2-Ethoxyethanol supplier | CasNO.110-80-5

Name
2-Ethoxyethanol
EINECS 203-804-1
CAS No. 110-80-5
Article Data88
CAS DataBase
Density 0.915 g/cm³
Solubility miscible with water
Melting Point -100 °C
Formula C₄H₁₀O₂
Boiling Point 135.6 °C at 760 mmHg
Molecular Weight 90.1222
Flash Point 44 °C
Transport Information UN 1171 3/PG 3
Appearance clear, colorless, nearly odorless liquid
Safety 53-45
Risk Codes 60-61-10-20/21/22
Molecular Structure
Hazard Symbols T
Synonyms Ethanol, 2-ethoxy-;2-Ethoxyethyl alcohol;Bikanol E 1;Cellosolve;Dowanol EE;Ektasolve EE;Emkanol;Ethoxyethanol;Ethyl 2-hydroxyethyl ether;Ethyl Cellosolve;Ethyleneglycol ethyl ether;Ethylene glycol monoethyl ether;Glycol monoethyl ether;Monoethylene glycol ethyl ether;b-Ethoxyethanol;
PSA 29.46000
LogP 0.01520

Synthetic route

: 628-89-7
2-(2-Chloroethoxy)ethanol

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 3h; Catalytic behavior; Irradiation;	94%

: 75-21-8
oxirane

: 64-17-5
ethanol

A: 110-80-5
2-ethoxy-ethanol

B: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
at 149.84℃; under 22502.3 Torr; for 3h; Inert atmosphere;	A 79.3% B 21.4%

...Expand

: 75-21-8
oxirane

: 64-17-5
ethanol

: 124-38-9
carbon dioxide

A: 96-49-1
[1,3]-dioxolan-2-one

B: 110-80-5
2-ethoxy-ethanol

C: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With lanthanum(III) oxide; potassium iodide at 149.84℃; under 22502.3 Torr; for 3h;	A 77.3% B 14.1% C 6.8%

...Expand

: 75-21-8
oxirane

: 64-17-5
ethanol

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With carbon dioxide at 149.84℃; under 22502.3 Torr; for 3h;	47.2%
in Gegenwart aktivierten Hydrosilicaten;
With hydrogen fluoride at 81℃;

: 75-21-8
oxirane

: 64-17-5
ethanol

: 124-38-9
carbon dioxide

A: 96-49-1
[1,3]-dioxolan-2-one

B: 110-80-5
2-ethoxy-ethanol

C: 107-21-1
ethylene glycol

D: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
With sodium ethanolate; potassium bromide at 423℃; under 22502.3 Torr; for 3h;	A 44.4% B 6.5% C 39.2% D 29.6%
With sodium ethanolate at 149.84℃; under 22502.3 Torr; for 3h;	A 19.1% B 42.6% C 16.8% D 11.6%
With potassium ethoxide at 149.84℃; under 22502.3 Torr; for 3h;	A 33.1% B 28.3% C 21.6% D 12.8%

...Expand

: 75-21-8
oxirane

: 64-17-5
ethanol

A: 110-80-5
2-ethoxy-ethanol

B: 111-90-0
ethoxyethoxyethanol

Conditions

Conditions	Yield
With sulfuric acid at 100 - 130℃; im Autoklaven;
With toluene-4-sulfonic acid at 100 - 130℃;
With 2,3-Dimethylaniline at 100 - 130℃;
With sulfuric acid at 80 - 100℃;
With metal oxide at 100 - 130℃;

...Expand

: 75-21-8
oxirane

: 141-52-6
sodium ethanolate

: 110-80-5
2-ethoxy-ethanol

: 75-21-8
oxirane

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With nickel; barium(II) oxide at 130 - 150℃; Hydrogenation.unter Druck;

: 817-95-8
ethyl 2-ethoxyethanoate

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 4673-60-3
1-ethoxy-2-trityloxy-ethane

A: 110-80-5
2-ethoxy-ethanol

B: 629-14-1
monoethylene glycol diethyl ether

C: 519-73-3
triphenylmethane

D: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
at 325 - 330℃;

...Expand

: 7388-28-5, 10604-71-4, 24768-69-2, 26915-75-3, 50856-01-4, 92004-30-3
sodium 2-hydroxyethoxide

