Conditions | Yield |
---|---|
With cerium(IV) oxide; iron(III) chloride; sulfur dioxide; antimony(III) chloride at 140℃; under 45004.5 Torr; for 2h; Pressure; Temperature; Inert atmosphere; Autoclave; | 97.8% |
With aminosulfonic acid; acetic anhydride at -10 - 20℃; for 24h; Autoclave; | 73.22% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N,N,N,N,-tetramethylethylenediamine In acetonitrile at 60℃; for 36h; Reagent/catalyst; Solvent; Temperature; | 96.5% |
Stage #1: ethylene glycol With fluorosulfonyl fluoride; sodium sulfate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In tert-butyl methyl ether at 5 - 10℃; for 1h; Autoclave; Stage #2: With 15-crown-5; 18-crown-6 ether In dichloromethane Solvent; Reagent/catalyst; Temperature; | 81.8% |
With potassium hydroxide; sulfuryl dichloride; silica gel 1.) reflux; 2.) rt., 3 h; Yield given. Multistep reaction; | |
Stage #1: ethylene glycol With potassium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140℃; for 20h; Stage #2: With fluorosulfonyl fluoride In acetonitrile at -15 - -5℃; for 1h; Temperature; Reagent/catalyst; Solvent; Sealed tube; Inert atmosphere; | 106.3 g |
With sulfuryl dichloride In chloroform at 5 - 60℃; for 3h; | 375 g |
Conditions | Yield |
---|---|
With manganese(IV) oxide In water at 5℃; for 0.75h; Reagent/catalyst; Temperature; | 95.84% |
With sodium hydrogencarbonate; iron(II) sulfate In dichloromethane pH=7 - 8; Concentration; | 90.66% |
With ruthenium trichloride; calcium hypochlorite at 15℃; | 83% |
Conditions | Yield |
---|---|
With PhI(1+)OSO2O(1-) In dichloromethane at 15℃; for 0.3h; | 85% |
With μ-oxodiphenyldiiodine(III) sulfate; phenyliodine(III) sulfate Yield given; |
Conditions | Yield |
---|---|
With carbon dioxide; sulfur trioxide at 25 - 65℃; for 8h; Inert atmosphere; | 76% |
Conditions | Yield |
---|---|
Stage #1: thionyl chloride; ethylene glycol at 25 - 30℃; for 3h; Inert atmosphere; Stage #2: With sodium hypochlorite; ruthenium(III) chloride trihydrate at 0 - 10℃; for 3h; pH=7-8; Concentration; Temperature; | 74% |
ethyleneglycol sulfate
Conditions | Yield |
---|---|
With sodium periodate; ruthenium(III) chloride trihydrate In water; acetonitrile for 0.25h; Cooling with ice; Inert atmosphere; | 70% |
Conditions | Yield |
---|---|
With silver sulfate; xylene | |
With silver sulfate In xylene |
Conditions | Yield |
---|---|
With sodium hypochlorite In dichloromethane; isopropyl alcohol |
potassium ethyleneglycolate
ethyleneglycol sulfate
Conditions | Yield |
---|---|
Stage #1: potassium ethyleneglycolate With sulfuryl dichloride In dichloromethane at -10 - 10℃; for 2h; Inert atmosphere; Stage #2: With 18-crown-6 ether In toluene at 20℃; for 1h; Reagent/catalyst; Solvent; | 37.9 g |
Conditions | Yield |
---|---|
With fuming sulphuric acid; iodine at 90℃; under 22502.3 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; |
ethyleneglycol sulfate
tert-butyl cinnamate
(-)-tert-butyl (2S,3R)-1-benzyl-2-phenylpyrrolidine-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: C12H20NSi(1-)*Li(1+) With (1S,2S)-1,2-dimethoxy-1,2-diphenylethane In toluene at -78℃; for 0.583333h; Stage #2: tert-butyl cinnamate In toluene at -78℃; for 1.63h; Stage #3: ethyleneglycol sulfate enantioselective reaction; Further stages; | 97% |
Conditions | Yield |
---|---|
With nitrobenzene In acetonitrile at 50℃; for 24h; Schlenk technique; Inert atmosphere; | 95.6% |
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; lithium hexamethyldisilazane In tetrahydrofuran; water at 20℃; for 2h; | 94% |
Stage #1: ethyleneglycol sulfate; difluoromethyl phenyl sulfone With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; for 3.5h; Inert atmosphere; Stage #2: With sulfuric acid In tetrahydrofuran at 60℃; | 90% |
6-methylbenzo[b]thiophene
ethyleneglycol sulfate
2-(6-methyl-benzo[b]thiophen-2-yl)-ethanol
Conditions | Yield |
---|---|
Stage #1: 6-methylbenzo[b]thiophene With n-butyllithium In tetrahydrofuran; hexanes at -60℃; for 0.75h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexanes at -60 - 20℃; Stage #3: With acetyl chloride In methanol at 0 - 20℃; for 4.25h; | 89% |
1-methyl-1H-imidazole
ethyleneglycol sulfate
lithium diphenylphosphide
Conditions | Yield |
---|---|
