3-Hydroxyphenylacetic acid supplier

Name
3-Hydroxyphenylacetic acid
EINECS 210-684-4
CAS No. 621-37-4
Article Data27
CAS DataBase
Density 1.319 g/cm³
Solubility
Melting Point 129-133 °C(lit.)
Formula C₈H₈O₃
Boiling Point 349 °C at 760 mmHg
Molecular Weight 152.15
Flash Point 179.1 °C
Transport Information
Appearance White Powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-(3-hydroxyphenyl)acetic acid;3-Hydroxyphenylacetic acid;
PSA 57.53000
LogP 1.01930

Synthetic route

: 156945-58-3
<3-(allyloxy)phenyl>acetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 1h;	98%

: 2-(pyrimidin-5-yl)phenyl 2-(3-acetoxyphenyl)acetate

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 12h;	85%

: 1878-69-9
3-iodophenylacetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With copper(I) oxide; 1D-1-O-Methyl-muco-inostol; sodium hydroxide In water at 100℃; for 6h;	71%
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; sodium hydroxide In water at 100℃; for 6h;	71%

: 1878-65-5
3-chlorophenylacetic acid

A: 621-37-4
3-hydroxyphenylacetic acid

B: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With caesium carbonate In methanol for 1h; UV-irradiation; Inert atmosphere;	A 53% B 45%

: 67-56-1
methanol

: 1878-65-5
3-chlorophenylacetic acid

A: 538-86-3
benzyl methyl ether

B: 621-37-4
3-hydroxyphenylacetic acid

C: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With caesium carbonate In aq. buffer for 1h; UV-irradiation; Inert atmosphere;	A 8% B 47% C 34%

...Expand

: C10H9Cl3O3

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With indium; deuterated ammonium chloride In tetrahydrofuran-d8; water-d2 at 20℃; for 24h; Reflux; chemoselective reaction;	32%

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With sodium hydroxide; aluminum nickel

: 121-71-1
3-Hydroxyacetophenone

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With diammonium sulfide; sulfur; isopropyl alcohol at 160℃; Erhitzen des von Ammoniak, Schwefelwasserstoff und Isopropylalkohol befreiten Reaktionsgemisches mit wss. Natronlauge;
Yield given. Multistep reaction;

: 1798-09-0
m-methoxyphenylacetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With hydrogen iodide
With hydrogen iodide

: 25263-44-9
3-Hydroxyphenylacetonitrile

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 14338-36-4
3-amino phenylacetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With sodium nitrite

: 53313-95-4
α,3-dihydroxybenzeneacetonitrile

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With phosphorus; hydrogen iodide

: 103-82-2
phenylacetic acid

A: 156-38-7
4-hydroxyphenylacetate

B: 621-37-4
3-hydroxyphenylacetic acid

C: 614-75-5
2-Hydroxyphenylacetic acid

Conditions

Conditions	Yield
With iron(III) sulfate; dihydrogen peroxide; 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate In water Yield given. Yields of byproduct given;
With Fe2(SO4); dihydrogen peroxide; 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate In water Product distribution;
With dihydrogen peroxide; iron(III); benzene-1,2-diol In water Product distribution; Ambient temperature; further redox-systems and aromatic compounds investigated;

...Expand

: 103-82-2
phenylacetic acid

A: 156-38-7
4-hydroxyphenylacetate

B: 621-37-4
3-hydroxyphenylacetic acid

C: 451-13-8
homogentisic acid

D: 64700-73-8
2-(2,6-dihydroxyphenyl)acetic acid

E: 614-75-5
2-Hydroxyphenylacetic acid

Conditions

Conditions	Yield
In various solvent(s) at 30℃; for 170h; Product distribution; Mechanism; biosynthesis by Trichosporum cutaneum strains, pH = 6, other incubation times;

...Expand

: 124-38-9
carbon dioxide

: 108-39-4
3-methyl-phenol

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With n-butyllithium; potassium tert-butylate 1.) hexane, reflux, 3 h, 2.) THF; Yield given. Multistep reaction;

: 91970-76-2
3-hydroxy-4-isopropylphenylacetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
(i) CH2N2, Et2O, (ii) AlCl3, PhCl; Multistep reaction;

: homopiperonylic acid

: 623-11-0
1-methyl-4-nitrosobenzene

nickel-aluminium-alloy: nickel-aluminium-alloy

: 621-37-4
3-hydroxyphenylacetic acid

...Expand

: 591-31-1
3-methoxy-benzaldehyde

sodium-disulfite: sodium-disulfite

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
man behandelt mit KCN und kocht das entstandene rohe 3-Methoxy-mandelsaeurenitril mit Jodwasserstoffsaeure;

