3-Buten-1-ol supplier | CasNO.627-27-0

Name
3-Buten-1-ol
EINECS 210-991-3
CAS No. 627-27-0
Article Data167
CAS DataBase
Density 0.827 g/cm³
Solubility soluble in water
Melting Point 193ºC
Formula C₄H₈O
Boiling Point 113.5 °C at 760 mmHg
Molecular Weight 72.1069
Flash Point 32.2 °C
Transport Information UN 1987 3/PG 3
Appearance Clear colorless liquid
Safety 16-26-36
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Allylcarbinol;Vinylethyl alcohol;but-3-en-1-ol;1-Buten-4-ol;3-Butenyl alcohol;
PSA 20.23000
LogP 0.55480

Synthetic route

: 927-74-2
1-butyn-4-ol

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With 2,6-bis[1-(2,6-diisopropylphenylimino)ethyl]pyridine cobalt(II) dichloride; diethoxymethylane; sodium triethylborohydride In neat (no solvent) at -78 - 40℃; for 1h;	97%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 4.5h; Green chemistry;	92%
With hydrogen In methanol under 760.051 Torr; for 5h;	87%

: 50-00-0
formaldehyd

: 64549-05-9
allyldibutyltin chloride

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
In water at 20℃; for 0.0833333h;	97%

: 142860-83-1
1-(4-methoxybenzyloxy)-3-butene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With t-butyl bromide In acetonitrile for 1h; Reflux; chemoselective reaction;	93%

: 2516-33-8
Cyclopropylmethanol

A: 627-27-0
homoalylic alcohol

B: 2919-23-5
cyclobutanol

Conditions

Conditions	Yield
With hydrogenchloride In water for 3h; Heating;	A 3% B 92%
With hydrogenchloride In water at 100℃; for 3h;	A n/a B 57%
With hydrogenchloride In water at 100℃; for 0.00166667h;

: 50-00-0
formaldehyd

: 106-95-6
allyl bromide

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
Stage #1: formaldehyd; allyl bromide With zinc In ethyl acetate at 75℃; for 5h; Large scale; Stage #2: With ammonium chloride for 2h; Large scale;	87%
With magnesium In diethyl ether for 6h; Heating;	72%
With magnesium In diethyl ether	39%
Stage #1: allyl bromide With tin In water at 20℃; for 0.166667h; Green chemistry; Stage #2: formaldehyd In water at 20℃; for 3h; Green chemistry;	75 %Chromat.
With ammonium chloride; zinc In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere;

: 110-63-4
Butane-1,4-diol

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With hydrogen at 350℃; Reagent/catalyst;	85.9%
With 1-hexadecylcarboxylic acid at 330 - 345℃; under 760 Torr; for 32h;	50%
With Er2O3 nanoparticles HT-150-24 at 350℃; for 5h;
Heating;
With yttria-stabilized zirconia at 325℃; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;

: 110-63-4
Butane-1,4-diol

A: 109-99-9
tetrahydrofuran

B: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With hydrogen at 350℃; for 0.6h; Reagent/catalyst; Temperature; Flow reactor;	A n/a B 85.9%
With Mg and Yb-containing organic foam into the binaryoxides at 350℃; Reagent/catalyst; Temperature; Inert atmosphere;	A n/a B 71.1%
With Er2O3 nanoparticles CM-1000 at 350℃; for 5h;
at 350℃; Reagent/catalyst; Flow reactor; Inert atmosphere;

: 930-22-3
epoxybutene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With formic acid; tributyl-amine; tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine In water at 50 - 120℃; for 4.5 - 26h; Product distribution / selectivity;	85.8%
With formic acid; tributyl-amine; tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine In tetrahydrofuran; water at 62℃; for 1.21667 - 2.56667h; Product distribution / selectivity;	78.5%
With ammonium formate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tributylphosphine In 1,4-dioxane for 2h; Heating;	100 % Chromat.

