1-Bromo-4-iodobenzene supplier

Name
1-Bromo-4-iodobenzene
EINECS 209-662-7
CAS No. 589-87-7
Article Data159
CAS DataBase
Density 2.215 g/cm³
Solubility Insoluble in water.
Melting Point 89-91 °C(lit.)
Formula C₆H₄BrI
Boiling Point 244.8 °C at 760 mmHg
Molecular Weight 282.906
Flash Point 101.9 °C
Transport Information
Appearance white to brown cryst. powder, crystals or needles
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Bromo-1-iodobenzene;4-Bromoiodobenzene;4-Bromophenyl iodide;4-Iodo-1-bromobenzene;4-Iodobromobenzene;NSC 8033;p-Bromoiodobenzene;p-Bromophenyl iodide;p-Iodobromobenzene;
PSA 0.00000
LogP 3.05370

Synthetic route

: 106-40-1
4-bromo-aniline

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
Stage #1: 4-bromo-aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Inert atmosphere; Stage #2: With potassium iodide In ethyl acetate for 0.5h;	100%
With sulfuric acid; potassium iodide; sodium nitrite In water at -5 - 60℃; Inert atmosphere;	92%
Stage #1: 4-bromo-aniline With sulfuric acid; silica gel; sodium nitrite at 20℃; grinding; Neat (no solvent); Stage #2: With water at 20℃; grinding; Neat (no solvent); Stage #3: With potassium iodide at 20℃; for 0.166667h; Sandmeyer reaction; grinding; Neat (no solvent);	87%

: 4-bromophenyldiazonium nitrate

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With potassium iodide for 24h;	100%

: 673-40-5
4-bromobenzenediazonium tetrafluoroborate

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With potassium iodide In water at 25℃; for 0.0833333h; Solvent; Sandmeyer Reaction;	99%
With diiodomethane; tetrabutylammonium perchlorate In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction;	61%
With iodine; potassium iodide In dimethyl sulfoxide at 15℃;

: triethyl(4-iodophenyl)germane

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 4h;	96%

: 23268-74-8
(4-bromophenyl)triethylgermane

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With N-iodo-succinimide In N,N-dimethyl-formamide at 50℃; for 4h;	96%

: 1514-50-7
4-iodobenzenediazonium tetrafluoroborate

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With potassium bromide In acetonitrile at 20℃; for 1h; Sandmeyer Reaction; Inert atmosphere;	95%
With N-Bromosuccinimide; tetrabutylammonium perchlorate In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction;	68%
With (triphenylphosphine)gold(I) chloride; sodium bromide In acetonitrile at 50℃; for 5h; Sandmeyer Reaction;	73 %Chromat.

: 52010-62-5
1-(4-Bromophenyl)-3,3-diethyltriazene

: 74-88-4
methyl iodide

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
at 110 - 120℃; for 6h;	94%

: 5467-74-3
4-Bromophenylboronic acid

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With sodium nitrite In acetonitrile at 80℃; for 1.5h; Sealed tube;	94%
With N-iodo-succinimide In acetonitrile at 81℃; for 6h;	88%
With potassium fluoride; iodine In 1,4-dioxane at 80℃; for 1h;	86%

: 374564-35-9
potassium 4-bromophenyltrifluoroborate

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With caesium tribromide In water; N,N-dimethyl-formamide at 80℃; for 5h; chemoselective reaction;	94%
With chloroamine-T; sodium iodide In tetrahydrofuran; water at 20℃; for 0.25h;	87%

: 100-64-1
Cyclohexanone oxime

: 41018-52-4
(4-bromophenyl)-λ3-iodanediyl diacetate

A: 589-87-7
1,4-bromoiodobenzene

B: 10259-08-2
acetoxy-1 nitroso-1 cyclohexane

Conditions

Conditions	Yield
In acetic acid at -15℃; for 0.25h;	A n/a B 94%

...Expand

: 100124-06-9
4-dibenzofurylboronic acid

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
	94%

: 108-86-1
bromobenzene

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; [bis(pyridine)iodine]+ tetrafluoroborate In dichloromethane for 2h; Ambient temperature;	90%
With sodium periodate; sulfuric acid; iodine In acetic anhydride; acetic acid at 20℃; for 5h; Iodination;	87%
With cerium(III) chloride heptahydrate; dihydrogen peroxide; sodium iodide In water for 12h; Reflux; regioselective reaction;	86%

