1,2,4-Trimethoxybenzene supplier

Name
1,2,4-Trimethoxybenzene
EINECS 205-219-7
CAS No. 135-77-3
Article Data48
CAS DataBase
Density 1.041 g/cm³
Solubility Not miscible in water.
Melting Point 19 - 21oC
Formula C₉H₁₂O₃
Boiling Point 247 °C at 760 mmHg
Molecular Weight 168.192
Flash Point 77.9 °C
Transport Information
Appearance clear light yellow to yellow-brown liquid
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Benzene,1,2,4-trimethoxy-;TMB 124;EPA Pesticide Chemical Code 040515;1,2,4-Trimethoxy Benzene;
PSA 27.69000
LogP 1.71240

Synthetic route

: 613-03-6
1,2,4-triacetoxybenzene

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
Stage #1: 1,2,4-triacetoxybenzene With methanol; potassium hydroxide at 40℃; for 0.133333h; Inert atmosphere; Stage #2: dimethyl sulfate With potassium carbonate at 60℃; for 0.5h; pH=8.5; Reagent/catalyst; Inert atmosphere;	99.4%
With methanol; sodium hydroxide
Alkaline aq. solution;

: 533-73-3
1,2,4-Trihydroxybenzene

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 12h;	99%
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 16h; Inert atmosphere;	96%
With sodium hydroxide

: 21702-84-1
2,4-dibromoanisole

: 124-41-4
sodium methylate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With methanol; Methyl formate; copper(l) chloride at 115℃; for 2h; Autoclave; Green chemistry;	98%

: 2033-89-8
3,4-dimethoxyphenol

: 74-88-4
methyl iodide

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
Stage #1: 3,4-dimethoxyphenol With potassium carbonate In acetone at 40 - 45℃; for 1h; Inert atmosphere; Stage #2: methyl iodide In acetone for 7h; Reflux; Inert atmosphere;	97%
With n-butyllithium In tetrahydrofuran at 0℃;

: 2033-89-8
3,4-dimethoxyphenol

: 616-38-6
carbonic acid dimethyl ester

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With magnesium oxide In N,N-dimethyl-formamide at 170℃; for 0.5h; Microwave irradiation; Green chemistry;	96%

: 18113-18-3
2,5-dimethoxyphenol

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide	95%

: 2033-89-8
3,4-dimethoxyphenol

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With potassium hydroxide for 1.5h; Heating;	90%

: 1-styryl-2,4,5-trimethoxybenzene

A: 612-94-2
2-phenylnaphthalene

B: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With trifluoroacetic acid In water at 80℃; for 0.5h; Diels-Alder Cycloaddition;	A 90% B n/a

: 2,4,5-trimethoxybenzoic acid potassium salt

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With trifluoroacetic acid; palladium(II) trifluoroacetate In dimethyl sulfoxide at 70℃;	55%
Stage #1: 2,4,5-trimethoxybenzoic acid potassium salt With palladium(II) trifluoroacetate In dimethyl sulfoxide at 80℃; for 0.5h; Stage #2: With trifluoroacetic acid In dimethyl sulfoxide at 70℃;	55%

: 576-15-8
N-acetylindole

: 83813-98-3
sodium 2,4,5-trimethoxybenzoate

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 1235306-66-7
2-(2',4',5'-trimethoxyphenyl)-N-acetylindole

C: 1702-67-6
2,2',4,4',5,5'-hexamethoxybiphenyl

Conditions

Conditions	Yield
Stage #1: sodium 2,4,5-trimethoxybenzoate With palladium(II) trifluoroacetate In dimethyl sulfoxide at 80℃; for 0.5h; Inert atmosphere; Stage #2: N-acetylindole With dimethyl sulfoxide; propionic acid In 1,4-dioxane at 80℃; for 15h; Inert atmosphere;	A 51% B 13% C 11%

...Expand

: 2075-46-9
4-nitro-1H-pyrazole

: 15791-03-4
1,1,4,4-tetramethoxycyclohexa-2,5-diene

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 1,4-dimethoxy-2-(4-nitropyrazol-1-yl)benzene

Conditions

Conditions	Yield
at 110℃; for 5h;	A 44% B 44%

...Expand

: 490-64-2
asaronic acid

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With silver(I) acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 16h; Inert atmosphere;	43%
With palladium(II) trifluoroacetate; trifluoroacetic acid In dimethyl sulfoxide; N,N-dimethyl-formamide at 70℃; for 24h;	25%
With extinguished lime; calcium carbonate bei der Destillation;
With Tetrabutylammonium hydrogen diacetate; silver carbonate; tricyclohexylphosphine In 1,2-dimethoxyethane at 120℃; for 24h; Inert atmosphere;	90 %Chromat.

