2-Bromopropionyl bromide supplier

Name
2-Bromopropionyl bromide
EINECS 209-261-7
CAS No. 563-76-8
Article Data22
CAS DataBase
Density 2.118 g/cm³
Solubility
Melting Point
Formula C₃H₄Br₂O
Boiling Point 154.6 °C at 760 mmHg
Molecular Weight 215.872
Flash Point 66.5 °C
Transport Information UN 3265 8/PG 2
Appearance Pale yellow transparent liquid
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols
Synonyms Propionylbromide, 2-bromo- (6CI,7CI);2-Bromopropanoyl bromide;DL-2-Bromopropionyl bromide;a-Bromopropanyl bromide;a-Bromopropionyl bromide;
PSA 17.07000
LogP 1.69130

Synthetic route

: 13195-80-7
1,1-dibromopropene

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
With oxygen at 20℃;

: 598-22-1
propanoyl bromide

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
With bromine at 100℃;

: 79-03-8
propionyl chloride

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
durch Bromierung;

: 79-03-8
propionyl chloride

A: 563-76-8
α-bromopropionyl bromide

B: 7148-74-5
2-Bromopropionyl chloride

Conditions

Conditions	Yield
With bromine am besten im Sonnenlicht;

: 802294-64-0
propionic acid

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
With phosphorus; bromine zuletzt unter Erwaermen;
With bromine; sulfur zuletzt unter Erwaermen;
With phosphorus; bromine
With phosphorus; bromine; sodium hydroxide at 110℃; Hell-Vollard-Zelinsky halogenation; regioselective reaction;
With bromine; phosphorus tribromide at 80℃; for 3.5h; Inert atmosphere; Schlenk technique;

: 105-37-3
Ethyl propionate

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
With phosphorus; bromine

: 598-72-1
2-Bromopropionic acid

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
With phosphorus; bromine

: 7726-95-6
bromine

: 79-03-8
propionyl chloride

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
at 80℃;

: 7726-95-6
bromine

: 79-03-8
propionyl chloride

A: 563-76-8
α-bromopropionyl bromide

B: 7148-74-5
2-Bromopropionyl chloride

...Expand

: 7726-95-6
bromine

: 802294-64-0
propionic acid

red phosphorus: red phosphorus

: 563-76-8
α-bromopropionyl bromide

...Expand

: 7726-95-6
bromine

: 105-37-3
Ethyl propionate

red phosphorus: red phosphorus

A: 74-96-4
ethyl bromide

B: 563-76-8
α-bromopropionyl bromide

...Expand

: 13195-80-7
1,1-dibromopropene

oxygen: oxygen

: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
at 20℃;

: 13195-80-7
1,1-dibromopropene

: 7732-18-5
water

oxygen: oxygen

A: 14602-62-1
1,1,2-tribromo-propane

B: 563-76-8
α-bromopropionyl bromide

Conditions

Conditions	Yield
at 20℃;

...Expand

: 563-76-8
α-bromopropionyl bromide

: 71-43-2
benzene

: 2114-00-3
2-bromo-1-phenyl-1-propanone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 20 - 40℃; for 2.5h;	100%
With aluminum (III) chloride at 20 - 30℃; for 3h; Friedel-Crafts Acylation;	90.1%
With carbon disulfide; aluminium trichloride
With aluminium trichloride

: 372-18-9
1,3-Difluorobenzene

: 563-76-8
α-bromopropionyl bromide

: 135206-83-6
2-bromo-1-(2,4-difluorophenyl)-1-propanone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 20 - 40℃; for 3.5h;	100%
With aluminium trichloride at 25 - 30℃; for 4h;	96%

: 563-76-8
α-bromopropionyl bromide

: 107-18-6
allyl alcohol

: 87129-38-2
allyl α-bromopropionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 20℃; for 18h;	76%
With pyridine In dichloromethane 1) 0 deg C, 1 h, 2) r.t, overnight;	70%
With dmap; triethylamine In dichloromethane at 0 - 23℃;

: 57-88-5
cholesterol

: 563-76-8
α-bromopropionyl bromide

: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2-bromopropanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane Acylation;	100%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 563-76-8
α-bromopropionyl bromide

: 2-bromo-N-methoxy-N-methylpropanamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	100%

: 563-76-8
α-bromopropionyl bromide

: 132416-36-5
4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine

: 1258873-86-7
C20H30BrNO3

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 17h; Cooling;	100%

: 100-02-7
4-nitro-phenol

: 563-76-8
α-bromopropionyl bromide

: 56985-87-6
p‐nitrophenyl 2‐bromopropionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%
With triethylamine In dichloromethane at 0℃; for 1h;

