4-Chloroanisole supplier | CasNO.623-12-1

Name
4-Chloroanisole
EINECS 210-772-2
CAS No. 623-12-1
Article Data266
CAS DataBase
Density 1.137 g/cm³
Solubility Immiscible with water
Melting Point -18 °C
Formula C₇H₇ClO
Boiling Point 184.4 °C at 760 mmHg
Molecular Weight 142.585
Flash Point 72.3 °C
Transport Information UN 2810
Appearance colourless liquid
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols Xn
Synonyms Anisole,p-chloro- (6CI,7CI,8CI);1-Chloro-4-methoxybenzene;1-Methoxy-4-chlorobenzene;4-Chlorophenol methyl ether;4-Methoxychlorobenzene;4-Methoxyphenyl chloride;Anisyl chloride;NSC 4129;p-Chloroanisole;p-Chloromethoxybenzene;p-Chlorophenyl methyl ether;p-Methoxychlorobenzene;p-Methoxyphenyl chloride;
PSA 9.23000
LogP 2.34860

Synthetic route

: 50619-99-3
4,4'-dimethoxy-diphenyliodonium chloride

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
In benzene-d6 at 120℃; for 120h; Sealed tube;	100%

: 104-92-7
1-bromo-4-methoxy-benzene

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With nickel dichloride In N,N-dimethyl-formamide at 170℃; for 0.0833333h; microwave irradiation;	99%
With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 12h; Finkelstein Reaction; Schlenk technique; Inert atmosphere;	91%
With copper(I) oxide; tetramethlyammonium chloride; L-proline In ethanol at 110℃; for 18h; Inert atmosphere;	80%

: 106-48-9
4-chloro-phenol

: 616-38-6
carbonic acid dimethyl ester

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 16h; Product distribution; Further Variations:; Temperatures; Solvents; Pressures; reaction times; microwave irradiation;	99%
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2h; Microwave irradiation; Green chemistry;	94%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0416667h; microwave irradiation;	92%

: potassium 4-(methoxy)phenyltrifluoroborate

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With trichloroisocyanuric acid In water; ethyl acetate at 20℃; for 0.666667h; Open flask;	98%

: 100-66-3
methoxybenzene

A: 104-92-7
1-bromo-4-methoxy-benzene

B: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With sodium chlorite; silica gel; manganese(III) acetylacetonate; sodium bromide In dichloromethane at 25℃; for 2h;	A 97% B 3%
With tetraethylammonium chloride; tetraethylammonium bromide Product distribution; 1.) CH2Cl2, RT, 1 h, electrolysis, 2.) CH2Cl2, RT, 24 h; other halogenating agents; other benzene derivatives and olefins;

: 106-39-8
bromochlorobenzene

: 124-41-4
sodium methylate

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With methanol; Methyl formate; copper(l) chloride at 115℃; for 2h; Autoclave; Green chemistry;	97%

: 106-48-9
4-chloro-phenol

: 77-78-1
dimethyl sulfate

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide; potassium carbonate for 0.00694444h; Irradiation; microwave;	89%
With sodium hydroxide at 100℃;
With alkaline solution
With potassium carbonate In acetone
With lithium hydroxide In tetrahydrofuran for 1h; Ambient temperature; Yield given;

: 2732-80-1
2-bromo-1-chloro-4-methoxybenzene

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With methanol; gold; hydrogen; caesium carbonate at 100℃; under 3800.26 Torr; for 71h;	89%

: 1330681-27-0
(4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With copper(l) chloride In acetonitrile at 80℃; for 2h;	87%

: 14596-60-2
N-chloro-N-(4-methylphenyl)acetamide

: 100-66-3
methoxybenzene

A: 623-12-1
4-chloromethoxybenzene

B: 766-51-8
2-Chloroanisole

C: 18931-78-7
N-(2-chloro-4-methylphenyl)acetamide

D: 103-89-9
4-Methylacetanilide

Conditions

Conditions	Yield
at 110℃; for 12h; Mechanism; Orton Haloaniline Rearrangement; Inert atmosphere; Darkness;	A 82% B n/a C n/a D 87%

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 106-48-9
4-chloro-phenol

A: 623-12-1
4-chloromethoxybenzene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 6h; Heating;	A 85% B n/a

...Expand

: 106-48-9
4-chloro-phenol

: 121-45-9
phosphorous acid trimethyl ester

: 623-12-1
4-chloromethoxybenzene

Conditions

Conditions	Yield
With boron trifluoride In diethyl ether for 0.05h; microwave irradiation;	85%

