1,3-Indanedione supplier | CasNO.606-23-5

Name
1,3-Indanedione
EINECS 210-109-7
CAS No. 606-23-5
Article Data80
CAS DataBase
Density 1.31 g/cm³
Solubility Soluble in ethanol, ether, benzene, slightly soluble in water.
Melting Point 129-132 °C
Formula C₉H₆O₂
Boiling Point 302.5 °C at 760 mmHg
Molecular Weight 146.145
Flash Point 113 °C
Transport Information
Appearance Yellow to green fine crystalline powder
Safety 24/25-36/37/39-27-26
Risk Codes 33-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3-Diketohydrindene;1,3-Indandione;3-hydroxyinden-1-one;1H-indene-1,3(2H)-dione;1H-Indene-1, 3 (2H)-dione;indan-1,3-dione;indene-1,3-dione;1,3-Indanedione 97%;
PSA 34.14000
LogP 1.45570

Synthetic route

: (-)-trans-(1R,3R)-1,3-Dihydroxyindane

A: 606-23-5
1H-indene-1,3(2H)-dione

B: (R)-3-hydroxy-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With Shvo's Catalyst In acetone at 35℃; for 20h; Air;	A n/a B 95%

: 26976-59-0
3-hydroxy-2,3-dihydro-1H-inden-1-one

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With Jones reagent In acetone at 20℃; for 2h;	95%

: 60414-82-6
2,3-dihydro-1H-indene-1,3-diol

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In 1,4-dioxane at 20℃; for 0.333333h;	92%

: 98-88-4
benzoyl chloride

: 1663-67-8
malonoyl dichloride

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With aluminium trichloride In nitrobenzene at 80℃; for 5h; Mechanism; other aromatic acyl chlorides;	90%
With aluminium trichloride In nitrobenzene at 80℃; for 5h;	90%

: 117560-06-2
3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
In acetonitrile for 1h; Heating;	90%

: 131-11-3
phthalic acid dimethyl ester

: 141-78-6
ethyl acetate

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
Stage #1: phthalic acid dimethyl ester; ethyl acetate With sodium methylate at 12 - 80℃; Large scale; Stage #2: With hydrogenchloride In water at 45 - 55℃; for 5h; Large scale;	83.2%

: 6351-10-6
1-Indanol

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 83-33-0
inden-1-one

Conditions

Conditions	Yield
With manganese(III) Schiff-base; dihydrogen peroxide at 20℃; for 5h;	A 14% B 83%
With C26H30F6MnN6O6S2; dihydrogen peroxide; acetic acid In acetonitrile at 20℃; for 1h; chemoselective reaction;	A 9% B 61%

: 131-11-3
phthalic acid dimethyl ester

: 64-19-7
acetic acid

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
Stage #1: phthalic acid dimethyl ester; acetic acid With sodium methylate at 12 - 80℃; Stage #2: With hydrogenchloride In water at 45 - 55℃; for 5h;	82.7%

: 1-oxo-1H-inden-3-yl pivalate

: 107428-05-7
dimethyl 2,2-di(but-2-yn-1-yl)malonate

A: 606-23-5
1H-indene-1,3(2H)-dione

B: dimethyl 4,10-dimethyl-9-oxo-3,9-dihydrocyclopenta[b]fluorene-2,2(1H)-dicarboxylate

Conditions

Conditions	Yield
With calcium hydride; 1,5-hexadienerhodium(I)-chloride dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dichloro-ethane at 80℃; for 15h; Schlenk technique; Inert atmosphere;	A 10% B 76%