: 108-86-1
bromobenzene

A: 583-55-1
1-Bromo-2-iodobenzene

B: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With iodine; fluorine In chloroform; trichlorofluoromethane at -20℃; for 0.5h;	A 5% B 90%
With dipotassium peroxodisulfate; iodine In dichloromethane; trifluoroacetic acid at 36 - 38℃; for 44h;	A n/a B 74%
With sulfuric acid; iodine; nitric acid In acetic acid at 80 - 100℃; Product distribution;

: 540-37-4
p-aminoiodobenzene

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With tert.-butylnitrite; tetrabutylammomium bromide; copper(I) bromide; 10-camphorsulfonic acid In acetonitrile at 20℃; for 24h; Reagent/catalyst; Time; Solvent;	90%
With tert.-butylnitrite; tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(ll) bromide In acetonitrile at 20℃; for 1h;	78%
With tert.-butylnitrite; tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(ll) bromide	64%

: 2712-78-9
bis-[(trifluoroacetoxy)iodo]benzene

A: 583-55-1
1-Bromo-2-iodobenzene

B: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With bromine In chloroform Ambient temperature;	A 10% B 89%

: 41018-52-4
(4-bromophenyl)-λ3-iodanediyl diacetate

: 127-06-0
acetone oxime

A: 6931-04-0
2-acetoxy-2-nitrosopropane

B: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
In acetic acid at -15℃; for 0.25h;	A 88% B n/a

...Expand

: 52010-62-5
1-(4-Bromophenyl)-3,3-diethyltriazene

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With sulfonic acid resin (H+ form, Bio-Rad AG 50W-12); sodium iodide In acetonitrile at 75℃; for 0.133333h;	85%

: 586-76-5
4-Bromobenzoic acid

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With N-iodo-succinimide; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; iodine; caesium carbonate In 1,2-dichloro-ethane at 50℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;	85%
With 3-iodo-4,4-dimethyloxazolidin-2-one In 1,2-dichloro-ethane for 24h; Concentration; Time; Solvent; Reagent/catalyst; Reflux; Irradiation;	51%

: 1192-28-5
Cyclopentanone oxime

: 41018-52-4
(4-bromophenyl)-λ3-iodanediyl diacetate

A: 589-87-7
1,4-bromoiodobenzene

B: 10259-07-1
1-acetoxy-1-nitrosocyclopentane

Conditions

Conditions	Yield
In acetic acid at -15℃; for 0.25h;	A n/a B 83%

...Expand

: 591-50-4
iodobenzene

A: 583-55-1
1-Bromo-2-iodobenzene

B: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With potassium bromide; sodium nitrite In water; trifluoroacetic acid at 20℃; for 2h; Product distribution; under argon, other time, other reagent;	A 18% B 82%
With oxygen; potassium bromide; potassium nitrate In water; trifluoroacetic acid at 20℃; for 8h; Product distribution;	A 18% B 82%
With lead(II,IV) oxide; trifluoroacetic acid; potassium bromide at 20℃; Product distribution;

: 106-37-6
1.4-dibromobenzene

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
Stage #1: 1.4-dibromobenzene With tert.-butyl lithium In diethyl ether at -78℃; for 0.5h; Stage #2: With iodine In tetrahydrofuran; diethyl ether at -78 - 20℃; for 4.75h;	82%
Stage #1: 1.4-dibromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran; hexane at -78 - 25℃; for 1.5h; Inert atmosphere;	75%
With caesium carbonate; potassium iodide; copper(l) iodide In toluene at 110℃; for 12h;

: 147227-33-6
1-(4-bromophenyl)-2-(pyrrolidin-1-yl)diazene

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 80℃; for 4h;	80%

: 82113-65-3
bis(trifluoromethanesulfonyl)amide

: 106-40-1
4-bromo-aniline

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
Stage #1: bis(trifluoromethanesulfonyl)amide With tert.-butylnitrite; acetic acid In ethanol Cooling with ice; Stage #2: 4-bromo-aniline With tetraethylammonium iodide In water at 20℃;	80%