: 19311-38-7
3-chlorotetrahydrofuran

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With sodium In diethyl ether	84%
With diethyl ether; sodium

: (2R,3R)-2-But-3-enyloxy-3-heptadecafluorooctyl-tetrahydro-pyran

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With methanol; toluene-4-sulfonic acid In tetrahydrofuran at 70℃; for 24h; deprotection of alcoholic OH;	78%

: 3068-00-6
D,L-1,2,4-butanetriol

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With rhenium(VII) oxide; triphenylphosphine at 165℃; for 1h;	77%
With rac-3-octanol at 170℃; for 1h;	28%

: 2-But-3-enyl-benzo[1,3,2]dioxaborole

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With hydroxide; dihydrogen peroxide	76%

: 75-21-8
oxirane

: 75-01-4
chloroethylene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
Stage #1: chloroethylene With magnesium In diethyl ether; ethylene dibromide for 2h; Reflux; Stage #2: oxirane In diethyl ether; ethylene dibromide at -5 - 5℃; for 1h; Temperature; Solvent;	73.6%

: 3536-96-7
vinylmagnesium chloride

: 540-51-2
2-bromoethanol

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
copper(I) bromide In tetrahydrofuran at -40 - 3℃; for 2.5h;	72%

: 110-63-4
Butane-1,4-diol

A: 109-99-9
tetrahydrofuran

B: 627-27-0
homoalylic alcohol

C: 6117-91-5
(E/Z)-2-buten-1-ol

Conditions

Conditions	Yield
With hydrogen at 350℃; for 0.6h; Reagent/catalyst; Flow reactor;	A n/a B 69.9% C n/a

...Expand

: 625-38-7
but-3-enoic acid

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride	50%
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride

: 50-00-0
formaldehyd

: 2622-05-1
allylmagnesium bromide

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
Grignar reaction;	46%
With diethyl ether

: 70458-21-8
cyclobutanecarbonyl m-chlorobenzoyl peroxide

A: 627-27-0
homoalylic alcohol

B: 2516-33-8
Cyclopropylmethanol

C: 70458-29-6
3-butenyl m-chlorobenzoate

D: 70458-27-4
cyclobutyl m-chlorobenzoate

E: 70458-28-5
cyclopropylmethyl m-chlorobenzoate

F: 2919-23-5
cyclobutanol

Conditions

Conditions	Yield
With acetic acid; potassium iodide In tetrachloromethane at 26℃; Rate constant; on silica;	A 4.3% B 9.6% C 19.5% D 11.8% E 45.5% F 6.5%
With acetic acid; potassium iodide In neat (no solvent) at 26℃; Rate constant; on silica;
With acetic acid; potassium iodide In chloroform at 55℃; Rate constant;
With acetic acid; potassium iodide In tetrachloromethane at 55℃; Rate constant;

...Expand

: 70458-21-8
cyclobutanecarbonyl m-chlorobenzoyl peroxide

A: 627-27-0
homoalylic alcohol

B: 70458-29-6
3-butenyl m-chlorobenzoate

C: 70458-27-4
cyclobutyl m-chlorobenzoate

D: 70458-28-5
cyclopropylmethyl m-chlorobenzoate

Conditions

Conditions	Yield
With acetic acid; potassium iodide In tetrachloromethane at 26℃; Further byproducts given;	A 4.3% B 19.5% C 11.8% D 45.5%

...Expand

: 5162-44-7
1-bromo-4-butene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With sodium carbonate for 15h; Heating;	45%

: 50-00-0
formaldehyd

: 107-05-1
3-chloroprop-1-ene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With magnesium In diethyl ether for 2h; Heating;	45%

: 130552-90-8
(E)-N-benzylidenebenzenesulfonamide

: 762-72-1
allyl-trimethyl-silane

A: 627-27-0
homoalylic alcohol

B: 217947-24-5
N-(1-phenylbut-3-en-1-yl)benzenesulfonamide

Conditions

Conditions	Yield
With indium(III) chloride; chloro-trimethyl-silane In nitromethane at 20℃; for 6h; Sakurai-Hosomi reaction;	A 8 % Spectr. B 40%

...Expand

: Ti(OCH2CH(CH2)2)4

A: 627-27-0
homoalylic alcohol

B: 2516-33-8
Cyclopropylmethanol

C: 22597-56-4
Di-(1-butenyl)ether (trans/trans)

D: 74976-40-2
bis(cyclopropylmethyl) ether

E: 74976-38-8
allylcarbinyl cyclopropylcarbinyl ether

Conditions

Conditions	Yield
In gas byproducts: CH2CH(CH2)2, CH2(CH)2CH2; decomposition at a pressure of 0.01 mm Hg at 550°C; further compounds: (CH2)2CHCHO (trace), TiO2, H2 (<0.5%), C (4%); NMR; GC; mass spectra;	A 37% B 23% C 12% D 10% E 18%

...Expand

: 50-00-0
formaldehyd

: 187737-37-7
propene

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
In water at 220℃; under 6000.6 Torr; for 10h; Reagent/catalyst; Autoclave;	2.47%
at 246℃;
In 1,4-dioxane at 149.84℃; for 4h;

