Product Name

  • Name

    2-Thiopheneacetic acid

  • EINECS 217-639-8
  • CAS No. 1918-77-0
  • Article Data51
  • CAS DataBase
  • Density 1.336 g/cm3
  • Solubility Soluble in water, ethanol, ether and carbon tetrachloride.
  • Melting Point 63-64 °C(lit.)
  • Formula C6H6O2S
  • Boiling Point 269.2 °C at 760 mmHg
  • Molecular Weight 142.178
  • Flash Point 116.6 °C
  • Transport Information UN 3261 8/PG 2
  • Appearance white to light yellow crystal powder
  • Safety 26-36/37/39-45-24/25-27
  • Risk Codes 34-37-36/37/38
  • Molecular Structure Molecular Structure of 1918-77-0 (2-Thiopheneacetic acid)
  • Hazard Symbols CorrosiveC,IrritantXi
  • Synonyms 2-(2-Thienyl)aceticacid;2-(Thiophen-2-yl)acetic acid;2-Thienylethanoicacid;Thiophen-2-ylacetic acid;
  • PSA 65.54000
  • LogP 1.37520

Synthetic route

ethyl thiophen-2-ylacetate
57382-97-5

ethyl thiophen-2-ylacetate

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 20℃; for 1h;100%
With water; sodium hydroxide In ethanol at 20℃; for 1h;100%
2-thiophenethanol
5402-55-1

2-thiophenethanol

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With oxygen; triethylamine at 80℃; for 15h; Reagent/catalyst; Temperature;96.5%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 12h;85%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Green chemistry;85%
With iridium hexafluoride; sulphate-doped anatase; potassium oxide In dichloromethane at 85℃; Temperature;
methyl 2-thiopheneacetate
19432-68-9

methyl 2-thiopheneacetate

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With sodium hydroxide for 2h; Heating;94%
2,2,2-trichloro-1-(thien-2-yl)-ethanol
35320-27-5

2,2,2-trichloro-1-(thien-2-yl)-ethanol

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Stage #1: 2,2,2-trichloro-1-(thien-2-yl)-ethanol With sodium tetrahydroborate; diphenyl diselenide In ethanol Inert atmosphere;
Stage #2: With sodium hydroxide In ethanol at 40℃; Inert atmosphere;
94%
2-cyanomethylthiophene
20893-30-5

2-cyanomethylthiophene

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;93.4%
With water; potassium hydroxide In ethanol for 3h; Inert atmosphere; Reflux;74%
With potassium hydroxide
N-((E)-1-Cyano-2-thiophen-2-yl-vinyl)-4,N-dimethyl-benzamide
89244-23-5, 89244-24-6

N-((E)-1-Cyano-2-thiophen-2-yl-vinyl)-4,N-dimethyl-benzamide

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;89%
2-methoxy-2-(thiophen-2-yl)acetic acid
5371-94-8

2-methoxy-2-(thiophen-2-yl)acetic acid

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With sodium chloride; iodine In water; acetic acid; ethyl acetate86%
α-(N-Methylanilino)-β-(2-thienyl)acrylonitrile
91668-56-3

α-(N-Methylanilino)-β-(2-thienyl)acrylonitrile

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran for 10h; Heating;83%
2-oxo-3-(thiophen-2-yl)propanoic acid
15504-41-3

2-oxo-3-(thiophen-2-yl)propanoic acid

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With sodium perborate In water for 48h; Ambient temperature;68%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

Bromoform
75-25-2

Bromoform

ethanethiol
75-08-1

ethanethiol

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With potassium hydroxide In diethyl ether; water; dimethyl sulfoxide58%
carbon dioxide
124-38-9

carbon dioxide

N,N,N-trimethyl-1-(thiophen-2-yl)methanaminium trifluoromethanesulfonate

N,N,N-trimethyl-1-(thiophen-2-yl)methanaminium trifluoromethanesulfonate

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium carbonate; caesium carbonate In N,N-dimethyl-formamide at 25 - 30℃; for 36h; Schlenk technique; Glovebox; Sealed tube; Irradiation;55%
((Z)-1-Dimethylamino-2-thiophen-2-yl-vinyl)-phosphonic acid diethyl ester
82670-75-5