: 14531-55-6
3,5-dimethyl-4-nitro-1H-pyrazole

: 15791-03-4
1,1,4,4-tetramethoxycyclohexa-2,5-diene

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 2-(3,5-dimethyl-4-nitropyrazol-1-yl)-1,4-dimethoxybenzene

Conditions

Conditions	Yield
at 110℃; for 5h;	A 36% B 33%

...Expand

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
at 50℃; Reaktion ueber mehrere Stufen;

: 487-49-0
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide at 50℃; Reaktion ueber mehrere Stufen;

: 824-46-4
methoxyhydroquinone

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

: 610-90-2
2,4,5-trihydroxybenzoic acid

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With potassium hydroxide

: 824-46-4
methoxyhydroquinone

: 74-88-4
methyl iodide

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With potassium hydroxide

: 13330-65-9
2,4-dimethoxyphenol

: 124-41-4
sodium methylate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide

: 2100-42-7
2-chloro-1,4-dimethoxybenzene

: 865-33-8
potassium methanolate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With 18-crown-6 ether; iodine; chromium(0) hexacarbonyl 1.) diglyme, cyclohexane, reflux, 95 h, 2.) benzene, 70 deg C, 3.5 h, 3.) THF, R.T., 30 min; Yield given. Multistep reaction;

: 17078-88-5
1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)ethanol

: 124-41-4
sodium methylate

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 73220-26-5
1-methoxy-2-(methoxymethoxy)benzene

C: 120-14-9
3,4-dimethoxy-benzaldehyde

D: 90-05-1
2-methoxy-phenol

Conditions

Conditions	Yield
With sodium perchlorate In methanol; dichloromethane Product distribution; Mechanism; anodic oxidation (undivided cell, Pt foil anode, W wire cathode, 50 mA, 3 F mol-1), other substrates;

...Expand

: 150-76-5
4-methoxy-phenol

: 77-78-1
dimethyl sulfate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With oxygen; copper; sodium carbonate; copper(I) chloride 1.) CH3CN; Multistep reaction;

(+-)-2.4-dihydroxy-benzoin: (+-)-2.4-dihydroxy-benzoin

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide at 50℃; Reaktion ueber mehrere Stufen;

: 490-64-2
asaronic acid

lime/chalk/: lime/chalk/

A: 124-38-9
carbon dioxide

B: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
bei der Destillation;

...Expand

: 67-56-1
methanol

diazotized 6-amino-2.3-dimethoxy-benzoic acid: diazotized 6-amino-2.3-dimethoxy-benzoic acid

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 1521-38-6
2,3-dimethoxybenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride

...Expand

: 67-56-1
methanol

: 610-90-2
2,4,5-trihydroxybenzoic acid

: 77-78-1
dimethyl sulfate

KOH-solution: KOH-solution

A: 135-77-3
1,2,4-trimethoxy-benzene

B: 490-64-2
asaronic acid

C: 1702-67-6
2,2',4,4',5,5'-hexamethoxybiphenyl

D: 5722-93-0
2-hydroxy-4,5-dimethoxybenzoic acid

...Expand

: 135-77-3
1,2,4-trimethoxybenzene radical cation

: 88847-89-6
7,8-dihydro-8-oxo-2'-deoxyguanosine

A: 2-Amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one

B: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
In water at 20 - 25℃; pH=3.0; Kinetics; Equilibrium constant; Oxidation;

...Expand

: 106-51-4
p-benzoquinone

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: Alkaline aq. solution View Scheme

: 83813-98-3
sodium 2,4,5-trimethoxybenzoate

: 135-77-3
1,2,4-trimethoxy-benzene

Conditions

Conditions	Yield
With palladium diacetate; Tetrabutylammonium hydrogen diacetate; tricyclohexylphosphine In 1,2-dimethoxyethane at 120℃; for 24h; Inert atmosphere;	8 %Chromat.

