2,3,5-Trimethylphenol supplier

Name
2,3,5-Trimethylphenol
EINECS 211-806-9
CAS No. 697-82-5
Article Data62
CAS DataBase
Density 0.996 g/cm³
Solubility insoluble in water
Melting Point 92-95 °C(lit.)
Formula C₉H₁₂O
Boiling Point 231.1 °C at 760 mmHg
Molecular Weight 136.194
Flash Point 103.6 °C
Transport Information UN 2430 8/PG 3
Appearance White to off-white powder
Safety 26-36/37/39-45-24/25
Risk Codes 34-36/37/38
Molecular Structure
Hazard Symbols C, Xi
Synonyms Phenol,2,3,5-trimethyl-;1-Hydroxy-2, 3,5-trimethylbenzene;1-Hydroxy-2,3,5-trimethylbenzene;
PSA 20.23000
LogP 2.31740

Synthetic route

: O-(4-Nitrobenzyl)-2,3,5-trimethylphenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With indium; ammonium chloride In ethanol for 18h; Debenzylation; Heating;	100%
With indium; ammonium chloride In methanol for 18h; Heating;	100%

: 1,2,5-Trimethyl-3-trityloxy-benzene

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With tetrahydrofuran; titanium(III) chloride; lithium for 14h; Heating;	92%

: 312609-91-9
2,3,5-Trimethyl-(4-methylphenylsulfonyloxy)benzene

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With titanium(III) chloride; lithium In tetrahydrofuran at 25℃; for 18h; Substitution;	91%

: 773-01-3
2,4,6-trimethylpyrylium tetrafluoroborate

: 70775-39-2, 5367-24-8
dimethylsulfoxonium methylide

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
In tetrahydrofuran; dimethyl sulfoxide 1.) -5 deg C, 1 h, 2.) room temperature, 7 h;	80%

: 67-56-1
methanol

: 526-75-0
2,3-Dimethylphenol

A: 2416-94-6
2,3,6-trimethylphenol

B: 526-85-2
2,3,4-trimethylphenol

C: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
Pd-containing mordenite at 350℃;	A 80% B 5% C 5%

...Expand

: 67-56-1
methanol

: 108-68-9
3,5-Dimethylphenol

A: 527-54-8
3,4,5-trimethylphenol

B: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
Pd-containing mordenite at 350℃;	A 6% B 70%

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

A: 16308-92-2
2,4-dimethylbenzyl alcohol

B: 700-13-0
Trimethylhydroquinone

C: 496-78-6
2,4,5-trimethylphenol

D: 2416-94-6
2,3,6-trimethylphenol

E: 697-82-5
2,3,5-trimethylphenol

F: 53957-33-8
2,5-dimethylbenzyl alcohol

Conditions

Conditions	Yield
With glucose dehydrogenase; D-glucose; P450 BM3 R47S, Y51W, A330F, I401M mutant; NADPH; catalase; ascorbic acid In aq. phosphate buffer; dimethyl sulfoxide pH=7.5; Catalytic behavior; Enzymatic reaction;	A 25% B 23% C 28% D 5% E 8% F 9%

...Expand

: 50-00-0
formaldehyd

: 1123-09-7
3,5-dimethyl-2-cyclohexen-1-one

: 660-68-4
diethyl amine hydrochloride

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With hydrogenchloride; ethanol Behandeln des Reaktionsprodukts mit HCl in Aether und Erhitzen der erhaltenen Hydrochloride unter vermindertem Druck auf 200-235grad;

...Expand

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

A: 527-54-8
3,4,5-trimethylphenol

B: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With bromine; 1,2,4-Trichlorobenzene

: 68097-90-5
3,5-dimethyl-2-piperidin-1-ylmethyl-phenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With calcium hydroxide
With 1,4-dioxane; copper oxide-chromium oxide at 165℃; Hydrogenolyse;

: 14944-83-3
2-(Morpholinomethyl)-3,5-dimethylphenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With 1,4-dioxane; copper oxide-chromium oxide at 165℃; Hydrogenolyse;

