3-Hydroxypropionitrile supplier

Name
3-Hydroxypropanenitrile
EINECS 203-704-8
CAS No. 109-78-4
Article Data71
CAS DataBase
Density 1.04 g/cm³
Solubility >=10 g/100 mL at 20 °C in water
Melting Point -46 °C
Formula C₃H₅NO
Boiling Point 229.6 °C at 760 mmHg
Molecular Weight 71.0788
Flash Point 92.7 °C
Transport Information 2810
Appearance Colourless or straw-coloured liquid
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Hydracrylonitrile(8CI);1-Cyano-2-hydroxyethane;2-Cyanoethanol;2-Cyanoethyl alcohol;2-Hydroxycyanoethane;2-Hydroxyethyl cyanide;3-Hydroxypropanenitrile;Ethylene cyanhydrine;Ethylene cyanohydrin;Glycolcyanohydrin;NSC 2598;b-Cyanoethanol;b-Hydroxyethyl cyanide;b-Hydroxypropionitrile;
PSA 44.02000
LogP -0.10762

Synthetic route

: 107-13-1
acrylonitrile

A: 111-97-7
3,3'-thiobis-propanenitrile

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sodium sulfide; benzyltri(n-butyl)ammonium chloride In water for 0.166667h;	A 98% B n/a

: 75-21-8
oxirane

: 74-90-8
hydrogen cyanide

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With aluminum oxide; boron trifluoride diethyl etherate In propylene glycol at -10 - 10℃; for 28h; Reagent/catalyst; Temperature;	97.3%

: 143-33-9
sodium cyanide

: 107-07-3
2-chloro-ethanol

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With PEG400 for 6h; Heating;	93%

: 107-13-1
acrylonitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sodium hydroxide at 50℃; for 0.2h;	92%
With sodium hydroxide In water at 50℃; for 4h;	65%
With water; copper(II) oxide

: 90087-76-6, 89923-32-0
3-((tetrahydro-2H-pyran-2-yl)oxy)propanenitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With silica-supported NaHSO4 In methanol at 20℃; for 0.25h;	92%
With zinc(II) trifluoromethanesulfonate In methanol at 20℃; for 0.666667h;	81%

: 3-(4-methoxybenzyloxy)propanenitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium nitrite at 20℃; for 18h; Green chemistry; chemoselective reaction;	84%

: 151-50-8
potassium cyanide

: 107-07-3
2-chloro-ethanol

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sodium iodide In ethanol for 5h; Heating;	80%
at 100℃;
With ethanol

: 131379-56-1
3-(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)propanenitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With 2,3-dimethyl-1,4-benzoquinone; tetrabutyl ammonium fluoride; oxygen In tetrahydrofuran for 0.833333h; Ambient temperature;	71%

: 107-13-1
acrylonitrile

: 108-95-2
phenol

A: 3055-86-5
3-phenoxypropionitrile

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With tetramethyl ammoniumhydroxide In water at 60℃; for 0.5h; Temperature; Reagent/catalyst; Time; Michael Addition; Microwave irradiation;	A 68% B n/a

...Expand

: 22059-21-8
aminocyclopropane-1-carboxylic acid

A: 74-85-1
ethene

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With lithium hypochlorite In water Ambient temperature;	A 9.8% B 60%
With lithium hypochlorite In water Product distribution; Mechanism; Ambient temperature; other solvent and additives; var. cyclopropanamines;	A 9.8% B 60%

: 105-34-0
methyl 2-cyanoacetate

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With lithium aluminium hydride on silica gel In diethyl ether for 3h; Heating;	54%

: 2417-90-5
bromopropionitrile

A: 64-19-7
acetic acid

B: 107-13-1
acrylonitrile

C: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With oxygen; tetraethylammonium perchlorate In N,N-dimethyl-formamide at 20℃; electroreduction at -1.1 V;	A 40 % Chromat. B 10 % Chromat. C 36%

...Expand

: 765-30-0
Cyclopropylamine

A: 74-85-1
ethene

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With lithium hypochlorite In water Ambient temperature;	A 15% B 30 mg

