2,6-LUTIDINE supplier | CasNO.108-48-5

Name
2,6-Lutidine
EINECS 203-587-3
CAS No. 108-48-5
Article Data120
CAS DataBase
Density 0.9252 g/cm³
Solubility 40 g/100 mL (20 °C) in water
Melting Point -6 °C
Formula C₇H₉N
Boiling Point 144 °C at 760 mmHg
Molecular Weight 107.155
Flash Point 33.3 °C
Transport Information UN 1993 3/PG 3
Appearance Colorless to yellow liquid
Safety 26-36/37-16-36-36/37/39
Risk Codes 10-22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms a,a'-Lutidine;2,6-Dimethylpyridine;NSC 2155;a,a'-Dimethylpyridine;2,6-Lutidine(8CI);
PSA 12.89000
LogP 1.69840

Synthetic route

: 108-48-5
2,6-dimethylpyridine

: C25H12BF18N

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

A: 108-48-5
2,6-dimethylpyridine

B

C

Conditions

Conditions	Yield
In hexane at 60℃; for 10h;	A n/a B n/a C 68%

...Expand

2.6-bis(hydroxymethyl)pyridine: 2.6-bis(hydroxymethyl)pyridine

A: 108-48-5
2,6-dimethylpyridine

B: 1122-71-0
2-(Hydroxymethyl)-6-methylpyridine

Conditions

Conditions	Yield
With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube;	A 64% B 10%

: 67-64-1
acetone

: 74-86-2
acetylene

A: 109-06-8
α-picoline

B: 108-48-5
2,6-dimethylpyridine

C: 108-75-8
2,4,6-trimethyl-pyridine

D: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
With ammonia; MG-4 at 375℃; under 760 Torr;	A 6.3% B 7.3% C 58.3% D 5.9%
With ammonia; MG-4 at 375℃; under 760 Torr; Product distribution; other catalysts;	A 6.3% B 7.3% C 58.3% D 5.9%
With ammonia; MG-4 at 350℃; under 760 Torr;	A 6.2% B 15.6% C 36.4% D 6.8%

...Expand

: 504-03-0
2.6-dimethylpiperidine

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With [iPrPN(H)P]2Fe(H)(CO)(BH4) In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 30h; Inert atmosphere; Schlenk technique; Glovebox;	58%
With OsH3(acac)(PiPr3)2 In para-xylene at 140℃; for 48h; Schlenk technique; Irradiation;	29 %Chromat.
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In para-xylene for 20h; Reflux; Inert atmosphere; Schlenk technique;	88 %Chromat.
In octane at 120℃; under 760.051 Torr; for 18h; Inert atmosphere; Schlenk technique;	>99 %Chromat.
With tert-butylethylene; C21H26ClIrNOP; sodium t-butanolate In para-xylene at 150℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	88 %Chromat.

: 598-32-3
2-hydroxy-3-butene

: 18312-45-3
propan-2-one O-acetyl oxime

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With oxygen; copper diacetate; palladium diacetate; potassium carbonate In acetonitrile at 80℃; under 760.051 Torr; Heck Reaction;	52%

: 1073-23-0
2,6-lutidine N-oxide

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

A: 108-48-5
2,6-dimethylpyridine

B: C10H14N2OS

Conditions

Conditions	Yield
In acetonitrile at 81℃; for 4h;	A 51% B 14%

...Expand

: 78-93-3
butanone

A: 108-48-5
2,6-dimethylpyridine

B: 583-61-9
2,3-Lutidine

C: 1462-84-6
2,3,6-trimethylpyridine

D: 2233-29-6
2,3,4-lutidine

Conditions

Conditions	Yield
With ammonia; chromium(III) oxide; aluminium at 375℃;	A 6.8% B 24.6% C 45.4% D 25.7%
With ammonia; chromium(III) oxide; aluminium at 425℃;	A 25.3% B 34.5% C 13.8% D 13.8%
With ammonia; chromium(III) oxide; aluminium at 450℃;	A 21.8% B 22.4% C 29.4% D 11.7%
With ammonia; chromium(III) oxide; aluminium at 300 - 450℃; Product distribution;

...Expand

: 87117-15-5
1-methoxy-2,6-dimethylpyridinium methyl sulfate

A: 108-48-5
2,6-dimethylpyridine

B: 696-44-6
N-methyl-m-toluidine

Conditions

Conditions	Yield
With Dimethylammonium sulphite In water at 150℃; for 24h;	A 20% B 42%

: 20451-53-0
Phenyl vinyl sulfoxide

: 77202-09-6
4,6-dimethyl-1,2,3-triazine

A: 108-48-5
2,6-dimethylpyridine

B: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
at 180℃; 1-2.5 h;	A n/a B 35%

