Conditions | Yield |
---|---|
With poly-4-vinylpyridine In N,N-dimethyl-formamide for 0.05h; microwave irradiation; | 93% |
In water for 0.25h; Decarboxylation; microwave irradiation; | 80% |
at 170 - 180℃; |
(2-ethyl-1-butyl)boronic acid
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With chromium(VI) oxide In dichloromethane; acetic acid at 25℃; for 12h; | 92% |
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; for 3h; Schlenk technique; | 88% |
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; under 760.051 Torr; for 3h; Catalytic behavior; Solvent; Schlenk technique; | 88% |
With calcium hypochlorite; acetic acid In water; acetonitrile Ambient temperature; | 75% |
Conditions | Yield |
---|---|
at 70℃; for 3.5h; electrolysis: nickel net anode, cylindrical stainless steel cathode; electrolyte: 1M NaOH/H2O; | 73% |
at 70℃; for 3.5h; Product distribution; electrolysis: nickel net anode, cylindrical stainless steel cathode; electrolyte: 1M NaOH/water; variation of temperature; | 73% |
Stage #1: 2-ethyl-1-butanol With [RuCl2(p-cymene)(iPr2-imy)]; tricyclohexylphosphine tetrafluoroborate; potassium hydroxide In toluene for 18h; Schlenk technique; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water pH=1; | 60% |
With dichloro(1,5-cyclooctadiene)ruthenium(II); C30H30N3P2(1+)*Cl(1-); potassium hydroxide In toluene at 120℃; for 24h; Inert atmosphere; Schlenk technique; | 55% |
With permanganate(VII) ion |
3,3-diethyl-2-phenylsulphonyl-2-trimethylsilyloxirane
A
2-Ethylbutanoic acid
B
2-bromo-2-ethylbutanoyltrimethylsilane
C
(E)-2-ethylbut-2-enoyltrimethylsilane
D
2-ethyl-2-phenylsulphonylbutanoyltrimethylsilane
Conditions | Yield |
---|---|
With magnesium bromide ethyl etherate In diethyl ether at 0℃; for 2h; | A 19% B 57% C 9% D 0.5% |
3-Dibutoxymethyl-pentane
A
2-Ethylbutanoic acid
B
butyl 2-ethylbutyrate
C
butyric acid
D
butan-1-ol
Conditions | Yield |
---|---|
With oxygen; cobalt(II) acetate at 90℃; under 750.06 Torr; Mechanism; Rate constant; other pressure; | A 2% B 6% C 10% D 46% |
ethyl 2,2-diethyl-3-oxobutanoate
A
2-Ethylbutanoic acid
B
3-ethyl-2-pentanone
Conditions | Yield |
---|---|
With barium dihydroxide In water for 18h; Heating; | A 10% B 38% |
carbon monoxide
pentane
A
2-Ethylbutanoic acid
B
2-Methylpentanoic acid
Conditions | Yield |
---|---|
With potassium peroxodisulfate; Cu(1,10-phenanthroline)(1,2-ethanediphosphonic acid); water In acetonitrile at 60℃; under 15201 Torr; for 4h; Autoclave; High pressure; Overall yield = 35.8 %Chromat.; | A 10.6% B 24% |
With dipotassium peroxodisulfate; BF4(1-)*C24H51BCu3N3O16(1+)*2H2O; water In acetonitrile at 60℃; under 15201 Torr; for 6h; Autoclave; | A 8.6% B 17% |
With dipotassium peroxodisulfate; C26H38Cu3N4O16; water In acetonitrile at 60℃; for 6h; Reagent/catalyst; Autoclave; Green chemistry; | A 7.4% B 17.2% |
peracetic acid
hex-3-yne
A
2-Ethylbutanoic acid
B
propionic acid
diethyl ether
allyl 2-ethylbutyrate
A
allylbenzene
B
2-Ethylbutanoic acid
C
2-ethyl-1,1-diphenylbutanol
Conditions | Yield |
---|---|
With ethanol man verseift das erhaltene Nitril durch Kochen mit waessr.-alkoholischer Kalilauge; |
Conditions | Yield |
---|---|
With peracetic acid; acetic acid |
Conditions | Yield |
---|---|
With potassium hydroxide; potassium acetate at 370℃; unter Zutritt von Luft; |
2-ethyl-3-bromo-butyric acid
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With sodium amalgam; water man haelt die Loesung durch Zugabe von verduennter Schwefelsaeure bei ganz schwach alkalischer Reaktion; |
Conditions | Yield |
---|---|
Destillation; |
Conditions | Yield |
---|---|
With hydrogenchloride at 160℃; |
2,2-diethyl-acetoacetic acid methyl ester
A
2-Ethylbutanoic acid
B
3-ethyl-2-pentanone
Conditions | Yield |
---|---|
With sodium hydroxide |
diethyl malonic acid
A
2-Ethylbutanoic acid
B
methylammonium carbonate
Conditions | Yield |
---|---|
at 170 - 180℃; |
Conditions | Yield |
---|---|
at 150℃; |
Conditions | Yield |
---|---|
With sodium Man erhitzt den erhaltenen Natriumacetessigester mit Aethyljodid auf 100grad , destilliert das Reaktionsprodukt, behandelt den 151grad siedende Aethylester mit siedendem Barytwasser, diesen verseift man durch alkoh.Kalilauge; | |
With sodium Erhitzen des Reaktionsprodukts mit Aethyljodid auf 100grad, Destillieren; |
Conditions | Yield |
---|---|
With sodium amide In n-heptane at 240 - 250℃; |
Conditions | Yield |