: 91-01-0
1,1-Diphenylmethanol

: 135-77-3
1,2,4-trimethoxy-benzene

: diphenyl(2,4,5-trimethoxyphenyl)methane

Conditions

Conditions	Yield
With o-benzenedisulfonimide In neat (no solvent) at 20℃; for 1.5h; Friedel-Crafts Alkylation;	100%
With 2C2H6O2*ZnCl2 at 90℃; for 1h; Temperature; Reagent/catalyst; Friedel-Crafts Alkylation;	85%
With hydrogenchloride; ethanol

: 135-77-3
1,2,4-trimethoxy-benzene

: 14227-14-6
1,2,4-trimethoxy-5-nitrobenzene

Conditions

Conditions	Yield
With Nitrogen dioxide In dichloromethane in the dark; -78 deg C, 2 min; RT, 15 min;	100%
With tert.-butylnitrite In acetonitrile at 20℃; for 1h;	95%
With 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imide at 20℃; for 2h; Ionic liquid;	93%

: 135-77-3
1,2,4-trimethoxy-benzene

: 23149-33-9
1-iodo-2,4,5-trimethoxybenzene

Conditions

Conditions	Yield
With iodine; silver trifluoroacetate In dichloromethane at 0℃; for 8h;	100%
With N-iodo-succinimide; trifluoroacetic acid In acetonitrile at 20℃; for 0.1h;	99%
With N-iodo-succinimide In acetonitrile at 20℃; for 16h; Inert atmosphere; Schlenk technique;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 20129-11-7
1-bromo-2,4,5-trimethoxybenzene

Conditions

Conditions	Yield
With poly(4-vinylpyridine)-supported bromate; potassium bromide In acetonitrile for 5h;	100%
With bromine In dichloromethane at 0℃;	100%
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 2.5h; Heating;	100%

: 135-77-3
1,2,4-trimethoxy-benzene

: 555-16-8
4-nitrobenzaldehdye

: 54921-89-0
1,1'-[(4-nitrophenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With o-benzenedisulfonimide at 130℃; for 0.25h; Friedel Crafts alkylation;	100%
With air; iodine In toluene at 20℃; for 72h; Friedel Crafts alkylation;	99%
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	98%

: 135-77-3
1,2,4-trimethoxy-benzene

: 74-88-4
methyl iodide

: 25576-97-0
2,3,6-trimethoxytoluene

Conditions

Conditions	Yield
Stage #1: 1,2,4-trimethoxy-benzene With n-butyllithium Stage #2: methyl iodide	100%
Stage #1: 1,2,4-trimethoxy-benzene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; hexane for 1h; Inert atmosphere;	99%
Stage #1: 1,2,4-trimethoxy-benzene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1.33333h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 728-87-0
4,4'-Dimethoxybenzhydrol

: 1562305-57-0
bis(4-methoxyphenyl)(2,4,5-trimethoxyphenyl)methane

Conditions

Conditions	Yield
With o-benzenedisulfonimide In neat (no solvent) at 20℃; for 0.25h; Friedel-Crafts Alkylation;	100%

: 135-77-3
1,2,4-trimethoxy-benzene

: C9H10(2)H2O3

Conditions

Conditions	Yield
With perchloric acid; d(4)-methanol at 75℃; for 15h; Inert atmosphere;	100%

: 50-00-0
formaldehyd

: 135-77-3
1,2,4-trimethoxy-benzene

: 30038-32-5
bis(2,4,5-trimethoxyphenyl)methane

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In acetonitrile at 0 - 20℃; for 1h; Friedel-Crafts Alkylation;	99%
With 1-methyl-3-(propyl-3-sulfonyl)imidazolium trifluoromethanesulfonate In neat (no solvent) at 40℃; for 0.5h; Friedel-Crafts Alkylation; Green chemistry;	99%
With sulfuric acid; acetic acid

: 135-77-3
1,2,4-trimethoxy-benzene

: 100-52-7
benzaldehyde

: 54921-86-7
1,1'-(phenylmethanediyl)bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With 1-methyl-3-(propyl-3-sulfonyl)imidazolium trifluoromethanesulfonate In neat (no solvent) at 40℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Temperature; Friedel-Crafts Alkylation; Green chemistry;	99%
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.0833333h; Friedel-Crafts Alkylation;	95%
With o-benzenedisulfonimide at 130℃; for 3.5h; Friedel Crafts alkylation; neat (no solvent);	93%

