1-styrenyloxytrimethylsilane
1-[hydroxy(tosyloxy)iodo]-1H,1H-perfluoroethane
A
1,1,1-trifluoro-2-iodoethane
B
1-phenyl-2-(p-tolylsulfonyloxy)ethanone
Conditions | Yield |
---|---|
In dichloromethane for 1h; Ambient temperature; | A n/a B 58% |
1-(Trimethylsilyloxy)cyclohexene
1-[hydroxy(tosyloxy)iodo]-1H,1H-perfluoroethane
A
1,1,1-trifluoro-2-iodoethane
B
2-(tosyloxy)cyclohexanone
Conditions | Yield |
---|---|
In dichloromethane at 0℃; for 3h; | A n/a B 56% |
Conditions | Yield |
---|---|
With potassium bromide at 300℃; for 0.333333h; | 36% |
Conditions | Yield |
---|---|
With Pentaethylene glycol; sodium iodide |
1-bromo-1,1-difluoro-2-iodoethane
A
1,1,1-trifluoro-2-iodoethane
B
Vinylidene fluoride
Conditions | Yield |
---|---|
With mercury(I) fluoride at 140℃; |
Conditions | Yield |
---|---|
With hydrogen iodide; toluene at -75℃; |
Conditions | Yield |
---|---|
With sodium iodide; diethylene glycol |
Iodoacetic acid
A
1,1,1-trifluoro-2-iodoethane
B
bis-(1,1-difluoro-2-iodo-ethyl) ether
Conditions | Yield |
---|---|
With sulfur tetrafluoride at 60℃; for 3h; | |
With sulfur tetrafluoride at 26℃; for 21h; |
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; cadmium(II) iodide In N,N,N,N,N,N-hexamethylphosphoric triamide at 120℃; for 8h; | 78 % Turnov. |
1,1,1-trifluoro-2-chloroethane
A
chloroethylene
B
1,1,1-trifluoro-2-iodoethane
C
1-Chloro-2,2-difluoroethene
D
Hexafluoroethane
E
1,1,2-trifluoroethylene
F
1,2-dichloro-ethane
Conditions | Yield |
---|---|
Rate constant; Thermodynamic data; Ambient temperature; Irradiation; Eo; |
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
In solid at 160 - 190℃; Yield given; |
2,2,2-trifluorodiazoethane
hydrogen iodide
toluene
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
at -75℃; |
1-bromo-1,1-difluoro-2-iodoethane
A
1,1,1-trifluoro-2-iodoethane
B
Vinylidene fluoride
Conditions | Yield |
---|---|
at 140℃; |
Conditions | Yield |
---|---|
In benzene Kinetics; iodinolysis with I2 in benzene soln. at 305 K; |
1,1,1-trifluoro-2-iodoethane
trifluoroacetic anhydride
(2,2,2-trifluoroethyl)-λ3-iodanediyl bis(2,2,2-trifluoroacetate)
Conditions | Yield |
---|---|
Stage #1: trifluoroacetic anhydride With dihydrogen peroxide; trifluoroacetic acid In water at 0℃; for 0.0833333h; Stage #2: 1,1,1-trifluoro-2-iodoethane at 0 - 20℃; | 100% |
Stage #1: trifluoroacetic anhydride With dihydrogen peroxide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 1,1,1-trifluoro-2-iodoethane at 0 - 22℃; for 24h; Inert atmosphere; | 90% |
Stage #1: trifluoroacetic anhydride With dihydrogen peroxide; trifluoroacetic acid In water at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: 1,1,1-trifluoro-2-iodoethane In water at 0 - 20℃; for 20h; Inert atmosphere; |
1,1,1-trifluoro-2-iodoethane
trifluoroacetic acid
trifluoroacetic anhydride
(2,2,2-trifluoroethyl)-λ3-iodanediyl bis(2,2,2-trifluoroacetate)
Conditions | Yield |
---|---|
Stage #1: trifluoroacetic acid; trifluoroacetic anhydride With dihydrogen peroxide In water at 0℃; for 0.0833333h; Stage #2: 1,1,1-trifluoro-2-iodoethane In water at 0 - 20℃; for 20h; | 100% |
In water; dihydrogen peroxide at 0 - 20℃; | 40% |
5-amino-4-fluoro-2-methylbenzene-1-thiol
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
With rongalite; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h; | 99% |
With rongalite; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h; | 99% |
With rongalite; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h; | 99% |
1,1,1-trifluoro-2-iodoethane
(2,6-bis[(di-tert-butylphosphino)methyl]phenyl)rhodium dinitrogen
Rh(I)(CH2CF3)(2,6-(CH2P(t)Bu2)2C6H3)
Conditions | Yield |
---|---|
