Product Name

  • Name

    4'-Bromoacetophenone

  • EINECS 202-799-3
  • CAS No. 99-90-1
  • Article Data622
  • CAS DataBase
  • Density 1.451 g/cm3
  • Solubility methanol: 0.1 g/mL, clear
  • Melting Point 108-110 °C(lit.)
  • Formula C8H7BrO
  • Boiling Point 259.898 °C at 760 mmHg
  • Molecular Weight 199.047
  • Flash Point 94.278 °C
  • Transport Information UN 3261 8/PG 2
  • Appearance white to light yellow crystals
  • Safety 26-36/37/39-45-22-36/37
  • Risk Codes 34-36/38-42/43-36/37/38
  • Molecular Structure Molecular Structure of 99-90-1 (4'-Bromoacetophenone)
  • Hazard Symbols CorrosiveC,IrritantXi,HarmfulXn
  • Synonyms 4-Bromoacetophenone;p-Bromophenyl methyl ketone;Ethanone, 1-(4-bromophenyl)-;1-(4-Bromophenyl)ethanone;p-Bromoacetophenone;Methyl p-bromophenyl ketone;Ethanone, 1- (4-bromophenyl)-;Acetophenone, 4-bromo- (8CI);p-Bromo acetophenone;Acetophenone, 4-bromo-;4-Bromo Acetophenone;4-Bromoacetophenone 99%;
  • PSA 17.07000
  • LogP 2.65170

Synthetic route

1-(4-bromophenyl)ethanol
5391-88-8

1-(4-bromophenyl)ethanol

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With polymer-supported phenyliodine(III) diacetate; JandaJel-CH2O-TEMPO In 1,2-dichloro-ethane at 70℃; for 12h;100%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; sodium hydrogencarbonate; gold(I) chloride In water at 100℃; under 38002.6 Torr; for 24h;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ5-benzo[d][1,2]-iodoxol-1-ol anion; trifluoroacetic acid at 20℃; for 0.25h;100%
α-(benzoyloxy)-p-bromoacetophenone
7506-12-9

α-(benzoyloxy)-p-bromoacetophenone

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; azobisisobutyronitrile In acetonitrile at 61℃; for 48h; Rate constant; other temp., other reagents;100%
With 4-methyl-morpholine; 1.3-propanedithiol; tetrabutyl ammonium fluoride In tetrahydrofuran for 0.0833333h; Ambient temperature;74%
2-(4-bromophenyl)-2-methyl-1,3-dioxolane
4360-68-3

2-(4-bromophenyl)-2-methyl-1,3-dioxolane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With diiodosilane In chloroform at -42℃; for 0.0166667h; other reagent: iodotrimethylsilane (TMSI); other temp. and mol percent; other ketals and acetals;99%
With diiodosilane In chloroform at -42℃; for 0.0166667h; other reagent: iodotrimethylsilane (TMSI);99%
With caro's acid; silica gel In acetonitrile at 20℃; for 0.666667h;95%
4-bromoacetophenone phenylhydrazone
10591-75-0

4-bromoacetophenone phenylhydrazone

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With quinolinium dichromate(VI) In acetonitrile for 1h; Heating;99%
With polumer-supported phenyliodine bis(trifluoroacetate); water In tetrahydrofuran for 0.75h;85%
With manganese(IV) oxide; potassium permanganate In dichloromethane at 20℃; for 10h;68%
4-bromo-1-ethynylbenzene
766-96-1

4-bromo-1-ethynylbenzene

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; C75H52AuClN2O2 In methanol; dichloromethane; water at 20℃; for 20h;99%
With water at 60℃; for 20h; Sealed tube;99%
With 5,10,15-tris(pentafluorophenyl)corrole cobalt(III) triphenyl phosphine; sulfuric acid; water In methanol at 80℃; for 72h;99%
1-bromo-4-(1,1-diethoxyethyl)benzene
61390-40-7

1-bromo-4-(1,1-diethoxyethyl)benzene

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
bismuth(III) iodide In water at 100℃; for 2h;99%
With copper(II) sulfate; sodium iodide In acetone at 56℃; for 2.5h;81%
1-(4-acetylphenyl)diazonium tetrafluoroborate
350-47-0

