4-Formylbenzoic acid supplier

Name
4-Formylbenzoic acid
EINECS 210-607-4
CAS No. 619-66-9
Article Data181
CAS DataBase
Density 1.321 g/cm³
Solubility Soluble in water, methanol, DMSO, ether, and chloroform.
Melting Point 247 °C(lit.)
Formula C₈H₆O₃
Boiling Point 332.6 °C at 760 mmHg
Molecular Weight 150.134
Flash Point 169.2 °C
Transport Information
Appearance Yellowish fine crystalline powder
Safety 26-36-24/25
Risk Codes 36/37/38-33
Molecular Structure
Hazard Symbols Xi
Synonyms Terephthalaldehydicacid (6CI,7CI,8CI);4-Carboxybenzaldehyde;4-Carboxylbenzaldehyde;NSC 15797;Terephthalaldehyde acid;Terephthaldehydicacid;p-Benzoic acid aldehyde;p-Carboxybenzaldehyde;p-Formylbenzoic acid;
PSA 54.37000
LogP 1.19730

Synthetic route

: 623-27-8
terephthalaldehyde,

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube;	99%
With 4H3N4H(1+)CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;	99%
With carbon dioxide; potassium carbonate; 1,3-bis(mesityl)imidazolium chloride In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 72h;	95%

: 1314659-42-1
4-formyl-N,N-bis(pyridin-2-ylmethyl)benzamide

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 4-formyl-N,N-bis(pyridin-2-ylmethyl)benzamide With methanol; copper(II) bis(trifluoromethanesulfonate) at 20℃; for 16h; Stage #2: With barium(II) hydroxide In methanol; water at 20℃; Stage #3: With hydrogenchloride In methanol; water	99%

: 106-42-3
para-xylene

A: 100-21-0
terephthalic acid

B: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With air; hydrogen bromide; acetic acid; cobalt(II) acetate; manganese(II) acetate at 180℃; under 25745 Torr; for 0.166667h;	A 98.3% B 1.4%
With 9,10-Dibromoanthracene; acetic acid; cobalt(II) acetate; cerium(III) acetate at 165℃; under 25745 Torr; for 0.166667h;	A 98.2% B 1.1%
With 9,10-Dibromoanthracene; acetic acid; cobalt(II) acetate; manganese(II) acetate at 170℃; under 25745 Torr; for 0.166667h;	A 97.5% B 1.9%

: 106-42-3
para-xylene

A: 100-21-0
terephthalic acid

B: 104-87-0
4-methyl-benzaldehyde

C: 619-66-9
4-Carboxybenzaldehyde

D: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With hydrogen bromide; oxygen; acetic acid; cobalt(II) acetate; manganese(II) acetate In water at 190℃; under 16501.7 Torr; for 1h; Product distribution / selectivity;	A 98.1% B 0.2% C 0.4% D 0.4%
With oxygen; acetic acid; palladium diacetate; antimony(III) acetate In water at 182 - 195℃; under 16501.7 - 20929.4 Torr; for 1 - 1.5h; Product distribution / selectivity;	A 50.3% B 7.2% C 6.4% D 6.2%
With hydrogen bromide; oxygen; acetic acid; zirconium oxyacetate; cobalt(II) acetate In water at 190℃; under 16501.7 Torr; for 1h; Product distribution / selectivity;	A 4.9% B 3% C 1.9% D 36.9%

...Expand

: 619-65-8
4-cyanobenzoic Acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;	98%

: 124-38-9
carbon dioxide

: 128376-65-8
5,5-dimethyl-2-(4-formylphenyl)-1,3,2-dioxaborinane

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;	97%
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-formylphenyl)-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In tetrahydrofuran at 70℃; under 15201 Torr; for 16h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;	76%

: 590-29-4
potassium formate

: 104-88-1
4-chlorobenzaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With [PhCOPd(PtBu3)I]; dtbpf In diethylene glycol dimethyl ether at 120℃; for 18h; Inert atmosphere;	97%

: 18414-58-9
diphenylmethylsilanecarboxylic acid

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With potassium trimethylsilonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 0.333333h;	97%

: 124-38-9
carbon dioxide

: 1122-91-4
4-bromo-benzaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique; Stage #2: 4-bromo-benzaldehyde With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 2h; Schlenk technique; Sealed tube;	97%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 60℃; for 0.416667h; Schlenk technique; Stage #2: 4-bromo-benzaldehyde With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 6h; Schlenk technique;	66%

