1
methanol

: 58431-32-6
tris(pentafluoroethyl)phosphine oxide

: 632-22-4
tetramethylurea

: 2-methyl-1,1,3,3-tetramethylisouronium bis(pentafluoroethyl)phosphinate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 5h; Heating / reflux;	91.9%

...Expand

: 92-44-4
2,3-naphthalenediol

: 632-22-4
tetramethylurea

: 87448-53-1
Naphthalene-2,3-diol; compound with tetramethyl-urea

Conditions

Conditions	Yield
	91%

: bis(acetylacetonato)dioxidomolybdenum(VI)

: 632-22-4
tetramethylurea

: [Mo2O5(acetylacetonate)2(tetramethylurea)2]

Conditions

Conditions	Yield
In ethanol; water a mixture of MoO2(acac)2 and tetramethylurea in 96% ethanol stirred for 45 min at room temp.; concentrated under vacuum; diethyl ether added and the precipitate collected by filtration, washed with diethyl ether three times and dried under vacuum; elem. anal.;	91%

: 40876-94-6
1-ethyl-2-methylindole

: 632-22-4
tetramethylurea

: 36798-54-6
bis(1-ethyl-2-methyl-1H-indol-3-yl)methane

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; ruthenium(III) chloride trihydrate In decane at 110℃; for 0.166667h; Microwave irradiation;	91%

: 51-28-5
2,4-Dinitrophenol

: 632-22-4
tetramethylurea

: 87448-56-4
2,4-Dinitro-phenol; compound with tetramethyl-urea

Conditions

Conditions	Yield
	90%

: 632-22-4
tetramethylurea

: tetramethylbromoamidinium tribromide

Conditions

Conditions	Yield
With Oxalyl bromide In chloroform at 65℃; Ionic liquid; Schlenk technique;	90%

: 87-86-5
Pentachlorophenol

: 632-22-4
tetramethylurea

: 87448-58-6
2,3,4,5,6-Pentachloro-phenol; compound with tetramethyl-urea

Conditions

Conditions	Yield
In diethyl ether; hexane	89%

: [tetrakis(μ-acetate)diaquadiruthenium(II,III)] hexafluorophosphate

: 632-22-4
tetramethylurea

: Ru2(μ-O2CCH3)4[(CH3)4N2CO]2(PF6)

Conditions

Conditions	Yield
In neat (no solvent) mixed, gently heated, stirred for 1 h at room temp.; crystd.(diethyl ether), filtered, dried (vac.), recrystd.(diethyl ether-1,2-dichloroethane), elem. anal.;	89%

: 75-44-5
phosgene

: 632-22-4
tetramethylurea

: copper dichloride

: bis(dimethylamino)chlorocarbenium tetrachlorocuprate

Conditions

Conditions	Yield
In toluene (N2); stirring (0°C); ppt. washing (CHCl3, Et2O), drying (vac.); elem. anal.;	89%

...Expand

: 632-22-4
tetramethylurea

: 2782-91-4
1,1,3,3-tetramethyl-2-thiourea

Conditions

Conditions	Yield
With 2C6H15NClHCl2HOPS In chloroform for 10h; Reflux;	89%

: 16212-06-9
phenyl styryl sulfone

: 632-22-4
tetramethylurea

: 1-cinnamyl-1,3,3-trimethylurea

Conditions

Conditions	Yield
With 4,4'-Dichlorobenzophenone at 30℃; for 35h; Irradiation;	89%

: 75790-42-0
2-<<1-(trifluoromethyl)-1,2,2,2-tetrafluoroethyl>thio>-4-(trifluoromethyl)-4,5,5,5-tetrafluoro-1-pentene-1,3-dione

: 632-22-4
tetramethylurea

: 75782-18-2
Dimethyl-carbamic acid 1-[1-dimethylcarbamoyl-1-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethylsulfanyl)-meth-(E)-ylidene]-2,3,3,3-tetrafluoro-2-trifluoromethyl-propyl ester

Conditions

Conditions	Yield
Ambient temperature;	88%

: 875-79-6
1,2-dimethylindole

: 632-22-4
tetramethylurea

: 102660-41-3
bis(1,2-dimethyl-1H-indol-3-yl)methane

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; ruthenium(III) chloride trihydrate In decane at 110℃; for 0.166667h; Microwave irradiation;	88%

1,1,3,3-Tetramethylurea Consensus Reports

Reported in EPA TSCA Inventory.