1-(4-acetylphenyl)diazonium tetrafluoroborate

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With dibenzo-18-crown-6; potassium bromide; copper(ll) bromide; 1,10-Phenanthroline; copper(I) bromide In acetonitrile at 20℃; for 0.333333h; Sandmeyer bromination;99%
With (triphenylphosphine)gold(I) chloride; sodium bromide In acetonitrile at 50℃; for 5h; Sandmeyer Reaction;81%
2-(4-bromophenyl)propane
586-61-8

2-(4-bromophenyl)propane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With oxygen at 190℃; under 760.051 Torr; for 24h; Autoclave;99%
With hydrogenchloride; sodium nitrite In water at 23℃; for 3h; Sealed tube;50%
para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With sodium dithionite; potassium carbonate; 1,1′-dioctyl-4,4′-bipyridinium In water; toluene at 35℃; for 3h;98%
With sodium tetrahydroborate; nickel dichloride In N,N-dimethyl-formamide for 0.25h;98%
With Methyltrichlorosilane; sodium iodide In acetonitrile for 2h; Ambient temperature;98%
piperidine
110-89-4

piperidine

bis(1-naphthoyl) telluride
107469-89-6

bis(1-naphthoyl) telluride

A

(naphthalen-1-yl)(piperidin-1-yl)methanone
5454-14-8

(naphthalen-1-yl)(piperidin-1-yl)methanone

B

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With para-bromophenacyl bromide In toluene at 25℃; for 2h;A 98%
B 50%
...Expand
p-bromoacetophenone oxime
59862-55-4, 73744-33-9, 5798-71-0

p-bromoacetophenone oxime

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With quinolinium dichromate(VI) In acetonitrile for 0.8h; Heating;98%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In acetonitrile for 1h; Heating;98%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In dichloromethane for 0.05h; microwave irradiation;98%
1,2-bis-[1-(4-bromophenyl)ethylidene]hydrazine
56587-87-2, 21399-36-0

1,2-bis-[1-(4-bromophenyl)ethylidene]hydrazine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate In water; acetonitrile at 20℃; for 18h; Oxidation;98%
With 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; dihydrogen peroxide In methanol; water at 65℃; for 24h;96%
1-(4-bromophenyl)-2-chloroethan-1-one
4209-02-3

1-(4-bromophenyl)-2-chloroethan-1-one

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With bismuth(III) chloride; sodium tetrahydroborate; sodium iodide In acetone Ambient temperature;98%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; acetic acid for 3h; Irradiation; Inert atmosphere;92%
[1-(4-Bromo-phenyl)-eth-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

[1-(4-Bromo-phenyl)-eth-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With water; oxalic acid In diethyl ether for 4h; Ambient temperature;98%
1-(4-Bromo-phenyl)-1-{2-[1-(4-bromo-phenyl)-1-hydroxy-ethyl]-quinazolin-4-yl}-ethanol

1-(4-Bromo-phenyl)-1-{2-[1-(4-bromo-phenyl)-1-hydroxy-ethyl]-quinazolin-4-yl}-ethanol

A

para-bromoacetophenone
99-90-1

para-bromoacetophenone

B

2-(α-methyl-α-hydroxy-p-bromobenzyl)quinazoline

2-(α-methyl-α-hydroxy-p-bromobenzyl)quinazoline

Conditions
ConditionsYield
With tetra-n-butylammonium cyanide In tetrahydrofuran for 0.333333h; Heating;A 89%
B 98%
N'-[1-(4-Bromo-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine
5757-83-5

N'-[1-(4-Bromo-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With sodium perborate In acetic acid at 50 - 60℃; for 5h;97%
With cerium(III) chloride; silica gel for 0.0833333h; Microwave irradiation;90%
para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