: sodium metavanadate tetrahydrate

: 12775-96-1, 15158-11-9, 15721-63-8, 16941-75-6, 17493-86-6, 19498-52-3, 20499-83-6, 20499-84-7, 20499-85-8, 20499-86-9, 20573-10-8, 20573-11-9, 21595-51-7, 21595-52-8, 22206-52-6, 26445-28-3, 28959-95-7, 37362-93-9, 39417-05-5, 54603-16-6, 54603-23-5, 54603-32-6, 54603-40-6, 54603-48-4, 54603-81-5, 54603-89-3, 56316-56-4, 95985-91-4, 122297-32-9, 7440-50-8
copper

: 107-13-1
acrylonitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
In water	1.3%

...Expand

: 627-18-9
1-bromo-3-propanol

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
(i) NaN3, H2O, (ii) Pd, 2,5-dimethyl-hex-3-yne-2,5-diol, benzene; Multistep reaction;

: 72784-43-1
methyl 1-aminocyclopropane-1-carboxylate

A: 74-85-1
ethene

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With lithium hypochlorite In water at 5 - 10℃; for 0.333333h;

: 107-13-1
acrylonitrile

A: 79-06-1
2-propenamide

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sodium hydroxide; Pt(Ppy3)4; water at 80℃; for 1h; Product distribution; var. platinum(0) catalysts;
at 70℃; for 8h; Product distribution; The selective hydration with several metal oxide catalysts.;
manganese(IV) oxide at 70℃; for 8h; Yield given;

: 107-13-1
acrylonitrile

A: 1656-48-0
2-cyanoethyl ether

B: 79-06-1
2-propenamide

C: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
trans- at 80℃; Mechanism; Rate constant; Product distribution; in the absence or in the presence of different quantity of water;
trans- at 25℃; Rate constant; Product distribution; also in the presence of different quantity of acetamide;
sodium hydroxide In water at 80℃; Product distribution;

...Expand

: 105-56-6
ethyl 2-cyanoacetate

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol for 16h;

: 62984-38-7
N-nitro-β-aminopropionitrile

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
With sulfuric acid at 25 - 85℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), -ΔS(excit.);

: 98-01-1
furfural

: 7732-18-5
water

: 100-85-6
N-benzyl-trimethylammonium hydroxide

: 107-13-1
acrylonitrile

A: 101291-29-6
bis-(2-cyano-3ξ-[2]furyl-allyl)-ether

B: 109-78-4
3-Hydroxypropionitrile

C 3t-<2>furyl-2-hydroxymethyl-acrylonitrile: 3t-<2>furyl-2-hydroxymethyl-acrylonitrile

D 3c-<2>furyl-2-hydroxymethyl-acrylonitrile and 2-<(2-cyano-ethoxy-methyl>-3-<2>furyl-acrylonitrile: 3c-<2>furyl-2-hydroxymethyl-acrylonitrile and 2-<(2-cyano-ethoxy-methyl>-3-<2>furyl-acrylonitrile

...Expand

: 107-07-3
2-chloro-ethanol

alkali cyanide: alkali cyanide

: 109-78-4
3-Hydroxypropionitrile

: 540-51-2
2-bromoethanol

alkali cyanide: alkali cyanide

: 109-78-4
3-Hydroxypropionitrile

: 75-21-8
oxirane

salts of/the/ hydrocyanic acid: salts of/the/ hydrocyanic acid

: 109-78-4
3-Hydroxypropionitrile

: 107-13-1
acrylonitrile

aqueous NaOH-solution: aqueous NaOH-solution

A: 79-06-1
2-propenamide

B: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
at 20℃; Kinetics;
at 40℃; Kinetics;

...Expand

: 107-13-1
acrylonitrile

A: 1656-48-0
2-cyanoethyl ether

B: 79-06-1
2-propenamide

C: 109-78-4
3-Hydroxypropionitrile

D ethylene cyanohydrine, bis(2-cyanoethyl) ether: ethylene cyanohydrine, bis(2-cyanoethyl) ether

Conditions

Conditions	Yield
With water; Ni(b),Cu(35) (X%) at 75℃; for 6h; Product distribution; Thermodynamic data; other time and catalyst composition; ΔE(excit); effect on the rate and product distribution;

...Expand

: 75-21-8
oxirane

: 74-90-8
hydrogen cyanide

: 7732-18-5
water

: 109-78-4
3-Hydroxypropionitrile

Conditions

Conditions	Yield
Reaktion von Calciumcyanid;
Reaktion von Calciumcyanid;