((Z)-1-Dimethylamino-2-thiophen-2-yl-vinyl)-phosphonic acid diethyl ester

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With hydrogenchloride Heating;43%
carbon monoxide
201230-82-2

carbon monoxide

2-thiophenemethanol
636-72-6

2-thiophenemethanol

A

2-Methylthiophene
554-14-3

2-Methylthiophene

B

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction;A 12%
B 18%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With diethyl ether Erwaermen einer Loesung des Reaktionsprodukts in Dioxan mit Silberoxid und Natriumthiosulfat in Wasser;
2-Chloromethylthiophene
765-50-4

2-Chloromethylthiophene

A

2-methylthiophene-3-carboxylic acid
1918-78-1

2-methylthiophene-3-carboxylic acid

B

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With diethyl ether; magnesium Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
2-Acetylthiophene
88-15-3

2-Acetylthiophene

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With 1,4-dioxane; ammonium polysulfide solution; sulfur Erhitzen des erhaltenen Saeureamids mit wss. Kalilauge;
With 1,4-dioxane; ammonium polysulfide solution; sulfur Erhitzen des erhaltenen Saeureamids mit wss. Salzsaeure;
Multi-step reaction with 2 steps
1: 83 percent / BF3*O(C2H5)3, Pb(OAc)4 / benzene / 11 h / Ambient temperature
2: 94 percent / aq. NaOH / 2 h / Heating
View Scheme
2-thenyl magnesium chloride
19432-64-5

2-thenyl magnesium chloride

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

A

2-methylthiophene-3-carboxylic acid
1918-78-1

2-methylthiophene-3-carboxylic acid

B

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

isopropyl 2-(thiophen-2-yl)acetate
68100-13-0

isopropyl 2-(thiophen-2-yl)acetate

A

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

B

propene
187737-37-7

propene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
tert-butyl 2-(thiophen-2-yl)acetate
58416-18-5

tert-butyl 2-(thiophen-2-yl)acetate

A

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

B

isobutene
115-11-7

isobutene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
α-thienylglycolic acid

α-thienylglycolic acid

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With phosphorus; hydrogen iodide
methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

<2>thienyl-methyl magnesium chloride

<2>thienyl-methyl magnesium chloride

A

2-methylthiophene-3-carboxylic acid
1918-78-1

2-methylthiophene-3-carboxylic acid

B

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With diethyl ether
2-diazo-1-(thiophen-2-yl)ethanone
72676-21-2

2-diazo-1-(thiophen-2-yl)ethanone

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With silver(l) oxide In 1,4-dioxane Rearrangement;
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether / 0 °C
2: aq. Ag2O / dioxane
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether / Erwaermen des Reaktionsprodukts mit Silberoxid und Methanol
View Scheme
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (COCl)2; DMF / CH2Cl2
2: diethyl ether / 0 °C
3: aq. Ag2O / dioxane
View Scheme
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / KH / tetrahydrofuran / 4 h / Ambient temperature
2: 83 percent / 10percent aq. HCl / tetrahydrofuran / 10 h / Heating
View Scheme
2-ethynyl-thiophene
4298-52-6

2-ethynyl-thiophene

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene, NaHCO3 / methanol / 110 h / Heating
2: 2N NaOH
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: oxone||potassium monopersulfate triple salt; water / acetone / 12 h / 50 °C / Inert atmosphere
View Scheme
3-thiophen-2-yl-2-thioxo-propionic acid
89677-36-1

3-thiophen-2-yl-2-thioxo-propionic acid

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol; hydroxylamine
2: acetic acid anhydride
3: aq.-ethanolic KOH-solution
View Scheme
5-(2'-thiophenemethylene)rhodamine
6319-47-7, 98800-08-9, 98800-09-0