4-Ethyltellanyl-butan-1-ol
189247-72-1

4-Ethyltellanyl-butan-1-ol

A

para-bromoacetophenone
99-90-1

para-bromoacetophenone

B

2-Bromo-2-ethyl-2λ4-[1,2]oxatellurane

2-Bromo-2-ethyl-2λ4-[1,2]oxatellurane

Conditions
ConditionsYield
In dichloromethane for 2h; Ambient temperature;A 97%
B 63%
...Expand
1-bromo-4-ethylbenzene
1585-07-5

1-bromo-4-ethylbenzene

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With tert.-butylhydroperoxide In water at 20℃; for 18h; Sealed tube;97%
With Iron(III) nitrate nonahydrate; 1-hydroxy-pyrrolidine-2,5-dione; oxygen In benzonitrile at 90℃; for 30h;97%
With Oxone; potassium bromide In nitromethane at 50℃; for 24h;96%
4-acetylphenylboronic acid
149104-90-5

4-acetylphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With N-Bromosuccinimide In acetonitrile at 80℃; for 12h;97%
With tetrabutylammomium bromide; copper(ll) bromide In water at 100℃; Sealed tube;87%
With sodium nitrite In acetonitrile at 80℃; for 10h; Sealed tube;85%
With 1,10-Phenanthroline; oxygen; potassium bromide; copper(ll) bromide In N,N-dimethyl-formamide at 130℃; for 20h;78%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium methylate In methanol; water; acetonitrile at 40℃; for 4h;99 % Chromat.
3,3-dimethyldioxirane
74087-85-7

3,3-dimethyldioxirane

1-(4-bromophenyl)ethanol
5391-88-8

1-(4-bromophenyl)ethanol

A

4-bromo-2-hydroxyacetophenone
3343-45-1

4-bromo-2-hydroxyacetophenone

B

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
In acetone at 25℃; for 3h;A 3%
B 96%
In acetone at 25℃; for 3h; Thermodynamic data; Rate constant; Ea, ΔH(excit.), ΔS(excit.), ΔG(excit.);A 3%
B 96%
...Expand
para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

3-(methyltellanyl)propan-1-ol
110851-05-3

3-(methyltellanyl)propan-1-ol

A

para-bromoacetophenone
99-90-1

para-bromoacetophenone

B

2-Bromo-2-methyl-2λ4-[1,2]oxatellurolane

2-Bromo-2-methyl-2λ4-[1,2]oxatellurolane

Conditions
ConditionsYield
In dichloromethane for 2.5h; Ambient temperature;A 96%
B 72%
...Expand
1-(4-bromophenyl)-2-(phenylsulfonyl)ethanone
41024-55-9

1-(4-bromophenyl)-2-(phenylsulfonyl)ethanone

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With formic acid; eosin Y bis(tetrabutyl ammonium salt) In acetonitrile at 20℃; Irradiation; Inert atmosphere;96%
With samarium; acetic acid In ethanol at 20℃; for 3h;75%
4-acetophenyl triflate
109613-00-5

4-acetophenyl triflate

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With [Cp*Ru(CH3CN)3]OTf; lithium bromide at 100℃; for 12h; Inert atmosphere;96%
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); t-BuBrettPhos; potassium bromide In 1,4-dioxane at 130℃; for 16h; Inert atmosphere;79%
4'-bromoacetophenone semicarbazone
120445-88-7, 20576-97-0

4'-bromoacetophenone semicarbazone

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With (H2DABCO)2(HDABCO)2(Br)2(Br3)4 In water at 80℃; for 0.333333h;95%
With tribromo-isocyanuric acid In acetonitrile at 20℃; for 6h;94%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In acetonitrile for 2h; Heating;93%
(1-(4-bromophenyl)ethoxy)trimethylsilane

(1-(4-bromophenyl)ethoxy)trimethylsilane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With 2,6-dicarboxypyridinium chlorochromate In acetonitrile at 20℃; for 0.15h;95%
With potassium dichromate; aluminium trichloride for 0.416667h;90%
2-(4-bromophenyl)-2-methyl-1,3-dithiane
77464-23-4

2-(4-bromophenyl)-2-methyl-1,3-dithiane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With quinolinium monofluorochromate(VI) In acetonitrile for 2.5h; Heating;95%
With potassium permanganate; tungstate sulfuric acid In dichloromethane at 20℃; for 1.16667h;95%
With silica gel; iodic acid at 20℃; for 0.0111111h;93%
2-(p-bromo-α-methylbenzyloxy)tetrahydropyran
52779-71-2