: 10576-12-2
ethyl acetohydroximate

: 139139-81-4
bis(4-bromophenyl)iodonium triflate

A: 589-87-7
1,4-bromoiodobenzene

B: 1644570-70-6
ethyl N-4-bromophenoxyacetimidate

Conditions

Conditions	Yield
Stage #1: ethyl acetohydroximate With sodium t-butanolate In acetonitrile at 0 - 20℃; for 0.25h; Stage #2: bis(4-bromophenyl)iodonium triflate In acetonitrile at 20℃; for 0.5h; chemoselective reaction;	A 144 mg B 78%

...Expand

: 10576-12-2
ethyl acetohydroximate

: 139139-81-4
bis(4-bromophenyl)iodonium triflate

: 98-86-2
acetophenone

A: 13141-26-9
5-bromo-2-phenylbenzo[b]furan

B: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
Stage #1: ethyl acetohydroximate With sodium t-butanolate In acetonitrile at 0 - 20℃; for 0.25h; Stage #2: bis(4-bromophenyl)iodonium triflate In acetonitrile at 20℃; for 0.5h; Stage #3: acetophenone With hydrogenchloride In water; acetonitrile at 20 - 70℃; for 3.25h; Inert atmosphere; chemoselective reaction;	A 73% B 147 mg

...Expand

: 67-66-3
chloroform

: 53601-22-2
4,4'-dibromodiphenyliodonium chloride

A: 589-87-7
1,4-bromoiodobenzene

B: 586-76-5
4-Bromobenzoic acid

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide at 50℃; for 1h; Carbonylation;	A n/a B 72%

...Expand

: 148651-39-2
(4-bromophenyl)zinc iodide

A: 589-87-7
1,4-bromoiodobenzene

B: 92-86-4
4-(4-bromophenyl)bromobenzene

Conditions

Conditions	Yield
Stage #1: (4-bromophenyl)zinc iodide With N-chloro-succinimide; tetrakis(triphenylphosphine) palladium(0) In various solvent(s) at 20℃; for 4h; Stage #2: With iodine In various solvent(s)	A 36% B 63%

: 201230-82-2
carbon monoxide

: 79054-62-9
1-bromo-4-iodoxybenzene

A: 589-87-7
1,4-bromoiodobenzene

B: 586-76-5
4-Bromobenzoic acid

C: 100-21-0
terephthalic acid

Conditions

Conditions	Yield
With sodium tetrachloropalladate; sodium carbonate In water at 40℃; for 5h; Yields of byproduct given;	A n/a B 61% C 15%

...Expand

: 93680-30-9
C7H6BrN7

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With tertamethylammonium iodide; trifluoroacetic acid In acetonitrile at 70 - 80℃;	61%

: potassium (4-iodophenyl)trifluoroborate

: 589-87-7
1,4-bromoiodobenzene

Conditions

Conditions	Yield
With acetic acid; lithium bromide In dimethyl sulfoxide at 100℃; for 8h; Schlenk technique;	51%

: 589-87-7
1,4-bromoiodobenzene

: 124582-37-2
methyl 2-(tributylstannanyl)-2-propenoate

: methyl 2-(4-bromophenyl)acrylate

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	100%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide for 24h; Ambient temperature;	92%

: 589-87-7
1,4-bromoiodobenzene

: 1066-54-2
trimethylsilylacetylene

: 16116-78-2
(4-bromophenyl)(trimethylsilyl)acetylene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 100℃; for 0.5h; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran Sonogashira Cross-Coupling; Inert atmosphere;	100%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine at 0℃; Schlenk technique; Inert atmosphere;	99%

: 201230-82-2
carbon monoxide

: 589-87-7
1,4-bromoiodobenzene

: 586-76-5
4-Bromobenzoic acid

Conditions

Conditions	Yield
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation;	100%
With water; potassium carbonate In acetonitrile at 100℃; under 3750.38 Torr; for 0.0161111h;	93%
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 6h;	91%

: 589-87-7
1,4-bromoiodobenzene

: 89343-06-6
tris-iso-propylsilyl acetylene

: 271242-20-7
(2-(4-bromophenyl)ethynyl)triisopropylsilane

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 20℃; for 16h;	100%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; for 16h; Sonogashira Coupling;	100%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; for 16h; Sonogashira Coupling;	100%