---|---|
With phosphoric acid |
ethyl 2-ethyl-2-cyanobutyrate
A
2-Ethylbutanoic acid
B
ethyl 2-ethylbutanoate
Conditions | Yield |
---|---|
With potassium In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether at 0℃; |
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
hexane
carbon monoxide
A
2-Ethylbutanoic acid
B
2-Methylpentanoic acid
C
hexanoic acid
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; palladium diacetate In methanol; trifluoroacetic acid at 80℃; under 22800 Torr; for 20h; Yield given. Yields of byproduct given; |
1-penten
carbon monoxide
A
2-Ethylbutanoic acid
B
2,2-dimethylbutyric acid
C
Trimethylacetic acid
Conditions | Yield |
---|---|
With sulfuric acid; silver(l) oxide at 30℃; under 760 Torr; for 4h; Product distribution; | A 9 % Turnov. B 74 % Turnov. C 7 % Turnov. |
carbon monoxide
2-pentene
A
2-Ethylbutanoic acid
B
2-Methylpentanoic acid
C
hexanoic acid
Conditions | Yield |
---|---|
With water; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine In 1,4-dioxane at 95℃; under 15200 Torr; for 4h; Product distribution; Rate constant; other catalyst, time; |
diethylketene
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With water In acetonitrile at 20℃; Rate constant; var. H2O conc.; |
Conditions | Yield |
---|---|
Hydrogenation; |
diethylbarbituric acid
A
2-Ethylbutanoic acid
B
ammonia
C
methylammonium carbonate
Conditions | Yield |
---|---|
In toluene mixt. 2-ethylbutanoic acid (6 equiv.) and zinc oxide (4 equiv.) and toluene heated with stirring for 3 h (water removed); product filtered, solvent removed from filtrate; elem. anal.; | 99% |
2-Ethylbutanoic acid
2-ethylbutyric anhydride
Conditions | Yield |
---|---|
With triethylamine; chlorophosphoric acid diphenyl ester In dichloromethane at 20℃; for 0.25h; | 98.2% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20 - 25℃; | 78% |
With sulfuric acid; acetic anhydride |
Conditions | Yield |
---|---|
tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene for 60h; Heating; | 98% |
With molecualar sevies 4A; tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene at 120℃; for 60h; | 98% |
Conditions | Yield |
---|---|
With tetra-N-butylammonium tribromide for 3h; Inert atmosphere; Reflux; | 98% |
With dimesitylammonium pentafluorobenzenesulfonate In n-heptane at 80℃; for 24h; | 94% |
With N-butyl-2,4-dinitroanilinium p-toluenesulfonate In 2,2,4-trimethylpentane for 22h; Reflux; | 54% |
With 2-oleamido-5-nitro-pyridinium p-toluenesulfonate In 2,2,4-trimethylpentane for 48h; Reflux; | 50% |
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2-Ethylbutanoic acid With N,N'-carbonyl diimidazole In tetrahydrofuran at 20℃; for 0.5h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In tetrahydrofuran at 20℃; for 6h; Reflux; | 98% |
With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; |
Conditions | Yield |
---|---|
With sulfuric acid | 95% |
With sulfuric acid for 10h; | 10% |
With sulfuric acid | |
With thionyl chloride at 80℃; | |
With thionyl chloride at 80℃; |
Conditions | Yield |
---|---|
With 4,5,6,7-tetrachlorobenzo[d][1,3,2]dioxaborole In toluene for 24h; Heating; | 93% |
With ammonium chloride |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 19h; Inert atmosphere; | 93% |
2-Ethylbutanoic acid
2',3',5'-tri-O-acetylnebularine
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(pentan-3-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
Conditions | Yield |
---|---|
With ammonium peroxydisulfate; silver nitrate In dichloromethane; water at 20℃; for 6h; Minisci Aromatic Substitution; regioselective reaction; | 92% |
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine; HATU for 1h; | 92% |
2-Ethylbutanoic acid
1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one
1-(2-ethylbutanoyl)-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one
Conditions | Yield |
---|---|
Stage #1: 2-Ethylbutanoic acid; 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one With triethylamine In dichloromethane for 0.0833333h; Inert atmosphere; Cooling with ice; Stage #2: With bis(trichloromethyl) carbonate In dichloromethane at 20℃; Inert atmosphere; | 91% |
2-Ethylbutanoic acid
benzo[e][1,2,3]oxathiazine 2,2-dioxide
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 60℃; for 48h; | 91% |
2-Ethylbutanoic acid
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In ethanol at 20 - 25℃; for 24h; Irradiation; | 90% |
