Product Name

  • Name

    3-Chlorophenol

  • EINECS 203-582-6
  • CAS No. 108-43-0
  • Article Data192
  • CAS DataBase
  • Density 1.218 g/cm3
  • Solubility 27.7 g/L (20 °C) in water
  • Melting Point 31-34 °C(lit.)
  • Formula C6H5ClO
  • Boiling Point 214 °C at 760 mmHg
  • Molecular Weight 128.558
  • Flash Point 76.9 °C
  • Transport Information UN 2020 6.1/PG 3
  • Appearance White to light yellow crystal
  • Safety 28-61-28A
  • Risk Codes 20/21/22-51/53
  • Molecular Structure Molecular Structure of 108-43-0 (3-Chlorophenol)
  • Hazard Symbols HarmfulXn,DangerousN
  • Synonyms Phenol,m-chloro- (7CI,8CI);3-Hydroxychlorobenzene;NSC 59700;m-Chlorophenic acid;m-Chlorophenol;
  • PSA 20.23000
  • LogP 2.04560

Synthetic route

1-tert-butoxy-3-chlorobenzene
123195-73-3

1-tert-butoxy-3-chlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With sodium iodide; cerium(III) chloride In acetonitrile at 40℃; for 3.5h;100%
1-(benzyloxy)-3-chlorobenzene
24318-02-3

1-(benzyloxy)-3-chlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.0833333h; Microwave irradiation; Inert atmosphere;99%
With triethylsilane; triethylamine; palladium diacetate In dichloromethane at 23℃; for 12h; Hydrogenolysis;
2,3-dichlorophenol
576-24-9

2,3-dichlorophenol

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
With 9,10-dihydroanthracene; water at 356.85℃; for 3h; Kinetics;A 99%
B 0.3%
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In 1,4-dioxane; water at 100℃; for 1h;99%
Multi-step reaction with 2 steps
1: copper dichloride; potassium carbonate / 20 h / 130 °C / Inert atmosphere; Schlenk technique
2: potassium hydroxide / dimethyl sulfoxide / 3 h / 100 °C / Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1: fac-tris(2-phenylpyridinato-N,C2')iridium(III); tributyl-amine; water / acetonitrile / 36 h / 25 °C / Schlenk technique; Inert atmosphere; Sealed tube; Irradiation
2: air / 16 h / 25 °C / Inert atmosphere
View Scheme
With copper(l) iodide; C20H20N4O4; caesium carbonate; Benzaldoxime In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; Glovebox;
3-chlorophenylboronic acid
63503-60-6

3-chlorophenylboronic acid

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With water In tetrahydrofuran at 100℃; for 12h;99%
With copper(I) oxide; potassium hydroxide In water at 20℃; for 24h; Green chemistry;98%
With copper(II) ferrite; water; sodium hydroxide at 40℃; for 24h; Green chemistry;96%
1-chloro-3-ethoxybenzene
2655-83-6

1-chloro-3-ethoxybenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.666667h; Microwave irradiation; Inert atmosphere;99%
2-(3-chlorophenoxy)ethanol
6161-83-7

2-(3-chlorophenoxy)ethanol

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;99%
3-iodochlorobenzene
625-99-0

3-iodochlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;98%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction;95%
With copper(I) oxide; 2-(N,N-dimethylamino)ethanol; water; potassium hydroxide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;91%
3-chlorophenylboronic acid
63503-60-6

3-chlorophenylboronic acid

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;97%
1-chloro-3-vinyloxybenzene
1005-41-0

1-chloro-3-vinyloxybenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;92%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;92%
1-chloro-3-(2-phenylallyloxy)benzene

1-chloro-3-(2-phenylallyloxy)benzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 0.5h;91%
(1S,2S)-3-Chloro-cyclohexa-3,5-diene-1,2-diol
86992-79-2, 98575-77-0, 65986-73-4

