Product Name

  • Name

    2-Methylbenzenethiol

  • EINECS 205-276-8
  • CAS No. 137-06-4
  • Article Data48
  • CAS DataBase
  • Density 1.049 g/cm3
  • Solubility insoluble in water
  • Melting Point 10-12 °C(lit.)
  • Formula C7H8S
  • Boiling Point 195 °C at 760 mmHg
  • Molecular Weight 124.207
  • Flash Point 63.9 °C
  • Transport Information UN 2810
  • Appearance Clear colourless to slighty yellow-brown liquid
  • Safety 26-39-36/37/39
  • Risk Codes 37/38-41-36/37/38-20/21/22
  • Molecular Structure Molecular Structure of 137-06-4 (2-Methylbenzenethiol)
  • Hazard Symbols HarmfulXn, IrritantXi
  • Synonyms o-Toluenethiol(8CI);2-Methylbenzenethiol;2-Methylbenzothiol;2-Methylphenylthiol;2-Toluenethiol;NSC 80655;o-Mercaptotoluene;o-Methylbenzenethiol;o-Methylthiophenol;o-Thiocresol;o-Tolyl mercaptan;o-Tolylthiol;Benzenethiol, 2-methyl-;
  • PSA 38.80000
  • LogP 2.28370

Synthetic route

ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Inert atmosphere;96%
Stage #1: ortho-methylphenyl iodide With copper(l) iodide; potassium carbonate; sulfur In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Cooling with ice;		90%
With sodiumsulfide nonahydrate; copper; ethane-1,2-dithiol In dimethyl sulfoxide at 100℃; for 20h; Inert atmosphere; Green chemistry;88%
With copper(l) iodide; thiourea; L-proline; sodium t-butanolate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;86%
2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With hydrogen sulfide at 360℃; Reagent/catalyst;98.5%
Stage #1: 2-methylphenyl bromide With water; caesium carbonate; sodium thiosulfate; bis(dibenzylideneacetone)-palladium(0); XPhos In toluene; tert-butyl alcohol at 80℃; for 24h; Inert atmosphere;
Stage #2: With hydrogenchloride; zinc In water for 1h; Cooling with ice;		75%
With sulfur; magnesium 1.) ether; Multistep reaction;
Dimethyldisulphide
624-92-0

Dimethyldisulphide

phenol
108-95-2

phenol

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With hydrogenchloride; aluminium chloride In diethyl ether; toluene; Petroleum ether
bis(2-methylphenyl)disulfide
4032-80-8

bis(2-methylphenyl)disulfide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 0 - 35℃;96%
With sodium tetrahydroborate; zirconium(IV) chloride In tetrahydrofuran at 35℃; for 0.166667h; Reduction;95%
Dimethyldisulphide
624-92-0

Dimethyldisulphide

phenol
108-95-2

phenol

A

para-thiocresol
106-45-6

para-thiocresol

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With iron(III) chloride In Petroleum ether
...Expand
methyl o-tolyl sulfide
14092-00-3

methyl o-tolyl sulfide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; diethylamine In xylene for 6h; Heating;85%
toluene
108-88-3

toluene

A

para-thiocresol
106-45-6

para-thiocresol

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
Stage #1: toluene With trifluoromethylsulfonic anhydride; (MeO2CH2CH2)2SO In dichloromethane at -35 - 20℃;
Stage #2: With triethylamine In tetrahydrofuran at 20℃; for 12h;
Stage #3: With potassium tert-butylate In tetrahydrofuran at -78℃; for 0.166667h; Title compound not separated from byproducts;
S-o-tolyl dimethylcarbamothioate
7305-14-8

S-o-tolyl dimethylcarbamothioate

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; methanol for 3h; Ambient temperature;
O‐(o‐tolyl) dimethylcarbamothioate
10345-39-8