: 64-19-7
acetic acid

: 99-94-5
p-Toluic acid

A: 100-21-0
terephthalic acid

B: 3006-96-0
3-hydroxymethyl-benzoic acid

C: 15561-46-3
p-acetoxymethyl benzoic acid

D: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With N-hydroxyphthalimide; air; cobalt(II) acetate; manganese(II) acetate at 150℃; under 22800 Torr; for 3h;	A 95% B n/a C n/a D n/a

...Expand

: 3006-96-0
3-hydroxymethyl-benzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With LACTIC ACID; dihydrogen peroxide at 30℃; for 7h;	95%
With Burgess Reagent; dimethyl sulfoxide at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere;	92%
With ammonium hydroxide; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In water for 24h; Reflux; Green chemistry;	90%

: 124-38-9
carbon dioxide

: 104-88-1
4-chlorobenzaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique; Stage #2: 4-chlorobenzaldehyde With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 5h; Schlenk technique; Sealed tube;	93%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 60℃; for 0.416667h; Schlenk technique; Stage #2: 4-chlorobenzaldehyde With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 16h; Schlenk technique;	41%

: 1571-08-0
methyl 4-formylbenzoate

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With water; potassium hydroxide In methanol at 20℃; for 18h;	92%
Stage #1: methyl 4-formylbenzoate With water; sodium hydroxide In methanol Stage #2: In water Acidic conditions;	80%
With sulfuric acid
With lithium hydroxide In tetrahydrofuran; methanol
With water; sodium hydroxide In methanol at 20℃; for 4h;

: 34301-39-8
p-Trimethylsiloxymethylbenzoesaeure

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; tetramethylammonium chlorochromate In acetonitrile for 0.916667h; Heating;	90%

: 104292-82-2
4-<(tetrahydropyran-2-yloxy)methyl>benzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; tetramethylammonium chlorochromate In acetonitrile for 0.833333h; Heating;	90%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 4-formylphenyl 2,3,4,5,6-pentafluorobenzenesulfonate

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	90%

: 78767-55-2
benzyl 4-formylbenzoate

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 25℃; for 3h; Inert atmosphere;	90%
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere;	90%

: 106-42-3
para-xylene

A: 100-21-0
terephthalic acid

B: 619-66-9
4-Carboxybenzaldehyde

C: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With carbon dioxide; oxygen; 1-hydroxy-pyrrolidine-2,5-dione; cobalt(II) acetate In acetic acid at 60℃; under 44269 Torr; for 1h; Product distribution / selectivity;	A 89.2% B n/a C n/a
With oxygen; 1-hydroxy-pyrrolidine-2,5-dione; cobalt(II) acetate In acetic acid at 25 - 125℃; under 12049.9 - 44475.9 Torr; for 1 - 6h; Product distribution / selectivity;	A 79.77% B 0.67% C 0.3%
With carbon dioxide; oxygen; 1-hydroxy-pyrrolidine-2,5-dione; cobalt acetylacetonate In acetic acid at 60℃; under 49337.2 Torr; for 1h; Product distribution / selectivity;	A 74% B n/a C n/a

...Expand

: C12H12O6

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With poly(amidoamine) dendrimer functionalized sulfonic acid In methanol at 20℃; for 0.25h;	89%

: 67003-50-3
4-(Methoxymethyl)benzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With nitric acid In dichloromethane at 20℃; for 1h;	88%

: C16H20O2

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With diethoxymethylane; ferric benzoylacetonate In i-Amyl alcohol at 100℃; for 24h;	85%

: 100-21-0
terephthalic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With 1,2-bis(2,4,8,10-tetra-tert-butyl-5,7-dioxa-6-phosphadibenzo[a,c]cyclohepten-6-yloxy)ethane; methylphenylsilane; copper(l) cyanide; 2,2-dimethylpropanoic anhydride In dimethyl sulfoxide at 80℃; for 20h; Schlenk technique; Inert atmosphere;	84%

: 106-42-3
para-xylene

A: 100-21-0
terephthalic acid

B: 3006-96-0
3-hydroxymethyl-benzoic acid

C: 619-66-9
4-Carboxybenzaldehyde

D: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With N-hydroxyphthalimide; oxygen; manganese(II) acetate; cobalt(II) acetate In acetic acid at 100℃; under 760 Torr; for 14h; Kinetics; Product distribution; Further Variations:; Catalysts; Reagents; Solvents; Temperatures; ratio;	A 82% B n/a C n/a D 4%

...Expand

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 17763-69-8
4-(trifluormethanesulfonyloxy)benzaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	81%