: 75-21-8
oxirane

: 109-99-9
tetrahydrofuran

: 1826-67-1
vinyl magnesium bromide

: 627-27-0
homoalylic alcohol

...Expand

: 75-21-8
oxirane

: 3536-96-7
vinylmagnesium chloride

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With tetrahydrofuran

: 75-21-8
oxirane

: 1826-67-1
vinyl magnesium bromide

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With tetrahydrofuran

: 19311-37-6
(RS)-3-bromotetrahydrofuran

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With diethyl ether; magnesium und Zersetzen mit Wasser;
With diethyl ether; sodium und Zersetzen mit Wasser;

: 1120-97-4
4-methyl-1,3-dioxane

: 627-27-0
homoalylic alcohol

Conditions

Conditions	Yield
With tricalcium diphosphate; water at 350℃;

: 627-27-0
homoalylic alcohol

: 98-59-9
p-toluenesulfonyl chloride

: 778-29-0
but-3-enyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	100%
With potassium hydroxide In diethyl ether at 20℃; for 3h;	99%
With dmap; triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere;	99%

: 627-27-0
homoalylic alcohol

: 124-63-0
methanesulfonyl chloride

: 40671-34-9
4-methanesulfonyloxy-1-butene

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -15℃; for 1h; Green chemistry;	100%
With triethylamine In dichloromethane at -15℃; for 1.5h;	100%
With triethylamine In dichloromethane at 0℃; for 5h;	98%

: 110-87-2
3,4-dihydro-2H-pyran

: 627-27-0
homoalylic alcohol

: 59574-65-1
2-(3-butenyloxy)tetrahydropyran

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In diethyl ether for 5h; Ambient temperature;	100%
In dichloromethane at 0℃; for 2h;	95%
With hydrogenchloride at 20℃; Addition;	91%

: 627-27-0
homoalylic alcohol

: 98-88-4
benzoyl chloride

: 18203-32-2
3-butenyl benzoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	91%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	91%

: 627-27-0
homoalylic alcohol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 135006-32-5
4-tert-butyldiphenylsilyloxy-1-butene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 17h; Ambient temperature;	99%

: 627-27-0
homoalylic alcohol

: 123-54-6
acetylacetone

: (Z)-4-But-3-enyloxy-pent-3-en-2-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 627-27-0
homoalylic alcohol

: 824-79-3
sodium 4-methylbenzenesulfinate

: 3-Iodo-4-(toluene-4-sulfonyl)-butan-1-ol

Conditions

Conditions	Yield
With iodine In water; ethyl acetate at 20℃; for 2.5h; iodosulfonization;	100%

: 627-27-0
homoalylic alcohol

: 2746-25-0
p-Methoxybenzyl bromide

: 142860-83-1
1-(4-methoxybenzyloxy)-3-butene

Conditions

Conditions	Yield
Stage #1: homoalylic alcohol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.0833333h; Stage #2: p-Methoxybenzyl bromide In tetrahydrofuran at 0℃; for 1h;	100%
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: p-Methoxybenzyl bromide With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 0 - 20℃; for 17h; Inert atmosphere;	100%
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h;	96%

: 627-27-0
homoalylic alcohol

: 824-94-2
p-methoxybenzyl chloride

: 142860-83-1
1-(4-methoxybenzyloxy)-3-butene

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide	100%
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 20h; Inert atmosphere; Schlenk technique;	97%
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.333333h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; mineral oil at 0 - 20℃; for 3h;	96%

: 524-38-9
N-hydroxyphthalimide

: 627-27-0
homoalylic alcohol

: 80042-17-7
2-(but-3-en-1-yloxy)isoindoline-1,3-dione

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2.5h; Inert atmosphere;	100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃; for 4.5h; Mitsunobu Displacement; Inert atmosphere;
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃;
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 16.5h;

: 627-27-0
homoalylic alcohol

: 13154-24-0
triisopropylsilyl chloride

: 169310-77-4
1-triisopropylsiloxy-3-butene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h; Inert atmosphere;	100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	98%
With 1H-imidazole In tetrahydrofuran at 20℃; for 5.5h;	95%

: 627-27-0
homoalylic alcohol

: 111-64-8
n-octanoic acid chloride

: 1070316-20-9
but-3-enyl octanoate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	100%