O‐(o‐tolyl) dimethylcarbamothioate

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2 h / 210 °C
2: KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature
View Scheme
ortho-cresol
95-48-7

ortho-cresol

colloid/al platinum

colloid/al platinum

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1,4-diazabicyclo<2.2.2>octane (dabco) / dimethylformamide / 1.5 h / 60 - 70 °C
2: 2 h / 210 °C
3: KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature
View Scheme
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With sodium hydroxide; n-butanethiol 1) N-methyl-2-pyrrolidone, removal of water by toluene reflux, 2) reflux (ca. 186 deg C), 20 h; Yield given. Multistep reaction;
With pumice stone; hydrogen sulfide at 700℃;
With pumice stone; hydrogen sulfide; thorium dioxide at 700℃;
Benzo[b]thiophene
95-15-8

Benzo[b]thiophene

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With potassium hydroxide at 300 - 310℃; im Autoklaven;
ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

thiourea
17356-08-0

thiourea

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With sodium hydroxide; bis(triethylphosphine)nickel(II) chloride; sodium cyanoborohydride 1.) DMF, 60 deg C, 10 h, 2.) water, room temperature; Yield given. Multistep reaction;
2,2,4,4-tetrachloro-2,4-dihydro-1,3-benzodithiin
87641-74-5

2,2,4,4-tetrachloro-2,4-dihydro-1,3-benzodithiin

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 7h; Heating; Title compound not separated from byproducts;
dithiocarbonic acid O-ethyl ester-S-o-tolyl ester
24022-34-2

dithiocarbonic acid O-ethyl ester-S-o-tolyl ester

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
(3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-o-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione
248584-39-6

(3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-o-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione

A

grosheimin
22489-66-3

grosheimin

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=7.4; Kinetics; Hydrolysis;
Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With sulfuric acid elektrochemische Reduktion;
With hydrogenchloride; iron
[(2-Methylphenyl)sulfanyl]acetic acid
18619-15-3

[(2-Methylphenyl)sulfanyl]acetic acid

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With perchloric acid; pyridinium chlorochromate In water; acetic acid at 24.85 - 44.85℃; Kinetics; Oxidation;
ortho-tolylmagnesium bromide
932-31-0

ortho-tolylmagnesium bromide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With diethyl ether; sulfur Zersetzung des Reaktionsproduktes mit angesaeuertem Wasser;
2-methylbenzene diazonium
17333-74-3

2-methylbenzene diazonium

A

di-o-tolyl sulfide
4537-05-7

di-o-tolyl sulfide

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With sodium sulfide
With sodium sulfide
4-bromo-toluene-2-sulfonic acid
56919-17-6

4-bromo-toluene-2-sulfonic acid

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With hydrogenchloride; tin Behandeln des Reaktionsprodukts in Alkohol mit Natriumamalgam;
o-toluidine
95-53-4

o-toluidine

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite Eintragen des Reaktionsgemisches in wss. Natriumpolysulfid und Erhitzen des danach erhaltenen Reaktionsprodukts mit wss. NaOH;
2-Methyl-benzenethiol

2-Methyl-benzenethiol

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With triethylamine In various solvent(s) Kinetics; Reduction;
potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

o-toluene-diazonium chloride
2028-34-4

o-toluene-diazonium chloride

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
Erwaermen auf ca. 70grad und Verseifung mit alkoh. Kalilauge;
[(2-Methylphenyl)sulfanyl]acetic acid
18619-15-3

[(2-Methylphenyl)sulfanyl]acetic acid

A

Glyoxilic acid
298-12-4

Glyoxilic acid

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With perchloric acid; sodium perborate; acetic acid at 24.9℃; Rate constant; Thermodynamic data; Mechanism; var. temp., ΔH(excit.), ΔS(excit.);
1-chloro-2-(chloromethyl)benzene
611-19-8

1-chloro-2-(chloromethyl)benzene

A

2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

B

(E)-2,2'-dichlorostilbene
25144-38-1

(E)-2,2'-dichlorostilbene

C

1,2-bis(2-chlorophenyl)ethane
6639-40-3

1,2-bis(2-chlorophenyl)ethane

D

1,1-di(2-chlorophenyl)ethylene
97063-37-1

1,1-di(2-chlorophenyl)ethylene

E

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
With hydrogen sulfide at 560℃; Product distribution; thermolysis in stream of hydrogen sulfide;
...Expand
2-ethoxy-S-allylthiophenol
102968-96-7

