Product Name

  • Name

    2-Ethylbutyric acid

  • EINECS 201-796-4
  • CAS No. 88-09-5
  • Article Data94
  • CAS DataBase
  • Density 0.924
  • Solubility sparingly soluble miscible with the usual organic solvents
  • Melting Point -13 C
  • Formula C6H12 O2
  • Boiling Point 194 C
  • Molecular Weight 116.16
  • Flash Point 87 ºC
  • Transport Information 2810
  • Appearance clear liquid
  • Safety Moderately toxic by ingestion and skin contact. An irritant to skin and mucous membranes. A severe eye irritant. See also ESTERS. Narcotic in high concentrations. Flammable liquid. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits acrid smoke and fumes.
  • Risk Codes R21;R34   
  • Molecular Structure Molecular Structure of 88-09-5 (2-Ethylbutyric acid)
  • Hazard Symbols
  • Synonyms Butyricacid, 2-ethyl- (6CI,7CI,8CI); Butyric acid, a-ethyl- (3CI); 2-Ethyl-n-butyric acid; 2-Ethylbutanoicacid; 2-Ethylbutyric acid; 3-Pentanecarboxylic acid; Acetic acid, diethyl-;Diethylacetic acid; NSC 11765; NSC 8758; a-Ethylbutyric acid
  • PSA 37.30000
  • LogP 1.50720

Synthetic route

diethyl malonic acid
510-20-3

diethyl malonic acid

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With poly-4-vinylpyridine In N,N-dimethyl-formamide for 0.05h; microwave irradiation;93%
In water for 0.25h; Decarboxylation; microwave irradiation;80%
at 170 - 180℃;
(2-ethyl-1-butyl)boronic acid
140614-19-3

(2-ethyl-1-butyl)boronic acid

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With chromium(VI) oxide In dichloromethane; acetic acid at 25℃; for 12h;92%
2-Ethylbutyraldehyde
97-96-1

2-Ethylbutyraldehyde

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; for 3h; Schlenk technique;88%
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; under 760.051 Torr; for 3h; Catalytic behavior; Solvent; Schlenk technique;88%
With calcium hypochlorite; acetic acid In water; acetonitrile Ambient temperature;75%
2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
at 70℃; for 3.5h; electrolysis: nickel net anode, cylindrical stainless steel cathode; electrolyte: 1M NaOH/H2O;73%
at 70℃; for 3.5h; Product distribution; electrolysis: nickel net anode, cylindrical stainless steel cathode; electrolyte: 1M NaOH/water; variation of temperature;73%
Stage #1: 2-ethyl-1-butanol With [RuCl2(p-cymene)(iPr2-imy)]; tricyclohexylphosphine tetrafluoroborate; potassium hydroxide In toluene for 18h; Schlenk technique; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride In water pH=1;
60%
With dichloro(1,5-cyclooctadiene)ruthenium(II); C30H30N3P2(1+)*Cl(1-); potassium hydroxide In toluene at 120℃; for 24h; Inert atmosphere; Schlenk technique;55%
With permanganate(VII) ion
3,3-diethyl-2-phenylsulphonyl-2-trimethylsilyloxirane
128608-23-1

3,3-diethyl-2-phenylsulphonyl-2-trimethylsilyloxirane

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

2-bromo-2-ethylbutanoyltrimethylsilane
128589-01-5

2-bromo-2-ethylbutanoyltrimethylsilane

C

(E)-2-ethylbut-2-enoyltrimethylsilane
128589-05-9, 139117-12-7

(E)-2-ethylbut-2-enoyltrimethylsilane

D

2-ethyl-2-phenylsulphonylbutanoyltrimethylsilane
139117-13-8

2-ethyl-2-phenylsulphonylbutanoyltrimethylsilane

Conditions
ConditionsYield
With magnesium bromide ethyl etherate In diethyl ether at 0℃; for 2h;A 19%
B 57%
C 9%
D 0.5%
3-Dibutoxymethyl-pentane
104723-47-9