: 627-27-0
homoalylic alcohol

: 124-13-0
Octanal

: cis-2-heptyl-4-fluorotetrahydro-2H-pyran

Conditions

Conditions	Yield
With Et4NF*5HF at 20℃; for 0.166667h; Prins reaction; stereoselective reaction;	100%
With Et4NF*5HF at 20℃; for 0.166667h; Prins cyclization; stereoselective reaction;

: 627-27-0
homoalylic alcohol

: 555-16-8
4-nitrobenzaldehdye

: cis-4-fluoro-2-(4-nitrophenyl)tetrahydro-2H-pyran

Conditions

Conditions	Yield
With Et4NF*5HF at 20℃; for 0.333333h; Prins reaction; stereoselective reaction;	100%
With HSO4- exchanged Amberlyst A26 resin-supported hydrogen fluoride In 1,2-dichloro-ethane at 20℃; for 5h; diastereoselective reaction;	82%
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone complex with hydrogen fluoride In dichloromethane at 20℃; for 3h; diastereoselective reaction;	81%
With Et4NF*5HF at 20℃; for 0.333333h; Prins cyclization; stereoselective reaction;

: 627-27-0
homoalylic alcohol

: 100-52-7
benzaldehyde

: cis-4-fluoro-2-phenyltetrahydro-2H-pyran

Conditions

Conditions	Yield
With Et4NF*5HF at 20℃; for 0.333333h; Prins reaction; stereoselective reaction;	100%
With HSO4- exchanged Amberlyst A26 resin-supported hydrogen fluoride In 1,2-dichloro-ethane at 20℃; for 5h; diastereoselective reaction;	83%
With titanium(IV) fluoride In dichloromethane at 20℃; for 2.5h; Prins cyclization reaction;	82%
With tetrafluoroboric acid diethyl ether In dichloromethane at 23℃; for 20h; diastereoselective reaction;	76%
With Et4NF*5HF at 20℃; for 0.333333h; Prins cyclization; stereoselective reaction;

: 100-02-7
4-nitro-phenol

: 627-27-0
homoalylic alcohol

: 40742-21-0
1‐(but‐3‐en‐1‐yloxy)‐4‐nitrobenzene

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction; Reflux;	100%

: 627-27-0
homoalylic alcohol

: 554-84-7
meta-nitrophenol

: 374588-08-6
1-but-3-enyloxy-3-nitrobenzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran	100%

: 627-27-0
homoalylic alcohol

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 142860-83-1
1-(4-methoxybenzyloxy)-3-butene

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In toluene for 0.25h; Inert atmosphere;	100%
With lanthanum triflate In toluene at 20℃; Inert atmosphere;

: 627-27-0
homoalylic alcohol

: 107-02-8
acrolein

: 112596-89-1
(E)-5-hydroxypent-2-enal

Conditions

Conditions	Yield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 20℃; for 24h;	100%

: 627-27-0
homoalylic alcohol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 1343915-25-2
4-(2,2-diethoxyethoxy)but-1-ene

Conditions

Conditions	Yield
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: Bromoacetaldehyde diethyl acetal In tetrahydrofuran; mineral oil at 0 - 68℃; for 66h; Inert atmosphere;	100%
Stage #1: homoalylic alcohol With sodium hydride In water at 0℃; for 1h; Stage #2: Bromoacetaldehyde diethyl acetal In water at 0 - 80℃; for 24h; Temperature;	100%
Stage #1: homoalylic alcohol In tetrahydrofuran at 0℃; for 1h; Stage #2: Bromoacetaldehyde diethyl acetal In tetrahydrofuran at 70℃; for 48h; Temperature;	96.3%
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: Bromoacetaldehyde diethyl acetal In tetrahydrofuran; mineral oil at 0 - 68℃; for 66h;	77 g

: 627-27-0
homoalylic alcohol

: 924107-85-7
2-bromo-N-(2-methoxyphenyl)benzenesulfonamide

: 1582316-68-4
2-bromo-N-(but-3-en-1-yl)-N-(2-methoxyphenyl)benzenesulfonamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 3.16667h; Mitsunobu Displacement;	100%

: 627-27-0
homoalylic alcohol

: 1286918-84-0
C16H17BrN2O3S

: 1582316-69-5
2-bromo-N-(but-3-en-1-yl)-N-(2-morpholinophenyl)benzenesulfonamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 3.16667h; Mitsunobu Displacement;	100%