2-ethoxy-S-allylthiophenol

A

styrene
292638-84-7

styrene

B

1-benzofurane
271-89-6

1-benzofurane

C

acetophenone
98-86-2

acetophenone

D

2-thiocresol
137-06-4

2-thiocresol

E

phenol
108-95-2

phenol

Conditions
ConditionsYield
at 750℃; under 0.001 - 0.005 Torr; for 0.333333h; Mechanism; pyrolysis of o-substituted N-, O-, and S-allyl compounds;
...Expand
(Dimethylamino-o-tolylsulfanyl-methylene)-dimethyl-ammonium; iodide

(Dimethylamino-o-tolylsulfanyl-methylene)-dimethyl-ammonium; iodide

A

tetramethylurea
632-22-4

tetramethylurea

B

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
at 20℃; Rate constant; pH=11;
Benzo[b]thiophene
95-15-8

Benzo[b]thiophene

potassium hydroxide

potassium hydroxide

2-thiocresol
137-06-4

2-thiocresol

Conditions
ConditionsYield
at 300 - 310℃; im Autoklaven;
2-thiocresol
137-06-4

2-thiocresol

bis(2-methylphenyl)disulfide
4032-80-8

bis(2-methylphenyl)disulfide

Conditions
ConditionsYield
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃; for 0.0166667h;100%
With aluminum oxide; sodium iodate In hexane at 20℃; for 0.5h;99%
With N,N,N,N,-tetramethylethylenediamine; eosin y In ethanol for 2h; Irradiation;99%
2-thiocresol
137-06-4

2-thiocresol

methyl iodide
74-88-4

methyl iodide

methyl o-tolyl sulfide
14092-00-3

methyl o-tolyl sulfide

Conditions
ConditionsYield
With potassium carbonate In acetone at 25℃; for 17h;100%
With sodium hydride In N,N-dimethyl-formamide 1.) 0 deg C, 15 min, 2.) room temperature, 45 min;97%
With potassium carbonate In acetone at 20℃; for 18h;95%
4-iodobenzoic acid
619-58-9

4-iodobenzoic acid

2-thiocresol
137-06-4

2-thiocresol

4-[(2-methylphenyl)thio]benzamide

4-[(2-methylphenyl)thio]benzamide

Conditions
ConditionsYield
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h;
Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h;
Stage #3: With trifluoroacetic acid In dichloromethane		100%
4-iodobenzoic acid
619-58-9

4-iodobenzoic acid

2-thiocresol
137-06-4

2-thiocresol

4-[(2-methylphenyl)thio]benzoic acid

4-[(2-methylphenyl)thio]benzoic acid

Conditions
ConditionsYield
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h;
Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h;
Stage #3: With trifluoroacetic acid In dichloromethane		100%
3-iodo-4-toluic acid
82998-57-0

3-iodo-4-toluic acid

2-thiocresol
137-06-4

2-thiocresol

4-methyl-3-[(2-methylphenyl)thio]benzoic acid

4-methyl-3-[(2-methylphenyl)thio]benzoic acid

Conditions
ConditionsYield
Stage #1: 3-iodo-4-toluic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h;
Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h;
Stage #3: With trifluoroacetic acid In dichloromethane		100%
4-iodo-3-methylbenzoic acid
52107-87-6

4-iodo-3-methylbenzoic acid

2-thiocresol
137-06-4

2-thiocresol

3-methyl-4-[(2-methylphenyl)thio]benzoic acid

3-methyl-4-[(2-methylphenyl)thio]benzoic acid

Conditions
ConditionsYield
Stage #1: 4-iodo-3-methylbenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h;
Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h;
Stage #3: With trifluoroacetic acid In dichloromethane		100%
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

2-thiocresol
137-06-4

2-thiocresol

2-(2'-Methylphenylthio)benzoic acid
87548-96-7

2-(2'-Methylphenylthio)benzoic acid

Conditions
ConditionsYield
With potassium hydroxide; copper In water for 7h; Heating;99%
methanol
67-56-1

methanol

2-thiocresol
137-06-4

2-thiocresol

2-methylbenzenesulfinic acid methyl ester
94626-19-4

2-methylbenzenesulfinic acid methyl ester

Conditions
ConditionsYield
With N-Bromosuccinimide In dichloromethane at 0℃; for 1h;99%
With oxygen; potassium carbonate at 60℃; for 24h; Schlenk technique; chemoselective reaction;75%
With eosin at 20℃; for 1h; Irradiation;75%
(i) Pb(OAc)4, (ii) /BRN= 1098229/, Pb(OAc)4; Multistep reaction;
2-thiocresol
137-06-4