Stage #1: 1-methyl-1H-imidazole With n-butyllithium In tetrahydrofuran; hexane at -78 - 60℃; Inert atmosphere; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexane at -78 - 0℃; Inert atmosphere; Stage #3: lithium diphenylphosphide In tetrahydrofuran; hexane at 0℃; Inert atmosphere; Reflux; | 89% |
ethyleneglycol sulfate
2-fluoro-3-iodopyridine
2-(2-fluoro-4-iodopyridin-3-yl)ethane-1-ol
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-3-iodopyridine With lithium diisopropyl amide In tetrahydrofuran; n-heptane at -78℃; for 1.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; n-heptane at -78 - 20℃; for 2.33333h; Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; water at 0 - 20℃; for 3h; | 87% |
Stage #1: 2-fluoro-3-iodopyridine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 1.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; n-heptane; ethylbenzene at -78 - 30℃; for 2.67h; Stage #3: With hydrogenchloride; water In tetrahydrofuran; n-heptane; ethylbenzene at 0 - 30℃; for 3h; | 87% |
ethyleneglycol sulfate
2-fluoro-4-iodopyridine
2-(2-fluoro-4-iodopyridin-3-yl)ethane-1-ol
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-4-iodopyridine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 1.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; n-heptane; ethylbenzene at -78 - 20℃; for 2.66667h; Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; ethylbenzene; water at 0 - 20℃; for 3h; | 87% |
Stage #1: 2-fluoro-4-iodopyridine With lithium diisopropyl amide In tetrahydrofuran at -65℃; for 1.5h; Inert atmosphere; Stage #2: ethyleneglycol sulfate In tetrahydrofuran at -65 - 20℃; Inert atmosphere; | 86.2% |
Stage #1: 2-fluoro-4-iodopyridine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 1.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; n-heptane; ethylbenzene at -78 - 20℃; for 2.67h; | 1950 mg |
ethyleneglycol sulfate
2,2-bis((decyloxy)methyl)propane-1,3-diol
Conditions | Yield |
---|---|
Stage #1: 2,2-bis((decyloxy)methyl)propane-1,3-diol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Cooling with ice; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; mineral oil at 20℃; for 26h; | 86% |
Stage #1: 2,2-bis((decyloxy)methyl)propane-1,3-diol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Cooling with ice; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; mineral oil for 24.33h; |
ethyleneglycol sulfate
1-bromo-4-(2-bromo-1,1,2,2-tetrafluoroethoxy)benzene
Conditions | Yield |
---|---|
Stage #1: 1-bromo-4-(2-bromo-1,1,2,2-tetrafluoroethoxy)benzene With TurboGrignard In tetrahydrofuran at -78℃; Inert atmosphere; Schlenk technique; Stage #2: ethyleneglycol sulfate In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere; Schlenk technique; Stage #3: With sulfuric acid In water Inert atmosphere; Schlenk technique; Reflux; | 86% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 30℃; for 2h; | 85% |
ethyleneglycol sulfate
1-methyl-2-((trimethylsilyl)methyl)-1H-imidazole
lithium diphenylphosphide
Conditions | Yield |
---|---|
Stage #1: ethyleneglycol sulfate; 1-methyl-2-[(trimethylsilyl)methyl]-1H-imidazole In tetrahydrofuran at -78 - 100℃; for 6h; Stage #2: lithium diphenylphosphide at -78℃; Reflux; | 85% |
ethyleneglycol sulfate
(3S)-4-(4,6-dichloropyrimidin-2-yl)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: (3S)-4-(4,6-dichloropyrimidin-2-yl)-3-methylmorpholine With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran for 0.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 40℃; for 22h; | 85% |
ethyleneglycol sulfate
Conditions | Yield |
---|---|
Stage #1: benzyl N-[2-[2-(cyanomethyl)phenoxy]ethyl]-N-methylcarbamate With sodium hydroxide In dimethyl sulfoxide at 20 - 25℃; for 0.166667h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; dimethyl sulfoxide at 20 - 25℃; for 16h; | 84.6% |
4,6-dichloro-2-(morpholine-4-yl)pyrimidine
ethyleneglycol sulfate
Conditions | Yield |
---|---|
Stage #1: 4,6-dichloro-2-(morpholine-4-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 0.5h; Inert atmosphere; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexane at -65℃; for 1.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 18h; | 84% |
Stage #1: 4,6-dichloro-2-(morpholine-4-yl)pyrimidine With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran for 0.666667h; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 20 - 40℃; for 22h; | 42% |
ethyleneglycol sulfate