: 135-77-3
1,2,4-trimethoxy-benzene

: 194720-38-2
2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

A: 1,2,4-trimethoxy-5-phenylsulfanylbenzene

B: 4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 0.166667h; Yields of byproduct given;	A 99% B n/a

...Expand

: 135-77-3
1,2,4-trimethoxy-benzene

: 194720-38-2
2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

: 1,2,4-trimethoxy-5-phenylsulfanylbenzene

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 20℃; for 0.166667h;	99%

: 34713-70-7
2-Phenylpropanal

: 135-77-3
1,2,4-trimethoxy-benzene

: 1195735-85-3
C27H32O6

Conditions

Conditions	Yield
With air; iodine In toluene at 20℃; for 130h; Friedel Crafts alkylation;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 104-88-1
4-chlorobenzaldehyde

: 1190880-27-3
1,1'-[(4-chlorophenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	99%
With 1-methyl-3-(propyl-3-sulfonyl)imidazolium trifluoromethanesulfonate In neat (no solvent) at 40℃; for 0.5h; Friedel-Crafts Alkylation; Green chemistry;	91%
With silica supported o-benzenedisulfonimide at 20℃; for 1.25h; Friedel Crafts alkylation; neat (no solvent);	90%
With air; iodine In toluene at 20℃; for 72h; Friedel Crafts alkylation;	88%

: 135-77-3
1,2,4-trimethoxy-benzene

: 2043-61-0
cyclohexanecarbaldehyde

: 1195735-86-4
5,5'-(cyclohexylmethylene)bis(1,2,4-trimethoxybenzene)

Conditions

Conditions	Yield
With air; iodine In toluene at 20℃; for 72h; Friedel Crafts alkylation;	99%
With trifluorormethanesulfonic acid In acetonitrile at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	83%

: 22809-37-6
6-bromohexanoyl chloride

: 135-77-3
1,2,4-trimethoxy-benzene

: 1268333-97-6
6-bromo-1-(2,4,5-trimethoxyphenyl)hexan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 20℃; Friedel Crafts Acylation;	99%

: 500-22-1
3-pyridinecarboxaldehyde

: 135-77-3
1,2,4-trimethoxy-benzene

: 1431862-12-2
3-[bis(2,4,5-trimethoxyphenyl)methyl]pyridine

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In acetonitrile at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	99%

: 24165-60-4
1-(4-methoxyphenyl)but-3-en-1-ol

: 135-77-3
1,2,4-trimethoxy-benzene

: 1431862-22-4
1,2,4-trimethoxy-5-[1-(4-methoxyphenyl)but-3-en-1-yl]benzene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In acetonitrile at 0 - 20℃; for 0.75h;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 122-52-1
triethyl phosphite

: diethyl (2,4,5-trimethoxyphenyl)phosphonate

Conditions

Conditions	Yield
With ammonium peroxydisulfate; tris(2,2′-bipyrazine-N1,N1′)ruthenium(II) hexafluorophosphate In acetonitrile at 25℃; for 20h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Irradiation;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 149-73-5
trimethyl orthoformate

: 14470-07-6
tris(2,4,5-trimethoxyphenyl)methane

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In neat liquid at 20℃; for 3h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Friedel-Crafts Alkylation;	99%

: 135-77-3
1,2,4-trimethoxy-benzene

: 1702-67-6
2,2',4,4',5,5'-hexamethoxybiphenyl

Conditions

Conditions	Yield
With molybdenum(V) chloride In dichloromethane at 20℃; for 0.5h;	98%
With boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at -40℃; for 1.5h;	92%
With iron(III) chloride on silica In dichloromethane Product distribution; Mechanism; variation of conditions, other dimethoxyaryls;	89%

: 135-77-3
1,2,4-trimethoxy-benzene

: 99-61-6
3-nitro-benzaldehyde

: 54921-75-4
1,1′-[(3-nitrophenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	98%
With PEG-400 at 50 - 60℃; for 2h; Friedel-Crafts Alkylation; Green chemistry;	95%
With hydrogenchloride; acetic acid