<3-hydroxy-phenyl>-thioacetic acid morpholide: <3-hydroxy-phenyl>-thioacetic acid morpholide

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 121-71-1
3-Hydroxyacetophenone

: 67-63-0
isopropyl alcohol

aqueous ammonium polysulfide: aqueous ammonium polysulfide

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
at 160℃; und Erhitzen des von NH3, H2S und Isopropylalkohol befreiten Reaktionsgemisches mit wss.NaOH auf Siedetemperatur;

...Expand

: 151-50-8
potassium cyanide

disulfite compound of 3-methoxy-benzaldehyde: disulfite compound of 3-methoxy-benzaldehyde

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
man kocht das Reaktionsprodukt mit Jodwasserstoffsaeure;

oxydicarboxy-phenylacetic acid: oxydicarboxy-phenylacetic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With hydrogenchloride at 200℃; im geschlossenen Rohr;

: 7647-01-0
hydrogenchloride

: 4-carboxymethyl-6-hydroxy-isophthalic acid

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
at 200℃; im geschlossenen Rohr;

: 13398-94-2
2-(3-hydroxyphenyl)ethanol

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
With Serratia marcescens In water at 30℃;

: 621-50-1
(3-nitrophenyl)acetonitrile

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tin; hydrochloric acid 2: diluted hydrochloric acid; NaNO2 3: concentrated hydrochloric acid View Scheme

: 4623-24-9
2-(3-aminophenyl)acetonitrile

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diluted hydrochloric acid; NaNO2 2: concentrated hydrochloric acid View Scheme

: 140-29-4
phenylacetonitrile

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: bei der Nitrierung 2: tin; hydrochloric acid 3: diluted hydrochloric acid; NaNO2 4: concentrated hydrochloric acid View Scheme

: 64248-54-0
6-isopropyl 6-acetoxy cyclohexa-2,4-dienone

: 621-37-4
3-hydroxyphenylacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i), (ii) (alkaline hydrolysis) 2: (i) CH2N2, Et2O, (ii) AlCl3, PhCl View Scheme

: 103-82-2
phenylacetic acid

A: 621-37-4
3-hydroxyphenylacetic acid

B: 102-32-9
3,4-dihydroxyphenylacetate

C: 451-13-8
homogentisic acid

Conditions

Conditions	Yield
With sulfuric acid; water at 30℃; for 34h; Electrolysis;

...Expand

: 621-37-4
3-hydroxyphenylacetic acid

: 13398-94-2
2-(3-hydroxyphenyl)ethanol

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran at 0℃; for 1h;	100%
Stage #1: m-hydroxyphenylacetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 60℃; for 2h; Stage #2: With hydrogenchloride; water In tetrahydrofuran	88%
Stage #1: m-hydroxyphenylacetic acid With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran for 3h; Heating / reflux; Stage #2: With water In tetrahydrofuran	85%

: 64-17-5
ethanol

: 621-37-4
3-hydroxyphenylacetic acid

: 22446-38-4
ethyl 3-hydroxyphenylacetate

Conditions

Conditions	Yield
thionyl chloride at 20℃; for 6h;	100%
thionyl chloride at 20℃; for 6h;	100%
With sulfuric acid Reflux;	100%

: 621-37-4
3-hydroxyphenylacetic acid

: 108-46-3
recorcinol

: 89019-84-1
1-(2,4-dihydroxyphenyl)-2-(3-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate for 1.5h; Reflux;	100%
With boron trifluoride diethyl etherate at 60 - 70℃; for 1h;	93%
With boron trifluoride diethyl etherate In toluene at 90℃; for 2h;	57%
With boron trifluoride diethyl etherate at 110℃; for 2h; Inert atmosphere;
With boron trifluoride diethyl etherate In N,N-dimethyl-formamide at 90℃; for 2h;

: 67-56-1
methanol

: 621-37-4
3-hydroxyphenylacetic acid

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

Conditions

Conditions	Yield
With sulfuric acid for 8h; Heating;	100%
With sulfuric acid for 18h; Heating / reflux;	100%
With sulfuric acid for 18h; Heating / reflux;	100%

: 621-37-4
3-hydroxyphenylacetic acid

: 149-73-5
trimethyl orthoformate

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 4h; Heating;	100%
With toluene-4-sulfonic acid In methanol for 5h; Reflux;
With toluene-4-sulfonic acid In methanol for 5h; Reflux;