(1S,2S)-3-Chloro-cyclohexa-3,5-diene-1,2-diol

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

2-monochlorophenol
95-57-8

2-monochlorophenol

Conditions
ConditionsYield
With sodium hydroxide In water at 25℃; Kinetics; Concentration; Solvent;A 89%
B n/a
3-chlorophenyl N,N-diethylcarbamate
159390-33-7

3-chlorophenyl N,N-diethylcarbamate

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With zirconocene dichloride In tetrahydrofuran at 20℃; Inert atmosphere;88%
3-fluorophenol
372-20-3

3-fluorophenol

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
85%
chlorobenzene
108-90-7

chlorobenzene

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

2-monochlorophenol
95-57-8

2-monochlorophenol

Conditions
ConditionsYield
With [Ni(N,N-bis(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-N',N'-dimethylpropane-1,3-diamine)(CH3CN)2](Ph4B)2; dihydrogen peroxide; triethylamine In water; acetonitrile at 60℃; for 5h;A 16%
B 84%
With C25H29N7O*Fe(2+)*2CF3O3S(1-); dihydrogen peroxide
With dihydrogen peroxide; C23H37ClCuN4O6(1+)*ClO4(1-); triethylamine In acetonitrile at 60℃; for 5h;
3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
Stage #1: m-Chlorobenzaldehyde With 3-chloro-benzenecarboperoxoic acid for 0.0833333h; Dakin oxidation;
Stage #2: With sodium hydroxide for 0.0833333h; Further stages.;
80%
1-(but-3-enyloxy)-3-chlorobenzene
1314570-58-5

1-(but-3-enyloxy)-3-chlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;75%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;75%
3-chloro-aniline
108-42-9

3-chloro-aniline

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
Stage #1: 3-chloro-aniline With sodium nitrite In water at 20℃; Milling; Green chemistry;
Stage #2: With water at 85℃; for 0.5h; Neutral conditions; Green chemistry;
73%
With uranyl nitrate hydrate; water; trifluoroacetic acid for 48h; Irradiation;56%
diethyl phosphite potassium salt
54058-00-3

diethyl phosphite potassium salt

3-chloro-1-trifluoromethanesulfonyloxybenzene
86364-03-6

3-chloro-1-trifluoromethanesulfonyloxybenzene

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

3-chlorophenyl diethyl phosphate
32019-36-6

3-chlorophenyl diethyl phosphate

Conditions
ConditionsYield
In ammonia at -33℃; under 2.5 Torr;A 30%
B 67%
2,5-dichlorophenol
583-78-8

2,5-dichlorophenol

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
With 9,10-dihydroanthracene; water at 356.85℃; for 3h; Kinetics;A 62%
B 0.3%
α-(3-Chlorophenoxy)acetophenone
19514-06-8

α-(3-Chlorophenoxy)acetophenone

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

2-oxo-2-phenyl-ethyl
50781-28-7

2-oxo-2-phenyl-ethyl

C

2-(3-chlorophenyl)-1-phenylethanone
27798-43-2

2-(3-chlorophenyl)-1-phenylethanone

D

3-chlorophenoxyl radical
54560-44-0

3-chlorophenoxyl radical

E

acetophenone
98-86-2

acetophenone

Conditions
ConditionsYield
thiophenol In benzene Product distribution; Quantum yield; Kinetics; Irradiation;A 34.2%
B n/a
C 42.1%
D n/a
E 23.8%
chlorobenzene
108-90-7

chlorobenzene

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

2-monochlorophenol
95-57-8

2-monochlorophenol

C

4-chloro-phenol
106-48-9

4-chloro-phenol

D

phenol
108-95-2

phenol

Conditions
ConditionsYield
With KCu(III)(biuret)2; water; trifluoroacetic acid for 2h; Product distribution; Heating;A n/a
B 6%
C 7%
D 33%
With tert.-butylhydroperoxide; air In gas at 290℃; under 760 Torr; Product distribution; Mechanism;
In tert-butyl alcohol at 488 - 587℃; under 760 Torr; Mechanism; Slow combustion of dichlorobenzene has been studied at low degrees of conversion at low degrees of conversion, in athmospheric pressure, between 410-1053 K , in various solvents.;
cyclohexa-1,3-diene at 570 - 622℃; under 760 Torr; Mechanism;
With air at 686.85℃; Formation of xenobiotics; Further byproducts given. Title compound not separated from byproducts;
3-chlorobenzenediazonium
17333-84-5