5-(2'-thiophenemethylene)rhodamine

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aq. NaOH solution
2: ethanol; hydroxylamine
3: acetic acid anhydride
4: aq.-ethanolic KOH-solution
View Scheme
methanol
67-56-1

methanol

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

methyl 2-thiopheneacetate
19432-68-9

methyl 2-thiopheneacetate

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;100%
With thionyl chloride at 0 - 20℃; for 18h;100%
With thionyl chloride at 0 - 20℃; for 18h;100%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

5,6-dimethoxy-2-(N-propylamino)indan
162751-96-4

5,6-dimethoxy-2-(N-propylamino)indan

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-2-yl-acetamide
745060-18-8

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-2-yl-acetamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h;100%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-(thiophen-2-yl)acetamide

N-benzyl-2-(thiophen-2-yl)acetamide

Conditions
ConditionsYield
With (2-(thiophen-2-ylmethyl)phenyl)boronic acid In dichloromethane at 20℃; for 24h; Inert atmosphere; Molecular sieve;99%
With bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Sealed tube; Inert atmosphere;90%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

oxalyl dichloride
79-37-8

oxalyl dichloride

2-(2'-Thienyl)methyl-penem-3-carboxylic Acid

2-(2'-Thienyl)methyl-penem-3-carboxylic Acid

Conditions
ConditionsYield
98.8%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

4'-methoxy-N-(azulen-1-ylmethylene)aniline
854154-95-3

4'-methoxy-N-(azulen-1-ylmethylene)aniline

1-(azulen-1'-yl)-2-(thien-2''-yl)ethene
652142-07-9

1-(azulen-1'-yl)-2-(thien-2''-yl)ethene

Conditions
ConditionsYield
for 0.25h; Heating;98%
for 0.5h; Heating;98%
hydrogenchloride
7647-01-0

hydrogenchloride

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

lead(II) nitrate

lead(II) nitrate

potassium hydroxide

potassium hydroxide

[Pb(thiophene-2-acetate)2(H2O)]n

[Pb(thiophene-2-acetate)2(H2O)]n

Conditions
ConditionsYield
Stage #1: hydrogenchloride; lead(II) nitrate; potassium hydroxide at 70℃; for 0.5h; Green chemistry;
Stage #2: Thiophene-2-acetic acid for 6h; Heating; Green chemistry;
98%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

aniline
62-53-3

aniline

N-phenyl-2-(thiophen-2-yl)acetamide
69047-40-1

N-phenyl-2-(thiophen-2-yl)acetamide

Conditions
ConditionsYield
With triethylamine; Phenyl N-phenylphosphoramidochloridate In dichloromethane for 1h; Ambient temperature;97%
With zeolite-HY In neat (no solvent) for 1h; Irradiation;97%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In dichloromethane at 20 - 25℃; for 1h;90%
Stage #1: Thiophene-2-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h;
Stage #2: aniline In tetrahydrofuran at 20℃; for 2h;
81%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 6h;97%
With tricarbonyl(η(4)-cycloocta-1,5-diene)iron; phenylsilane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; UV-irradiation; chemoselective reaction;95%
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In chloroform at 60℃; for 2h; Inert atmosphere;73%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

phenyl isocyanate
1197040-29-1

phenyl isocyanate

N-formyl-N-phenyl-2-(thiophen-2-yl)acetamide
1414349-67-9

N-formyl-N-phenyl-2-(thiophen-2-yl)acetamide

Conditions
ConditionsYield
In toluene at 110℃; Sealed tube; Inert atmosphere;97%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-(2-(4-methoxyphenyl)ethyl)-2-thiophen-2-ylacetamide
349433-11-0