: 621-37-4
3-hydroxyphenylacetic acid

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

Conditions

Conditions	Yield
With sulfuric acid In methanol for 18h; Heating / reflux;	100%
With thionyl chloride In methanol; hexane; ethyl acetate	94%
	27.8 g (100%)
With sodium bicarbonate In methanol

conc. H2 SO4: conc. H2 SO4

: 621-37-4
3-hydroxyphenylacetic acid

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In methanol	100%

: 621-37-4
3-hydroxyphenylacetic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1344214-04-5
2-(3-hydroxyphenyl)-N-methoxy-N-methylacetamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;	100%

: 621-37-4
3-hydroxyphenylacetic acid

: 86576-85-4
2-(3-hydroxycyclohexyl)acetic acid

Conditions

Conditions	Yield
With hydrogen; Rh on carbon In sodium hydroxide at 60℃; under 760 Torr; for 3h;	99%
With rhodium contaminated with carbon; hydrogen; sodium hydroxide In water at 80℃; under 7500.75 Torr; for 12h;	600 mg

: 621-37-4
3-hydroxyphenylacetic acid

: 100-39-0
benzyl bromide

: 139377-33-6
phenylmethyl 2-[3-(phenylmethoxy)phenyl]acetate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;	92%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 72h; Etherification;	83%
With potassium carbonate In N-methyl-acetamide

: 621-37-4
3-hydroxyphenylacetic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

Conditions

Conditions	Yield
In methanol; hexane; toluene	99%

: 621-37-4
3-hydroxyphenylacetic acid

: 106-95-6
allyl bromide

: 156945-58-3
<3-(allyloxy)phenyl>acetic acid

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 15h; Heating;	98%
With n-Bu4POH In tetrahydrofuran; water at 0 - 20℃;	83%
Stage #1: m-hydroxyphenylacetic acid; allyl bromide With potassium carbonate In ethanol for 5h; Reflux; Stage #2: With potassium hydroxide In ethanol at 20℃; for 12h;	71.2%
Stage #1: m-hydroxyphenylacetic acid; allyl bromide With potassium carbonate In ethanol at 70℃; for 5h; Stage #2: With potassium hydroxide In ethanol at 20℃; for 12h;	71.2%

: 7664-93-9
sulfuric acid

: 621-37-4
3-hydroxyphenylacetic acid

: 22446-38-4
ethyl 3-hydroxyphenylacetate

Conditions

Conditions	Yield
In ethanol; water	97%
	11.66 g (98%)

: 621-37-4
3-hydroxyphenylacetic acid

: 5557-81-3, 5557-83-5, 34404-37-0
L-alanine benzyl ester hydrochloride

: N-{2-(3-hydroxyphenyl)acetyl}-L-alanine benzyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; Inert atmosphere;	95%

: 1-[3-(naphth-2-ylmethoxy)phenyl]propan-2-one

: 621-37-4
3-hydroxyphenylacetic acid

: 939-26-4
2-bromomethylnaphthyl bromide

: 123723-87-5
3-(naphth-2-ylmethoxy)phenylacetic acid

Conditions

Conditions	Yield
With sodium hydroxide; concentrated aqueous hydrochloric acid; potassium carbonate In ethanol; acetone	94%

...Expand

: 811-98-3
d(4)-methanol

: 621-37-4
3-hydroxyphenylacetic acid

: [D3]methyl [2,4,6‐D3]‐3‐hydroxyphenylethanoate

Conditions

Conditions	Yield
With sulfuric acid-d2 at 60℃; for 1h; Sealed tube;	94%

: 621-37-4
3-hydroxyphenylacetic acid

: 100-39-0
benzyl bromide

: 1860-58-8
3-benzyloxyphenylacetic acid

Conditions

Conditions	Yield
With potassium hydroxide; sodium iodide In ethanol for 16h; Heating;	93%
With potassium iodide; potassium hydroxide In tetrahydrofuran for 18h; Reflux;	91%
Stage #1: m-hydroxyphenylacetic acid With thionyl chloride In methanol at 0℃; for 4h; Heating / reflux; Stage #2: benzyl bromide With potassium carbonate In acetone at 20℃; Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;	91%

: 621-37-4
3-hydroxyphenylacetic acid

: 88443-77-0
3-acetoxyphenylacetic acid

Conditions

Conditions	Yield
With pyridine In P2O5; water; acetic anhydride	90%
With pyridine In P2O5; water; acetic anhydride

: 621-37-4
3-hydroxyphenylacetic acid

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 142741-11-5
N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide

Conditions

Conditions	Yield
	89%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

: 621-37-4
3-hydroxyphenylacetic acid

: (S)-2-[(R)-2-Amino-2-(4-hydroxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester

: 199486-35-6
(3S)-3-(4-fluoro-3-nitrophenyl)-2-<(2R)-2-(4-hydroxy-phenyl)-2-<2-(3-hydroxyphenyl)-acetylamino>acetylamino>-propionic acid methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane	89%