: 623-12-1
4-chloromethoxybenzene

: 60633-25-2
2-bromo-4-chloroanisole

Conditions

Conditions	Yield
With (CH3)4Br In liquid sulphur dioxide at -23℃; Rate constant;	100%
With (CH3)4Br In liquid sulphur dioxide at -23℃;	100%
With iron(III) chloride; N-Bromosuccinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide In toluene regioselective reaction;	99%

: 623-12-1
4-chloromethoxybenzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one for 0.5h; Heating;	100%
With calcium hydride; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 220℃; for 0.5h;	99%
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;	96%

: 623-12-1
4-chloromethoxybenzene

: 98-80-6
phenylboronic acid

: 613-37-6
4-methoxylbiphenyl

Conditions

Conditions	Yield
With 2-(dicyclohexylphosphino)-4'-(N,N-dimethylamino)-1,1'-biphenyl at 100℃; Suzuki-Miyaura coupling;	100%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In tetrahydrofuran at 50℃; for 24h; Suzuki coupling; Inert atmosphere;	100%
With 1,2-di-(N-2-methoxyethylbenzimidazoliummethyl)-benzene dichloride; potassium tert-butylate; palladium diacetate In water; N,N-dimethyl-formamide at 50℃; for 3h; Reagent/catalyst; Suzuki Coupling;	100%

: 110-91-8
morpholine

: 623-12-1
4-chloromethoxybenzene

: 27347-14-4
N-(4-methoxyphenyl)morpholine

Conditions

Conditions	Yield
With (55)Pd068(44)Ni032; potassium carbonate In water at 80℃; for 8h; Catalytic behavior; Buchwald-Hartwig Coupling;	100%
With 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl; sodium t-butanolate In tetrahydrofuran at 80℃; for 2.5h; Reagent/catalyst;	100%
With potassium tert-butylate; [(IPr)Pd(acac)Cl] In 1,2-dimethoxyethane at 50℃; for 4h; Buchwald-Hartwig coupling;	99%

: 623-12-1
4-chloromethoxybenzene

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 4-Chloro-2-(4-fluoro-benzenesulfonyl)-1-methoxy-benzene

Conditions

Conditions	Yield
With indium(III) chloride; trifluorormethanesulfonic acid In trifluoroacetic acid at 70℃; for 1.5h;	100%

: 623-12-1
4-chloromethoxybenzene

: (2,6-dimethoxyphenyl)zinc chloride

: 54960-98-4
2,4’,6-trimethoxybiphenyl

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); ruphos In tetrahydrofuran at 70℃; Negishi coupling;	100%

: 623-12-1
4-chloromethoxybenzene

: (2,4,6-triisopropylphenyl)zinc chloride

: 4-methoxy-2',4',6'-tri-isopropylbiphenyl

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); ruphos In tetrahydrofuran at 70℃; for 15h; Negishi coupling;	100%

: 623-12-1
4-chloromethoxybenzene

: 121-97-1
4-Methoxypropiophenone

: 35258-41-4
1,2-bis-(4-methoxy-phenyl)-propan-1-one

Conditions

Conditions	Yield
With 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; palladium diacetate; sodium t-butanolate In toluene at 110℃; for 18h; Schlenk technique; Inert atmosphere;	100%
With PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2); potassium tert-butylate In toluene at 80℃; for 6h; Inert atmosphere;	89%
With C40H44ClN3Pd; sodium t-butanolate In toluene at 80℃; for 3h; Inert atmosphere;	87%

: 108-86-1
bromobenzene

: 623-12-1
4-chloromethoxybenzene

: 613-37-6
4-methoxylbiphenyl

Conditions

Conditions	Yield
Stage #1: bromobenzene With lithium Stage #2: With zinc(II) chloride Stage #3: 4-chloromethoxybenzene; nickel phosphine amido pincer complex In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 70℃; for 12h; Negishi cross-coupling; Further stages.;	99.2%
Stage #1: bromobenzene With iodine; magnesium In diethyl ether at 50℃; for 1h; Inert atmosphere; Stage #2: 4-chloromethoxybenzene With magnesium In diethyl ether at 45 - 50℃; for 2h; Inert atmosphere;	90%