Conditions | Yield |
---|---|
Stage #1: 2,2-bis((dodecyloxy)methyl)propane-1,3-diol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Cooling with ice; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; mineral oil at 20℃; | 83.3% |
Stage #1: 2,2-bis((dodecyloxy)methyl)propane-1,3-diol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Cooling with ice; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; mineral oil at 20℃; for 21h; | 83% |
ethyleneglycol sulfate
tert-butyl cinnamate
Lithium N-benzyl-N-(trimethylsilyl)amide
(-)-tert-butyl (2S,3R)-1-benzyl-2-phenylazetidine-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: Lithium N-benzyl-N-(trimethylsilyl)amide With (1S,2S)-1,2-dimethoxy-1,2-diphenylethane In toluene at -78℃; for 0.583333h; Stage #2: tert-butyl cinnamate In toluene at -78℃; for 1.63h; Stage #3: ethyleneglycol sulfate enantioselective reaction; Further stages; | 82% |
ethyleneglycol sulfate
Conditions | Yield |
---|---|
In acetonitrile for 8h; Inert atmosphere; Schlenk technique; Reflux; | 81% |
ethyleneglycol sulfate
N,N-dibenzylamino-acetonitrile
1-<(dibenzyl)amino>cyclopropanecarbonitrile
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -70℃; | 80% |
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -70℃; for 1.5h; Product distribution; further dielectophiles; access to cyclopropane aminonitriles; | |
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -70℃; for 1.5h; Yield given; |
ethyleneglycol sulfate
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In isopropyl alcohol at 45℃; for 0.166667h; | 80% |
ethyleneglycol sulfate
tetrabutyl-ammonium chloride
tetra-n-butylammonium bis(2-phenylpyridinato-N,C2)-mono(4-[sulfatoethyloxymethyl]-2-pyridinecarboxylato-N,O)iridium(III)
Conditions | Yield |
---|---|
With NaH In N,N-dimethyl-formamide (N2, in the absence of light); a soln. of Ir complex stirred at 0°C for 30 min, NaH added, stirred at room temp. for 16 h, (CH2O)2SO2 added, stirred for 12 h; concd., pptd. in Et2O, dissolved in CH2Cl2, added to an aq. soln. of N(C4H9)4Cl, stirred for 16 h, the org. layer sepd., washed (H2O), dried (MgSO4), concd., pptd. in Et2O; elem. anal.; | 80% |
ethyleneglycol sulfate
Conditions | Yield |
---|---|
Stage #1: methyl 2-(pyrimidin-5-yl)acetate With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 1h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran at -70 - -20℃; for 1.5h; Stage #3: With lithium hexamethyldisilazane In tetrahydrofuran at -72 - 20℃; for 15h; | 80% |
Conditions | Yield |
---|---|
Stage #1: thiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With sulfuric acid In tetrahydrofuran; hexane for 3h; Heating; Further stages.; | 79% |
ethyleneglycol sulfate
Benzo[b]thiophene
2-(β-Hydroxyethyl)-benzothiophene
Conditions | Yield |
---|---|
Stage #1: Benzo[b]thiophene In tetrahydrofuran; hexanes at -50 - -40℃; for 0.75h; Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexanes at -40 - 20℃; Stage #3: With acetyl chloride In methanol at 20℃; for 4.25h; | 79% |
Conditions | Yield |
---|---|
Stage #1: cyclopentylacetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: ethyleneglycol sulfate In tetrahydrofuran at -78 - 20℃; for 5h; Stage #3: With sulfuric acid In toluene Reflux; | 79% |
ethyleneglycol sulfate
di-isopropylphosphine
diphenylphosphane
(CH(CH3)2)2PCH2CH2P(C6H5)2
Conditions | Yield |
---|---|
Multistep reaction; | 76% |
IUPAC Name: 1,3,2-Dioxathiolane 2,2-dioxide
The MF of 1,3,2-Dioxathiolane 2,2-dioxide (CAS NO.1072-53-3) is C2H4O4S.
The MW of 1,3,2-Dioxathiolane 2,2-dioxide (CAS NO.1072-53-3) is 124.12.
Synonyms of 1,3,2-Dioxathiolane 2,2-dioxide (CAS NO.1072-53-3): Ethylene glycol, cyclic sulphate ; 1,3,2-Dioxathiolane 2,2-dioxide ; Sulfuric acid, cyclic ethylene ester
Product Categories: Biphenyl & Diphenyl ether;Heterocyclic Compounds;Heterocyclic Building Blocks;Others;S-Containing
Index of Refraction: 1.469
Density: 1.604 g/ml
Flash Point: 93.5 °C
Boiling Point: 231.1 °C
Melting Point: 95-97 °C
Storage temp: 2-8 °C
Raw materials: Xylene-->1,2-Dibromoethane-->Silver sulfate
1. | mmo-sat 1 µmol/plate | CBINA8 Chemico-Biological Interactions. 19 (1977),241. | ||
2. | hma-mus/sat 5 mmol/kg | CBINA8 Chemico-Biological Interactions. 19 (1977),241. |
EPA Genetic Toxicology Program.
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