In benzene-d6 inert atmosphere; 1-4 equiv. of CF3CH2I, room temp.; evapn.; NMR-spectroscopy; | 99% |
1,1,1-trifluoro-2-iodoethane
trans-Pt(N,N,N',N'-tetramethylethylenediamine)(CH2CF3)(CH3)2I
Conditions | Yield |
---|---|
In toluene (N2); CF3CH2I added to a suspn. of Pt complex at -78°C, stirred for ca. 10 min; evapd. (vac., below 0°C); | 99% |
1,1,1-trifluoro-2-iodoethane
trifluoroprop-1-yn-1-ylxenonium(II) tetrafluoroborate
Conditions | Yield |
---|---|
With hydrogen fluoride at -20 - 15℃; for 1h; Inert atmosphere; | 99% |
In hydrogen fluoride byproducts: Xe; HF (liquid); soln. of CF3CCXe(BF4) (-20°C) in anhyd. HF added to stirred neat CF3CH2I (-20°C), stirred at 15°C for 1 h; volatiles evapd., residue washed (CH2Cl2, 5°C), dried (vac.); (1)H, (13)C, (19)F NMR; | 99% |
2-(3-chloro-pyridin-2-yl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 100℃; |
2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h; | 99% |
1,1,1-trifluoro-2-iodoethane
para-iodoanisole
(2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; 1,10-Phenanthroline; [(1,10-phenanthroline)Cu(μ-SCH2CF3)]2 In N,N-dimethyl-formamide at 90℃; for 12h; Kinetics; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Sealed tube; | 99% |
With sodium tetrahydroborate; 1,10-Phenanthroline; iodine; sulfur In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere; | 84% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; 1,10-Phenanthroline; iodine; sulfur In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere; | 99% |
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 99% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; 1,10-Phenanthroline; iodine; sulfur In N,N-dimethyl-formamide at 95℃; for 1h; Inert atmosphere; | 99% |
With sulfur; sodium tetrahydroborate; copper(l) iodide; dimedone In N,N-dimethyl-formamide at 95℃; for 12h; Inert atmosphere; Sealed tube; | 96% |
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 99% |
1,1,1-trifluoro-2-iodoethane
4-iodobenzoic acid ethyl ester
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 99% |
1,1,1-trifluoro-2-iodoethane
1-Fluoro-3-iodobenzene
(2,2,2-trifluoroethyl) (3-fluorophenyl) sulfide
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 99% |
Conditions | Yield |
---|---|
With potassium hexafluorophosphate; selenium; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 95℃; for 16h; Sealed tube; | 99% |
4-iododibenzo[b,d]thiophene
1,1,1-trifluoro-2-iodoethane
4-(2,2,2-trifluoroethyl)dibenzo[b,d]thiophene
Conditions | Yield |
---|---|
With nickel(II) iodide; 1,1'-bis-(diphenylphosphino)ferrocene; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 80℃; for 24h; Inert atmosphere; Sealed tube; | 99% |
1,1,1-trifluoro-2-iodoethane
trifluoroacetic anhydride
A
(2,2,2-trifluoroethyl)-λ3-iodanediyl bis(2,2,2-trifluoroacetate)
B
trifluoroacetic acid
Conditions | Yield |
---|---|
With dihydrogen peroxide at -15 - 20℃; for 72h; | A 98% B n/a |
Conditions | Yield |
---|---|
With potassium hexafluorophosphate; selenium; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 95℃; for 16h; Sealed tube; | 98% |
With selenium; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 95℃; for 16h; Inert atmosphere; | 98% |
1,1,1-trifluoro-2-iodoethane
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 150℃; for 0.166667h; Cooling with ice; Microwave irradiation; | 97% |
Stage #1: 8-bromo-2-phenyl-4H-pyrazolo[1,5-a]quinazolin-5-one With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.25h; Cooling with ice; Stage #2: 1,1,1-trifluoro-2-iodoethane In N,N-dimethyl-formamide; mineral oil at 150℃; for 0.0833333h; Cooling with ice; Microwave irradiation; | 97% |