...Expand

: 496-11-7
INDANE

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 6351-10-6
1-Indanol

C: 83-33-0
inden-1-one

Conditions

Conditions	Yield
With sodium percarbonate; adogen 464; bis-(tributyltin oxide) dioxochromium(VI); toluene-4-sulfonic acid In acetonitrile at 80 - 83℃; for 20h;	A 4% B 5% C 70%
With sodium percarbonate; adogen 464; bis-(tributyltin oxide) dioxochromium(VI) In acetonitrile at 80 - 83℃; for 20h; Product distribution; benzylic oxidation with various reagents, solvent dependence;	A 2% B 10% C 60%
With dipyridinium dichromate; sodium percarbonate; adogen 464 In 1,2-dichloro-ethane at 80 - 83℃; for 20h;	A 6% B 7% C 30%

...Expand

: 496-11-7
INDANE

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With tert.-butylnitrite; N-hydroxyphthalimide In acetonitrile at 80℃; for 24h; Schlenk technique;	61%
With tert.-butylnitrite; N-hydroxyphthalimide; oxygen In acetonitrile at 80℃; under 760.051 Torr; for 24h; Schlenk technique;	61%

: 1807-62-1
2-(9-xanthylidene)indane-1,3-dione

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 87688-44-6
2-(9-xanthyl)indane-1,3-dione

Conditions

Conditions	Yield
With thiophenol at 100℃; for 10h; Product distribution; other reagent;	A 12% B 55%

: 107428-05-7
dimethyl 2,2-di(but-2-yn-1-yl)malonate

: 1-oxo-1H-inden-3-yl acetate

A: 606-23-5
1H-indene-1,3(2H)-dione

B: dimethyl 4,10-dimethyl-9-oxo-3,9-dihydrocyclopenta[b]fluorene-2,2(1H)-dicarboxylate

C: dimethyl-3-(1-acetoxyethylidene)-4-ethylidenecyclopentane-1,1-dicarboxylate

Conditions

Conditions	Yield
With silver tetrafluoroborate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; calcium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dichloro-ethane at 80℃; Schlenk technique; Inert atmosphere;	A 27% B 14% C 45%
With calcium hydride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dichloro-ethane at 80℃; Reagent/catalyst; Schlenk technique; Inert atmosphere;	A 27% B 32% C 40%
With calcium hydride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dichloro-ethane at 80℃; Schlenk technique; Inert atmosphere;	A 10% B 39% C 12%

...Expand

: 496-11-7
INDANE

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 83-33-0
inden-1-one

Conditions

Conditions	Yield
With dipyridinium dichromate; adogen 464; dihydrogen peroxide; sodium carbonate In various solvent(s) for 24h; Oxidation; Heating;	A 18% B 38%

: C18H17NO2

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 1h; Inert atmosphere;	35%

: 14570-43-5
2-propylindan-1,3-dione

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
In acetonitrile for 4h; UV-irradiation;	28%

: 496-11-7
INDANE

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 26976-59-0
3-hydroxy-2,3-dihydro-1H-inden-1-one

C: 83-33-0
inden-1-one

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; [(pymox-Me2)2RuCl2]+BF4- In water at 20℃; for 2h;	A 5% B n/a C n/a

...Expand

: 2740-22-9
2-formylindane-1,3-dione

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With hydrogenchloride

: 7319-63-3
2-bromo-indan-1,3-dione

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 1685-97-8
2,2-dibromo-indan-1,3-dione

Conditions

Conditions	Yield
With water

: 6940-95-0
[2,2']biindenyl-1,3,1',3'-tetraone

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With dihydrogen peroxide Uebersaettigen der Loesung mit Schwefelsaeure;

: 103165-42-0
2,2-bis-(1,3-dioxo-indan-2-yl)-acenaphthen-1-one

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 850645-51-1
2-(2-oxo-acenaphthen-1-ylidene)-indan-1,3-dione

Conditions

Conditions	Yield
With sulfuric acid

: 87768-18-1
3-methoxy-1-oxo-indene-2-carboxylic acid ethyl ester

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
at 100℃;

: 74307-85-0
2-bromo-1,3-dioxo-indan-2-carboxylic acid ethyl ester

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 1685-97-8
2,2-dibromo-indan-1,3-dione