: 623-12-1
4-chloromethoxybenzene

: 2132-80-1
4,4'-Dimethoxybiphenyl

Conditions

Conditions	Yield
With cesium fluoride; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane	99%
With cesium fluoride; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane	99%
With tetrabutylammomium bromide; sodium methylate In water at 80℃; for 20h; Ullmann reaction;	97%

pyrrolidine: pyrrolidine

: 623-12-1
4-chloromethoxybenzene

N-(4-methoxyphenyl)pyrrolidine: N-(4-methoxyphenyl)pyrrolidine

Conditions

Conditions	Yield
With [IPr*·H][Pd(η3-cin)Cl2]; potassium tert-butylate at 60 - 80℃; for 2h; Buchwald-Hartwig Coupling; Sealed tube;	99%
With potassium hydroxide; johnphos; 2-(di-t-butylphosphino)biphenyl palladium In toluene at 90℃; for 20h;	94%
With [Pd(2-aminobiphenyl)(PiPr2ArXyl2)](OMs); sodium t-butanolate In tetrahydrofuran at 80℃; for 19h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	94%

: 623-12-1
4-chloromethoxybenzene

o-toluidine: o-toluidine

N-(4-methoxyphenyl)-2-methylbenzenamine: N-(4-methoxyphenyl)-2-methylbenzenamine

Conditions

Conditions	Yield
With [IPr*·H][Pd(η3-cin)Cl2]; potassium tert-butylate at 60 - 80℃; for 2h; Buchwald-Hartwig Coupling; Sealed tube;	99%
With (2-phenyl-1H-inden-3-yl)-dicyclohexylphosphinium tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In 1,2-dimethoxyethane at 20 - 120℃; Buchwald-Hartwig amination; Inert atmosphere;	91%
With 1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate In toluene at 100℃; for 15h;	88%
With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In 1,4-dioxane at 100℃; for 1.5h; Inert atmosphere;	50%

: 623-12-1
4-chloromethoxybenzene

: 100-61-8
N-methylaniline

: 55251-46-2
N-(4-methoxyphenyl)-N-methylaniline

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); di-tert-butylneopentylphosphonium tetrafluoroborate; sodium t-butanolate In toluene at 100℃; for 18h; Hartwig-Buchwald amination;	99%
With dichloro(3-chloropyridinyl)(1,3-(diisopropylphenyl)-4,5-bis(dimethylamino)imidazol-2-ylidene)palladium(II); potassium tert-butylate In 1,4-dioxane at 80℃; for 18h; Reagent/catalyst; Solvent; Temperature; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	99%
With [IPr*·H][Pd(η3-cin)Cl2]; potassium tert-butylate at 60 - 80℃; for 2h; Buchwald-Hartwig Coupling; Sealed tube;	99%

: 292638-84-7
styrene

: 623-12-1
4-chloromethoxybenzene

: 1694-19-5
E-1-(phenyl)-2-(4'-methoxyphenyl)ethene

Conditions

Conditions	Yield
With tetrakis[μ-1-[(3-methoxyphenyl)methyl]-2-phenyl-3-[2-oxo-2-[(2-phenolato-kO)aminokN]ethyl]-1H-imidazoliumato-kC4]tetrapalladium; tetrabutylammomium bromide; sodium acetate at 140℃; for 12h; Heck Reaction;	99%
With tetrabutylammonium acetate; palladium diacetate; DavePhos In 1,4-dioxane at 80℃; for 24h; Heck reaction; Inert atmosphere; Sealed tube;	95%
With C128H58Cl2O2P4Pd; potassium carbonate In methanol at 60℃; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Heck Reaction; Inert atmosphere; Schlenk technique;	93%

: 623-12-1
4-chloromethoxybenzene

diphenylamine: diphenylamine

N,N-diphenyl-4-methoxyaniline: N,N-diphenyl-4-methoxyaniline

Conditions

Conditions	Yield
With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 80℃; for 12h;	99%
With bis(η3-allyl-μ-chloropalladium(II)); 2,6-bis(2,4,6-triisopropylphenyl)phenyl(dicyclohexylphosphine); sodium t-butanolate In dodecane; toluene at 100℃; for 6h; Catalytic behavior; Reagent/catalyst; Glovebox;	99%
With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 70℃; for 16h;	97%

piperidine: piperidine

: 623-12-1
4-chloromethoxybenzene

: 5097-25-6
N-(4-methoxylphenyl)piperidine

Conditions

Conditions	Yield
With potassium tert-butylate; C50H75ClP2Pd In tetrahydrofuran at 20℃; for 6h; Schlenk technique; Inert atmosphere;	99%
With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane In toluene at 70℃;	95%
With sodium t-butanolate In toluene at 100 - 110℃; for 24h; Buchwald-Hartwig amination; Inert atmosphere; Sealed vial;	94%