N-(2-(4-methoxyphenyl)ethyl)-2-thiophen-2-ylacetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;97%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

silver nitrate

silver nitrate

silver(I) 2-thiopheneacetate

silver(I) 2-thiopheneacetate

Conditions
ConditionsYield
With triethylamine In ethanol; acetonitrile at 0℃; for 2h; Inert atmosphere; Schlenk technique;97%
With triethylamine In ethanol; acetonitrile at 0℃; for 2h;97%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

diethyl 4-(6-hydroxyhexan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 4-(6-hydroxyhexan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 2,6-dimethyl-4-(6-(2-(thiophen-2-yl)acetoxy)hexan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 2,6-dimethyl-4-(6-(2-(thiophen-2-yl)acetoxy)hexan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;97%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

o-toluidine
95-53-4

o-toluidine

2-(thiophen-2-yl)-N-(o-tolyl)acetamide
69047-43-4

2-(thiophen-2-yl)-N-(o-tolyl)acetamide

Conditions
ConditionsYield
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In dichloromethane at 20 - 25℃; for 1h;96%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

trimethylsilyl 2-(thien-2-yl)acetate
934415-23-3

trimethylsilyl 2-(thien-2-yl)acetate

Conditions
ConditionsYield
Stage #1: Thiophene-2-acetic acid With pyridine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: chloro-trimethyl-silane With 1,1,1,3,3,3-hexamethyl-disilazane In tetrahydrofuran at 0 - 20℃; for 12h;
96%
piperidine
110-89-4

piperidine

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

1-(piperidin-1-yl)-2-(thiophen-2-yl)ethan-1-one
114373-80-7

1-(piperidin-1-yl)-2-(thiophen-2-yl)ethan-1-one

Conditions
ConditionsYield
With tris(2,2,2-trifluoroethyl) borate for 24h; Dean-Stark; Reflux;96%
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;78%
morpholine
110-91-8

morpholine

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

1-morpholino-2-(thiophen-2-yl)ethan-1-one

1-morpholino-2-(thiophen-2-yl)ethan-1-one

Conditions
ConditionsYield
With phenylsilane In acetonitrile at 20℃; for 2.5h;96%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

ethanol
64-17-5

ethanol

ethyl thiophen-2-ylacetate
57382-97-5

ethyl thiophen-2-ylacetate

Conditions
ConditionsYield
With hydrogenchloride In water at 70℃; for 19h;95%
With hydrogenchloride In water at 20 - 70℃; for 19h;95%
With sulfuric acid Reflux;71%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

tantalum pentaethoxide
150747-55-0

tantalum pentaethoxide

[Ta(OC2H5)3(C4H3SCH2COO)2]
98605-57-3

[Ta(OC2H5)3(C4H3SCH2COO)2]

Conditions
ConditionsYield
In benzene byproducts: C2H5OH; react. under anhydrous conditions, addn. of 2-thiopheneacetic acid to asoln. of Ta(OEt)5 in benzene (2:1 molar ratio), refluxing for 8 h; collecting of liberated ethanol azeotropically, distg. off excess solvent, drying in vac., elem. anal.;95%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

4-Bromo-benzene-1,2-diamine
1575-37-7

4-Bromo-benzene-1,2-diamine

6-bromo-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole
1340048-81-8

6-bromo-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole

Conditions
ConditionsYield
Stage #1: Thiophene-2-acetic acid With borane-THF In tetrahydrofuran; toluene at 20℃; for 0.5h; Cooling with ice;
Stage #2: 4-Bromo-benzene-1,2-diamine In tetrahydrofuran; toluene for 12h; Reflux;
95%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

(Z)-3-(cyclohexylamino)-3-oxo-1-(thiophen-2-yl)prop-1-en-2-yl 2-(thiophen-2-yl)acetate
1414349-77-1

(Z)-3-(cyclohexylamino)-3-oxo-1-(thiophen-2-yl)prop-1-en-2-yl 2-(thiophen-2-yl)acetate

Conditions
ConditionsYield
In nitromethane at 40℃; for 24h; Solvent; Concentration; Temperature; Sealed tube;95%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

3,4-methylenedioxyphenylethylamine
1484-85-1

3,4-methylenedioxyphenylethylamine

N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(thiophen-2-yl)acetamide
92851-34-8