: 578-58-5
2-methylmethoxybenzene

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With aluminium trichloride at 100℃;

: 527-54-8
3,4,5-trimethylphenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With aluminium trichloride at 100℃;

: 90416-29-8
2-chloro-3,5,6-trimethylphenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With sodium hydroxide; aluminum nickel

: 767-77-1
2,3,5-trimethylaniline

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
Diazotization;
With sulfuric acid; sodium nitrite 1.) 0 deg C, 1 h, 2.) reflux, 2 h; Yield given. Multistep reaction;

: 63487-28-5
2-Dimethylaminomethyl-3,5-dimethyl-phenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With 1,4-dioxane; copper oxide-chromium oxide at 165℃; Hydrogenolyse;

: 700-13-0
Trimethylhydroquinone

: 108-24-7
acetic anhydride

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid at 150℃;

: 103045-07-4
4-Hexadecyloxy-2,3,6-trimethyl-phenol

: 108-24-7
acetic anhydride

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid at 150℃;

: 873-94-9
dihydroisophorone

A: 527-54-8
3,4,5-trimethylphenol

B: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With sulfuric acid at 20℃;

: 67-56-1
methanol

: 108-68-9
3,5-Dimethylphenol

: 697-82-5
2,3,5-trimethylphenol

Conditions

Conditions	Yield
With activated bauxit at 450℃; under 12503.6 Torr;

: 67-56-1
methanol

: 108-68-9
3,5-Dimethylphenol

A: 697-82-5
2,3,5-trimethylphenol

B: 527-35-5
2,3,5,6-tetramethylphenol

C: 2819-86-5
pentamethylphenol

Conditions

Conditions	Yield
at 450℃; under 7355.08 - 12503.6 Torr; Leiten ueber aktivierten Bauxit;

...Expand

: 697-82-5
2,3,5-trimethylphenol

: 96-32-2
bromoacetic acid methyl ester

: 95450-49-0
(2,3,5-Trimethyl-phenoxy)-acetic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In butanone for 5.5h; Heating;	100%

: 358-23-6
trifluoromethylsulfonic anhydride

: 697-82-5
2,3,5-trimethylphenol

: 209684-76-4
2,3,5-Trimethylphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
In pyridine at 0 - 20℃; for 1h;	100%
With triethylamine In toluene at 20℃; Flow reactor;

: 697-82-5
2,3,5-trimethylphenol

: 74-88-4
methyl iodide

: 20469-61-8
2,3,5-trimethylanisole

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide for 10h; Ambient temperature;	99.8%
With sodium hydride In dimethyl sulfoxide for 10h;	98%
Stage #1: 2,3,5-trimethylphenol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: methyl iodide In tetrahydrofuran at 0℃; for 3h;	92%

: 697-82-5
2,3,5-trimethylphenol

: 1394064-56-2
C18H23O2PS2

Conditions

Conditions	Yield
With tetraphosphorus decasulfide for 0.0694444h; Microwave irradiation;	99.3%

: 697-82-5
2,3,5-trimethylphenol

: 616-38-6
carbonic acid dimethyl ester

: 20469-61-8
2,3,5-trimethylanisole

Conditions

Conditions	Yield
With dimanganese decacarbonyl at 180℃; for 1h; Reagent/catalyst;	99%

: 697-82-5
2,3,5-trimethylphenol

: 121-44-8
triethylamine

: 1394064-58-4
C18H23O2PS2*C6H15N

Conditions

Conditions	Yield
Stage #1: 2,3,5-trimethylphenol With tetraphosphorus decasulfide In chloroform at 35℃; Stage #2: triethylamine In chloroform	98%

: 697-82-5
2,3,5-trimethylphenol

: 802294-64-0
propionic acid

: 2-ethyl-3,5,7,8-tetramethyl-4H-chromen-4-one

Conditions

Conditions	Yield
With titanium tetrachloride In neat (no solvent) at 100℃; for 5h; Inert atmosphere;	98%