: 589-87-7
1,4-bromoiodobenzene

: 927-74-2
1-butyn-4-ol

: 59099-79-5
4-(4-bromophenyl)-3-butyn-1-ol

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) In dichloromethane at 50℃; Sonogashira reaction;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran for 4h; Inert atmosphere; Reflux;	85%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide Schlenk technique;	82%

: 183158-33-0
acenaphthene-5-boronic acid

: 589-87-7
1,4-bromoiodobenzene

: 871320-08-0
5-(4-bromophenyl)acenaphthene

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 6h; Heating / reflux;	100%

: 766-96-1
4-bromo-1-ethynylbenzene

: 589-87-7
1,4-bromoiodobenzene

: 2789-89-1
1,2-bis(4-bromophenyl)acetylene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran Sonogashira Cross-Coupling; Inert atmosphere;	100%
With C18H18N2O8PdS2(2-)2Na(1+)3H2O; triethylamine In water at 80℃; for 8h; Sonogashira Cross-Coupling;	97%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide	91%

: 1039027-73-0
5,15-bis[3,5-di(tert-butyl)phenyl]-10,20-bis(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)porphyrinato-N(21),N(22),N(23),N(24)zinc(II)

: 589-87-7
1,4-bromoiodobenzene

: 1202170-65-7
5,15-bis[3,5-di(tert-butyl)phenyl]-10,20-bis(4-bromophenyl)porphyrinato-N(21),N(22),N(23),N(24)zinc(II)

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); water; caesium carbonate In toluene Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;	100%

: 589-87-7
1,4-bromoiodobenzene

: 1187734-92-4
5,10-bis[3,5-di(tert-butyl)phenyl]-15,20-bis(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)porphyrinato-N(21),N(22),N(23),N(24)zinc(II)

: 1202170-64-6
5,10-bis[3,5-di(tert-butyl)phenyl]-15,20-bis(4-bromophenyl)porphyrinato-N(21),N(22),N(23),N(24)zinc(II)

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); water; caesium carbonate In toluene Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;	100%

: 589-87-7
1,4-bromoiodobenzene

: 3393-78-0
4,4'-dibromodiphenyl sulfide

Conditions

Conditions	Yield
With potassium thioacyanate; cetyltrimethylammonim bromide; potassium hydroxide In water at 135℃; for 7h; Green chemistry;	100%
With copper(l) iodide; sodiumsulfide nonahydrate; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 18h; Inert atmosphere; chemoselective reaction;	94%
With copper(l) iodide; sodiumsulfide nonahydrate; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 18h; Inert atmosphere; Darkness;	94%

: 589-87-7
1,4-bromoiodobenzene

: C12H13BrO

: C18H16Br2O

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In tetrahydrofuran for 16h; Sonogashira Cross-Coupling; Inert atmosphere;	100%

: 589-87-7
1,4-bromoiodobenzene

: N-(3,3-dimethoxypropyl)hex-5-ynamide

: N-(3,3-dimethoxypropyl)-6-(4-bromophenyl)hex-5-ynamide

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 50℃; for 4h; Sonogashira Cross-Coupling; Inert atmosphere;	100%

: 589-87-7
1,4-bromoiodobenzene

: 260061-31-2
(R)-(+)-4-methylpyrrolidin-2-one

: (R)-1-(4-bromophenyl)-4-methylpyrrolidin-2-one

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; N,N`-dimethylethylenediamine In ethyl acetate at 50℃; for 16h; Inert atmosphere;	100%

: 66899-02-3
4,4-dimethylpyrrolidin-2-one

: 589-87-7
1,4-bromoiodobenzene

: 1-(4-bromophenyl)-4,4-dimethylpyrrolidin-2-one

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; N,N`-dimethylethylenediamine In ethyl acetate at 50℃; for 16h; Inert atmosphere;	100%

: 31551-66-3
(S)-(-)-4-methylpyrrolidin-2-one

: 589-87-7
1,4-bromoiodobenzene

: (S)-1-(4-bromophenyl)-4-methylpyrrolidin-2-one

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; N,N`-dimethylethylenediamine In ethyl acetate at 50℃; for 16h; Inert atmosphere;	100%