3-Dibutoxymethyl-pentane

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

butyl 2-ethylbutyrate
5129-48-6

butyl 2-ethylbutyrate

C

butyric acid
107-92-6

butyric acid

D

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With oxygen; cobalt(II) acetate at 90℃; under 750.06 Torr; Mechanism; Rate constant; other pressure;A 2%
B 6%
C 10%
D 46%
ethyl 2,2-diethyl-3-oxobutanoate
1619-57-4

ethyl 2,2-diethyl-3-oxobutanoate

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

3-ethyl-2-pentanone
6137-03-7

3-ethyl-2-pentanone

Conditions
ConditionsYield
With barium dihydroxide In water for 18h; Heating;A 10%
B 38%
carbon monoxide
201230-82-2

carbon monoxide

pentane
109-66-0

pentane

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

2-Methylpentanoic acid
97-61-0, 22160-39-0

2-Methylpentanoic acid

Conditions
ConditionsYield
With potassium peroxodisulfate; Cu(1,10-phenanthroline)(1,2-ethanediphosphonic acid); water In acetonitrile at 60℃; under 15201 Torr; for 4h; Autoclave; High pressure; Overall yield = 35.8 %Chromat.;A 10.6%
B 24%
With dipotassium peroxodisulfate; BF4(1-)*C24H51BCu3N3O16(1+)*2H2O; water In acetonitrile at 60℃; under 15201 Torr; for 6h; Autoclave;A 8.6%
B 17%
With dipotassium peroxodisulfate; C26H38Cu3N4O16; water In acetonitrile at 60℃; for 6h; Reagent/catalyst; Autoclave; Green chemistry;A 7.4%
B 17.2%
peracetic acid
79-21-0

peracetic acid

hex-3-yne
928-49-4

hex-3-yne

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

propionic acid
802294-64-0

propionic acid

diethyl ether
60-29-7

diethyl ether

allyl 2-ethylbutyrate
7493-69-8

allyl 2-ethylbutyrate

phenylmagnesium bromide

phenylmagnesium bromide

A

allylbenzene
300-57-2

allylbenzene

B

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

C

2-ethyl-1,1-diphenylbutanol
126328-30-1

2-ethyl-1,1-diphenylbutanol

3-pentyl iodide
1809-05-8

3-pentyl iodide

potassium cyanide
151-50-8

potassium cyanide

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With ethanol man verseift das erhaltene Nitril durch Kochen mit waessr.-alkoholischer Kalilauge;
hex-3-yne
928-49-4

hex-3-yne

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With peracetic acid; acetic acid
4-ethylhexanoic acid
6299-66-7

4-ethylhexanoic acid

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With potassium hydroxide; potassium acetate at 370℃; unter Zutritt von Luft;
2-ethyl-3-bromo-butyric acid
861310-83-0

2-ethyl-3-bromo-butyric acid

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With sodium amalgam; water man haelt die Loesung durch Zugabe von verduennter Schwefelsaeure bei ganz schwach alkalischer Reaktion;
2,2-diethyl-3-hydroxy-butyric acid

2,2-diethyl-3-hydroxy-butyric acid

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
Destillation;
2-ethyl-2-cyano-butyric acid
4386-07-6

2-ethyl-2-cyano-butyric acid

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With hydrogenchloride at 160℃;
2,2-diethyl-acetoacetic acid methyl ester
85153-63-5

2,2-diethyl-acetoacetic acid methyl ester

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

3-ethyl-2-pentanone
6137-03-7

3-ethyl-2-pentanone

Conditions
ConditionsYield
With sodium hydroxide
diethyl malonic acid
510-20-3

diethyl malonic acid

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

Conditions
ConditionsYield
at 170 - 180℃;
diethylketene dimer
3898-61-1

diethylketene dimer

furan-2,3,5(4H)-trione pyridine (1:1)

furan-2,3,5(4H)-trione pyridine (1:1)

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

3,5-diethylheptan-4-one
75072-46-7

3,5-diethylheptan-4-one

Conditions
ConditionsYield
at 150℃;
ethyl acetate
141-78-6

ethyl acetate

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

ethyl 2-ethylbutanoate
2983-38-2

ethyl 2-ethylbutanoate

Conditions
ConditionsYield
With sodium Man erhitzt den erhaltenen Natriumacetessigester mit Aethyljodid auf 100grad , destilliert das Reaktionsprodukt, behandelt den 151grad siedende Aethylester mit siedendem Barytwasser, diesen verseift man durch alkoh.Kalilauge;
With sodium Erhitzen des Reaktionsprodukts mit Aethyljodid auf 100grad, Destillieren;
ethene
74-85-1

ethene

potassium acetate
127-08-2

potassium acetate

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With sodium amide In n-heptane at 240 - 250℃;
pentan-1-ol
71-41-0

pentan-1-ol

carbon monoxide
201230-82-2

carbon monoxide

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With phosphoric acid
ethyl 2-ethyl-2-cyanobutyrate
1619-56-3

ethyl 2-ethyl-2-cyanobutyrate

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

ethyl 2-ethylbutanoate
2983-38-2

ethyl 2-ethylbutanoate

Conditions
ConditionsYield
With potassium In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether at 0℃;
2-ethyl-1-butene
760-21-4