: 52010-97-6
4-(hydroxylmethyl)benzaldehyde

A: 100-21-0
terephthalic acid

B: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; Schlenk technique;	A 6 %Spectr. B 80%
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 24 h / 25 °C / pH 8 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 8 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 8 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 7 / Enzymatic reaction View Scheme

: 64-18-6
formic acid

: 619-58-9
4-iodobenzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 2h; Sealed tube;	77%
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	75%

: H2O*CHLiO2

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With formic acid; 1,3-bis-(diphenylphosphino)propane; nickel(II) acetate tetrahydrate; acetic anhydride In tetrahydrofuran at 100℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	76%

: 39088-65-8
4-mercaptomethylbenzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; tetrakis(pyridine)silver(II) peroxodisulfate; oxygen In N,N-dimethyl-formamide at 23℃; under 760.051 Torr; Irradiation;	74%

: 56-91-7
p-aminomethylbenzoic acid

: 619-66-9
4-Carboxybenzaldehyde

Conditions

Conditions	Yield
With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; ascorbic acid In N,N-dimethyl acetamide at 40℃; for 2h; chemoselective reaction;	67%
With riboflavin tetraacetate In dimethylsulfoxide-d6; water-d2 for 0.166667h; Irradiation; In air;

: 619-66-9
4-Carboxybenzaldehyde

: 16173-52-7
4-formylbenzoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 20℃;	100%
With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%
With thionyl chloride In toluene for 1.5h; Heating;	97.9%

: 619-66-9
4-Carboxybenzaldehyde

: 107-15-3
ethylenediamine

: 178241-13-9
C18H16N2O4

Conditions

Conditions	Yield
In 1,4-dioxane; ethanol	100%

: 100-39-0
benzyl bromide

: 619-66-9
4-Carboxybenzaldehyde

: 78767-55-2
benzyl 4-formylbenzoate

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With alkali metal carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	100%
With caesium carbonate In ethyl acetate; N,N-dimethyl-formamide	97%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	97%

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 619-66-9
4-Carboxybenzaldehyde

: 109-73-9
N-butylamine

: N-butyl-4-(1-hydroxy-but-3-enyl)-benzamide

Conditions

Conditions	Yield
Multistep reaction;	100%

...Expand

: 619-66-9
4-Carboxybenzaldehyde

: 111616-43-4
4-formylphenyl isocyanate

Conditions

Conditions	Yield
With diphenylphosphoranyl azide; triethylamine In dichloromethane for 6h; Heating;	100%
With diphenyl phosphoryl azide; triethylamine In dichloromethane for 6h; Reflux;	100%
Multi-step reaction with 3 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C 2: sodium azide / water; acetone / 1 h / 0 °C 3: toluene / 1 h / 100 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere 2: sodium azide / water / 1 h 3: toluene / 2 h / Inert atmosphere; Reflux View Scheme

: 619-66-9
4-Carboxybenzaldehyde

: 424819-51-2
allylgallium dichloride

: 4-(1-hydroxybut-3-en-1-yl)benzoic acid

Conditions

Conditions	Yield
In tetrahydrofuran; hexane at 0℃; for 0.8h;	100%

: 619-66-9
4-Carboxybenzaldehyde

poly(ethylene glycol), MW = 4000: poly(ethylene glycol), MW = 4000

poly(ethylene glycol), ester with 4-formylbenzoic acid: poly(ethylene glycol), ester with 4-formylbenzoic acid

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	100%

: 619-66-9
4-Carboxybenzaldehyde

: ethyl N-(2-carboxyphenoxy)acetimidate

: 4-carboxybenzaldehyde-O-(2-carboxyphenoxy)oxime

Conditions

Conditions	Yield
With perchloric acid In 1,4-dioxane at 20℃;	100%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 619-66-9
4-Carboxybenzaldehyde

: 60444-78-2
succinimidyl 4-formylbenzoate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 25℃; for 14h;	100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	95%

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 619-66-9
4-Carboxybenzaldehyde

: 213462-15-8
(E)-4-(2-tert-Butoxycarbonylvinyl)benzoic acid

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane at 0 - 20℃; for 4h;	100%

trimethyl phosphonoacetate: trimethyl phosphonoacetate

: 619-66-9
4-Carboxybenzaldehyde

: 115974-97-5
methyl (E)-4-carboxyl cinnamate

Conditions

Conditions	Yield
Stage #1: trimethyl phosphonoacetate; 4-Carboxybenzaldehyde With potassium carbonate In water at 0 - 20℃; for 1.5h; Stage #2: In water pH=1; Acidic aqueous solution;	100%
With potassium carbonate In water at 0 - 20℃; pH=Ca. 2;	95%