...Expand

: 123-39-7
N-Methylformamide

: 1073-23-0
2,6-lutidine N-oxide

A: 108-48-5
2,6-dimethylpyridine

B: 107427-72-5
N,2,6-trimethylpyridine-4-carboxamide

Conditions

Conditions	Yield
for 29h; Heating;	A 32% B 8%

...Expand

: 109-06-8
α-picoline

: 67-56-1
methanol

A: 100-69-6
2-vinylpyridine

B: 108-48-5
2,6-dimethylpyridine

C: 100-71-0
2-Ethylpyridine

D: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
Cs exchanged zeolite at 450℃; Product distribution; investigation of the heterogeneous vapor-phase alkylation of α-picoline with methanol over Na+, K+, Rb+, or Cs+ exchanged X- or Y-type zeolite in an atmosphere of nitrogen;	A 3.1% B 7.3% C 30.2% D 3.6%

...Expand

: 109-06-8
α-picoline

A: 110-86-1
pyridine

B: 108-48-5
2,6-dimethylpyridine

C: 583-61-9
2,3-Lutidine

D: 589-93-5
2,5-dimethylpyridine

Conditions

Conditions	Yield
With hydrogen; aluminum oxide; nickel at 330℃; under 750.06 Torr; Product distribution;	A 14.9% B 11.4% C 3% D 1.6%

...Expand

: 1073-23-0
2,6-lutidine N-oxide

: 58109-40-3
diphenyliodonium hexafluorophosphate

A: 108-48-5
2,6-dimethylpyridine

B: 1391814-69-9
2-(2-methylpyridin-1-ium-1-yl)phenolate

Conditions

Conditions	Yield
Stage #1: 2,6-lutidine N-oxide; diphenyliodonium hexafluorophosphate In 1,2-dichloro-ethane at 120℃; for 48h; Inert atmosphere; Schlenk technique; Stage #2: With potassium carbonate In methanol; 1,2-dichloro-ethane at 20℃; for 1h;	A n/a B 13%

...Expand

: 110-86-1
pyridine

: 64-17-5
ethanol

A: 100-69-6
2-vinylpyridine

B: 108-48-5
2,6-dimethylpyridine

C

D: 100-71-0
2-Ethylpyridine

E: 536-75-4
4-Ethylpyridine

Conditions

Conditions	Yield
Cs exchanged zeolite at 450℃; Product distribution; investigation of the heterogeneous vapor-phase alkylation of pyridine with ethanol over Na+, K+, Rb+, or Cs+ exchanged X- or Y-type zeolite in an atmosphere of nitrogen;	A 1.3% B 1.1% C 1.1% D 5.9% E 3.2%

...Expand

: 3512-75-2
4-chloro-2,6-lutidine

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
durch Zinkstaub-Destillation;
bei der Zinkstaub-Destillation;

: 3430-31-7
3-bromo-2,6-dimethylpyridine

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With hydrogenchloride; zinc

: 5860-71-9
2,6-dimethylpyridine-3-carboxylic acid

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With soda lime at 300℃;

: 7516-31-6
2,6-dimethyl-1H-pyridin-4-one

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
durch Zinkstaub-Destillation;

: 690-94-8
dimethyl(vinylethynyl)carbinol

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With aluminum oxide; ammonia; cadmium(II) oxide at 360℃;
With chromium oxide-aluminium oxide-manganese oxide catalyst; ammonia at 420℃;

: 13505-34-5
2,6-heptandione

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With ethanol; ammonia Erhitzen des Reaktionsprodukts mit Xylol unter Durchleiten von Sauerstoff;

: 50-00-0
formaldehyd

: 67-64-1
acetone

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With aluminum oxide; ammonia; water at 340℃;
With ammonia; zeolite Gas phase;

: 110-86-1
pyridine

: 67-56-1
methanol

A: 109-06-8
α-picoline

B: 108-89-4
picoline

C: 108-48-5
2,6-dimethylpyridine

D: 100-71-0
2-Ethylpyridine

Conditions

Conditions	Yield
cation-exchanged zeolite; CsY at 400℃; Further byproducts given;	A 6.9 % Chromat. B 3.0 % Chromat. C 3.3 % Chromat. D 3.0 % Chromat.

...Expand

: 110-86-1
pyridine

: 67-56-1
methanol

A: 109-06-8
α-picoline

B: 108-89-4
picoline

C: 108-48-5
2,6-dimethylpyridine

D: 536-75-4
4-Ethylpyridine

Conditions

Conditions	Yield
cation-exchanged zeolite at 400℃;	A 6.8 % Chromat. B 2.3 % Chromat. C 2.5 % Chromat. D 0.6 % Chromat.