Conditions

Conditions	Yield
With water

: ethyl 3-amino-1-oxo-1H-indene-2-carboxylate

: furan-2,3,5(4H)-trione pyridine (1:1)

: 606-23-5
1H-indene-1,3(2H)-dione

: 15365-99-8
1-(1,3-dioxo-indan-2-yl)-4-(1,3-dioxo-indan-2-ylidene)-3,4-dihydro-2H-pyrrolium betaine

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
at 210 - 220℃; under 0.1 Torr;

: 25299-18-7
2‑(2‑hydroxybenzylidene)‑1H‑indene‑1,3(2H)‑dione

: 100-63-0
phenylhydrazine

A: 606-23-5
1H-indene-1,3(2H)-dione

B: 90-02-8
salicylaldehyde

...Expand

: 108-05-4
vinyl acetate

: 88-95-9
Phthaloyl dichloride

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With aluminium trichloride

: 3453-63-2
3-methylidenephthalide

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
at 1100℃; Mechanism; lower temperature;
at 1100℃; flash thermolysis; Yield given;
With potassium tert-butylate In tetrahydrofuran

: 28164-53-6
2-diazo-3-hydroxy-1-indanone

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
tin(ll) chloride In dichloromethane Ambient temperature;

: 19968-95-7
1,3-indandione anion

: 606-23-5
1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With 4-chlorobenzylmalononitrile; potassium chloride In water; dimethyl sulfoxide at 20℃; Rate constant; var. phenyl-substituted benzylmalononitriles;

: 606-23-5
1H-indene-1,3(2H)-dione

: 7319-63-3
2-bromo-indan-1,3-dione

Conditions

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide; potassium bromide In toluene at 20℃; for 0.5h;	100%
With hydroxy(tosyloxy)iodobenzene; copper(ll) bromide In acetonitrile at 0℃; for 0.0833333h;	90%
With bromomalononitrile In N,N-dimethyl-formamide at 20℃; for 0.5h; Reagent/catalyst;	90%

: 606-23-5
1H-indene-1,3(2H)-dione

: 551-93-9
2-aminoacetophenone

: 142790-83-8
10-methyl-11H-indeno[1,2-b]quinolin-11-one

Conditions

Conditions	Yield
With acetic acid at 130℃; for 4h;	100%
With malic acid In neat (no solvent) at 70℃; for 2.4h; Friedlaender Quinoline Synthesis; Green chemistry;	81%
With water; acetic acid at 130℃; for 4h;	50%

: 606-23-5
1H-indene-1,3(2H)-dione

: 1620-98-0
3,5-di-t-butyl-4-hydroxybenzaldehyde

: 53566-09-9
(Z)-2-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform for 21h; Knoevenagel reaction; Heating;	100%
With sulfuric acid In acetic acid for 51h; Ambient temperature;	75%
With piperidine In ethanol for 8h; Knoevenagel Condensation; Reflux;	51.5%
With piperidine In acetic acid

: 606-23-5
1H-indene-1,3(2H)-dione

: 234762-41-5
(Z)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

: C40H30N2O2

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; methylene exchange;	100%

: 606-23-5
1H-indene-1,3(2H)-dione

: 104-88-1
4-chlorobenzaldehyde

: 1896-62-4
(E)-benzalacetone

: 2-(4-chlorophenyl)-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; 4-chlorobenzaldehyde With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 66-77-3
1-naphthaldehyde

: 1896-62-4
(E)-benzalacetone

: 2-(naphthalen-1-yl)-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; 1-naphthaldehyde With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 123-08-0
4-hydroxy-benzaldehyde

: 1896-62-4
(E)-benzalacetone

: 2-(4-hydroxyphenyl)-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; 4-hydroxy-benzaldehyde With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 105-07-7
4-cyanobenzaldehyde

: 1896-62-4
(E)-benzalacetone

: 2-(4-cyanophenyl)-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; 4-cyanobenzaldehyde With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 1896-62-4
(E)-benzalacetone