: 106-47-8
4-chloro-aniline

: 619-66-9
4-Carboxybenzaldehyde

: 643012-91-3
4-[(4-chlorophenylamino)methyl]benzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chloro-aniline; 4-Carboxybenzaldehyde In methanol for 0.5h; Heating / reflux; Stage #2: With sodium cyanoborohydride; acetic acid In methanol at 20 - 35℃; for 0.5h; Stage #3: With water In methanol at 20℃; for 16h;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
In methanol	100%
In dichloromethane
In dichloromethane
Multi-step reaction with 2 steps 1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2: copper(II) bis(trifluoromethanesulfonate) / 16 h / 20 °C View Scheme

: 1070871-21-4
methyl {4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-[(3R)-3-piperidinyl]butyl}carbamate

: 619-66-9
4-Carboxybenzaldehyde

: 1070870-93-7
methyl (4-(6-chloro-3'-ethyl-2-biphenylyl)-4-{(3R)-1-[(4-formylphenyl)carbonyl]-3-piperidinyl}-4-hydroxybutyl)carbamate

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.166667h; Stage #2: methyl {4-(6-chloro-3'-ethyl-2-biphenylyl)-4-hydroxy-4-[(3R)-3-piperidinyl]butyl}carbamate In dichloromethane for 0.583333h;	100%

: 439692-56-5
6-(tert-butyl)-4-hydrazinothieno[2,3-d]pyrimidine

: 619-66-9
4-Carboxybenzaldehyde

: 439690-34-3
4-{[(6-tert-butylthieno[2,3-d]pyrimidin-4-yl)hydrazono]methyl}benzoic acid

Conditions

Conditions	Yield
In benzene for 3h; Reflux;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 74-89-5
methylamine

: 35003-57-7
4-[(Z)-Methyliminomethyl]-benzoic acid

Conditions

Conditions	Yield
at 20℃; for 12h;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 118264-59-8
t-butyl 3-N-t-butylaminopropionate

: 1393125-45-5
tert-butyl 3-(N-tert-butyl-4-formylbenzamido)propanoate

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 5.5h; Reflux; Stage #2: t-butyl 3-N-t-butylaminopropionate With triethylamine In dichloromethane at 20℃;	100%

: 4807-55-0
3-Methyl-2-thioxo-thiazolidin-4-on

: 619-66-9
4-Carboxybenzaldehyde

: 1474053-19-4
4-[(3-methyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl]benzoic acid

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 180℃; for 0.0833333h; Knoevenagel Condensation; Microwave irradiation;	100%

: 3889-20-1
3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one

: 619-66-9
4-Carboxybenzaldehyde

: 1474053-30-9
4-[(4-oxo-3-phenethyl-2-thioxothiazolidin-5-ylidene)methyl]benzoic acid

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 180℃; for 0.0833333h; Knoevenagel Condensation; Microwave irradiation;	100%

: 34392-97-7
3-(4-methylbenzyl)-2-thioxothiazolidin-4-one

: 619-66-9
4-Carboxybenzaldehyde

: 1474053-32-1
4-[(3-(4-methylbenzyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl]benzoic acid

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 180℃; for 0.0833333h; Knoevenagel Condensation; Microwave irradiation;	100%

: 1620085-50-8
1-(4-fluorophenyl)-2-(2-oxo-1,2-dihydropyridin-4-yl)ethane-1,2-dione

: 619-66-9
4-Carboxybenzaldehyde

: 1620085-57-5
4-(4-(4-fluorophenyl)-5-(2-oxo-1,2-dihydropyridin-4-yl)-1H-imidazol-2-yl)benzoic acid

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 180℃; for 0.166667h;	100%

: 15205-11-5
2-chloro-4-fluorobenzylamine

: 619-66-9
4-Carboxybenzaldehyde

: N-[(2-chloro-4-fluorophenyl)methyl]-4-formylbenzamide

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide Stage #2: 2-chloro-4-fluorobenzylamine In N,N-dimethyl-formamide at 20℃;	100%

: β-alanine tert-butyl ester hydrochloride

: 619-66-9
4-Carboxybenzaldehyde

: tert-butyl 3-(4-formylbenzamido)propanoate

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.666667h; Stage #2: β-alanine tert-butyl ester hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 110-70-3
N,N`-dimethylethylenediamine