2-(p-bromo-α-methylbenzyloxy)tetrahydropyran

para-bromoacetophenone
99-90-1

para-bromoacetophenone

Conditions
ConditionsYield
With β‐cyclodextrin; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; acetone at 20℃; for 0.666667h;95%
With N-Bromosuccinimide; β‐cyclodextrin In acetone at 20℃; for 0.5h;90%
1-bromo-4-ethenyl-benzene
2039-82-9

1-bromo-4-ethenyl-benzene

A

para-bromoacetophenone
99-90-1

para-bromoacetophenone

B

1-(4-bromophenyl)ethanol
5391-88-8

1-(4-bromophenyl)ethanol

Conditions
ConditionsYield
With triethylsilane; (1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-Hexadecafluorophthalocyaninato)iron(II); oxygen In ethanol at 20℃; under 760.051 Torr; for 8.5h; Wacker Oxidation; Sealed tube; Green chemistry; chemoselective reaction;A 95%
B 3%
pyridine
110-86-1

pyridine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

1-(2-(4-bromophenyl)-2-oxoethyl)pyridin-1-ium iodide
6320-91-8

1-(2-(4-bromophenyl)-2-oxoethyl)pyridin-1-ium iodide

Conditions
ConditionsYield
With iodine for 16h; Reflux; Inert atmosphere;100%
With iodine at 80℃; for 6h;78%
With iodine at 100℃; for 3h;76%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

ethylene glycol
107-21-1

ethylene glycol

2-(4-bromophenyl)-2-methyl-1,3-dioxolane
4360-68-3

2-(4-bromophenyl)-2-methyl-1,3-dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 39h; Heating;100%
With p-toluenesulfonic acid monohydrate In benzene for 50h; Inert atmosphere; Reflux; Dean-Stark;100%
With toluene-4-sulfonic acid In toluene at 160℃; for 16h; Dean-Stark; Inert atmosphere;99%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-bromophenylglyoxal
5195-29-9

4-bromophenylglyoxal

Conditions
ConditionsYield
With selenium (IV) oxide In 1,4-dioxane; water Heating;100%
With copper(II) choride dihydrate In dimethyl sulfoxide at 80℃;90%
With selenium(IV) oxide; water In ethanol for 8h; Reflux;78%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

1-(4-bromophenyl)ethanol
5391-88-8

1-(4-bromophenyl)ethanol

Conditions
ConditionsYield
With zirconium dioxide hydrate; isopropyl alcohol at 130℃; for 0.366667h; Meerwein-Ponndorf-Verley Reduction;100%
Stage #1: para-bromoacetophenone With C24H20Cl2F5NRuS; isopropyl alcohol at 82℃; for 0.166667h;
Stage #2: With potassium hydroxide at 82℃; for 0.5h;		100%
With methanol; sodium tetrahydroborate at 0℃; for 0.166667h; Reagent/catalyst;100%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

p-bromoacetophenone oxime
59862-55-4, 73744-33-9, 5798-71-0

p-bromoacetophenone oxime

Conditions
ConditionsYield
With hydroxylamine100%
With hydroxylamine hydrochloride100%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;100%
styrene
292638-84-7

styrene

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetylstilbene
3112-03-6

4-acetylstilbene

Conditions
ConditionsYield
With cis-(N,N'-bis(2,2-diethoxyethyl)imidazolin-2-ylidene)dichlorotriphenylphosphinepalladium(II); tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 2h; Heck reaction;100%
With 6F6P(1-)*C50H64N12Pd(6+); sodium acetate In N,N-dimethyl-formamide at 140℃; for 3h; Reagent/catalyst; Heck Reaction;100%
With C28H28N4O2(2+)*2Cl(1-); palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 145℃; for 0.0833333h; Heck reaction; Microwave irradiation;99%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4'-fluoro-4-acetyl-1,1'-biphenyl
720-74-1