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 3h; | 97% |
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 97% |
1,1,1-trifluoro-2-iodoethane
3'-iodoacetophenone
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 97% |
Conditions | Yield |
---|---|
With potassium hexafluorophosphate; selenium; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 95℃; for 16h; Catalytic behavior; Reagent/catalyst; Temperature; Sealed tube; | 97% |
1,1,1-trifluoro-2-iodoethane
p-(iodophenyl)carboxaldehyde
Conditions | Yield |
---|---|
With nickel(II) iodide; 1,1'-bis-(diphenylphosphino)ferrocene; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 80℃; for 24h; Inert atmosphere; Sealed tube; | 96% |
With copper In dimethyl sulfoxide at 120℃; for 55h; Schlenk technique; Inert atmosphere; Sealed tube; | 63% |
Conditions | Yield |
---|---|
With potassium hexafluorophosphate; selenium; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 95℃; for 16h; Sealed tube; | 96% |
1,1,1-trifluoro-2-iodoethane
2-hydroxy-3,17β-bis(benzyloxy)estra-1,3,5(10)-triene
2-(2',2',2'-Trifluoroethoxy)-3,17β-Dibenzyloxyestra-1,3,5(10)-Triene
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide a) 110 deg C, 3 h, b) 130 deg C, 2 h; | 95% |
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether In toluene at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 95% |
1,1,1-trifluoro-2-iodoethane
methyl 3-iodo-benzoate
methyl 3-((2,2,2-trifluoroethyl)thio)benzoate
Conditions | Yield |
---|---|
With sulfur; sodium tetrahydroborate; copper(l) iodide; 1,10-Phenanthroline In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere; Sealed tube; | 95% |
1,1,1-trifluoro-2-iodoethane
2-(4-bromophenyl)acrylic acid
1-(4'-bromophenyl)-4,4,4-trifluoro-1-butanone
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; copper acetylacetonate; silver sulfate; triethylamine In water; acetonitrile at 80℃; for 0.5h; Sealed tube; Microwave irradiation; | 95% |
1,1,1-trifluoro-2-iodoethane
2-[4-(4-iodobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Conditions | Yield |
---|---|
With nickel(II) iodide; 1,1'-bis-(diphenylphosphino)ferrocene; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 80℃; for 24h; Inert atmosphere; Sealed tube; | 95% |
The Ethane,1,1,1-trifluoro-2-iodo-, with CAS registry number 353-83-3, has the systematic name of 1,1,1-trifluoro-2-iodoethane. And its IUPAC name is the same one. This chemical is a kind of clear colorless to pink liquid. What's more, its EINECS is 206-541-0.
Physical properties of Ethane,1,1,1-trifluoro-2-iodo-: (1)ACD/LogP: 1.97; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.97; (4)ACD/LogD (pH 7.4): 1.97; (5)ACD/BCF (pH 5.5): 18.61; (6)ACD/BCF (pH 7.4): 18.61; (7)ACD/KOC (pH 5.5): 282.19; (8)ACD/KOC (pH 7.4): 282.19; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 0 Å2; (13)Index of Refraction: 1.424; (14)Molar Refractivity: 24.74 cm3; (15)Molar Volume: 96.7 cm3; (16)Polarizability: 9.8×10-24cm3; (17)Surface Tension: 21.8 dyne/cm; (18)Enthalpy of Vaporization: 28.45 kJ/mol; (19)Vapour Pressure: 266 mmHg at 25°C.
Uses of Ethane,1,1,1-trifluoro-2-iodo-: it can be used to produce 1,1,1-trifluoro-octane. This reaction will need reagent AIBN (2,2'-azobisisobutyronitrile).
When you are using this chemical, please be cautious about it as the following:
The Ethane,1,1,1-trifluoro-2-iodo- irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)(F)CI
(2)InChI: InChI=1/C2H2F3I/c3-2(4,5)1-6/h1H2
(3)InChIKey: RKOUFQLNMRAACI-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C2H2F3I/c3-2(4,5)1-6/h1H2
(5)Std. InChIKey: RKOUFQLNMRAACI-UHFFFAOYSA-N
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