3-chlorobenzenediazonium

3-monochlorophenol
108-43-0

3-monochlorophenol

3-chloro-aniline
108-42-9

3-chloro-aniline

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

PCB 11
2050-67-1

PCB 11

Conditions
ConditionsYield
With sulfuric acid Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuOH;
1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With sodium hydroxide at 260℃;
With sodium hydroxide at 200℃;
With methanol; sodium methylate at 180℃;
With sodium methylate; sodium thiomethoxide 1.) HMPA, 120 degC, 2h; 2.) 120 degC, 1h; Yield given. Multistep reaction;
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

(3-Chloro-phenoxy)-dimethyl-phenyl-silane

(3-Chloro-phenoxy)-dimethyl-phenyl-silane

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

(2,2,2-trifluoroethoxy)dimethylphenylsilane
109629-96-1

(2,2,2-trifluoroethoxy)dimethylphenylsilane

Conditions
ConditionsYield
With potassium 2,2,2-trifluoroethoxide at 30℃; Rate constant; μ = 0.05 M with potassium trifluoroacetate;
4-chloro-2-hydroxybenzophenone
2985-80-0

4-chloro-2-hydroxybenzophenone

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

3-chlorophenyl benzoate
13189-55-4

3-chlorophenyl benzoate

Conditions
ConditionsYield
trifluorormethanesulfonic acid In 1,2-dichloro-ethane at 170℃; for 24h; Mechanism; Product distribution; in dependence on concentration of TFMS, time;A 5.1 % Chromat.
B 47.7 % Chromat.
1-chloro-3-methylbenzene
108-41-8

1-chloro-3-methylbenzene

A

3-monochlorophenol
108-43-0

3-monochlorophenol

B

m-chlorobenzyl alcohol
873-63-2

m-chlorobenzyl alcohol

C

3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

D

3-chlorobenzoate
535-80-8

3-chlorobenzoate

Conditions
ConditionsYield
With water; iron; trifluoroacetic acid In acetone for 1h; Rate constant;
With water; iron; trifluoroacetic acid In pyridine for 1h; Rate constant;
With water; copper; trifluoroacetic acid In pyridine for 1h; Rate constant;
With water; copper; trifluoroacetic acid In acetone for 1h; Rate constant;
3-chlorophenyl acetate
13031-39-5

3-chlorophenyl acetate

3-monochlorophenol
108-43-0

3-monochlorophenol

Conditions
ConditionsYield
With N-butylamine; Tetraethylene glycol dimethyl ether In chlorobenzene at 25℃; Rate constant; efficacy of glyme catalysis, other glymes;
With potassium chloride; poly(ethyleneimine) In water at 25℃; Rate constant; Mechanism; Product distribution; various pH, aminolysis;
3-monochlorophenol
108-43-0

3-monochlorophenol

(2E)-3-ethoxyprop-2-enoyl chloride
6191-99-7, 99471-66-6

(2E)-3-ethoxyprop-2-enoyl chloride

3-Ethoxyacrylsaeure-3-chlorphenylester
105786-77-4

3-Ethoxyacrylsaeure-3-chlorphenylester

Conditions
ConditionsYield
In 1,2-dichloro-ethane for 14h; Heating;100%
3-monochlorophenol
108-43-0

3-monochlorophenol

propargyl bromide
106-96-7

propargyl bromide

1-chloro-3-(prop-2-yn-1-yloxy)benzene
33302-52-2

1-chloro-3-(prop-2-yn-1-yloxy)benzene

Conditions
ConditionsYield
With potassium carbonate In acetone Reflux;100%
With potassium carbonate In N,N-dimethyl-formamide; toluene at 60℃; for 16h; Sealed tube; Inert atmosphere;95%
With potassium carbonate In acetone at 56℃;93%
3-monochlorophenol
108-43-0