4'-fluoro-4-acetyl-1,1'-biphenyl

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate In acetone at 110℃; for 3.5h; Suzuki-Miyaura cross-coupling reaction;100%
With potassium phosphate; [Pd(Ph2PCH2CH(CH3)O)2] In tetrahydrofuran; water at 20℃; for 8h; Suzuki cross-coupling reaction;99%
With potassium phosphate; cis-bis((diphenylphosphino)acetate-κ2P,O)palladium(II) In tetrahydrofuran at 25 - 27℃; for 6h; Suzuki coupling;99%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

4'-(2-trimethylsilylethynyl)acetophenone
75883-03-3

4'-(2-trimethylsilylethynyl)acetophenone

Conditions
ConditionsYield
With copper diacetate; triethylamine; triphenylphosphine; palladium dichloride at 100℃; for 1.5h;100%
With copper diacetate; triethylamine; triphenylphosphine; palladium dichloride at 100℃; for 1.5h;100%
With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine at 60℃; for 12h;98%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

para-bromoacetophenone
99-90-1

para-bromoacetophenone

(E)-tert-butyl 3-(4-acetylphenyl)prop-2-enoate
389091-50-3

(E)-tert-butyl 3-(4-acetylphenyl)prop-2-enoate

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate In N,N-dimethyl-formamide at 120℃; for 15h; Heck cross-coupling reaction;100%
With 1,3-disubstituted imidazolium bromide; potassium carbonate; 4-methylmorpholine N-oxide; palladium diacetate In 1-methyl-pyrrolidin-2-one at 120℃; for 2h; Heck reaction;99%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 1h; Mizoroki-Heck reaction;99%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

phenylacetylene
536-74-3

phenylacetylene

4-(phenylethinyl)acetophenone
1942-31-0

4-(phenylethinyl)acetophenone

Conditions
ConditionsYield
With copper(l) iodide; 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 130℃; for 20h; Sonogashira cross-coupling;100%
With copper(l) iodide; 1-isobutyl-2,2,6,6-tetramethyl-phosphorinane*HBF4; diisopropylamine; bis(benzonitrile)palladium(II) dichloride In 1,4-dioxane at 20℃; for 24h; Sonogashira reaction;100%
With 1,4-diaza-bicyclo[2.2.2]octane; PdCl2[4,4'-bis(n-C10F21CH2OCH2)-2,2'-bipyridine] In N,N-dimethyl-formamide at 140℃; for 1h; Catalytic behavior; Sonogashira Cross-Coupling; Microwave irradiation;100%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

phenylboronic acid
98-80-6

phenylboronic acid

biphenyl-4-acetaldehyde
92-91-1

biphenyl-4-acetaldehyde

Conditions
ConditionsYield
With potassium carbonate; {1,3-di[(R)-1-PhEt]imidazolin-2-ylidene}(PPh3)PdI2 In xylene at 130℃; for 13h; Suzuki-Miyaura cross-coupling reaction;100%
With tetrabutylammomium bromide; potassium carbonate; quasi polymeric 4-pyridine-aldoxime Pd(II)-catalyst at 120℃; for 0.333333h; Suzuki-Miyaura reaction; microwave irradiation;100%
With 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole; tris(dibenzylideneacetone)dipalladium (0) In toluene at 65℃; for 2h; Suzuki coupling;100%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

para-bromoacetophenone
99-90-1

para-bromoacetophenone

(E)-3-(4-acetylphenyl)acrylic acid butyl ester
173464-57-8

(E)-3-(4-acetylphenyl)acrylic acid butyl ester

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate In N,N-dimethyl acetamide at 100℃; for 3h; Product distribution; Further Variations:; Reagents; Heck reaction;100%
With tributyl-amine In N,N-dimethyl-formamide at 150℃; for 1h; Heck reaction;100%
With C29H33Cl2N5Pd; tetrabutylammomium bromide; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 4h; Heck reaction; Inert atmosphere;100%
styrene
292638-84-7

styrene

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetyl-trans-stilbene
20488-43-1, 3112-03-6, 20488-42-0