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 563-76-8
α-bromopropionyl bromide

: 118484-79-0
2-bromo-1-(3,4-dihydroquinolin-1(2H)-yl)propan-1-one

Conditions

Conditions	Yield
With pyridine In dichloromethane at -78 - 20℃; for 1.75h;	100%

: 563-76-8
α-bromopropionyl bromide

: 100-61-8
N-methylaniline

: 2620-11-3
2-bromo-N-methyl-N-phenylpropanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 20h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 0 - 20℃; for 20h;	99%
In benzene at 20℃;	95%

: 563-76-8
α-bromopropionyl bromide

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

: 153880-69-4
N-(4-methoxyphenyl)-N-methyl-2-bromopropionylamide

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 2h; Heating;	99%

: 563-76-8
α-bromopropionyl bromide

: 1745-81-9
2-Allylphenol

: 2-bromo-propionic acid 2-allyl-phenyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 18h;	99%

: 563-76-8
α-bromopropionyl bromide

: 85-91-6
Methyl N-methylanthranilate

: methyl 2-(N-(2-bromopropionyl)-N-methylamino)benzoate

Conditions

Conditions	Yield
In dichloromethane at 20℃;	99%

: 118-72-9
2,6-dimethylbenzene-1-thiol

: 563-76-8
α-bromopropionyl bromide

: 1247748-11-3
S-2,6-dimethylphenyl α-bromothiopropionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	99%
Stage #1: 2,6-dimethylbenzene-1-thiol; α-bromopropionyl bromide With pyridine In dichloromethane at 0℃; Inert atmosphere; Stage #2: With dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	63%

: 108-98-5
thiophenol

: 563-76-8
α-bromopropionyl bromide

: 120346-72-7
S-phenyl α-bromothiopropionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	99%
Stage #1: thiophenol; α-bromopropionyl bromide With pyridine In dichloromethane at 0℃; Inert atmosphere; Stage #2: With dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	50%

: 1120-48-5
n-dioctylamine

: 563-76-8
α-bromopropionyl bromide

: 2-bromo-N,N-dioctylpropanamide

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 0 - 20℃; for 2h;	99%

: 563-76-8
α-bromopropionyl bromide

: 116-09-6
hydroxy-2-propanone

: 2-bromopropionic acid 2-oxopropyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 0.5h;	99%

: 89-95-2
2-methyl-benzyl alcohol

: 563-76-8
α-bromopropionyl bromide

: 2-(2-bromopropionyloxy)benzaldehyde

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 0.583333h;	98.1%

: 563-76-8
α-bromopropionyl bromide

: 6004-44-0
prop-1-en-1-one

Conditions

Conditions	Yield
With zinc In diethyl ether at 20℃; Solvent;	98%

: 5589-62-8
2-(benzylamino)benzonitrile

: 563-76-8
α-bromopropionyl bromide

: 106874-99-1
N-benzyl-N-(2-bromopropionyl)-2-cyanoaniline

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane Ambient temperature;	98%

: 65253-04-5
(-)-8-phenylmenthol

: 563-76-8
α-bromopropionyl bromide

: 203253-68-3
2-Bromo-propionic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Conditions

Conditions	Yield
With N,N-dimethyl-aniline In diethyl ether 1.) 0 deg C, 3 h, 2.) reflux, 3 h;	98%
With pyridine In dichloromethane Esterification; -5 deg C -> r.t., 2 h;	97%

: 2038-57-5
3-Phenylpropan-1-amine

: 563-76-8
α-bromopropionyl bromide

: 220316-75-6
N-(3-phenylpropyl)-2-bromopropionamide

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 2h; Acylation;	98%

: 563-76-8
α-bromopropionyl bromide

polymer, 5-(2-hydroxyethyl)thiophen-2-yl-terminated poly(3-hexylthiophene), degree of polymerization 46, polydispersity index 1.28; monomer(s): 2-bromo-3-hexylthiophene; 5-[2-(2-tetrahydropyranyloxy)ethyl]thiopen-2-yl zinc chloride: polymer, 5-(2-hydroxyethyl)thiophen-2-yl-terminated poly(3-hexylthiophene), degree of polymerization 46, polydispersity index 1.28; monomer(s): 2-bromo-3-hexylthiophene; 5-[2-(2-tetrahydropyranyloxy)ethyl]thiopen-2-yl zinc chloride

polymer, 5-(Br(CH3)CHCOOCH2CH2)-thiophen-2-yl-terminated poly(3-hexylthiophene); monomer(s): 2-bromo-3-hexylthiophene; 5-[2-(2-tetrahydropyranyloxy)ethyl]thiopen-2-yl zinc chloride; 2-bromopropionyl bromide: polymer, 5-(Br(CH3)CHCOOCH2CH2)-thiophen-2-yl-terminated poly(3-hexylthiophene); monomer(s): 2-bromo-3-hexylthiophene; 5-[2-(2-tetrahydropyranyloxy)ethyl]thiopen-2-yl zinc chloride; 2-bromopropionyl bromide