: 62452-62-4
benzofuran-2-ylmethyl acetate

: 697-82-5
2,3,5-trimethylphenol

: C18H18O2

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; XPhos In tetrahydrofuran; acetonitrile at 120℃; Inert atmosphere; regioselective reaction;	98%

: 697-82-5
2,3,5-trimethylphenol

: 563-47-3
3-Chloro-2-methylpropene

: 142874-36-0
2,3,5-Trimethyl-1-(2-methyl-2-propenyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide; acetone Heating;	97%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;

: 697-82-5
2,3,5-trimethylphenol

: 935-92-2
2,3,5-Trimethyl-1,4-benzoquinone

Conditions

Conditions	Yield
With titanium superoxide; dihydrogen peroxide; acetic acid In water at 50℃; for 2h;	96%
With oxygen In water; acetonitrile at 40℃; under 15001.5 Torr; for 1h; Green chemistry;	94%
With 5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin; oxygen In chloroform; acetonitrile for 24h; Product distribution; Further Variations:; Reagents; Irradiation;	93%

: 619-73-8
4-nitrobenzyl chloride

: 697-82-5
2,3,5-trimethylphenol

: O-(4-Nitrobenzyl)-2,3,5-trimethylphenol

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 3h;	96%

: 1458-98-6
2-methyl-3-bromo-1-propene

: 697-82-5
2,3,5-trimethylphenol

: 142874-36-0
2,3,5-Trimethyl-1-(2-methyl-2-propenyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 15h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 15h;	96%

: 2290-65-5
trimethylsilyl isothiocyanate

: 697-82-5
2,3,5-trimethylphenol

: 196944-10-2
2,3,5-trimethyl-4-thiocyanatophenol

Conditions

Conditions	Yield
With 1-chloro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one In dichloromethane at 20℃; for 1h;	96%

: 697-82-5
2,3,5-trimethylphenol

: 106-95-6
allyl bromide

: 53546-78-4
1,2,5-trimethyl-3-(prop-2-en-1-yloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	95%
With potassium carbonate; acetone
With sodium hydroxide In N,N-dimethyl-formamide

: 697-82-5
2,3,5-trimethylphenol

: 4-bromo-2,3,5-trimethylphenol

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In methanol; dichloromethane for 0.333333h;	95%
With 1-butyl-3-methylimidazolium tribromide at -10℃;	86%

: 697-82-5
2,3,5-trimethylphenol

: 598-21-0
2-Bromoacetyl bromide

: 110699-68-8
Bromo-acetic acid 2,3,5-trimethyl-phenyl ester

Conditions

Conditions	Yield
With pyridine In diethyl ether for 1h; Ambient temperature;	94%

: 697-82-5
2,3,5-trimethylphenol

: 116-02-9
2,3,5-trimethylcyclohexanol

Conditions

Conditions	Yield
With potassium hydroxide; Raney Ni-Al; water at 90℃; for 20h;	91.2%
With nickel at 155℃; Hydrogenation;
With nickel; sodium(2,3,5-(methyl)3phenoxide) at 170℃; under 95616 - 110326 Torr; Hydrogenation;

: 697-82-5
2,3,5-trimethylphenol

: 7282-02-2
4-iodo-2,3,5-trimethyl-phenol

Conditions

Conditions	Yield
With iodine; oxygen; copper(II) nitrate In water at 80℃; under 760.051 Torr; for 3h; Green chemistry; regioselective reaction;	91%
With hydrogenchloride; potassium iodate; potassium iodide In methanol at 20℃; for 0.5h;	62.2%

: 697-82-5
2,3,5-trimethylphenol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 1-(2,2-diethoxyethoxy)-2,3,5-trimethylbenzene

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl acetamide at 20℃; Heating;	91%

: 3805-10-5
2,2-(dimethyl)-2-phenylacetaldehyde

: 697-82-5
2,3,5-trimethylphenol

: 142874-60-0
2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydrobenzofuran

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In toluene at 110℃; for 1h;	90%