N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(thiophen-2-yl)acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 6h;95%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;74%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;95%
With dipotassium peroxodisulfate In water at 90℃; for 12h; Green chemistry;75%
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;72%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

hexachloro[60]fullerene
151013-83-1

hexachloro[60]fullerene

C90H25ClO10S5

C90H25ClO10S5

Conditions
ConditionsYield
With tin(IV) chloride In 1,2-dichloro-benzene at 70 - 80℃; for 1h; Inert atmosphere;95%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 5h; Temperature; Reagent/catalyst;94.7%
With phosgene; 4-cyclopentylaminopyridine hydrobromide In toluene92%
With 1-butyl-3-methylimidazolium hydroxide; thionyl chloride In chloroform at 10℃; for 8h; Reagent/catalyst; Temperature;89.8%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

(6R,7R)-7-Amino-3-(4,4-dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
124876-28-4

(6R,7R)-7-Amino-3-(4,4-dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-(4,4-Dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
124876-32-0

(6R,7R)-3-(4,4-Dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With N,N-bis(trimethylsilyl)acetamide; trichlorophosphate In ethyl acetate; N,N-dimethyl-formamide Ambient temperature;94%

2-Thiopheneacetic acid Chemical Properties


IUPAC Name: 2-Thiophen-2-ylacetic acid
Canonical SMILES: C1=CSC(=C1)CC(=O)O
InChI: InChI=1S/C6H6O2S/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2,(H,7,8)
InChIKey: SMJRBWINMFUUDS-UHFFFAOYSA-N
Molecular Weight: 142.17564 [g/mol]
Molecular Formula: C6H6O2S
XLogP3: 1
H-Bond Donor: 1
H-Bond Acceptor: 2 
EINECS: 217-639-8 
Index of Refraction: 1.587
Molar Refractivity: 35.75 cm3
Molar Volume: 106.3 cm3
Surface Tension: 54.3 dyne/cm
Density: 1.336 g/cm3
Flash Point: 116.6 °C
Enthalpy of Vaporization: 53.59 kJ/mol
Boiling Point: 269.2 °C at 760 mmHg
Vapour Pressure: 0.00363 mmHg at 25 °C
Appearance: white to light yellow crystal powder
Melting Point: 63-64 °C(lit.)
Product Categories: Drug Intermediates; Heterocycles; Thiophene&Benzothiophene; Organic acids; Thiophens; Cephaloridine

2-Thiopheneacetic acid Uses

 2-Thiopheneacetic acid (CAS NO.1918-77-0) is used as pharmaceutical intermediates to product cefaloridine, Cefalotin sodium,etc.

2-Thiopheneacetic acid Safety Profile

Safety Information of 2-Thiopheneacetic acid (CAS NO.1918-77-0):
Hazard Codes:C  ,Xi
Risk Statements:34-37-36/37/38
34:Causes burns 
37:Irritating to the respiratory system 
36/37/38:Irritating to eyes, respiratory system and skin  
Safety Statements: 26-36/37/39-45-24/25-27
26:In case of contact with eyes, rinse immediately with plenty of water
and seek medical advice 
36/37/39:Wear suitable protective clothing, gloves and eye/face
protection 
45:In case of accident or if you feel unwell, seek medical advice
immediately (show label where possible) 
24/25:Avoid contact with skin and eyes 
27:Take off immediately all contaminated clothing  
RIDADR:UN 3261 8/PG 2
WGK Germany:3
Hazard Note:Irritant
TSCA:T
HazardClass:8
PackingGroup:III

2-Thiopheneacetic acid Specification

 2-Thiopheneacetic acid (CAS NO.1918-77-0), its Synonyms are 2-Thienylacetic acid ; Thiopheneacetic acid ; 2-(2-Thienyl)aceticacid ; 2-(Thiophen-2-yl)acetic acid ; Thiophen-2-ylacetic acid ; 2-Thienylethanoicacid .

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