1,1,3,3-Tetramethylurea Specification

The 1,1,3,3-Tetramethylurea, also known as N,N,N',N'-Tetramethylurea, is the organic compound with the formula C₅H₁₂N₂O. This chemical belongs to the product category of Miscellaneous. Its EINECS registry number is 211-173-9. With the CAS registry number 632-22-4, its IUPAC name is called 1,1,3,3-Tetramethylurea.

Physical properties of 1,1,3,3-Tetramethylurea: (1)ACD/LogP: 0.19; (2)ACD/LogD (pH 5.5): 0.19; (3)ACD/LogD (pH 7.4): 0.19; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 30.22; (7)ACD/KOC (pH 7.4): 30.22; (8)#H bond acceptors: 3; (9)Index of Refraction: 1.445; (10)Molar Refractivity: 32.68 cm³; (11)Molar Volume: 122.6 cm³; (12)Surface Tension: 30.1 dyne/cm; (13)Density: 0.946 g/cm³; (14)Flash Point: 53.9 °C; (15)Enthalpy of Vaporization: 41.15 kJ/mol; (16)Boiling Point: 175.2 °C at 760 mmHg; (17)Vapour Pressure: 1.16 mmHg at 25°C.

Preparation of 1,1,3,3-Tetramethylurea: this chemical can be prepared by diphenyl carbonate and dimethylamine. The reaction mixture is heated at 200 °C for 4 h and is cooled down. The reactant is stired after addition of NaOH. Then it will be purified by diethyl ether. Hence, decompress fractionation are chosen to separate the product. Finally, you will obtained tetramethylurea.

(C₆H₅)₂CO+(CH3)₂NH → C₆H₅OH+C₆H₅OCON(CH₃)₂C₆H₅OCON(CH₃)₂ → C₆H₅OH+(CH₃)₂NCON(CH₃)₂

Uses of 1,1,3,3-Tetramethylurea: because of its low permittivity, this chemical is appropriate for isomerization and alkylation hydrocyanation of base catalysis. It can also be used as other condensation reaction solvent. In addition, it can be used as acetylene and polyacrylonitrile solvents.

When you are using this chemical, please be cautious about it. This chemical may cause damage to health. It is harmful if swallowed. You must avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)C(=O)N(C)C
(2)InChI: InChI=1S/C5H12N2O/c1-6(2)5(8)7(3)4/h1-4H3
(3)InChIKey: AVQQQNCBBIEMEU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LDLo	intravenous	750mg/kg (750mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 1600, Pg. 333, 1966.
mouse	LD50	intravenous	2230mg/kg (2230mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 160, Pg. 333, 1966.
mouse	LD50	oral	2920mg/kg (2920mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 160, Pg. 333, 1966.
mouse	LDLo	intraperitoneal	2900mg/kg (2900mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935.
rabbit	LD50	skin	3160mg/kg (3160mg/kg)	BEHAVIORAL: TREMOR	National Technical Information Service. Vol. OTS0559251,
rat	LCLo	inhalation	312ppm/4H (312ppm)	BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0559251,
rat	LD50	intravenous	1100mg/kg (1100mg/kg)		Angewandte Chemie, International Edition in English. Vol. 3, Pg. 260, 1964.
rat	LD50	oral	794mg/kg (794mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. OTS0559251,
rat	LD50	unreported	1400mg/kg (1400mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.

Product Name

1,1,3,3-Tetramethylurea

Synthetic route

1,1,3,3-Tetramethylurea Consensus Reports

1,1,3,3-Tetramethylurea Specification

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