: 623-12-1
4-chloromethoxybenzene

4-methylphenylboronic acid: 4-methylphenylboronic acid

: 53040-92-9
4-(4-tolyl)anisole

Conditions

Conditions	Yield
With potassium phosphate monohydrate; Ethyl 4-bromobenzoate; C52H49PRu; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere;	99%
With potassium phosphate; C114H132Cl6N10Pd3 In water; isopropyl alcohol at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	99%
With C58H82Cl4N6Pd2; potassium tert-butylate In water; isopropyl alcohol at 80℃; for 4h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere;	99%

: 623-12-1
4-chloromethoxybenzene

: 446-53-7
2-fluorophenylmagnesium bromide

: 72093-47-1
4-methoxy-2'-fluorobiphenyl

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride In tetrahydrofuran; 1,4-dioxane at 80℃; for 3h; Arylation;	99%

: 623-12-1
4-chloromethoxybenzene

: 4294-57-9
para-methylphenylmagnesium bromide

: 53040-92-9
4-(4-tolyl)anisole

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride In tetrahydrofuran; 1,4-dioxane at 80℃; for 3h; Arylation;	99%
With N-heterocyclic carbene-based nickel(II) complex In tetrahydrofuran at 20℃; for 12h; Kumada reaction;	99%
With iron(II) triflate; 1,3-bis(2,4,6-trimethylphenyl)-4,5,6,7-tetrahydro-1H-1,3-diazepinium bromide; sodium t-butanolate In tetrahydrofuran at 60℃; for 16h; Kumada Cross-Coupling; Sealed tube; Inert atmosphere;	99%

: 623-12-1
4-chloromethoxybenzene

: 16419-60-6
2-Methylphenylboronic acid

: 92495-54-0
4'-methoxy-2-methylbiphenyl

Conditions

Conditions	Yield
With potassium fluoride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In toluene at 80℃; for 72h; Suzuki coupling;	99%
With potassium phosphate tribasic trihydrate; PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2) In tetrahydrofuran; water at 20℃; for 24h; Suzuki-Miyaura coupling reaction; Inert atmosphere;	99%
With potassium phosphate; C114H132Cl6N10Pd3 In water; isopropyl alcohol at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	99%

: 623-12-1
4-chloromethoxybenzene

: 100-59-4
phenylmagnesium chloride

: 613-37-6
4-methoxylbiphenyl

Conditions

Conditions	Yield
Stage #1: 4-chloromethoxybenzene With nickel(II) acetylacetonate; bis(1-adamantyl)phosphine oxide In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: phenylmagnesium chloride In tetrahydrofuran at 20℃; Kumada cross-coupling;	99%
With [{C4H2N-2,5-(CH2PPh2)2-κ3PNP}NiCl] In tetrahydrofuran; toluene at 23℃; for 12h; Kumada Cross-Coupling; Inert atmosphere; Schlenk technique;	89%
With C61H78ClN4Ni2 In tetrahydrofuran at 20℃; for 18h; Reagent/catalyst; Kumada Cross-Coupling; Schlenk technique;	85%

: 623-12-1
4-chloromethoxybenzene

: 5720-07-0
4-methoxyphenylboronic acid

: 2132-80-1
4,4'-Dimethoxybiphenyl

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); bis(2,4-dimethoxyphenyl)phosphine oxide; cesium fluoride at 100℃; for 12h;	99%
With potassium carbonate; palladium dichloride In various solvent(s) at 20℃; for 5h; Suzuki-Miyaura cross-coupling;	98%
With potassium phosphate; 4-dicyclohexylphosphino-12-(2',6'-dimethoxy)phenyl-[2.2]paracyclophane; palladium diacetate In 1,4-dioxane at 80℃; for 12h; Suzuki-Miyaura coupling; Inert atmosphere;	93%

: 1013-88-3
Benzophenone imine

: 623-12-1
4-chloromethoxybenzene

: 42834-19-5
N-(4-methoxyphenyl)-1,1-diphenylmethanimine

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 1,4-dioxane at 100℃; for 6h;	99%
With sodium t-butanolate In toluene at 100 - 110℃; for 48h; Buchwald-Hartwig amination; Inert atmosphere; Sealed vial;	80%