: 589-87-7
1,4-bromoiodobenzene

: 5-azaspiro[2.4]heptan-6-one

: 5-(4-bromophenyl)-5-azaspiro[2.4]heptan-6-one

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; N,N`-dimethylethylenediamine In ethyl acetate at 50℃; for 16h; Inert atmosphere;	100%

: 589-87-7
1,4-bromoiodobenzene

: 2-(5-(4-(tert-butyl)phenyl)-4-(4-chlorophenyl)-2-(4-fluorophenyl)furan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 3-(4-bromophenyl)-5-(4-(tert-butyl)phenyl)-4-(4-chlorophenyl)-2-(4-fluorophenyl)furan

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; Schlenk technique;	100%

: 589-87-7
1,4-bromoiodobenzene

: 357383-42-7
N-(cyclopropylmethyl)-1,1,1-trifluoromethanesulfonamide

: N-((2-(4-bromophenyl)cyclopropyl)methyl)-1,1,1-trifluoromethanesulfonamide

Conditions

Conditions	Yield
With t-Boc-L-valine; sodium 2,2,2-trifluoroacetate; palladium diacetate; silver carbonate In tert-butyl alcohol at 80℃; for 18h; Sealed tube; enantioselective reaction;	99.9%

: 589-87-7
1,4-bromoiodobenzene

: 86-74-8
9H-carbazole

: 57102-42-8
N-(4-bromophenyl)carbazole

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; potassium hydroxide In 1,2-dimethoxyethane; water at 95℃; for 20h; Catalytic behavior; Solvent; Schlenk technique; Inert atmosphere; Sealed tube;	99%
With copper; potassium carbonate In N,N-dimethyl-formamide at 130℃; for 42h; Inert atmosphere;	96%
With copper(I) oxide; 2,2,6,6-tetramethylheptane-3,5-dione; potassium hydroxide In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere; Schlenk technique;	95%

: 589-87-7
1,4-bromoiodobenzene

: 107-19-7
propargyl alcohol

: 37614-58-7
3-(4-bromophenyl)prop-2-yn-1-ol

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃;	99%
Stage #1: 1,4-bromoiodobenzene With piperidine; copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium In toluene at 20℃; for 0.0333333h; Inert atmosphere; Stage #2: propargyl alcohol In toluene at 35℃; Sonogashira coupling; Inert atmosphere;	98%
With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In toluene at 60℃; for 2h; Inert atmosphere;	95%

: 589-87-7
1,4-bromoiodobenzene

: 536-74-3
phenylacetylene

: 13667-12-4
1-bromo-4-phenylethynylbenzene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 20℃; for 17h; Inert atmosphere;	99%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; triethylamine In acetonitrile at 20℃; Sonogashira Cross-Coupling; Inert atmosphere;	99%
With triethylamine In neat (no solvent) at 20℃; for 6h; Sonogashira Cross-Coupling;	97%

: 589-87-7
1,4-bromoiodobenzene

: C15H25BrOSiZn

: (4'-Bromo-biphenyl-4-yloxy)-triisopropyl-silane

Conditions

Conditions	Yield
(4-F(13)C6-C6H4)3P; bis(dibenzylideneacetone)-palladium(0) In toluene at 60℃;	99%

: 141-32-2
acrylic acid n-butyl ester

: 589-87-7
1,4-bromoiodobenzene

: 91911-22-7, 131061-14-8
butyl (E)-4-bromocinnamate

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; N,N'-(1,2-ethanediylidene)bishexahydro-1H-azepin-1-amine In N,N-dimethyl-formamide at 80℃; for 6h; Mizoroki-Heck reaction;	99%
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 1h; Heck Reaction;	98%
With tributyl-amine In water at 90℃; for 7h; Heck Reaction;	95%

: 589-87-7
1,4-bromoiodobenzene

: 98-80-6
phenylboronic acid

: 92-66-0
4-bromo-1,1'-biphenyl

Conditions

Conditions	Yield
With sodium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	99%
With potassium carbonate In water at 90℃; for 1h; Suzuki-Miyaura coupling; chemoselective reaction;	98%
With potassium carbonate In ethanol; water at 80℃; for 0.583333h; Catalytic behavior; Suzuki-Miyaura Coupling;	96%