2-ethyl-1-butene

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
Yield given. Multistep reaction;
hexane
110-54-3

hexane

carbon monoxide
201230-82-2

carbon monoxide

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

2-Methylpentanoic acid
97-61-0, 22160-39-0

2-Methylpentanoic acid

C

hexanoic acid
142-62-1

hexanoic acid

Conditions
ConditionsYield
With dipotassium peroxodisulfate; palladium diacetate In methanol; trifluoroacetic acid at 80℃; under 22800 Torr; for 20h; Yield given. Yields of byproduct given;
1-penten
109-67-1

1-penten

carbon monoxide
201230-82-2

carbon monoxide

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

2,2-dimethylbutyric acid
595-37-9

2,2-dimethylbutyric acid

C

Trimethylacetic acid
75-98-9

Trimethylacetic acid

Conditions
ConditionsYield
With sulfuric acid; silver(l) oxide at 30℃; under 760 Torr; for 4h; Product distribution;A 9 % Turnov.
B 74 % Turnov.
C 7 % Turnov.
carbon monoxide
201230-82-2

carbon monoxide

2-pentene
109-68-2

2-pentene

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

2-Methylpentanoic acid
97-61-0, 22160-39-0

2-Methylpentanoic acid

C

hexanoic acid
142-62-1

hexanoic acid

Conditions
ConditionsYield
With water; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine In 1,4-dioxane at 95℃; under 15200 Torr; for 4h; Product distribution; Rate constant; other catalyst, time;
diethylketene
24264-08-2

diethylketene

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
With water In acetonitrile at 20℃; Rate constant; var. H2O conc.;
2-methyl-3-furancarboxylic acid
6947-94-0

2-methyl-3-furancarboxylic acid

acetic acid
64-19-7

acetic acid

colloidal platinum

colloidal platinum

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

Conditions
ConditionsYield
Hydrogenation;
diethylbarbituric acid
57-44-3

diethylbarbituric acid

potassium hydroxide

potassium hydroxide

A

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

B

ammonia
7664-41-7

ammonia

C

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

zinc(II) oxide

zinc(II) oxide

tetrazinc μ4-oxohexa-mu.-2-ethylbutanoate

tetrazinc μ4-oxohexa-mu.-2-ethylbutanoate

Conditions
ConditionsYield
In toluene mixt. 2-ethylbutanoic acid (6 equiv.) and zinc oxide (4 equiv.) and toluene heated with stirring for 3 h (water removed); product filtered, solvent removed from filtrate; elem. anal.;99%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-ethylbutyric anhydride
54502-37-3

2-ethylbutyric anhydride

Conditions
ConditionsYield
With triethylamine; chlorophosphoric acid diphenyl ester In dichloromethane at 20℃; for 0.25h;98.2%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20 - 25℃;78%
With sulfuric acid; acetic anhydride
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 2-ethylbutanoate

benzyl 2-ethylbutanoate

Conditions
ConditionsYield
tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene for 60h; Heating;98%
With molecualar sevies 4A; tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene at 120℃; for 60h;98%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

octanol
111-87-5

octanol

octyl 2-ethylbutanoate

octyl 2-ethylbutanoate

Conditions
ConditionsYield
With tetra-N-butylammonium tribromide for 3h; Inert atmosphere; Reflux;98%
With dimesitylammonium pentafluorobenzenesulfonate In n-heptane at 80℃; for 24h;94%
With N-butyl-2,4-dinitroanilinium p-toluenesulfonate In 2,2,4-trimethylpentane for 22h; Reflux;54%
With 2-oleamido-5-nitro-pyridinium p-toluenesulfonate In 2,2,4-trimethylpentane for 48h; Reflux;50%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

(3aRS,4RS,6aSR)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

(3aRS,4RS,6aSR)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

2-ethyl-N-{(3aRS,4RS,6aSR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide

2-ethyl-N-{(3aRS,4RS,6aSR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h; Inert atmosphere;98%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-ethyl-N-methoxy-N-methylbutanamide

2-ethyl-N-methoxy-N-methylbutanamide

Conditions
ConditionsYield
Stage #1: 2-Ethylbutanoic acid With N,N'-carbonyl diimidazole In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In tetrahydrofuran at 20℃; for 6h; Reflux;
98%
With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃;
methanol
67-56-1

methanol

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-ethyl-butyric acid methyl ester
816-11-5

2-ethyl-butyric acid methyl ester

Conditions
ConditionsYield
With sulfuric acid95%
With sulfuric acid for 10h;10%
With sulfuric acid
With thionyl chloride at 80℃;
With thionyl chloride at 80℃;
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-ethylbutanamide