: 623-12-1
4-chloromethoxybenzene

: 62-53-3
aniline

: 1208-86-2
N-(4-methoxyphenyl)phenylamine

Conditions

Conditions	Yield
With [Pd(2-aminobiphenyl)(PCyp2ArXyl2)](OMs); sodium t-butanolate In tetrahydrofuran at 80℃; for 19h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	99%
With sodium t-butanolate; XPhos palladium(II) phenethylamine chloride In 1,4-dioxane at 100℃; for 0.166667h;	98%
With C40H42NP; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In 1,4-dioxane; water at 20℃; for 0.5h; Inert atmosphere; Sealed tube; Reflux;	98%

: 623-12-1
4-chloromethoxybenzene

: 75-66-1
2-methylpropan-2-thiol

: 7205-64-3
1-[(1,1-dimethylethyl)thio]-4-methoxybenzene

Conditions

Conditions	Yield
With sodium t-butanolate; palladium diacetate In 1,4-dioxane at 100℃; for 18h;	99%

: 496-15-1
1-indoline

: 623-12-1
4-chloromethoxybenzene

: 172887-18-2
1-(4-methoxyphenyl)-1H-indole

Conditions

Conditions	Yield
With [Pd(2-aminobiphenyl)(PCyp2ArXyl2)](OMs); sodium t-butanolate In tetrahydrofuran at 80℃; for 19h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	99%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane In toluene for 24h; Inert atmosphere; Reflux;	72%
In 1,4-dioxane for 5h;

: 623-12-1
4-chloromethoxybenzene

: 5720-06-9
2-Methoxyphenylboronic acid

: 49602-47-3
2,4'-dimethoxybiphenyl

Conditions

Conditions	Yield
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;	99%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; water; palladium diacetate In tetrahydrofuran at 20℃; for 3h; Suzuki-Miyaura reaction;	98%
With potassium phosphate; N,N'-bis-[2,4,6-tri(3,3,3-trifluoropropyl)phenyl]-4,5-dihydroimidazolium chloride; palladium diacetate In tetrahydrofuran; water at 20℃; for 12h; Suzuki-Miyaura cross-coupling; Inert atmosphere;	95%
With [(N,N′-bis-(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)PdCl2(pyrazole)]; sodium hydroxide In ethanol at 20℃; for 6h; Reagent/catalyst; Suzuki-Miyaura Coupling; Sealed tube;	85%
With potassium phosphate; C28H31ClN2Ni; triphenylphosphine In tert-Amyl alcohol; toluene at 110℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;	81%

4-Chloroanisole Chemical Properties

IUPAC Name:1-chloro-4-methoxybenzene
Molecular Formula:C₇H₇ClO
Molecular Weight:142.582880 g/mol
Appearance:yellow to colorless Clear liquid
Melting Point:-18 °C
Boiling Point:198-202 °C
Flash Point:173 °F
Solubility:ethanol and ether
Insolubility:water
Density:1.164 g/mL at 25 °C
Refractive index:n20/D 1.535
BRN:1858901
EINECS:210-772-2
Synonyms of 4-Chloroanisole (CAS NO.623-12-1): 1-chloro-4-methoxy-benzen ; 4-Chlorophenol methyl ether ; Anisole, p-chloro- ; Benzene,1-chloro-4-methoxy- ; para-Chloroanisole
Categories: Aromatic Ethers ; Anisoles, Alkyloxy Compounds & Phenylacetates ; Chlorine Compounds ; Ethers ; Organic Building Blocks ; Oxygen Compounds

4-Chloroanisole Uses

4-Chloroanisole (CAS NO.623-12-1) is used as an intermediate for fruit acid.

4-Chloroanisole Safety Profile

Safety Information of 4-Chloroanisole (CAS NO.623-12-1):
Hazard Codes:Xn
Safety Statements:23-24/25
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24/25:Avoid contact with skin and eyes
RIDADR:UN 2810
WGK Germany:3
HS Code:29093090

4-Chloroanisole Specification

First Aid Measures of 4-Chloroanisole (CAS NO.623-12-1):
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Skin:Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure and move to fresh air immediately.
Storage of 4-Chloroanisole (CAS NO.623-12-1):
Store in a cool, dry place. Keep container closed when not in use.

Product Name

4-Chloroanisole

Synthetic route

4-Chloroanisole Chemical Properties

4-Chloroanisole Uses

4-Chloroanisole Safety Profile

4-Chloroanisole Specification

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