: 589-87-7
1,4-bromoiodobenzene

: 108-98-5
thiophenol

: 65662-88-6
phenyl(4-bromophenyl)sulfide

Conditions

Conditions	Yield
With (tris(3,5-dimethyl-1-pyrazolyl)methane)CuI; lithium tert-butoxide In 1,4-dioxane at 110℃; for 24h; Ullmann condensation; Inert atmosphere; chemoselective reaction;	99%
With copper(l) iodide; potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 16h;	96%
With copper(l) iodide; 8-Hydroxyquinoline-N-oxide; caesium carbonate In dimethyl sulfoxide at 80℃; for 24h; Inert atmosphere; chemoselective reaction;	96%

: 589-87-7
1,4-bromoiodobenzene

: 693-02-7
hex-1-yne

: 190649-11-7
1-bromo-4-(hex-1-yn-1-yl)benzene

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 40℃;	99%
With CuI(xantphos); caesium carbonate In N,N-dimethyl-formamide at 135℃; for 0.166667h; Sonogashira type reaction; Inert atmosphere; Microwave irradiation;	78%
With copper(I) oxide; caesium carbonate In N,N-dimethyl-formamide at 135℃; for 24h; Sonogashira Cross-Coupling; Inert atmosphere;	67%

: 589-87-7
1,4-bromoiodobenzene

: 98-80-6
phenylboronic acid

: 92-94-4
[1,1';4',1'']terphenyl

Conditions

Conditions	Yield
With potassium carbonate In water at 50℃; for 1.5h; Suzuki Coupling;	99%
With magnesium hydroxide; potassium hydroxide; barium(II) hydroxide; calcium hydroxide In water at 20℃; for 1.5h; Suzuki Coupling;	99%
With sodium carbonate; palladium diacetate In water; N,N-dimethyl-formamide at 60℃; for 12h; Suzuki;	98%

1-Bromo-4-iodobenzene Chemical Properties

Empirical Formula: C₆H₄BrI
Molecular Weight: 282.9044 g/mol
EINECS: 209-662-7
Index of Refraction: 1.654
Density: 2.215 g/cm³
Flash Point: 101.9 °C
Melting point: 89-91 °C(lit.)
Sensitive: Light Sensitive
Enthalpy of Vaporization: 46.24 kJ/mol
Boiling Point: 244.8 °C at 760 mmHg
Vapour Pressure: 0.0464 mmHg at 25 °C
Appearance: white to brown cryst. powder, crystals or needles
Structure of 1-Bromo-4-iodobenzene (CAS NO.589-87-7):

Product Category of 1-Bromo-4-iodobenzene (CAS NO.589-87-7): Miscellaneous;Benzene derivates;Bromine and Iodine Compounds;Aryl;Halogenated Hydrocarbons;Halogenated benzene series

1-Bromo-4-iodobenzene Uses

1-Bromo-4-iodobenzene (CAS NO.589-87-7) can be used in organic synthesis.

1-Bromo-4-iodobenzene Toxicity Data With Reference

1-Bromo-4-iodobenzene (CAS NO.589-87-7) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

1-Bromo-4-iodobenzene Safety Profile

Hazard Codes: Xi
Risk Statements:
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing
S37/39: Wear suitable gloves and eye/face protection

1-Bromo-4-iodobenzene Specification

1-Bromo-4-iodobenzene , its cas register number is 589-87-7. It also can be called p-Bromoiodobenzene ; Benzene, 1-bromo-4-iodo- ; and p-Bromophenyl iodide . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, 1-Bromo-4-iodobenzene (CAS NO.589-87-7) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials, light. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide, hydrogen bromide, hydrogen iodide.

Product Name

1-Bromo-4-iodobenzene

Synthetic route

1-Bromo-4-iodobenzene Chemical Properties

1-Bromo-4-iodobenzene Uses

1-Bromo-4-iodobenzene Toxicity Data With Reference

1-Bromo-4-iodobenzene Safety Profile

1-Bromo-4-iodobenzene Specification

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