2-thiocresol

5-Isopropyl-6-methanesulfonyl-1-propoxy-1H-pyrimidine-2,4-dione
191472-62-5

5-Isopropyl-6-methanesulfonyl-1-propoxy-1H-pyrimidine-2,4-dione

5-Isopropyl-1-propoxy-6-o-tolylsulfanyl-1H-pyrimidine-2,4-dione

5-Isopropyl-1-propoxy-6-o-tolylsulfanyl-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
With sodium hydroxide for 0.333333h; Ambient temperature;99%
2-thiocresol
137-06-4

2-thiocresol

6-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate
345948-96-1

6-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

C17H14O2S
627100-56-5

C17H14O2S

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20 - 25℃;99%
N-tosyldiphenylmethylamine
853-83-8

N-tosyldiphenylmethylamine

2-thiocresol
137-06-4

2-thiocresol

benzhydryl-o-tolyl sulfide

benzhydryl-o-tolyl sulfide

Conditions
ConditionsYield
With chloro-trimethyl-silane; zinc(II) chloride In dichloromethane at 20℃; for 1h;99%
cyclohexenone
930-68-7

cyclohexenone

2-thiocresol
137-06-4

2-thiocresol

(S)-3-(o-tolylthio)cyclohexanone
177473-06-2

(S)-3-(o-tolylthio)cyclohexanone

Conditions
ConditionsYield
With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)urea In toluene at 20℃; for 7h; Michael addition; optical yield given as %ee; enantioselective reaction;99%
2-bromoanisole
578-57-4

2-bromoanisole

2-thiocresol
137-06-4

2-thiocresol

2-methoxyphenyl 2-methylphenyl sulfide
105510-24-5

2-methoxyphenyl 2-methylphenyl sulfide

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine In toluene for 3h; Inert atmosphere; Reflux;99%
With 1-(pyridin-2-yl)-1H-benzo[d][1,2,3]triazole; potassium tert-butylate; palladium diacetate In dimethyl sulfoxide at 100℃; for 12h; Inert atmosphere; Schlenk technique;87%
With copper(l) iodide; 1-Hydroxymethyl-1H-benzotriazole; potassium tert-butylate In dimethyl sulfoxide at 100℃;78%
2-Bromo-m-xylene
576-22-7

2-Bromo-m-xylene

2-thiocresol
137-06-4

2-thiocresol

(2,6-dimethylphenyl)(o-tolyl)sulfane
38630-01-2

(2,6-dimethylphenyl)(o-tolyl)sulfane

Conditions
ConditionsYield
Stage #1: 2-Bromo-m-xylene With dichloro[1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II); lithium isopropoxide In toluene at 80℃; for 0.5h; Inert atmosphere;
Stage #2: 2-thiocresol With potassium tert-butylate In toluene at 40℃; for 24h; Inert atmosphere;		99%
2-thiocresol
137-06-4

2-thiocresol

rac-2-(2-bromophenyl)-1-tosylaziridine
200803-17-4

rac-2-(2-bromophenyl)-1-tosylaziridine

3-(o-tolylthio)-1-tosylindoline
1429656-46-1

3-(o-tolylthio)-1-tosylindoline

Conditions
ConditionsYield
Stage #1: 2-thiocresol; 2-(2-bromophenyl)-N-tosylaziridine With potassium carbonate In toluene at 20℃; for 0.416667h; Inert atmosphere;
Stage #2: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110 - 115℃; for 3h; Inert atmosphere;		99%
Benzoylformic acid
611-73-4

Benzoylformic acid

2-thiocresol
137-06-4

2-thiocresol

S-(o-tolyl) benzothioate

S-(o-tolyl) benzothioate

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;99%
With ammonium peroxydisulfate; copper(II) oxide In water; dimethyl sulfoxide at 80℃; for 12h;73%
(4-methylphenyl)(oxo)acetic acid
7163-50-0