: 1571-08-0
methyl 4-formylbenzoate

: 2-[4-(methoxycarbonyl)phenyl]-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; methyl 4-formylbenzoate With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 99-61-6
3-nitro-benzaldehyde

: 18691-32-2
3′-(3-nitrophenyl)dispiro[indene-2,1′-cyclopropane-2′,2′′-indene]-1,1′′,3,3′′-tetraone

Conditions

Conditions	Yield
With bromocyane; triethylamine In methanol at 0 - 20℃; for 0.00416667h; Sealed tube;	100%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; sodium acetate In ethanol at 20℃; for 0.0333333h; Reagent/catalyst;	96%
With dmap; iodine at 20℃; for 1h; Neat (no solvent); Mechanical ball-milling; chemospecific reaction;	88%

: 606-23-5
1H-indene-1,3(2H)-dione

: 555-16-8
4-nitrobenzaldehdye

: 18691-31-1
3'-(4-nitrophenyl)-dispiro[indan-2,1'-cyclopropane-2',2''-indan]-1,1'',3,3''-tetrone

Conditions

Conditions	Yield
With bromocyane; triethylamine In methanol at 0 - 20℃; for 0.00416667h; Sealed tube;	100%
With dmap; iodine at 20℃; for 1h; Neat (no solvent); Mechanical ball-milling; chemospecific reaction;	89%

: 606-23-5
1H-indene-1,3(2H)-dione

: 874-42-0
2,4-dichlorobenzaldeyhde

: 7090-75-7
3′-(2,4-dichlorophenyl)dispiro[indene-2,1′-cyclopropane-2′,2′′-indene]-1,1′′,3,3′′-tetraone

Conditions

Conditions	Yield
With bromocyane; triethylamine In methanol at 0 - 20℃; for 0.00416667h; Sealed tube;	100%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; sodium acetate In ethanol at 20℃; for 0.166667h; Reagent/catalyst;	96%

: 50-00-0
formaldehyd

: 606-23-5
1H-indene-1,3(2H)-dione

: 106144-67-6
dispiro[indene-2,1'-cyclopropane-2',2''-indene]-1,1'',3,3''-tetraone

Conditions

Conditions	Yield
With bromocyane; sodium ethanolate In methanol at 0 - 20℃; for 0.00416667h; Sealed tube;	100%

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 606-23-5
1H-indene-1,3(2H)-dione

: 2-(3-ethoxy-4-hydroxybenzylidene)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water at 20℃; Inert atmosphere;	99.8%

: 606-23-5
1H-indene-1,3(2H)-dione

: 555-16-8
4-nitrobenzaldehdye

: 15875-60-2
2-(p-nitrobenzylidene)indan-1,3-dione

Conditions

Conditions	Yield
With L-proline In methanol at 25℃; for 12h; organocatalytic Knoevenagel condensation;	99%
In water at 20 - 80℃; Knoevenagel condensation;	97.5%
With magnesium oxide at 20℃; for 0.333333h; Knoevenagel condensation;	94%

: 606-23-5
1H-indene-1,3(2H)-dione

: 93-02-7
2,5-dimethoxybenzaldehyde

: 67200-96-8
2-(2,5-dimethoxybenzylidene)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In ethanol; water at 50 - 60℃; Reagent/catalyst; Solvent;	99%
Stage #1: 1H-indene-1,3(2H)-dione With pyridine Stage #2: 2,5-dimethoxybenzaldehyde at 100℃; for 1h;	75%
With ethanol

: 606-23-5
1H-indene-1,3(2H)-dione

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 78426-08-1
2-(2,4-dihydroxybenzylidene)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With pyridine In ethanol Reflux;	99%
In ethanol for 3h; Heating;	72%
With hydrogenchloride; acetic acid In water at 20℃; Inert atmosphere;	43.1%
With piperidine; ethanol
With potassium hydroxide bei der Kondensation;