Conditions

Conditions	Yield
With trimethylamine In tetrahydrofuran at 25℃;	98%

: 104-54-1
3-Phenylpropenol

: 563-76-8
α-bromopropionyl bromide

: 40630-85-1
cinnamyl 2-bromopropanoate

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 0℃; for 0.666667h; Inert atmosphere;	98%
With pyridine; dmap In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; Schlenk technique;	5.7 g

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 563-76-8
α-bromopropionyl bromide

: C13H16BrNO3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	98%

: 563-76-8
α-bromopropionyl bromide

: 221534-51-6
1,2-O-ethylene-4,5-O-methylene-β-D-fructopyranose

: 239446-13-0
C12H17BrO7

Conditions

Conditions	Yield
With pyridine In dichloromethane Esterification; -5 deg C -> r.t., 2 h;	97%

: 22717-57-3
methyl 6-hydroxy-m-toluate

: 563-76-8
α-bromopropionyl bromide

: methyl 2-(2-bromopropionyloxy)-5-methylbenzoate

Conditions

Conditions	Yield
In dichloromethane at 20℃;	97%

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 563-76-8
α-bromopropionyl bromide

: 872164-99-3
ethyl 2-(N-benzyl-2-bromopropanamido)acetate

Conditions

Conditions	Yield
With triethylamine In toluene for 3h; Heating;	97%

: 75-84-3
2,2-dimethyl-propanol-1

: 563-76-8
α-bromopropionyl bromide

: 5441-01-0
2,2-dimethylpropyl 2-bromopropanoate

Conditions

Conditions	Yield
With pyridine In dichloromethane	97%

: 66399-75-5, 84028-90-0
(S)-2-benzylamino-3-phenyl-propionic acid methyl ester

: 563-76-8
α-bromopropionyl bromide

: 1258512-80-9
(S)-(n-benzyl-N-(2-bromopropionyl))phenylalanine methyl esters

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 20℃; Inert atmosphere;	97%

: 66399-70-0
N-benzyl-L-leucine methyl ester

: 563-76-8
α-bromopropionyl bromide

: 1258512-81-0
(2S)-methyl 2-(n-benzyl-2-bromopropanamido)-4-methyl pentanoate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 20℃; Inert atmosphere;	97%

2-Bromopropionyl bromide Chemical Properties

IUPAC Name: 2-Bromopropanoyl bromide
Synonyms of 2-Bromopropionyl bromide (CAS NO.563-76-8): Propanoyl bromide, 2-bromo-
CAS NO: 563-76-8
Molecular Formula: C₃H₄Br₂O
Molecular Weight : 215.8713
Molecular Structure:
EINECS: 209-261-7
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.528
Molar Refractivity: 31.39 cm³
Molar Volume: 101.9 cm³
Surface Tension: 41.2 dyne/cm
Density: 2.118 g/cm³
Flash Point: 66.5 °C
Enthalpy of Vaporization: 39.13 kJ/mol
Boiling Point: 154.6 °C at 760 mmHg
Vapour Pressure: 3.16 mmHg at 25°C
Sensitive : Moisture Sensitive
Appearance: 2-Bromopropionyl bromide (CAS NO.563-76-8) is colorless or light yellow liquidSolubility: miscibility with benzene, acetic acid and propionic acid .
Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks

2-Bromopropionyl bromide Uses

2-Bromopropionyl bromide (CAS NO.563-76-8) is used as a intermediates of medicine and pesticide .

2-Bromopropionyl bromide Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 22-34
R22: Harmful if swallowed.
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: II

2-Bromopropionyl bromide Specification

2-Bromopropionyl bromide (CAS NO.563-76-8) decomposes with water and alcohol.

Product Name

2-Bromopropionyl bromide

Synthetic route

2-Bromopropionyl bromide Chemical Properties

2-Bromopropionyl bromide Uses

2-Bromopropionyl bromide Safety Profile

2-Bromopropionyl bromide Specification

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