: 75-03-6
ethyl iodide

: 110-80-5
2-ethoxy-ethanol

: 75-03-6
ethyl iodide

: 107-21-1
ethylene glycol

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With sodium

: 74-96-4
ethyl bromide

: 107-07-3
2-chloro-ethanol

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With sodium hydroxide

: 64-67-5
diethyl sulfate

: 107-07-3
2-chloro-ethanol

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With sodium hydroxide

: 141-52-6
sodium ethanolate

: 107-07-3
2-chloro-ethanol

: 110-80-5
2-ethoxy-ethanol

: 497-26-7
2-methyl-1,3-dioxolane

: 97-93-8
triethylaluminum

A: 110-80-5
2-ethoxy-ethanol

B: 7795-91-7
2-(1-Methylpropoxy)ethanol

Conditions

Conditions	Yield
With diethylaluminium hydride In hexane; kerosene for 50h; Heating;	A 0.01 mol B 0.03 mol

...Expand

: 497-26-7
2-methyl-1,3-dioxolane

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With triethylaluminum; diethylaluminium hydride In hexane; kerosene for 25h; Heating;	0.02 mol

: 497-26-7
2-methyl-1,3-dioxolane

A: 110-80-5
2-ethoxy-ethanol

B: 64-17-5
ethanol

C: 74-84-0
ethane

D: 629-14-1
monoethylene glycol diethyl ether

E: 64-19-7
acetic acid

F: 141-78-6
ethyl acetate

Conditions

Conditions	Yield
With hydrogen; Pt-Cab-O-Sil at 300℃; Product distribution; Mechanism; var. of catalyst, temp.;

...Expand

: 497-26-7
2-methyl-1,3-dioxolane

A: 110-80-5
2-ethoxy-ethanol

B: 141-78-6
ethyl acetate

Conditions

Conditions	Yield
With hydrogen; Pt on Cab-O-Sil at 200℃; Product distribution; Mechanism; var. of H2 coverage, temp.;

: 41051-51-8
2-ethoxyethyl nitrite

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With 2,2-dimethyl-propanol-1 In chloroform at 26℃; Equilibrium constant; Mechanism; var. alcohols;
With hydrogenchloride; sodium perchlorate at 25℃; Rate constant; acetate buffer pH 2;
With tris-(2-chloro-ethyl)-amine In 1,4-dioxane; water at 25℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.), solvent isotope effect (kH/kD);

: 34253-67-3
sulfuric acid mono-(2-ethoxy-ethyl ester)

: 110-80-5
2-ethoxy-ethanol

Conditions

Conditions	Yield
With sulfuric acid at 32.5℃; Equilibrium constant;

: 77078-19-4
ethylene glycol sec-butyl ethyl ether

A: 106-98-9
1-butylene

B: 110-80-5
2-ethoxy-ethanol

C: 590-18-1
(Z)-2-Butene

D: 624-64-6
trans-2-Butene

Conditions

Conditions	Yield
KU-23 sulfonated cation-exchange resins at 130℃; Equilibrium constant; other temperature;;

...Expand

: 201230-82-2
carbon monoxide

A: 67-56-1
methanol

B: 110-80-5
2-ethoxy-ethanol

C: 109-86-4
2-methoxy-ethanol

D: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With hydrogen; rhodium(III) acetylacetonate; tris(2,4-pentanedionato)ruthenium(III); tetrabutyl phosphonium bromide at 220℃; under 326800 Torr; Further byproducts given;	A 250 mmol B n/a C n/a D 77.2 mmol

...Expand

: 41051-51-8
2-ethoxyethyl nitrite

: 103-67-3
benzyl-methyl-amine

A: 110-80-5
2-ethoxy-ethanol

B: 937-40-6
Benzylmethylnitrosamin

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; Rate constant;

...Expand

: 41051-51-8
2-ethoxyethyl nitrite

: 51-35-4
3-hydroxy-dl-proline

A: 110-80-5
2-ethoxy-ethanol

B: 2443-30-3
N-nitrosohydroxyproline

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.), solvent isotope effect (kH/kD);

...Expand

: 110-85-0
piperazine

: 41051-51-8
2-ethoxyethyl nitrite

A: 110-80-5
2-ethoxy-ethanol

B: 5632-47-3
N-nitrosopiperazine

Conditions

Conditions	Yield
With sodium docusate In 2,2,4-trimethylpentane; water Rate constant;