: 627-27-0
homoalylic alcohol

: 1304050-40-5
2-bromo-N-(2-nitrophenyl)benzenesulfonamide

: 1582316-72-0
2-bromo-N-(but-3-en-1-yl)-N-(2-nitrophenyl)benzenesulfonamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 3.16667h; Mitsunobu Displacement;	100%

: 627-27-0
homoalylic alcohol

: 52898-32-5
N-(3-butenyl)phthalimide

Conditions

Conditions	Yield
With phthalimide; di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 3.03333h;	100%

: 627-27-0
homoalylic alcohol

: diethyl (1-((4-methylphenyl)sulfonamido)prop-1-en-1-yl)phosphonate

: (E)-diethyl (1-((N-(but-3-en-1-yl)-4-methylphenyl)sulfonamido)prop-1-en-1-yl)phosphonate

Conditions

Conditions	Yield
With tributylphosphine; di-isopropyl azodicarboxylate In tetrahydrofuran; toluene at 20℃; for 1h; Mitsunobu Displacement; Inert atmosphere;	100%

: 627-27-0
homoalylic alcohol

: 72-18-4
L-valine

: 104-15-4
toluene-4-sulfonic acid

: (S)-1-(but-3-en-1-yloxy)-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
In water; toluene for 24h; Reflux; Dean-Stark;	100%

...Expand

: 627-27-0
homoalylic alcohol

: 710-11-2
2-oxo-4-phenylbutyric acid

: 327620-61-1
but-3-en-1-yl 3-phenylpropanoate

Conditions

Conditions	Yield
With 3-nitro(diacetoxyiodo)benzene In dichloromethane at 20℃; for 8h; Sealed tube; Darkness; chemoselective reaction;	100%

: 627-27-0
homoalylic alcohol

: 18315-80-5, 18315-86-1, 16508-09-1
ethyl α-nitrocinnamate

: 16782-23-3
ethyl 3-phenyl-2-nitropropionate

Conditions

Conditions	Yield
With lithium hexamethyldisilazane at -78℃; Michael Addition;	100%

: 627-27-0
homoalylic alcohol

: 1403480-28-3
N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

: 1403480-44-3
2-(but-3-en-1-yloxy)-N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-Nmethylphenylsulfonamido)-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide

Conditions

Conditions	Yield
Stage #1: homoalylic alcohol With sodium hydride at 0℃; for 0.333333h; Stage #2: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide In tetrahydrofuran at 0℃;	99%
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-fluoro-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-5-nitrobenzenesulfonamide In tetrahydrofuran at 0℃; for 2.75h;	99.5%

: 627-27-0
homoalylic alcohol

: 38300-63-9
3,4-dichloro-butan-1-ol

Conditions

Conditions	Yield
With Oxone; sodium chloride In dichloromethane; water at 0℃; for 0.5h; Darkness; diastereoselective reaction;	99%
With chlorine
With tetrachloromethane; chlorine at -20℃;

3-Buten-1-ol Chemical Properties

IUPAC Name: But-3-en-1-ol
Empirical Formula: C₄H₈O
Molecular Weight: 72.1057 g/mol
EINECS: 210-991-3
Index of Refraction: 1.415
Density: 0.827 g/cm³
Flash Point: 32.2 °C
Enthalpy of Vaporization: 41.03 kJ/mol
Boiling Point: 113.5 °C at 760 mmHg
Vapour Pressure: 10.6 mmHg at 25 °C
Storage tempreture: Flammables area
Water solubility: Soluble
Appearance: Liquid
Structure of 3-Buten-1-ol (CAS NO.627-27-0):

Product Category of 3-Buten-1-ol (CAS NO.627-27-0): Alcohol& Phenol& Ethers;API intermediates;omega-Unsaturated Alkanols

3-Buten-1-ol Toxicity Data With Reference

3-Buten-1-ol (CAS NO.627-27-0) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65.

3-Buten-1-ol Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 10-36/37/38
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

3-Buten-1-ol Specification

Polixetonium chloride , its cas register number is 627-27-0. It also can be called 3-Butene-1-ol ; and Allyl carbinol . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Get medical aid immediately. Wash mouth out with water, and get medical aid immediately.
In addition, 3-Buten-1-ol (CAS NO.627-27-0) is not compatible with ignition sources, acids, acid chlorides, acid anhydrides, and you must not take it with incompatible materials, ignition sources. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

Product Name

3-Buten-1-ol

Synthetic route

3-Buten-1-ol Chemical Properties

3-Buten-1-ol Toxicity Data With Reference

3-Buten-1-ol Safety Profile

3-Buten-1-ol Specification

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