4-acetyl-trans-stilbene

Conditions
ConditionsYield
With sodium acetate; {1,1'-dibenzyl-3,3'-CH2-diimidazolin-2,2'-diylidene}PdBr2 In N,N-dimethyl acetamide at 165 - 175℃; for 1h; Heck coupling reaction;100%
With [Pd2(1,2-bis(diphenylphosphino)ethane)2(SC6H4S)]2(OTf)4; sodium acetate In N,N-dimethyl acetamide; water at 120℃; for 16h; Catalytic behavior; Reagent/catalyst; Temperature; Heck Reaction; Inert atmosphere;100%
With C180H144O4P8Pd4S4(4+)*4CF3O3S(1-); sodium acetate In N,N-dimethyl acetamide; water at 120℃; for 16h; Heck Reaction; Inert atmosphere;100%
4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetyl-4'-methylbiphenyl
5748-38-9

4-acetyl-4'-methylbiphenyl

Conditions
ConditionsYield
With C23H35N4O4Pd(1+)*Br(1-); potassium carbonate In water at 100℃; for 1h; Suzuki-Miyaura Coupling;100%
With potassium phosphate In N,N-dimethyl-formamide at 120℃; for 5h; Suzuki Coupling;100%
With potassium carbonate In water at 80℃; for 10.5h; Suzuki-Miyaura Coupling; Green chemistry;100%
tributylphenylstannane
960-16-7

tributylphenylstannane

para-bromoacetophenone
99-90-1

para-bromoacetophenone

biphenyl-4-acetaldehyde
92-91-1

biphenyl-4-acetaldehyde

Conditions
ConditionsYield
{1,3-di[(R)-1-PhEt]imidazolin-2-ylidene}(PCPh)PdI2 In toluene at 110℃; for 17h; Stille reaction;100%
With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; poly(ethylene glycol)-400; palladium diacetate In water at 80℃; for 10h; Stille coupling;100%
With potassium carbonate; trans-(1,3-di(1'-(R)-phenylethyl)imidazolin-2-ylidene)(tricyclohexylphosphine)palladium(II) diiodide In toluene at 110℃; for 17h; Stille cross coupling;99%
morpholine
110-91-8

morpholine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-morpholinoacetophenone
39910-98-0

4-morpholinoacetophenone

Conditions
ConditionsYield
With 2-(dicyclohexylphosphino)-4'-(N,N-dimethylamino)-1,1'-biphenyl at 100℃;100%
With potassium 2-methylbutan-2-olate In 1,2-dimethoxyethane at 80℃; for 3h; Hartwig-Buchwald amination; Inert atmosphere;99%
With C30H25BrN3PPdS; potassium carbonate In iso-butanol at 100℃; for 24h; Buchwald-Hartwig Coupling; Inert atmosphere;94.7%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

(R)-1-(4-bromophenyl)ethanol
5391-88-8, 25675-29-0, 76155-78-7, 100760-04-1

(R)-1-(4-bromophenyl)ethanol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C45H58NP; potassium tert-butylate; hydrogen In propan-1-ol at 25 - 30℃; under 4560.31 Torr; for 0.166667h; Autoclave; optical yield given as %ee; enantioselective reaction;100%
With (S,S)-RuCl2(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 26 - 30℃; under 6080 Torr; for 5h;99.9%
With Geotrichum candidum IFO 5767 In water at 30℃; for 24h; aerobic conditions;99%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

para-bromoacetophenone
99-90-1

para-bromoacetophenone

butyl 3-(4-acetylphenyl)acrylate

butyl 3-(4-acetylphenyl)acrylate

Conditions
ConditionsYield
With diethylene glycol dibutyl ether; [PdBr2]([Ph2PCH2C(Ph)=N(2,6-iPr2C6H3)]) In N,N-dimethyl acetamide at 130℃; for 20h; Product distribution; Further Variations:; Catalysts; Heck coupling;100%
With water; potassium carbonate In 1-methyl-pyrrolidin-2-one at 135℃; for 24h; Catalytic behavior; Heck Reaction;99%
With tributyl-amine; Palladium bipyridyl complex anchored on nanosized MCM-41 In various solvent(s) at 170℃; for 16h; Heck reaction;98%
2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetyl-2'-methylbiphenyl
56917-39-6