...Expand

: 41051-51-8
2-ethoxyethyl nitrite

: 109-77-3
malononitrile

A: 110-80-5
2-ethoxy-ethanol

B: 36568-05-5
2-(hydroxyimino)malononitrile

Conditions

Conditions	Yield
With sodium hydroxide at 25℃; Rate constant;

...Expand

: 201601-90-3
uridine 3'-(2-ethoxyethyl) phosphate

A: 110-80-5
2-ethoxy-ethanol

B: 84-53-7
uridine-3'-phosphate

Conditions

Conditions	Yield
With zinc(II) nitrate; sodium nitrate at 90℃; pH=5.6; Kinetics; Hydrolysis;

: 110-80-5
2-ethoxy-ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 17178-11-9
2-ethoxyethyl p-toluenesulfonate

Conditions

Conditions	Yield
With pyridine at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water	85%
With triethylamine In dichloromethane at 20℃; for 4h;	81.1%

: 110-80-5
2-ethoxy-ethanol

: 67617-64-5
N-(2,6-dimethylphenyl)alanine

: 712327-18-9
2-ethoxyethyl N-(2,6-dimethylphenyl)alaninate

Conditions

Conditions	Yield
With thionyl chloride	100%

: 110-80-5
2-ethoxy-ethanol

: 1386979-21-0
4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoic acid methyl ester

: 1386980-79-5
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Conditions

Conditions	Yield
Stage #1: 2-ethoxy-ethanol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: 4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoic acid methyl ester In N,N-dimethyl-formamide; mineral oil at 20℃; for 18h;	100%

: 110-80-5
2-ethoxy-ethanol

: 1355011-30-1
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

: 1395998-01-2
methyl 6-(4-(2-ethoxyethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Conditions

Conditions	Yield
Stage #1: 2-ethoxy-ethanol With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate In tetrahydrofuran	100%

: 110-80-5
2-ethoxy-ethanol

: 108-05-4
vinyl acetate

: 111-15-9
2-ethoxyethyl acetate

Conditions

Conditions	Yield
With dilithium tetra(tert-butyl)zincate In toluene at 0℃; for 1h; Inert atmosphere;	100%

: 110-80-5
2-ethoxy-ethanol

: diisopropoxidobis(2,4-pentanedionato)zirconium(IV)

: zirconium (OCH2CH2OCH2CH3)2-bis(acetylacetonate)

Conditions

Conditions	Yield
In benzene byproducts: (CH3)2CHOH; performed in a moisture free environment; benzene soln. of Zr(acac)2(OiPr)2 added to a benzene suspension of the organic ligand; refluxed for 4h; solvent removed under reduced pressure; purified by recrystallization from a mixture of dichloromethane and n-hexane; elem. anal.;	99%

: 110-80-5
2-ethoxy-ethanol

: 7550-45-0
titanium tetrachloride

: 1378027-13-4
TiCl3(2-ethoxyethanol-H)

Conditions

Conditions	Yield
In toluene under an inert atm.; to a soln. of TiCl4 (8.51 mmol) in toluene was added a toluene soln. of a ligand (8.51 mmol); stirring for 3 h; supernatant was decanted and the solid washed with petroleum spirits; the residue was dried under vac.; elem. anal.;	99%

: 110-80-5
2-ethoxy-ethanol

: 443286-95-1
bis(N-phenylsalicylideneiminato)aluminium(III)di(μ-isopropoxo)di(isopropoxo) aluminium(III)

: 443286-98-4
[(N-phenylsalicylideneiminato)2Al(III)(μ-O(i-Pr))2Al(III)(O(i-Pr))(OCH2CH2OC2H5)]

Conditions

Conditions	Yield
In benzene byproducts: (CH3)2CHOH; under anhyd. conditions; mixt. was refluxed for 4 h, 1:1 molar ratio of Al complex and ligand; solvent was removed; elem. anal.;	98.9%

: 110-80-5
2-ethoxy-ethanol

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 109-86-4
2-methoxy-ethanol

: 2-ethoxyethanolato-2-methoxyethanolato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃; Reflux;	98.3%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 443286-95-1
bis(N-phenylsalicylideneiminato)aluminium(III)di(μ-isopropoxo)di(isopropoxo) aluminium(III)

: 443286-99-5
[(N-phenylsalicylideneiminato)2Al(III)(μ-O(i-Pr))2Al(III)(OCH2CH2OC2H5)2]