3-monochlorophenol

N,N-diethylcarbamyl chloride
88-10-8

N,N-diethylcarbamyl chloride

3-chlorophenyl N,N-diethylcarbamate
159390-33-7

3-chlorophenyl N,N-diethylcarbamate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 70℃; for 13.5h;100%
Stage #1: 3-monochlorophenol With sodium hydride In tetrahydrofuran; mineral oil at 23℃; for 1h; Inert atmosphere;
Stage #2: N,N-diethylcarbamyl chloride In tetrahydrofuran; mineral oil at 23℃; for 16h; Inert atmosphere;
94%
Stage #1: 3-monochlorophenol With sodium hydride In tetrahydrofuran for 1.16667h;
Stage #2: N,N-diethylcarbamyl chloride In tetrahydrofuran at 20℃; for 14h;
93%
3-monochlorophenol
108-43-0

3-monochlorophenol

3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

2-chloro-1-(3-chlorophenoxy)-4-nitrobenzene
500540-67-0

2-chloro-1-(3-chlorophenoxy)-4-nitrobenzene

Conditions
ConditionsYield
Stage #1: 3-monochlorophenol; 3-chloro-4-fluoronitrobenzene With caesium carbonate In N,N-dimethyl-formamide; acetonitrile at 20℃;
Stage #2: With water In N,N-dimethyl-formamide; acetonitrile
100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;
3-monochlorophenol
108-43-0

3-monochlorophenol

benzyl 3-[4-(5-methanesulfonyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]cyclobutanecarboxylate
1417617-96-9

benzyl 3-[4-(5-methanesulfonyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]cyclobutanecarboxylate

benzyl 3-{4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate
1417617-97-0

benzyl 3-{4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 60℃; for 5.5h;100%
3-monochlorophenol
108-43-0

3-monochlorophenol

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

1-chloro-3-(4-nitrophenoxy)benzene
2303-23-3

1-chloro-3-(4-nitrophenoxy)benzene

Conditions
ConditionsYield
With cesium fluoride/clinoptilolite In dimethyl sulfoxide at 110℃; for 0.15h; Ullmann Condensation;100%
With potassium carbonate In dimethyl sulfoxide at 70℃;92%
With potassium carbonate In acetonitrile at 90℃; for 18h;
3-monochlorophenol
108-43-0

3-monochlorophenol

4-methoxymethoxy-2-naphthalencarboxylic acid

4-methoxymethoxy-2-naphthalencarboxylic acid

C19H15ClO4

C19H15ClO4

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;100%
3-monochlorophenol
108-43-0

3-monochlorophenol

N-(2,4-dimethoxybenzyl)-2,3-difluoro-5-nitrobenzenesulfonamide

N-(2,4-dimethoxybenzyl)-2,3-difluoro-5-nitrobenzenesulfonamide

2-(3-chlorophenoxy)-N-(2,4-dimethoxybenzyl)-3-fluoro-5-nitrobenzenesulfonamide

2-(3-chlorophenoxy)-N-(2,4-dimethoxybenzyl)-3-fluoro-5-nitrobenzenesulfonamide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 0 - 20℃;100%
3-monochlorophenol
108-43-0

3-monochlorophenol

2-chloroethyl cyanomethyl ether
31250-08-5

2-chloroethyl cyanomethyl ether

2-[2-(3-chlorophenoxy)ethoxy]acetonitrile

2-[2-(3-chlorophenoxy)ethoxy]acetonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 120℃; Inert atmosphere;100%
3-monochlorophenol
108-43-0

3-monochlorophenol

phenol
108-95-2

phenol

Conditions
ConditionsYield
With hydrogen; sodium hydroxide In water at 25℃; for 2h;99.9%
With hydrogen; sodium hydroxide In water at 20℃; under 760.051 Torr; for 1h;99.9%
With hydrogen; sodium hydroxide In water at 20℃; under 760.051 Torr; for 1.5h;99.8%
3-monochlorophenol
108-43-0