N-benzyl-2-ethylbutanamide

Conditions
ConditionsYield
With 4,5,6,7-tetrachlorobenzo[d][1,3,2]dioxaborole In toluene for 24h; Heating;93%
With ammonium chloride
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

C14H26O7
1313484-36-4

C14H26O7

C20H36O8

C20H36O8

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 19h; Inert atmosphere;93%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2',3',5'-tri-O-acetylnebularine
15981-63-2

2',3',5'-tri-O-acetylnebularine

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(pentan-3-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
1512860-57-9

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(pentan-3-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With ammonium peroxydisulfate; silver nitrate In dichloromethane; water at 20℃; for 6h; Minisci Aromatic Substitution; regioselective reaction;92%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

(S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-((2-ethylbutanoyl)oxy)formamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-(2-(benzyloxy)-2-oxoethoxy)-4-(5-((((R)-2-((R)-1-(N-((2-ethylbutanoyl)oxy)formamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

Conditions
ConditionsYield
With 4-methyl-morpholine; HATU for 1h;92%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one
52099-72-6

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

1-(2-ethylbutanoyl)-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one
1207377-19-2

1-(2-ethylbutanoyl)-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one

Conditions
ConditionsYield
Stage #1: 2-Ethylbutanoic acid; 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one With triethylamine In dichloromethane for 0.0833333h; Inert atmosphere; Cooling with ice;
Stage #2: With bis(trichloromethyl) carbonate In dichloromethane at 20℃; Inert atmosphere;
91%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

benzo[e][1,2,3]oxathiazine 2,2-dioxide
71730-46-6

benzo[e][1,2,3]oxathiazine 2,2-dioxide

4-(pentan-3-yl)benzo[e][1,2,3]oxathiazine 2,2-dioxide

4-(pentan-3-yl)benzo[e][1,2,3]oxathiazine 2,2-dioxide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 60℃; for 48h;91%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-methyl-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one

2-methyl-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)prop-2-en-1-one

C21H22N2O

C21H22N2O

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In ethanol at 20 - 25℃; for 24h; Irradiation;90%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

o-chlorocinnamic acid
3752-25-8

o-chlorocinnamic acid

C13H17Cl

C13H17Cl

Conditions
ConditionsYield
With dipotassium peroxodisulfate; copper; silver nitrate In water; acetonitrile at 90℃; for 12h;89%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-ethyl-butyryl fluoride
654-43-3

2-ethyl-butyryl fluoride

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.25h; Fluorination;88%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

C6H4NCH2CHCCH2
491-35-0

C6H4NCH2CHCCH2

4-methyl-2-(pentan-3-yl)quinoline

4-methyl-2-(pentan-3-yl)quinoline

Conditions
ConditionsYield
With bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 12h; Inert atmosphere; Irradiation; Schlenk technique;88%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

5-chloro-2-isocyano-1,1’-biphenyl
1428264-92-9

5-chloro-2-isocyano-1,1’-biphenyl

2-chloro-6-(pentan-3-yl)phenanthridine

2-chloro-6-(pentan-3-yl)phenanthridine

Conditions
ConditionsYield
With potassium phosphate; dipotassium peroxodisulfate; silver carbonate In water; acetonitrile at 70℃; for 3h; Inert atmosphere;87%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

dodecacarbonyl-triangulo-triruthenium
15243-33-1

dodecacarbonyl-triangulo-triruthenium

{Ru2(O2CCH(C2H5)CH2CH3)2(CO)4(P(C6H5)3)2}
125665-82-9

{Ru2(O2CCH(C2H5)CH2CH3)2(CO)4(P(C6H5)3)2}

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran under N2; Ru-compd. and excess of acid heated at reflux for 4h, addn. of PPh3, mixt. heated for a further 20 min; recrystd. (CH2Cl2/EtOH, open conditions); elem. anal.;86%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide
1600524-53-5

1-(3,4-diamino-5-(3-fluorophenyl)pyridin-2-yl)piperidine-3-carboxamide

1-(7-(3-fluorophenyl)-2-(pentan-3-yl)-1H-imidazo[4,5-c]pyridin-4-yl)piperidine-3-carbonitrile

1-(7-(3-fluorophenyl)-2-(pentan-3-yl)-1H-imidazo[4,5-c]pyridin-4-yl)piperidine-3-carbonitrile