Conditions

Conditions	Yield
In benzene byproducts: (CH3)2CHOH; under anhyd. conditions; mixt. was refluxed for 4 h, 1:2 molar ratio of Al complex and ligand; solvent was removed; elem. anal.;	98.2%

: 110-80-5
2-ethoxy-ethanol

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 5007-50-1
1-(2-furyl)ethanone oxime

: 2-acetylfuranoximato-2-ethoxyethanolato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃;	98.2%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 1445651-86-4
(Ap)Ti(OPri)2

: 5007-50-1
1-(2-furyl)ethanone oxime

: 1445651-84-2
C18H21NO6Ti

Conditions

Conditions	Yield
In toluene Reflux;	98.1%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 20728-73-8
5,7,3',4'-tetra-O-benzyl-(+)-catechin

: 478796-20-2
(2R,3S,4S)-5,7,3',4'-tetrabenzyloxy-4-(2"-ethoxyethoxy)flavan-3-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 2h;	98%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane	98%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 0 - 20℃; Inert atmosphere;	85%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone

: 110-80-5
2-ethoxy-ethanol

: lutetium(III) acetate

: ethoxyethanol adduct of lutetium acetate

Conditions

Conditions	Yield
In water under 760.051 Torr; for 7h; Heating / reflux;	98%

: 546-68-9
titanium(IV) isopropylate

: 110-80-5
2-ethoxy-ethanol

: 71965-15-6
tetrakis(2-ethoxyethanolato)titanium(IV)

Conditions

Conditions	Yield
In benzene for 4h; Reflux;	98%

: 110-80-5
2-ethoxy-ethanol

: 141-22-0
Ricinoleic acid

: 10031-89-7
ricinoleic acid ethylene glycol ethyl ether ester

Conditions

Conditions	Yield
With sodium hydrogensulfate monohydrate In dichloromethane at 150℃; for 0.416667h; Microwave irradiation; High pressure;	98%
With toluene-4-sulfonic acid In cyclohexane for 5h; Time; Reagent/catalyst; Solvent; Reflux;

: 110-80-5
2-ethoxy-ethanol

: 106-45-6
para-thiocresol

: 2-ethoxyethyl 4-methylbenzenesulfinate

Conditions

Conditions	Yield
With tetrabutylammonium perchlorate In acetonitrile at 20℃; for 8h; Electrochemical reaction;	98%

: 142-08-5
2-hydroxypyridin

: 110-80-5
2-ethoxy-ethanol

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 2-ethoxyethanolato-2-pyridineato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃; Reflux;	97.9%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 1956-45-2, 92313-45-6, 92313-54-7
2-acetylthiophene oxime

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 2-acetylthiopheneoximato-2-ethoxyethanolato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃; Reflux;	97.9%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 1758-54-9, 79462-42-3, 81563-77-1
1-pyridin-2-yl-ethanone oxime

: 2-acetylpyridineoximato-2-ethoxyethanolato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃;	97.9%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 1445651-86-4
(Ap)Ti(OPri)2

: 1758-54-9, 79462-42-3, 81563-77-1
1-pyridin-2-yl-ethanone oxime

: 1445651-77-3
C19H22N2O5Ti

Conditions

Conditions	Yield
In toluene Reflux;	97.6%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 23329-69-3, 454677-87-3
cis-di-2-propanolato-bis(8-quinolinato)-titanium(IV)

: 2-ethoxyethanolato-2-propanolato-bis(8-quinolinato)titanium(IV)

Conditions

Conditions	Yield
In toluene at 100 - 120℃; Reflux;	97.5%

: 110-80-5
2-ethoxy-ethanol

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 32895-19-5
2,4-dinitro-1-(2-ethoxyethoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In water	97.4%

: 110-80-5
2-ethoxy-ethanol

: 627-03-2
3-oxapentanoic acid

Conditions

Conditions	Yield
With sodium persulfate; sodium bis(1,2-dicarbollyl)cobaltate(III); potassium carbonate In water for 8h; pH=7; Irradiation;	97%
With sodium hydroxide; potassium hexacyanoferrate(III) at 30℃; Kinetics; Further Variations:; substrate and reagents concentration dependence; Oxidation;
With Jones reagent In acetone at 20℃;
With sodium hydroxide; cadmium(II) oxide at 225 - 250℃; im Kupferautoklaven;