: 606-23-5
1H-indene-1,3(2H)-dione

: 106-96-7
propargyl bromide

: 24241-98-3
2,2-di(prop-2-yn-1-yl)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With caesium carbonate In acetone; toluene at 20℃; for 16h;	99%
With potassium hydroxide In water; acetone at 2440℃; for 16h; Reflux;	93%
With potassium hydroxide In water at 40℃; for 24h;	93%

: 606-23-5
1H-indene-1,3(2H)-dione

: C22H22O5

poly{oxy[(E)-but-2-enylene](1,3-indandione-2,2-diyl)[(E)-but-2-enylene]}, Mn=14000; monomer(s): (2Z,7Z)-non-2,7-diene-5-oxa-1,9-ol dibenzoic acid ester; 1,3-indane-2,4-diene: poly{oxy[(E)-but-2-enylene](1,3-indandione-2,2-diyl)[(E)-but-2-enylene]}, Mn=14000; monomer(s): (2Z,7Z)-non-2,7-diene-5-oxa-1,9-ol dibenzoic acid ester; 1,3-indane-2,4-diene

Conditions

Conditions	Yield
With N,O-bis-(trimethylsilyl)-acetamide; tris(dibenzylideneacetone)dipalladium (0); 1,4-di(diphenylphosphino)-butane In dichloromethane; N,N-dimethyl-formamide Tsuji-Trost reaction;	99%

: 606-23-5
1H-indene-1,3(2H)-dione

: 107-18-6
allyl alcohol

: 81055-89-2
2,2-diallyl-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With trisodium tris(3-sulfophenyl)phosphine; sodium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In water; ethyl acetate at 20℃; for 18h; Tsuji-Trost reaction;	99%
With Ru(Cp*)(η3-C3H5)(p-CH3C6H5SO3)2 In dichloromethane; acetonitrile at 50℃; for 3h; regioselective reaction;	89%

: 606-23-5
1H-indene-1,3(2H)-dione

: 100-52-7
benzaldehyde

: 890-44-8
2-benzyl-indan-1,3-dione

Conditions

Conditions	Yield
With 1,2-diamino-benzene; rac-Pro-OH In ethanol at 25℃; for 1h;	99%
With 2,6-dimethyl-1,4-dihydropyrimidine-3,5-dicarboxylic acid diethyl ester; L-proline In ethanol at 25℃; Knoevenagel/hydrogenation reaction;	88%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline In ethanol at 25℃; for 26h; cascade Knoevenagel olefination/hydrogenation reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	88%

: 606-23-5
1H-indene-1,3(2H)-dione

: 71-43-2
benzene

: 55010-17-8
3,3-diphenyl-indan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 20℃; for 24h;	99%

: 106518-84-7
3-(4-bromophenylamino)-5,5-dimethylcyclohex-2-enone

: 606-23-5
1H-indene-1,3(2H)-dione

: 89-98-5
2-chloro-benzaldehyde

: 1009033-46-8
10-(4-bromophenyl)-5-(2-chlorophenyl)-7,8-dihydro-7,7-dimethyl-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 90℃; for 8h;	99%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 18940-21-1
5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one

: 552-89-6
2-nitro-benzaldehyde

: 1009033-44-6
7,8-dihydro-7,7-dimethyl-5-(2-nitrophenyl)-10-phenyl-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 90℃; for 6h;	99%

...Expand

: 1603-41-4
(5-methyl-pyridin-2-yl)amine

: 606-23-5
1H-indene-1,3(2H)-dione

: 61066-33-9, 61066-34-0, 61066-35-1, 61127-23-9
pyrimidine-2,4,5,6(1H,3H)-tetraone

: 1367748-11-5
5-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-5-hydroxypyrimidine-2,4,6(1H,3H,5H)-trione 2-amino-5-methylpyridinium salt

Conditions

Conditions	Yield
In chloroform for 1h; Reflux;	99%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 31486-86-9
thieno[3,2-b]thiophene-2-carbaldehyde