...Expand

: 75-21-8
oxirane

: 74-90-8
hydrogen cyanide

: 143-33-9
sodium cyanide

: 7732-18-5
water

: 109-78-4
3-Hydroxypropionitrile

...Expand

: 75-21-8
oxirane

: 74-90-8
hydrogen cyanide

: 7732-18-5
water

calcium cyanide: calcium cyanide

: 109-78-4
3-Hydroxypropionitrile

...Expand

: 109-78-4
3-Hydroxypropionitrile

: 53868-56-7
3-hydroxypropanimidamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 3-Hydroxypropionitrile With acetyl chloride In methanol; toluene at 0 - 20℃; for 18h; Stage #2: With ammonia In methanol at 0 - 20℃; for 18h;	100%
With hydrogenchloride; methanol; diethyl ether Umsetzen des Reaktionsprodukts mit NH3 in Metahnol bei 0grad;

: 109-78-4
3-Hydroxypropionitrile

: 162611-40-7, 162611-41-8, 171081-08-6
5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

: 171081-12-2
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

Conditions

Conditions	Yield
With 1H-tetrazole In acetonitrile for 0.166667h; Ambient temperature;	100%

: 109-78-4
3-Hydroxypropionitrile

: 162611-38-3, 162611-39-4, 171081-09-7
O-(5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite

: 171081-13-3
Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Conditions

Conditions	Yield
With 1H-tetrazole In acetonitrile for 0.166667h; Ambient temperature;	100%

: 32315-10-9
bis(trichloromethyl) carbonate

: 109-78-4
3-Hydroxypropionitrile

: 30436-27-2
β-cyanoethyl chlorocarbonate

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 3-Hydroxypropionitrile In tetrahydrofuran at 0 - 20℃; Stage #2: With pyridine In tetrahydrofuran at 0 - 20℃;	100%
In pyridine; toluene at 0℃;

: 18162-48-6
tert-butyldimethylsilyl chloride

: 109-78-4
3-Hydroxypropionitrile

: 89923-33-1
3-((tert-butyldimethylsilyl)oxy)propanenitrile

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 30℃;	100%
With 1H-imidazole In tetrahydrofuran at 40℃; for 15h; Condensation;	98%
With 1H-imidazole In dichloromethane at 20℃;	94%

: 13154-24-0
triisopropylsilyl chloride

: 109-78-4
3-Hydroxypropionitrile

: 3-triisopropylsilyloxypropionitrile

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 1189-71-5
isocyanate de chlorosulfonyle

: 109-78-4
3-Hydroxypropionitrile

: C4H5ClN2O4S

Conditions

Conditions	Yield
In dichloromethane for 1h;	100%

: 474755-59-4
(1'S)-1-(1'-phenylethyl)-3,4-epoxypyrrolidine

: 1634-04-4
tert-butyl methyl ether

: 109-78-4
3-Hydroxypropionitrile

: (1'S)-1-(1'-phenylethyl)-3-hydroxy-4-methoxy-pyrrolidine

Conditions

Conditions	Yield
With sodium methylate In methanol; water	100%

...Expand

: 109-78-4
3-Hydroxypropionitrile

: 5336-08-3
D-Ribono-1,4-lactone

: 1254077-05-8
C8H14N2O5

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 109-78-4
3-Hydroxypropionitrile

: 3-hydroxypropanimidamide hydrochloric acid salt

Conditions

Conditions	Yield
Stage #1: 3-Hydroxypropionitrile With acetyl chloride In methanol; toluene at 0 - 20℃; for 18h; Stage #2: With ammonia In tetrahydrofuran; methanol at 0 - 20℃; for 18h;	100%

: 109-78-4
3-Hydroxypropionitrile

: 219553-44-3
1-<3-(N-tert-butoxycarbonylamino)propyl>-4-phenylpiperidine-4-carboxylic acid

: 219553-50-1
1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 16h; Heating;	99%

: 109-78-4
3-Hydroxypropionitrile

: 1821-12-1
4-Phenylbutyric acid

: 2-cyanoethyl 4-phenylbutyrate

Conditions

Conditions	Yield
With Iron(III) isopropoxide; zirconium(IV) tetraisopropoxide In n-heptane for 23h;	99%
tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene for 24h; Heating;	94%
zirconium(IV) oxychloride In n-heptane for 5h; Heating;