: 4-(1,3-dimethylimidazolidin-2-yl)benzoic acid

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0333333h;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 261374-62-3
2,7-bis-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-benzo-[lmn]-[3,8]phenanthroline-1,3,6,8-tetraone

: 1052073-35-4
2,7-bis(2-(2-(2-(2-(4-formylphenylcarboxy)ethoxy)ethoxy)ethoxy)ethyl)benzo[lmn]-(3,8)phenanthroline-1,3,6,8-tetraone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 168h; Inert atmosphere; Darkness;	99.5%

: 64-17-5
ethanol

: 619-66-9
4-Carboxybenzaldehyde

: 6287-86-1
p-ethoxycarbonylbenzaldehyde

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 5h;	99%
With graphene oxide at 100℃; for 24h;	90%
With sulfuric acid for 18h; Heating / reflux;	83.1%

: 619-66-9
4-Carboxybenzaldehyde

: 109-77-3
malononitrile

: 15725-53-8
(4-carboxybenzylidene)malononitrile

Conditions

Conditions	Yield
With activated microporous polyurethane material with BET surface area of 312 m2 g-1 In tetrahydrofuran at 50℃; for 14h; Catalytic behavior; Knoevenagel Condensation;	99%
With MIL-53(Fe) metal organic framework encapsulated on silica-coated nickel ferrite magnetic nanoparticles In ethanol at 20℃; for 1.16667h; Knoevenagel Condensation;	97%
With (propyleneimine) dendrimer-G3 on silica coated magnetite nanohybrid In ethanol at 20℃; for 0.5h; Solvent; Knoevenagel Condensation; Inert atmosphere;	95%

: 619-66-9
4-Carboxybenzaldehyde

: 3006-96-0
3-hydroxymethyl-benzoic acid

Conditions

Conditions	Yield
With C55H44O2P4Ru; hydrogen at 80℃; under 38002.6 Torr; for 18h; Glovebox; Autoclave;	99%
With C55H44O2P4Ru; hydrogen In tetrahydrofuran at 80℃; under 38002.6 Torr; for 18h; Inert atmosphere; Glovebox; Autoclave;	99%
With sodium tetrahydroborate; Dowex1-x8 In tetrahydrofuran at 20℃; for 0.15h;	96%

: 619-66-9
4-Carboxybenzaldehyde

: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With hydrogen In ethanol at 100℃; under 2250.23 Torr; for 3h; Catalytic behavior; Inert atmosphere;	99%
With W-7 Raney-Nickel In ethanol for 5h; Heating;	89%

4-Formylbenzoic acid Chemical Properties

Empirical Formula: C₈H₆O₃
Molecular Weight: 150.1314 g/mol
Index of Refraction: 1.62
Density: 1.321 g/cm³
Flash Point: 169.2 °C
Melting point: 247 °C(lit.)
Sensitive: Air Sensitive
Enthalpy of Vaporization: 60.74 kJ/mol
Boiling Point: 332.6 °C at 760 mmHg
Vapour Pressure: 5.72E-05 mmHg at 25 °C
Appearance: Yellowish fine crystalline powder
Structure of 4-Formylbenzoic acid (CAS NO.619-66-9):

IUPAC Name: 4-Formylbenzoic acid
Product Category of 4-Formylbenzoic acid (CAS NO.619-66-9): Intermediates of Dyes and Pigments;Aromatic Aldehydes & Derivatives;Benzaldehyde

4-Formylbenzoic acid Uses

4-Formylbenzoic acid (CAS NO.619-66-9) has been used as intermediate of medicine, pesticides, and fluorescent brighteners.

4-Formylbenzoic acid Toxicity Data With Reference

4-Formylbenzoic acid (CAS NO.619-66-9) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. You can see actual entry in RTECS for complete information.

4-Formylbenzoic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38-33
R33:Danger of cumulative effects.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

4-Formylbenzoic acid Specification

4-Formylbenzoic acid , its cas register number is 619-66-9. It also can be called 4-Carboxybenzaldehyde ; p-Phthalaldehydic acid ; and Terephthalaldehydic acid . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Do not induce vomiting. In addition, 4-Formylbenzoic acid (CAS NO.619-66-9) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, strong bases, and you must not take it with incompatible materials, strong oxidants. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases, carbon monoxide, carbon dioxide.

Product Name

4-Formylbenzoic acid

Synthetic route

4-Formylbenzoic acid Chemical Properties

4-Formylbenzoic acid Uses

4-Formylbenzoic acid Toxicity Data With Reference

4-Formylbenzoic acid Safety Profile

4-Formylbenzoic acid Specification

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