(4-methylphenyl)(oxo)acetic acid

2-thiocresol
137-06-4

2-thiocresol

S-o-tolyl 4-methylbenzothioate

S-o-tolyl 4-methylbenzothioate

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;99%
2-oxo-2-o-tolylacetic acid

2-oxo-2-o-tolylacetic acid

2-thiocresol
137-06-4

2-thiocresol

S-o-tolyl 2-methylbenzothioate
101093-42-9

S-o-tolyl 2-methylbenzothioate

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;99%
phenylhydrazine
100-63-0

phenylhydrazine

2-thiocresol
137-06-4

2-thiocresol

2-(phenylthio)toluene
13963-35-4

2-(phenylthio)toluene

Conditions
ConditionsYield
With manganese(II)carbonate; C26H36N2O6; oxygen; potassium carbonate at 60℃; under 750.075 Torr; for 19h;99%
With copper(II) nitrate trihydrate; 4,7-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,10-phenanthroline; oxygen; caesium carbonate In water at 100℃; under 760.051 Torr; for 36h; Schlenk technique; Green chemistry; chemoselective reaction;95%
p-Methoxybenzoic anhydride
794-94-5

p-Methoxybenzoic anhydride

2-thiocresol
137-06-4

2-thiocresol

1-[(4-methoxyphenyl)thio]-2-methylbenzene
22894-90-2

1-[(4-methoxyphenyl)thio]-2-methylbenzene

Conditions
ConditionsYield
With manganese; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; nickel dichloride In toluene at 150℃; for 24h; Sealed tube; Inert atmosphere;99%

2-Methylthiophenol Chemical Properties


IUPAC Name: 2-Methylbenzenethiol 
Molecular formula: C7H8S 
Molecular Weight: 124.2
Density: 1.049 g/cm3  
Melting point: 0-12 °C(lit.)
Boiling point: 195 °C at 760 mmHg
Flash point: 63.9 °C
Solubility in water: insoluble
Sensitive: Stench
Index of Refraction: 1.577 
Molar Refractivity: 39.25 cm3
Molar Volume: 118.3 cm3
Surface Tension: 37.8 dyne/cm
Enthalpy of Vaporization: 41.36 kJ/mol  
Vapour Pressure: 0.601 mmHg at 25 °C
Appearance: clear colourless to slighty yellow-brown liguid
EINECS: 205-276-8
Product Categories of o-Toluenethiol (CAS NO.137-06-4): Phenol & Thiophenol & Mercaptan; thiol Flavor

2-Methylthiophenol Uses

 o-Toluenethiol (CAS NO.137-06-4) is used as a raw material in organic synthesis.

2-Methylthiophenol Production

It is derived by the o-toluidine by diazotization, esterification, hydrolysis.

2-Methylthiophenol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   National Technical Information Service. Vol. AD277-689,

2-Methylthiophenol Consensus Reports

Reported in EPA TSCA Inventory.

2-Methylthiophenol Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic fumes of SOx.
Hazard Codes: IrritantXi,HarmfulXn
Risk Statements:
R37/38: Irritating to respiratory system and skin .
R41: Risk of serious damage to eyes.
R36/37/38: Irritating to eyes, respiratory system and skin .
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39: Wear eye/face protection .
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection .
RIDADR: 2810
WGK Germany: 3
RTECS: XT8750000
Hazard Note: Harmful/Irritant/Stench
HazardClass: 6.1
PackingGroup of o-Toluenethiol (CAS NO.137-06-4): III

2-Methylthiophenol Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid, Poison (UN 1228); DOT Class: 6.1; Label: Poison, Flammable Liquid (UN 3071)

2-Methylthiophenol Specification

 o-Toluenethiol (CAS NO.137-06-4), its Synonyms are 2-Methylbenzenethiol ; 2-Methylphenylthiol ; 2-Methylthiophenol ; 2-Toluenethiol ; Benzenethiol, 2-methyl- ; o-Mercaptotoluene ; o-Methylbenzenethiol ; o-Methylthiophenol ; o-Thiocresol ; Toluene, 2-mercapto- ; Tolylmercaptan, o- ; Tolylthiol, o- .

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