4-acetyl-2'-methylbiphenyl

Conditions
ConditionsYield
With potassium phosphate; water In toluene at 100℃; for 1h; Suzuki coupling reaction;100%
With potassium carbonate; N,N-diethylaminopropyl-Al2O3-Pd(OAc)2 In ethanol; water at 80℃; for 2h; Suzuki-Miyaura reaction; microwave irradiation;100%
With potassium carbonate In ethanol; water at 20℃; for 0.5h; Suzuki-Miyaura reaction; Inert atmosphere;100%
4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

1-(4'-methoxy-biphenyl-4-yl)-ethanone
13021-18-6

1-(4'-methoxy-biphenyl-4-yl)-ethanone

Conditions
ConditionsYield
With sodium phosphate; palladium on activated charcoal In water; isopropyl alcohol at 20℃; for 2h; Suzuki-Miyaura reaction;100%
With potassium carbonate In water at 80℃; for 5h; Suzuki Coupling;100%
With potassium carbonate In methanol at 25℃; for 1h; Wavelength; Suzuki-Miyaura Coupling; Inert atmosphere; Irradiation;100%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

(E)-1-(4-bromophenyl)ethan-1-one oxime
59862-55-4

(E)-1-(4-bromophenyl)ethan-1-one oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;100%
With hydroxylamine hydrochloride; sodium acetate In methanol; water Reflux;100%
With 3 A molecular sieve; hydroxylamine hydrochloride at 20℃; for 0.25h;96%
2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetyl-2'-methoxybiphenyl
52807-17-7

4-acetyl-2'-methoxybiphenyl

Conditions
ConditionsYield
With sodium carbonate; palladium on activated charcoal In ethanol at 20℃; for 4h; Suzuki-Miyaura cross-coupling;100%
With potassium carbonate In ethanol; water at 60℃; for 12h; Suzuki Coupling; Green chemistry;99%
With potassium carbonate In ethanol; water at 20℃; for 1.5h; Suzuki-Miyaura reaction; Inert atmosphere;97%
4-trifluoromethylphenylboronic acid
128796-39-4

4-trifluoromethylphenylboronic acid

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetyl-4'-trifluoromethylbiphenyl
142557-76-4

4-acetyl-4'-trifluoromethylbiphenyl

Conditions
ConditionsYield
With tetrabutylammomium bromide; palladium diacetate; potassium carbonate In water at 60℃; for 2h; Inert atmosphere;100%
With 1-dodecyl-2,3-dimethylimidazolium bis(2,4,4-trimethylpentyl)phosphinate; potassium carbonate; palladium dichloride In n-heptane; water at 80℃; for 1h; Catalytic behavior; Suzuki Coupling;100%
With Br(1-)*C28H29BrN5O2Pd(1+); potassium carbonate In water at 100℃; for 3h; Suzuki-Miyaura coupling;99%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

4-acetylphenylboronic acid
149104-90-5

4-acetylphenylboronic acid

4,4'-diacetylbiphenyl
787-69-9

4,4'-diacetylbiphenyl

Conditions
ConditionsYield
With potassium carbonate; N,N-diethylaminopropyl-Al2O3-Pd(OAc)2 In ethanol; water for 0.0833333h; Suzuki-Miyaura reaction;100%
With potassium carbonate; Pd(NH3)2Cl2 In water at 100℃; for 3h; Suzuki cross-coupling reaction;99%
With iron(III) chloride; potassium fluoride In ethanol at 90℃; for 16h; Suzuki-Miyaura type coupling; sealed tube; air;99%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 4-(4-bromophenyl)-2,4-dioxobutanoate
40155-54-2

ethyl 4-(4-bromophenyl)-2,4-dioxobutanoate

Conditions
ConditionsYield
Stage #1: para-bromoacetophenone With sodium In ethanol at 0 - 10℃; for 1h;
Stage #2: oxalic acid diethyl ester In ethanol for 1.5h;		100%
With sodium ethanolate In ethanol at 20℃; for 12h;85%
Stage #1: oxalic acid diethyl ester With sodium ethanolate In benzene at 0℃; Inert atmosphere;
Stage #2: para-bromoacetophenone In benzene at 0 - 20℃; for 14.5h; Inert atmosphere;		75%
1H-imidazole
288-32-4