: 621-37-4
3-hydroxyphenylacetic acid

: 371-40-4
4-fluoroaniline

: 295320-11-5
N-(4-fluorophenyl)-2-(3-hydroxyphenyl)acetamide

Conditions

Conditions	Yield
	89%

: 621-37-4
3-hydroxyphenylacetic acid

: 250602-98-3
4-{[2-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole

: 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyl 2-[3-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 1 - 30℃;	89%

: 621-37-4
3-hydroxyphenylacetic acid

: 100-39-0
benzyl bromide

: 295320-25-1
benzyl (3-hydroxyphenyl)acetate

Conditions

Conditions	Yield
Stage #1: m-hydroxyphenylacetic acid With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 48h;	89%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 70℃;	87%

: 621-37-4
3-hydroxyphenylacetic acid

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 1316808-81-7
2-[3-(trimethylsilyloxy)phenyl]acetic acid

Conditions

Conditions	Yield
With cross-linked poly((30percent)4-vinylpyridine/(70percent)styrene) copolymer-supported bismuth(III) triflate In dichloromethane at 20℃; for 0.333333h;	88%

: 621-37-4
3-hydroxyphenylacetic acid

: 108-24-7
acetic anhydride

: 100-52-7
benzaldehyde

: 3-(2-oxo-2H-chromen-3-yl)phenyl acetate

Conditions

Conditions	Yield
With triethylamine at 100 - 170℃; Microwave irradiation;	87%

...Expand

: 621-37-4
3-hydroxyphenylacetic acid

: 64-04-0
phenethylamine

: 1285511-99-0
2-(3-hydroxyphenyl)-N-phenethylacetamide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	85%

: 613-84-3
2-hydroxy-5-methylbenzaldehyde

: 621-37-4
3-hydroxyphenylacetic acid

: 108-24-7
acetic anhydride

: 3-(3-acetoxyphenyl)-6-methylcoumarin

Conditions

Conditions	Yield
With triethylamine at 120℃; for 8h;	85%

...Expand

: 621-37-4
3-hydroxyphenylacetic acid

: 108-24-7
acetic anhydride

: 587-04-2
3-Chlorobenzaldehyde

: 3-(6-chloro-2-oxo-2H-chromen-3-yl)phenyl acetate

Conditions

Conditions	Yield
With triethylamine at 100 - 170℃; Microwave irradiation;	85%

...Expand

3-Hydroxyphenylacetic acid Specification

1. Introduction of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid, with the CAS registry number 621-37-4, is also known as 3-Hydroxyphenylacetic acid. It belongs to the product categories of Aromatic Phenylacetic Acids and Derivatives; Aromatics; Carbonyl Compounds; Carboxylic Acids. What's more, its IUPAC name is 2-(3-hydroxyphenyl)acetic acid.

2. Properties of 3-Hydroxyphenylacetic acid
(1)ACD/LogP: 0.77; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.58; (4)ACD/LogD (pH 7.4): -2.35; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.78; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 35.53 Å²; (13)Index of Refraction: 1.596; (14)Molar Refractivity: 39.24 cm³; (15)Molar Volume: 115.3 cm³; (16)Surface Tension: 59.8 dyne/cm; (17)Density: 1.319 g/cm³; (18)Flash Point: 179.1 °C; (19)Enthalpy of Vaporization: 62.63 kJ/mol; (20)Boiling Point: 349 °C at 760 mmHg; (21)Vapour Pressure: 1.81E-05 mmHg at 25°C.

3. Structure Descriptors of 3-Hydroxyphenylacetic acid
(1)Canonical SMILES: C1=CC(=CC(=C1)O)CC(=O)O
(2)InChI: InChI=1S/C8H8O3/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
(3)InChIKey: FVMDYYGIDFPZAX-UHFFFAOYSA-N

4. Safety Information of 3-Hydroxyphenylacetic acid
Hazard Symbols: Irritant Xi
Risk Codes:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

5. Preparation of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid can be prepared by (3-hydroxy-phenyl)-acetic acid and 3-bromo-propene by heating. This reaction will need reagent NaH and solvent tetrahydrofuran. The reaction time is 15 hours. The yield is about 98%.

6. Use of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid can be used to produce ethyl 3-hydroxyphenylacetate by heating. It will need reagent H₂SO₄ with reaction time of 7 hours. The yield is about 94%.

7. Other details of 3-Hydroxyphenylacetic acid
When you are using this chemical, please be cautious about it as the following:
3-Hydroxyphenylacetic acid is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You need wear suitable protective clothing.

Product Name

3-Hydroxyphenylacetic acid

Synthetic route

3-Hydroxyphenylacetic acid Specification

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