: 110-80-5
2-ethoxy-ethanol

: 20728-73-8
5,7,3',4'-tetra-O-benzyl-(+)-catechin

: 882867-43-8
(2R,3S)-5,7-Bis-benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-4-(2-ethoxy-ethoxy)-chroman-3-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 2h;	97%

: 546-68-9
titanium(IV) isopropylate

: 110-80-5
2-ethoxy-ethanol

: titanium(IV)(isopropoxide)(OCH2CH2OEt)3

Conditions

Conditions	Yield
In benzene for 4h; Reflux;	97%

: 110-80-5
2-ethoxy-ethanol

: 22056-82-2
ethoxyacetaldehyde

Conditions

Conditions	Yield
With Dess-Martin periodane In dichloromethane for 1h; Concentration;	96.5%
With bromamine T In hydrogenchloride at 45℃; Thermodynamic data; Rate constant; Mechanism; Ea, ΔH(excit.), ΔS(excit.), ΔG(excit.);
With pyridinium chlorochromate In dimethyl sulfoxide for 6h; Kinetics; Mechanism; Thermodynamic data; Εa, log A, ΔS(excit.), ΔG(excit.);

: 110-80-5
2-ethoxy-ethanol

: 79-11-8
chloroacetic acid

: 60682-94-2
chloro-acetic acid-(2-ethoxy-ethyl ester)

Conditions

Conditions	Yield
F-4SK (H form) In toluene at 120℃; for 3h;	96%
With toluene

: 110-80-5
2-ethoxy-ethanol

: 188478-29-7
8-dioxane-3-cobalt-bis(1,2-dicarbollide)

: 1310-73-2
sodium hydroxide

: Na(1+)*Co(C2B9H11)C2B9H10(O(CH2CH2O)3CH2CH3)(1-)=NaCo(C2B9H11)C2B9H10(O(CH2CH2O)3CH2CH3)

Conditions

Conditions	Yield
In 2-ethoxy-ethanol (N2); stirring alcohol with NaOH for 45 min, addn. of cobalt complex, stirring at room temp. for 15 min; evapn., thin layer chromy. (silica gel, CH2Cl2/ethanol 9:1); elem. anal.;	96%

...Expand

: 110-80-5
2-ethoxy-ethanol

: 7646-79-9
cobalt(II) chloride

: 625838-58-6
Co4Cl2(OC2H4OC2H5)6

Conditions

Conditions	Yield
With sodium In 2-ethoxy-ethanol; toluene N2, Na dissolved, CoCl2 added with vigorous stirring, refluxed for 40 min, left for 30 min at room temp.; soln. decanted, left overnight at -30°C, crysts. decanted, dried (vac.);	96%

2-Ethoxyethanol Chemical Properties

Molecule structure of 2-Ethoxyethanol (CAS NO.110-80-5):

IUPAC Name: 2-Ethoxyethanol
Molecular Weight: 90.121 g/mol
Molecular Formula: C₄H₁₀O₂
Density: 0.915 g/cm³
Melting Point: -100 °C
Boiling Point: 135.6 °C at 760 mmHg
Flash Point: 44.4 °C
Index of Refraction: 1.399
Molar Refractivity: 23.86 cm³
Molar Volume: 98.4 cm³
Surface Tension: 28.6 dyne/cm
Enthalpy of Vaporization: 39.22 kJ/mol
Vapour Pressure: 3.28 mmHg at 25 °C
storage temp.: flammables area
Water Solubility: miscible
XLogP3: -0.3
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 3
Exact Mass: 90.06808
MonoIsotopic Mass: 90.06808
Topological Polar Surface Area: 29.5
Heavy Atom Count: 6
Canonical SMILES: CCOCCO
InChI: InChI=1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3
InChIKey: ZNQVEEAIQZEUHB-UHFFFAOYSA-N
EINECS: 203-804-1
Product Categories: Industrial/Fine Chemicals; Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols

2-Ethoxyethanol Uses

2-Ethoxyethanol (CAS NO.110-80-5) is a solvent used widely in commercial and industrial applications.

2-Ethoxyethanol Production

2-Ethoxyethanol can be manufactured by the reaction of ethylene oxide with ethanol.