1H-imidazole

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4'-(imidazol-1-yl)acetophenone
10041-06-2

4'-(imidazol-1-yl)acetophenone

Conditions
ConditionsYield
With copper(I) oxide; 1,10-Phenanthroline; tetrabutyl ammonium fluoride at 140 - 145℃; for 24h;100%
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 24.5h;99%
With potassium carbonate; copper(l) iodide In N,N-dimethyl-formamide at 110℃; for 24h; Ullmann coupling reaction;98%
1,2-bis(tert-butyldimethylsilyl)hydrazine
10000-20-1

1,2-bis(tert-butyldimethylsilyl)hydrazine

para-bromoacetophenone
99-90-1

para-bromoacetophenone

4'-bromoacetophenone N-tert-butyldimethylsilylhydrazone
690275-01-5

4'-bromoacetophenone N-tert-butyldimethylsilylhydrazone

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) at 0 - 23℃;100%
dimethyl zinc(II)
544-97-8

dimethyl zinc(II)

para-bromoacetophenone
99-90-1

para-bromoacetophenone

para-methylacetophenone
122-00-9

para-methylacetophenone

Conditions
ConditionsYield
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane for 1h; Heating;100%

4'-Bromoacetophenone Chemical Properties

The Molecular Structure of  4'-Bromoacetophenone (CAS NO.99-90-1):

Empirical Formula: C8H7BrO
Molecular Weight: 199.0446 
IUPAC Name: 1-(4-bromophenyl)ethanone 
Product Categories: Acetophenone Series;FINE Chemical & INTERMEDIATES;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Bromine Compounds;Acetophenones (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials
Appearance: white to light yellow crystals
Nominal Mass: 198 Da
Average Mass: 199.0446 Da
Monoisotopic Mass: 197.96802 Da 
Index of Refraction: 1.554
Molar Refractivity: 43.97 cm3
Molar Volume: 137.1 cm3
Surface Tension: 39 dyne/cm
Density: 1.451 g/cm3
Flash Point: 94.3 °C
Enthalpy of Vaporization: 49.76 kJ/mol
Boiling Point: 259.9 °C at 760 mmHg
Vapour Pressure: 0.0126 mmHg at 25°C 
log P (octanol-water): 2.43
Water Solubility: 372 mg/L at 25°C 
Vapor Pressure: 0.031 mm Hg at 25°C 
Henry's Law Constant: 3.91E-06 atm-m3/mole at 25°C 
Atmospheric OH Rate Constant: 1.22E-12 cm3/molecule-sec at 25°C 
InChI
InChI=1/C8H7BrO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,1H3
Smiles
c1(C(C)=O)ccc(Br)cc1

4'-Bromoacetophenone Uses

 4'-Bromoacetophenone (CAS NO.99-90-1) is can be used as intermediates of liquid crystals.

4'-Bromoacetophenone Safety Profile

Hazard Codes: CorrosiveCIrritantXiHarmfulXn
Risk Statements: 34-36/38-42/43-36/37/38 
R34: Causes burns
R36/38: Irritating to eyes and skin
R42/43: May cause sensitization by inhalation and skin contact
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39-45-22-36/37 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
RIDADR: UN 3261 8/PG 2
WGK Germany: 2
RTECS: AM6950000
F: 19-21 
F19: Lachrymator
F21: Sensitive to humidity
Hazard Note: Irritant
HS Code: 29147090

4'-Bromoacetophenone Specification

 4'-Bromoacetophenone (CAS NO.99-90-1) is also called as  4-Bromoacetophenone ; p-Bromoacetophenone ; Methyl p-bromophenyl ketone ; p-Bromophenyl methyl ketone ; Acetophenone, 4'-bromo- (8CI) ; Ethanone, 1-(4-bromophenyl)- .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View