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; copper; silver nitrate In water; acetonitrile at 90℃; for 12h; | 89% |
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.25h; Fluorination; | 88% |
Conditions | Yield |
---|---|
With bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 12h; Inert atmosphere; Irradiation; Schlenk technique; | 88% |
2-Ethylbutanoic acid
5-chloro-2-isocyano-1,1’-biphenyl
Conditions | Yield |
---|---|
With potassium phosphate; dipotassium peroxodisulfate; silver carbonate In water; acetonitrile at 70℃; for 3h; Inert atmosphere; | 87% |
2-Ethylbutanoic acid
dodecacarbonyl-triangulo-triruthenium
{Ru2(O2CCH(C2H5)CH2CH3)2(CO)4(P(C6H5)3)2}
Conditions | Yield |
---|---|
With triphenylphosphine In tetrahydrofuran under N2; Ru-compd. and excess of acid heated at reflux for 4h, addn. of PPh3, mixt. heated for a further 20 min; recrystd. (CH2Cl2/EtOH, open conditions); elem. anal.; | 86% |
2-Ethylbutanoic acid
1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 180℃; for 0.2h; Inert atmosphere; Sealed tube; Microwave irradiation; | 86% |
Conditions | Yield |
---|---|
With thionyl chloride | 85% |
With phosphorus trichloride | |
With thionyl chloride |
Conditions | Yield |
---|---|
With benzenesulfonyl chloride | 85% |
With pyridine; benzenesulfonyl chloride Ambient temperature; | 72% |
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; silver nitrate In dichloromethane; water at 20℃; for 8h; | 85% |
With ammonium peroxydisulfate; anthocyanin In dichloromethane; water at 20℃; Minisci Aromatic Substitution; Irradiation; Green chemistry; | 59% |
2-Ethylbutanoic acid
A
2-ethyl-N-butylamine
B
bis(2-ethylbutyl)amine
C
2-ethylbutanamide
Conditions | Yield |
---|---|
Stage #1: 2-Ethylbutanoic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 48h; Cooling with ice; Green chemistry; | A 85% B 3% C 9% |
2-Ethylbutanoic acid
methyl 2-isocyano-3,3-diphenyl acrylate
Conditions | Yield |
---|---|
With potassium phosphate; dipotassium peroxodisulfate; silver carbonate In water; acetonitrile at 70℃; for 4h; Inert atmosphere; | 84% |
2-Ethylbutanoic acid
(E)-3-phenylacrylic acid
3-Aethyl-1-phenyl-penten-(1)
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; copper; silver nitrate In water; acetonitrile at 90℃; for 12h; | 82% |
2-Ethylbutanoic acid
2-phenyl-1,2,3,4-tetrahydroisoquinoline
[(p-methylphenyl)sulfonylmethyl]isonitrile
Conditions | Yield |
---|---|
With diethylazodicarboxylate In dichloromethane at 20℃; for 4h; Ugi Condensation; | 82% |
Chemical Name: 2-Ethylbutyric acid
IUPAC NAME: 2-Ethylbutanoic acid
CAS No.: 88-09-5
EINECS: 201-796-4
RTECS: ET1400000
Molecular Formula: C6H12O2
Molecular Weight: 116.16 g/mol
Melting Point: -14 °C
Density: 0.947 g/cm3
Flash Point: 88.4 °C
Boiling Point: 195.4 °C at 760 mmHg
Following is the structure of Diethylacetic acid (88-09-5):
The chemical synonymous of Diethylacetic acid (88-09-5) are 2-Ethyl-butanoicaci ; 2-Ethylbutansαure ; 2-Ethylbuttersαure ; 2-Ethylbutyric ; 2-Ethyl-butyricaci ; 2-Ethylbutyricaicd ; 3-Pentanecarboxylic acid
Diethylacetic acid (88-09-5) is used in flavourings, it also used as an intermediate for pharmaceuticals and dyestuffs and in the manufacture of esters and other chemicals.
1. | skn-rbt 10 mg/24H open MLD | AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61. | ||
2. | eye-rbt 250 µg open SEV | AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61. | ||
3. | orl-rat LD50:2200 mg/kg | AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61. | ||
4. | skn-rbt LD50:520 mg/kg | AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61. |
Reported in EPA TSCA Inventory.
Moderately toxic by ingestion and skin contact. An irritant to skin and mucous membranes. A severe eye irritant. See also ESTERS. Narcotic in high concentrations. Flammable liquid. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes:
Xn: Harmful
C: Corrosive
Risk Statements about Diethylacetic acid (88-09-5):
R21 Harmful in contact with skin.
R34 Causes burns.
Safety Statements about Diethylacetic acid (88-09-5):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Attention:
1. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Wash thoroughly after handling. Use only in a well ventilated area. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
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