3-monochlorophenol

2,4,6-tribromo-3-chlorophenol
40979-03-1

2,4,6-tribromo-3-chlorophenol

Conditions
ConditionsYield
With benzyltrimethylammonium tribromide; calcium carbonate In methanol; dichloromethane99%
With water; potassium bromide
3-monochlorophenol
108-43-0

3-monochlorophenol

acetic anhydride
108-24-7

acetic anhydride

3-chlorophenyl acetate
13031-39-5

3-chlorophenyl acetate

Conditions
ConditionsYield
With Zn(N4,N4'-di(pyridin-4-yl)biphenyl-4,4'-dicarboxamide)(5-aminoisophthalate) In dichloromethane at 20℃; for 14h;99%
With sulfuric acid at 20℃; for 17h;99%
With C36H30N4O4*2C3H7NO*2NO3(1-)*Zn(2+)*2C2H3N In dichloromethane at 20℃; for 11h;97%
3-monochlorophenol
108-43-0

3-monochlorophenol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (3-chlorophenoxy)acetate
52094-98-1

ethyl (3-chlorophenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Reflux;99%
With potassium carbonate In acetone for 20h; Reflux;98%
With hydrogenchloride; potassium carbonate In hexane; ethyl acetate; acetone58 g (87%)
3-monochlorophenol
108-43-0

3-monochlorophenol

3-(diphenylphosphinyl)-3-methyl-1,2-butadiene
15729-19-8

3-(diphenylphosphinyl)-3-methyl-1,2-butadiene

C22H20ClO2P
1176335-48-0

C22H20ClO2P

Conditions
ConditionsYield
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; [Rh(OH)(cod)]2 In tert-butyl alcohol at 80℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;99%
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester
299176-17-3

N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

3-monochlorophenol
108-43-0

3-monochlorophenol

tert-butyl [5-(3-chlorophenoxy)-2-nitrophenyl]methylcarbamate
1072002-99-3

tert-butyl [5-(3-chlorophenoxy)-2-nitrophenyl]methylcarbamate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl acetamide at 80℃; Cooling with ice;99%
With sodium hydride In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere;99%
3-monochlorophenol
108-43-0

3-monochlorophenol

Phenyl glycidyl ether
122-60-1

Phenyl glycidyl ether

1-(3'-chlorophenoxy)-3-phenoxypropan-2-ol
1260374-17-1

1-(3'-chlorophenoxy)-3-phenoxypropan-2-ol

Conditions
ConditionsYield
With 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine supported on polystyrene (PS-BEMP; PS = 200-400 mesh polystyryl with 2percent of divinylbenzene) at 60℃; for 40h; Neat (no solvent); regioselective reaction;99%
3-monochlorophenol
108-43-0

3-monochlorophenol

2-fluoro-4-methoxy-benzaldehyde
331-64-6

2-fluoro-4-methoxy-benzaldehyde

2-(3-chlorophenoxy)-4-methoxybenzaldehyde
1446253-88-8

2-(3-chlorophenoxy)-4-methoxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 3h; Inert atmosphere;99%
3-monochlorophenol
108-43-0

3-monochlorophenol

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

4-(3-chlorophenoxy)benzoic acid
1145-58-0

4-(3-chlorophenoxy)benzoic acid

Conditions
ConditionsYield
Stage #1: 3-monochlorophenol; 4-fluorobenzonitrile With potassium hydroxide In N,N-dimethyl-formamide at 175℃; for 0.333333h; Sealed tube;
Stage #2: With potassium hydroxide In water for 12h; Reflux;
99%
Stage #1: 3-monochlorophenol; 4-fluorobenzonitrile With potassium hydroxide In N,N-dimethyl-formamide at 175℃; for 0.333333h; Sealed tube;
Stage #2: With water; potassium hydroxide for 12h; Reflux;
99%
3-monochlorophenol
108-43-0