: 3'-deoxy-3'-C-[(hydroxyphosphinyl)methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine triethylamine salt

: 109-78-4
3-Hydroxypropionitrile

: 3'-deoxy-3'-C-[[(2-cyanoethoxy)phosphinyl]methyl]-5'-O-(4-methoxytrityl)-2'-O-methyl-4-N-(N-methylpyrrolidin-2-ylidene)-5-methylcytidine

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 65℃;	99%

: 22097-10-5
5-methyl-1,2,3-thiadiazolyl-4-carboxylic acid

: 109-78-4
3-Hydroxypropionitrile

: 2-cyanoethyl 5-methyl-1,2,3-thiadiazole-4-carboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 0 - 20℃; for 3.5h; Inert atmosphere;	99%

: 102-92-1
Cinnamoyl chloride

: 109-78-4
3-Hydroxypropionitrile

: 1426540-82-0
2-cyano-ethyl cinnamate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 12h; Inert atmosphere;	99%

: 75-77-4
chloro-trimethyl-silane

: 109-78-4
3-Hydroxypropionitrile

: 42202-44-8
3-trimethylsilanyloxypropionitrile

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 0 - 23℃; for 16.3333h;	98%
Stage #1: 3-Hydroxypropionitrile With triethylamine at 0℃; Stage #2: chloro-trimethyl-silane In diethyl ether at 0℃; for 0.583333h;	98.5%
With triethylamine In diethyl ether at 0 - 23℃; for 16h; Inert atmosphere; Schlenk technique;	98%

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 109-78-4
3-Hydroxypropionitrile

: 65193-87-5
2-cyanoethylacetoacetate

Conditions

Conditions	Yield
In o-xylene at 141℃; for 2h;	98.3%
In 5,5-dimethyl-1,3-cyclohexadiene at 140 - 145℃; for 1h;	90%
In xylene at 140 - 145℃; for 1h;	81.6%

: 109-78-4
3-Hydroxypropionitrile

: 2651-43-6
3-hydroxypropionamide

Conditions

Conditions	Yield
With manganese(IV) oxide; water In isopropyl alcohol at 100℃; under 5171.62 Torr; for 0.833333h;	98%
With CF3O3S(1-)*C36H35ClFeOP3Pt(1+); water; silver trifluoromethanesulfonate In tetrahydrofuran at 40℃; for 12h; Catalytic behavior; Inert atmosphere;	92%
With silver tetrafluoroborate; C36H35ClFeOP3Pt(1+)*BF4(1-) In tetrahydrofuran; water at 80℃; for 12h;	92%

: 109-78-4
3-Hydroxypropionitrile

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen; silver nitrate In methanol at 45 - 75℃; under 1500.15 Torr; Temperature; High pressure; Inert atmosphere; Autoclave;	98%
With hydrogen; nickel In isopropyl alcohol at 60℃; under 3102.9 Torr; 20-24 h;	88%
With ammonium hydroxide; hydrogen at 80℃; under 60006 Torr; for 6h; Sealed tube;	80%

: 109-78-4
3-Hydroxypropionitrile

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 96404-97-6
2-chlorophenyl bis<2-cyanoethyl>phosphate

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane for 4.5h; Ambient temperature;	98%

: 3898-66-6
2-(carboxymethyl)-5-nitrobenzoic acid

: 109-78-4
3-Hydroxypropionitrile

: 623172-50-9
2-(2-cyano-ethoxycarbonylmethyl)-5-nitro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid at 70℃; for 0.116667h;	98%

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 109-78-4
3-Hydroxypropionitrile

: 2-cyanoethyl (1-benzyloxycarbonyl-4-piperidine)carboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 5h; Ambient temperature;	97%

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 109-78-4
3-Hydroxypropionitrile

: 42202-44-8
3-trimethylsilanyloxypropionitrile

Conditions

Conditions	Yield
With ammonium thiocyanate In dichloromethane at 0℃; for 0.166667h;	97%
at 135℃; for 2h;	167 g
toluene-4-sulfonic acid at 100℃; for 2.5h;
toluene-4-sulfonic acid at 60 - 80℃; for 2.5 - 4.5h;