...Expand

: 110-86-1
pyridine

: 67-56-1
methanol

A: 109-06-8
α-picoline

B: 108-89-4
picoline

C: 108-48-5
2,6-dimethylpyridine

D: 108-99-6
3-Methylpyridine

Conditions

Conditions	Yield
BaX zeolite at 400℃; Further byproducts given;	A 19.7 % Chromat. B 9.0 % Chromat. C 2.5 % Chromat. D 4.1 % Chromat.

...Expand

: 110-86-1
pyridine

: 67-56-1
methanol

A: 109-06-8
α-picoline

B: 108-89-4
picoline

C: 108-48-5
2,6-dimethylpyridine

D: 108-99-6
3-Methylpyridine

E: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
BaY; cation-exchanged zeolite at 400℃; Product distribution; various H and alkaline or alkaline earth cation-exchanged X or Y type zeolite catalysts;	A 22.7 % Chromat. B 7.6 % Chromat. C 10.7 % Chromat. D 3.8 % Chromat. E 10.7 % Chromat.

...Expand

: 110-86-1
pyridine

: 67-56-1
methanol

A: 109-06-8
α-picoline

B: 108-89-4
picoline

C: 108-48-5
2,6-dimethylpyridine

D: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
BaY; cation-exchanged zeolite at 400℃; Further byproducts given;	A 22.7 % Chromat. B 7.6 % Chromat. C 10.7 % Chromat. D 10.7 % Chromat.
SrY; cation-exchanged zeolite at 400℃; Further byproducts given;	A 22.3 % Chromat. B 7.4 % Chromat. C 10.9 % Chromat. D 10.8 % Chromat.

...Expand

2,6-LUTIDINE Chemical Properties

Molecular Formula: C₇H₉N

Formula Weight: 107.15
mp of 2,6-LUTIDINE (108-48-5): -6 ^°C
bp : 143-145 ^°C(lit.)
density : 0.92 g/mL at 25 ^°C(lit.)
refractive index : n20/D 1.497(lit.)
Fp of 2,6-LUTIDINE (108-48-5): 92 ^°F
storage temp. : -20^°C
Water Solubility : 40 g/100 mL (20 ^oC)
Odor: Characteristic.
Color: Straw color.
Solubility: Easily soluble in cold water.
2,6-LUTIDINE (108-48-5) is a colorless to yellow oily liquid.

2,6-LUTIDINE Uses

In organic synthesis, 2,6-LUTIDINE (108-48-5) is widely used as a sterically hindered mild base. It is also used as a vulcanization accelerator for pesticides, dyes, dyes, resins and rubber. And also can be used as a solvent.

2,6-LUTIDINE Production

Recycling β-methylpyridine fractions from coal by-products of coking, then separating β-methylpyridine fractions, we can obtain 2,6-LUTIDINE (108-48-5).

2,6-LUTIDINE Toxicity Data With Reference

1.	sln-smc 5000 ppm	MUREAV Mutation Research. 163 (1986),23.
2.	orl-rat LD50:400 mg/kg	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.
3.	ihl-rat LCLo:7500 ppm/1H	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.
4.	skn-gpg LD50:2500 mg/kg	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.

2,6-LUTIDINE Consensus Reports

Reported in EPA TSCA Inventory.

2,6-LUTIDINE Safety Profile

Hazard Codes : Xn,F,Xi (Harmful; Highly Flammable; Irritant)
Risk Statements : 10-22-36/37/38-20/21/22 (Flammable; Harmful if swallowed; Irritating to eyes, respiratory system and skin; Harmful by inhalation, in contact with skin and if swallowed)
Safety Statements : 26-36/37-16-36-36/37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing and gloves; Keep away from sources of ignition - No smoking; Wear suitable protective clothing; Wear suitable protective clothing, gloves and eye/face protection)
RIDADR : UN 1993 3/PG 3
WGK Germany : 3
RTECS : OK9700000
F : 8 (Photosensitive)
Hazard Note : Irritant/Flammable
HazardClass : 3
PackingGroup : III
HS Code : 29333999
Poison by ingestion. Moderately toxic by skin contact. Mildly toxic by inhalation. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.

2,6-LUTIDINE Specification

Storage: Keep container tightly closed. Keep in a cool, well-ventilated place. Keep away from heat. Keep
away from sources of ignition. A refrigerated room would be preferable for materials with a flash point lower than
37.8^°C (100^°F). Flammable materials should be stored in a separate safety storage cabinet or room. Ground all
equipment containing material.

Product Name

2,6-Lutidine

Synthetic route

2,6-LUTIDINE Chemical Properties

2,6-LUTIDINE Uses

2,6-LUTIDINE Production

2,6-LUTIDINE Toxicity Data With Reference

2,6-LUTIDINE Consensus Reports

2,6-LUTIDINE Safety Profile

2,6-LUTIDINE Specification

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