2-Ethoxyethanol Toxicity Data With Reference

1.	eye-hmn 6000 ppm	PHRPA6 Public Health Reports. 45 (1930),1459.
2.	skn-rbt 500 mg open MLD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 5/20 ,1966.
3.	eye-rbt 500 mg/24H MLD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,624.
4.	eye-rbt 50 mg MOD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 5/20 ,1966.
5.	eye-gpg 10 μg MLD	JPPMAB Journal of Pharmacy and Pharmacology. 11 (1959),150.
6.	orl-rat LD50:2125 mg/kg	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 32 (3)(1988),48.
7.	ihl-rat LC50:2000 ppm/7H	NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),54.
8.	skn-rat LD50:3900 mg/kg	TOXID9 Toxicologist. 4 (1984),180.
9.	ipr-rat LD50:2800 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 21 (1971),880.
10.

2-Ethoxyethanol Consensus Reports

Reported in EPA TSCA Inventory. Glycol ether compounds are on the Community Right-To-Know List.

2-Ethoxyethanol Safety Profile

Hazard Codes: Toxic T
Risk Statements: 60-61-10-20/21/22
R60:May impair fertility.
R61:May cause harm to the unborn child.
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-45
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1171 3/PG 3
WGK Germany: 1
RTECS: KK8050000
HazardClass: 3
PackingGroup: III
Moderately toxic by ingestion, skin contact, intravenous, and intraperitoneal routes. Mildly toxic by inhalation and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. A mild eye and skin irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. Moderate explosion hazard in the form of vapor when exposed to heat or flame. Mixture with hydrogen peroxide + polyacrylamide gel + toluene is explosive when dry. To fight fire, use alcohol foam, dry chemical. See also GLYCOL ETHERS.

2-Ethoxyethanol Standards and Recommendations

OSHA PEL: TWA 200 ppm (skin)
ACGIH TLV: TWA 5 ppm (skin); BEI: 100 mg/g creatinine of 2-ethoxyacetic acid in urine end of shift at end of workweek
DFG MAK: 5 ppm (19 mg/m³)
NIOSH REL: (Glycol Ethers) Reduce to lowest level
DOT Classification: 3; Label: Flammable Liquid

2-Ethoxyethanol Analytical Methods

For occupational chemical analysis use OSHA: #53 or NIOSH: Alcohols IV, 1403.

2-Ethoxyethanol Specification

2-Ethoxyethanol (CAS NO.110-80-5) is also named as 2-Ethoxyethyl alcohol ; AI3-01236 ; Athylenglykol-monoathylather ; Athylenglykol-monoathylather [German] ; Bikanol E 1 ; CCRIS 2294 ; Cellosolve ; Cellosolve solvent ; Celosolv ; Celosolv [Czech] ; Dowanol 8 ; Dowanol EE ; EGEE ; Ektasolve EE ; Emkanol ; Eter monoetilico del etilenglicol ; Eter monoetilico del etilenglicol [Spanish] ; Ethanol, 2-ethoxy- ; Ether monoethylique de l'ethylene-glycol ; Ether monoethylique de l'ethylene-glycol [French] ; Ethyl cellosolve ; Ethyl ethylene glycol ; Ethylene glycol ethyl ether ; Ethylene glycol monoethyl ether ; Ethylethylene glycol ; Etoksyetylowy alkohol ; Etoksyetylowy alkohol [Polish] ; Glycol monoethyl ether ; HSDB 54 ; Hydroxy ether ; Jeffersol EE ; NCI-C54853 ; NSC 8837 ; Oxitol ; Plastiazan 60 ; Poly-Solv EE ; RCRA waste number U227 ; RCRA waste number U359 ; Solvid ; Solvulose ; UNII-IDK7C2HS09 ; beta-Ethoxyethanol . 2-Ethoxyethanol (CAS NO.110-80-5) is a clear, colorless, nearly odorless liquid that is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate. It is flammable. 2-Ethoxyethanol (CAS NO.110-80-5) may react with oxidizing materials, i.e. hydrogen peroxide, to form peroxides. It dissolves many oils, resins and waxes. Some eye irritation. Inhalation of vapors causes irritation of nose. Toxic gases, such as carbon monoxide, may be produced in fire.

Product Name

2-Ethoxyethanol

Synthetic route

2-Ethoxyethanol Chemical Properties

2-Ethoxyethanol Uses

2-Ethoxyethanol Production

2-Ethoxyethanol Toxicity Data With Reference

2-Ethoxyethanol Consensus Reports

2-Ethoxyethanol Safety Profile

2-Ethoxyethanol Standards and Recommendations

2-Ethoxyethanol Analytical Methods

2-Ethoxyethanol Specification

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