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 180℃; for 0.2h; Inert atmosphere; Sealed tube; Microwave irradiation;86%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

chlorure d'acide ethyl-2 butyrique
2736-40-5

chlorure d'acide ethyl-2 butyrique

Conditions
ConditionsYield
With thionyl chloride85%
With phosphorus trichloride
With thionyl chloride
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

testosterone
58-22-0

testosterone

testosterone-17β-2'-ethylbutanoate
69510-14-1

testosterone-17β-2'-ethylbutanoate

Conditions
ConditionsYield
With benzenesulfonyl chloride85%
With pyridine; benzenesulfonyl chloride Ambient temperature;72%
1,3-Benzothiazole
95-16-9

1,3-Benzothiazole

2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-(pentan-3-yl)benzo[d]thiazole
93194-82-2

2-(pentan-3-yl)benzo[d]thiazole

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver nitrate In dichloromethane; water at 20℃; for 8h;85%
With ammonium peroxydisulfate; anthocyanin In dichloromethane; water at 20℃; Minisci Aromatic Substitution; Irradiation; Green chemistry;59%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

A

2-ethyl-N-butylamine
617-79-8

2-ethyl-N-butylamine

B

bis(2-ethylbutyl)amine
54774-85-5

bis(2-ethylbutyl)amine

C

2-ethylbutanamide
1114-38-1

2-ethylbutanamide

Conditions
ConditionsYield
Stage #1: 2-Ethylbutanoic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry;
Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 48h; Cooling with ice; Green chemistry;
A 85%
B 3%
C 9%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

methyl 2-isocyano-3,3-diphenyl acrylate
76203-05-9

methyl 2-isocyano-3,3-diphenyl acrylate

methyl 4-phenyl-1-(pentan-3-yl)isoquinoline-3-carboxylate

methyl 4-phenyl-1-(pentan-3-yl)isoquinoline-3-carboxylate

Conditions
ConditionsYield
With potassium phosphate; dipotassium peroxodisulfate; silver carbonate In water; acetonitrile at 70℃; for 4h; Inert atmosphere;84%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

3-Aethyl-1-phenyl-penten-(1)
15314-18-8

3-Aethyl-1-phenyl-penten-(1)

Conditions
ConditionsYield
With dipotassium peroxodisulfate; copper; silver nitrate In water; acetonitrile at 90℃; for 12h;82%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

2-phenyl-1,2,3,4-tetrahydroisoquinoline
3340-78-1

2-phenyl-1,2,3,4-tetrahydroisoquinoline

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2, 36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

N-(2-ethylbutanoyl)-2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

N-(2-ethylbutanoyl)-2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Conditions
ConditionsYield
With diethylazodicarboxylate In dichloromethane at 20℃; for 4h; Ugi Condensation;82%

2-Ethylbutyric acid Chemical Properties

Chemical Name: 2-Ethylbutyric acid
IUPAC NAME: 2-Ethylbutanoic acid
CAS No.: 88-09-5
EINECS: 201-796-4
RTECS: ET1400000
Molecular Formula: C6H12O2
Molecular Weight: 116.16 g/mol
Melting Point: -14 °C
Density: 0.947 g/cm3 
Flash Point: 88.4 °C
Boiling Point: 195.4 °C at 760 mmHg
Following is the structure of Diethylacetic acid (88-09-5):


The chemical synonymous of Diethylacetic acid (88-09-5) are 2-Ethyl-butanoicaci ; 2-Ethylbutansαure ; 2-Ethylbuttersαure ; 2-Ethylbutyric ; 2-Ethyl-butyricaci ; 2-Ethylbutyricaicd ; 3-Pentanecarboxylic acid

2-Ethylbutyric acid Uses

 Diethylacetic acid (88-09-5) is used in flavourings, it also used as an intermediate for pharmaceuticals and dyestuffs and in the manufacture of esters and other chemicals.

2-Ethylbutyric acid Toxicity Data With Reference

1.    

skn-rbt 10 mg/24H open MLD

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
2.    

eye-rbt 250 µg open SEV

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
3.    

orl-rat LD50:2200 mg/kg

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.    

skn-rbt LD50:520 mg/kg

    AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.

2-Ethylbutyric acid Consensus Reports

Reported in EPA TSCA Inventory.

2-Ethylbutyric acid Safety Profile

Moderately toxic by ingestion and skin contact. An irritant to skin and mucous membranes. A severe eye irritant. See also ESTERS. Narcotic in high concentrations. Flammable liquid. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes:
Xn: Harmful
C: Corrosive
Risk Statements about Diethylacetic acid (88-09-5):
R21 Harmful in contact with skin. 
R34 Causes burns. 
Safety Statements about Diethylacetic acid (88-09-5):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection. 
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). 
Attention:
1. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Wash thoroughly after handling. Use only in a well ventilated area. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

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