: 4530-20-5
BOC-glycine

: 109-78-4
3-Hydroxypropionitrile

: 119866-74-9
Boc-Gly-OCet

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0℃; for 2h;	97%
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide Ambient temperature;	88%

: 109-78-4
3-Hydroxypropionitrile

: 475107-22-3
O-(2-thiono-1,3,2-oxathiaphospholanyl)-N-(tert-butoxycarbonyl)serine methyl ester

: 475107-34-7
2-tert-butoxycarbonylamino-3-[(2-cyano-ethoxy)-mercapto-phosphoryloxy]-propionic acid methyl ester

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3h;	97%

: 64-17-5
ethanol

: 109-78-4
3-Hydroxypropionitrile

: 20914-88-9
Ethyl 3-hydroxypropionimidate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 20℃; for 3h; Pinner Imino Ether Synthesis; Inert atmosphere;	97%

: 6773-29-1
dimethyl diazomalonate

: 109-78-4
3-Hydroxypropionitrile

: 3-propanonitrile

Conditions

Conditions	Yield
dirhodium tetraacetate In chloroform	96%

: 109-78-4
3-Hydroxypropionitrile

: N-(2-thiono-1,3,2-oxathiaphospholanyl)valine methyl ester

: 2-[(2-cyano-ethoxy)-mercapto-phosphorylamino]-3-methyl-butyric acid methyl ester

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3h;	96%

3-Hydroxypropionitrile Chemical Properties

Hydracrylonitrile(109-78-4)'s molecular formula is C₃H₅NO and its formula weight is 71.08.
The density of hydracrylonitrile(109-78-4) is 1.04 and it has a melting point of -46°C. The Boiling point is 228°C. The refractive index is about 1.4246-1.4266. Its flash point is 128°C. The water solubility should be equal to or greater than 10 g/100 mL at 20°C.
Hydracrylonitrile(109-78-4) has the property of being dissolved in water, ethanol, acetone and methyl ethyl ketone(MEK). It is not soluble in benzene, light petroleum, carbon bisulfide and Carbon tetrachloride.
The molecular structure of hydracrylonitrile(109-78-4) :

3-Hydroxypropionitrile Uses

Hydracrylonitrile(109-78-4) is used as a solvent for dissolving cellulose esters and some Inorganic salts. 3-Amino-1-propanol can be produced from hydracrylonitrile(109-78-4) by hydrogenation, which is used to produce synthetic drug( such as cyclophosphamide and inderal).

3-Hydroxypropionitrile Toxicity Data With Reference

1.	skn-rbt 10 mg/24H open	JIHTAB Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
2.	skn-rbt 520 mg open MLD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 8/18 ,1967.
3.	eye-rbt 500 mg	AJOPAA American Journal of Ophthalmology. 29 (1946),1363.
4.	orl-rat LD50:3200 mg/kg	38MKAJ Pattys Industrial Hygiene and Toxicology. 2C (1982),4875.
5.	orl-mus LD50:1800 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 8 (1953),371.
6.	ihl-mus LC33:300 mg/m3/2H	85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,66.
7.	ipr-mus LD50:500 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
8.	orl-rbt LDLo:900 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 8 (1953),371.
9.	skn-rbt LD50:5000 mg/kg	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide

3-Hydroxypropionitrile Consensus Reports

Reported in EPA TSCA Inventory. Cyanide compounds are on the Community Right-To-Know List.

3-Hydroxypropionitrile Safety Profile

Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. A skin and eye irritant. Combustible when exposed to heat or flame. Reacts violently with mineral acids (e.g., chlorosulfonic acid, oleum, sulfuric acid), amines, or inorganic bases (e.g., NaOH). Reacts with water or steam to produce toxic and flammable vapors. To fight fire, use CO₂, dry chemical, alcohol foam. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN⁻. See also NITRILES.

Product Name

3-Hydroxypropanenitrile

Synthetic route

3-Hydroxypropionitrile Chemical Properties

3-Hydroxypropionitrile Uses

3-Hydroxypropionitrile Toxicity Data With Reference

3-Hydroxypropionitrile Consensus Reports

3-Hydroxypropionitrile Safety Profile

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