: 628-34-2
2-chloroethyl ethyl ether

: 697-82-5
2,3,5-trimethylphenol

: 865138-71-2
1-(2-ethoxyethoxy)-2,3,5-trimethylbenzene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20 - 70℃; for 48h;	90%

: 697-82-5
2,3,5-trimethylphenol

: 116760-59-9
4,4-dimethoxy-3,5-dimethylcyclohexa-2,5-dien-1-one

: 5-methoxy-2',3',4,6,6'-pentamethyl-[1,1'-biphenyl]-2,4'-diol

Conditions

Conditions	Yield
With methanesulfonic acid at 20℃; regioselective reaction;	90%

: 697-82-5
2,3,5-trimethylphenol

: 471-25-0
Propiolic acid

: 40662-19-9
5,7,8-trimethyl-2H-chromen-2-one

Conditions

Conditions	Yield
With C62H54Cl2N4Pd2; trifluoroacetic acid at 20℃; for 12.0833h; Cooling with ice; regioselective reaction;	90%

: 697-82-5
2,3,5-trimethylphenol

: 103187-28-6
7-(4-fluorophenyl)-7-hydroxyheptanoic acid

: 121099-61-4
7-(4-fluorophenyl)-7-(2-hydroxy-3,4,6-trimethylphenyl)heptanoic acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In 1,2-dichloro-ethane at 60℃; for 6h;	89%

: 697-82-5
2,3,5-trimethylphenol

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 156462-53-2
ethyl 2-(2,3,5-trimethylphenyl)oxypropionate

Conditions

Conditions	Yield
With potassium iodide In N,N-dimethyl-formamide; acetone Heating;	89%

: 697-82-5
2,3,5-trimethylphenol

: 820258-31-9
1-(3-methoxyphenyl)-2-(2,3,5-trimethylphenoxy)ethanone

Conditions

Conditions	Yield
	88%

: 697-82-5
2,3,5-trimethylphenol

: 802294-64-0
propionic acid

: 2,3,5-trimethylphenyl propionate

Conditions

Conditions	Yield
With tin(IV) chloride In neat (no solvent) at 100℃; for 8h; Inert atmosphere; chemoselective reaction;	88%

2,3,5-Trimethylphenol Chemical Properties

IUPAC Name: 2,3,5-trimethylphenol
The Molecular formula of 2,3,5-Trimethylphenol (697-82-5) : C₉H₁₂O
The Molecular Weight of 2,3,5-Trimethylphenol (697-82-5) : 136.19
Molecular Structure :
EINECS: 211-806-9
Melting point: 92-95 °C(lit.)
Boiling point: 231.1 °C at 760 mmHg
Flash point: 103.6 °C
Density: 0.996 g/cm3
Vapour Pressure: 0.0419 mmHg at 25°C
Storage temp.: Store in dark
Solubility: insoluble
Water Solubility: insoluble
Synonyms: ISOPSEUDOCUMENOL;2,3,5-Trimethylphenol/TMP/Isopseudocumenol; 2,3,5-Thrimethylphenol;AKOS BBS-00008093;2,3,5-trimethyl-pheno;2,3,5-TRIMETHYLPHENOL;6-HYDROXYPSEUDOCUMENE;1-Hydroxy-2,3,5-trimethylbenzene;

2,3,5-Trimethylphenol Uses

2,3,5-Trimethylphenol (697-82-5) is used for synthesis of aromatic vitamin A acid.

2,3,5-Trimethylphenol Safety Profile

The Hazard Codes of 2,3,5-Trimethylphenol (697-82-5): C, Xi
The Risk Statements information of 2,3,5-Trimethylphenol (697-82-5):
34: Causes burns
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2,3,5-Trimethylphenol (697-82-5):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
HazardClass: 8
PackingGroup: III
HS Code: 29071900
RIDADR: UN 2430 8/PG 3
WGK Germany: 3

Product Name

2,3,5-Trimethylphenol

Synthetic route

2,3,5-Trimethylphenol Chemical Properties

2,3,5-Trimethylphenol Uses

2,3,5-Trimethylphenol Safety Profile

Related Products

Hot Products