: 135-77-3
1,2,4-trimethoxy-benzene

: 459-57-4
4-fluorobenzaldehyde

: 1195735-76-2
1,1'-[(4-fluorophenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	98%
With air; iodine In toluene at 20℃; for 72h; Friedel Crafts alkylation;	97%
With 1-methyl-3-(propyl-3-sulfonyl)imidazolium trifluoromethanesulfonate In neat (no solvent) at 40℃; for 1h; Friedel-Crafts Alkylation; Green chemistry;	92%

: 135-77-3
1,2,4-trimethoxy-benzene

: 1122-91-4
4-bromo-benzaldehyde

: 1195735-78-4
1,1'-[(4-bromophenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With air; iodine In toluene at 20℃; for 72h; Friedel Crafts alkylation;	98%
With trifluorormethanesulfonic acid In acetonitrile at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	96%
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	96%

: 1535-67-7
difluoromethyl phenyl sulfide

: 135-77-3
1,2,4-trimethoxy-benzene

: 4460-86-0
asaraldehyde

Conditions

Conditions	Yield
Stage #1: difluoromethyl phenyl sulfide; 1,2,4-trimethoxy-benzene With tin(IV) chloride In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dichloromethane; water; dimethyl sulfoxide at 20℃; for 2h;	98%

: 135-77-3
1,2,4-trimethoxy-benzene

: 870-63-3
prenyl bromide

: 1,2,4-trimethoxy-3-(3-methylbut-2-en-1-yl)benzene

Conditions

Conditions	Yield
Stage #1: 1,2,4-trimethoxy-benzene With n-butyllithium In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: prenyl bromide In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;	98%

: 135-77-3
1,2,4-trimethoxy-benzene

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 54921-97-0
1,1'-[(3,4,5-trimethoxyphenyl)methanediyl]bis(2,4,5-trimethoxybenzene)

Conditions

Conditions	Yield
With niobium pentachloride In dichloromethane at 0 - 20℃; for 24h; Friedel-Crafts Alkylation;	98%

1,2,4-Trimethoxybenzene Chemical Properties

The molecular structure of 1,2,4-Trimethoxybenzene (CAS NO.135-77-3):

IUPAC Name: 1,2,4-Trimethoxybenzene
Molecular Weight: 168.18978 g/mol
Molecular Formula: C₉H₁₂O₃
Density: 1.041 g/cm³
Boiling Point: 247 °C at 760 mmHg
Flash Point: 77.9 °C
Index of Refraction: 1.485
Molar Refractivity: 46.28 cm³
Molar Volume: 161.4 cm³
Surface Tension: 29.8 dyne/cm
Enthalpy of Vaporization: 46.45 kJ/mol
Vapour Pressure: 0.0413 mmHg at 25 °C
XLogP3: 2.1
H-Bond Acceptor: 3
Rotatable Bond Count: 3
Exact Mass: 168.078644
MonoIsotopic Mass: 168.078644
Topological Polar Surface Area: 27.7
Heavy Atom Count: 12
Canonical SMILES: COC1=CC(=C(C=C1)OC)OC
InChI: InChI=1S/C9H12O3/c1-10-7-4-5-8(11-2)9(6-7)12-3/h4-6H,1-3H3
InChIKey: AGIQIOSHSMJYJP-UHFFFAOYSA-N
EINECS: 205-219-7
Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives; Benzene derivates; Anisoles, Alkyloxy Compounds & Phenylacetates

1,2,4-Trimethoxybenzene Uses

1,2,4-Trimethoxybenzene (CAS NO.135-77-3) is used as pharmaceutical intermediates.

1,2,4-Trimethoxybenzene Safety Profile

Hazard Codes: Xi
Safety Statements: 23-24/25
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: DC2770000
Hazard Note: Irritant
HS Code: 29093090

1,2,4-Trimethoxybenzene Specification

1,2,4-Trimethoxybenzene (CAS NO.135-77-3) is also named as AI3-20797 ; EPA Pesticide Chemical Code 040515 ; Benzene, 1,2,4-trimethoxy- ; 1,2,4-Trimethoxy Benzene . 1,2,4-Trimethoxybenzene (CAS NO.135-77-3) is clear light yellow to yellow-brown liquid.

Product Name

1,2,4-Trimethoxybenzene

Synthetic route

1,2,4-Trimethoxybenzene Chemical Properties

1,2,4-Trimethoxybenzene Uses

1,2,4-Trimethoxybenzene Safety Profile

1,2,4-Trimethoxybenzene Specification

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