3-monochlorophenol

3,5-dibromo-1-(2,2-difluoroethyl)-1H-1,2,4-triazole

3,5-dibromo-1-(2,2-difluoroethyl)-1H-1,2,4-triazole

3-bromo-5-(3-chlorophenoxy)-1-(2,2-difluoroethyl)-1H-1,2,4-triazole

3-bromo-5-(3-chlorophenoxy)-1-(2,2-difluoroethyl)-1H-1,2,4-triazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 18h; Temperature;99%
3-monochlorophenol
108-43-0

3-monochlorophenol

3,5-dibromo-1-methyl-1H-1,2,4-triazole
23579-79-5

3,5-dibromo-1-methyl-1H-1,2,4-triazole

3-bromo-5-(3-chlorophenoxy)-1-methyl-1H-1,2,4-triazole

3-bromo-5-(3-chlorophenoxy)-1-methyl-1H-1,2,4-triazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 15h; Sealed tube;99%

3-CHLOROPHENOL Chemical Properties

IUPAC:3-chlorophenol
CAS:108-43-0
The Molecular formula of 3-Chlorophenol(108-43-0):C6H5ClO
The Molecular Weight of 3-Chlorophenol(108-43-0):128.56
Synonyms:3-chloro-1-hydroxybenzene;3-chloro-pheno;3-Hydroxychlorobenzene;m-chlorophenicacid;m-chloro-pheno;meta-Chlorophenol;Phenol, m-chloro-;Phenol
EINECS:203-582-6
Density:1.218 g/cm3
Melting Point:33-35oC
Boiling Point:214oC
Flash Point:97oC
Refractive index:n20/D 1.563(lit.)
Water Solubility:27.7 g/L (20oC)
Storage temp.:2-8oC
Stability:Stable.Combustible.Incompatible with acid chlorides,oxidizing agents,acid anhydrides.Discolours in air.
Vapour Pressure:0.109 mmHg at 25o
Appearance:white crystalline solid with an unpleasant smell
Product Categories:Organics;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Chlorine Compounds;Phenols;Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites;Organic Building Blocks;Oxygen Compounds
Mol File:108-43-0.mol

3-CHLOROPHENOL Uses

3-Chlorophenol(108-43-0) is widely used in the pharmaceutical, dyes and organic synthesis industry.It is also used as a disinfectant.It is an important intermediate in the synthesis of pesticides such as triadimefon,propaphos,phosazetim.

3-CHLOROPHENOL Toxicity Data With Reference

1.   

mmo-sat 10 µg/plate

   TECSDY    Toxicological and Environmental Chemistry. 14 (1987),143.
2.   

orl-rat LD50:570 mg/kg

   FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
3.   

ipr-rat LD50:355 mg/kg

   BJPCAL    British Journal of Pharmacology and Chemotherapy. 13 (1958),20.
4.   

scu-rat LD50:1390 mg/kg

   FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
5.   

orl-mus LD50:521 mg/kg

   TOLED5    Toxicology Letters. 29 (1985),39.

3-CHLOROPHENOL Consensus Reports

Reported in EPA TSCA Inventory. Chlorophenol compounds are on the Community Right-To-Know List.

3-CHLOROPHENOL Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Flammable or combustible liquid. When heated to decomposition it emits toxic fumes of Cl. See also CHLOROPHENOLS.

Safty informations about 3-Chlorophenol(108-43-0):
Hazard Codes:Xn,N
Risk Statements:20/21/22-51/53
 20/21/22(Harmful by inhalation, in contact with skin and if swallowed)
 51/53(Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Statements:28-61
 28(  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer))
 61(Avoid release to the environment. Refer to special instructions safety data sheet)
RIDADR:UN 2020 6.1/PG 3
WGK Germany:2
RTECS:SK2450000
F:9
HazardClass:6.1
HS Code:29081000

3-CHLOROPHENOL Specification

Handling and Storage:
Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling:Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
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