: C16H8O2S2

Conditions

Conditions	Yield
With aluminum oxide In dichloromethane at 25℃; for 12h; Knoevenagel Condensation;	99%

: 606-23-5
1H-indene-1,3(2H)-dione

: 31486-85-8
2-Formylthieno<2,3-b>thiophene

: C16H8O2S2

Conditions

Conditions	Yield
With aluminum oxide In dichloromethane at 25℃; for 12h; Knoevenagel Condensation;	99%

: 606-23-5
1H-indene-1,3(2H)-dione

: 1-benzyl-4-(pyrrolidin-1-yl)indoline-2,3-dione

: 4-benzyl-4,5a,6a,7,8,9-hexahydro-5H-spiro[dipyrrolo[1,2-a:4′,3′,2′-de]quinoline-6,2′-indene]-1′,3′,5-trione

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 60℃; for 12h; Solvent; Molecular sieve; diastereoselective reaction;	99%

: 606-23-5
1H-indene-1,3(2H)-dione

: 1-(2-chlorobenzyl)-4-(pyrrolidin-1-yl)indoline-2,3-dione

: 4-(2-chlorobenzyl)-4,5a,6a,7,8,9-hexahydro-5H-spiro[dipyrrolo-[1,2-a:4′,3′,2′-de]quinoline-6,2′-indene]-1′,3′,5-trione

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 60℃; for 12h; Molecular sieve; diastereoselective reaction;	99%

: 606-23-5
1H-indene-1,3(2H)-dione

: 1-(4-bromophenyl)-4-(4-chlorophenyl)but-3-yne-1,2-dione

: 2-(5-(4-bromophenyl)-2-(4-chlorophenyl)-5-hydroxy-1',3'-dioxo-1',3'-dihydrospiro[cyclopent[2]ene-1,2'-inden]-4-ylidene)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 24h; Inert atmosphere; Schlenk technique;	99%

1,3-Indanedione Chemical Properties

The molecular formula of 1,3-Indanedione(606-23-5) is C₉H₆O₂ and its formula weight is 146.14.
The density of 1,3-Indanedione(606-23-5) is 1.37 g/cm³ and it has a melting point of 129-132 °C(lit.). The boiling point is 283°C.
The chemical synonyms of 1,3-Indanedione(606-23-5) are 1,3-DIOXOINDANE;1,3-DIKETOHYDRINDENE;1,3-HYDRINDENEDIONE;1,3-Indanedione;1,3-INDANEDIONE;AURORA KA-7365;DIKETOHYDRINDENE;1,3-Indanone
The molecular structure of 1,3-Indanedione(606-23-5):

1,3-Indanedione Uses

1,3-Indanedione(606-23-5) is an anticoagulant used as a rodenticide.
Certain derivatives are used in human medicine.

1,3-Indanedione Toxicity Data With Reference

RTECS#: CAS# 606-23-5: NK5070000
LD50/LC50: ipr-mus LDLo:100 mg/kg ARTODN Archives of Toxicology. 33 (1975),191.
Carcinogenicity: 1,3-INDANEDIONE, 97% - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: See actual entry in RTECS for complete information.

1,3-Indanedione Consensus Reports

Reported in EPA TSCA Inventory.

1,3-Indanedione Safety Profile

A poison by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes Xi
Risk Statements 33-36/37/38
Safety Statements 24/25-36/37/39-27-26
WGK Germany 3
RTECS NK5070000
HS Code 29143900

1,3-Indanedione Specification

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Irritating and toxic fumes and gases.
Hazardous Polymerization Has not been reported.

Product Name

1,3-Indanedione

Synthetic route

1,3-Indanedione Chemical Properties

1,3-Indanedione Uses

1,3-Indanedione Toxicity Data With Reference

1,3-Indanedione Consensus Reports

1,3-Indanedione Safety Profile

1,3-Indanedione Specification

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