Conditions | Yield |
---|---|
With triethylsilane; chloro-trimethyl-silane In acetic acid methyl ester at 20℃; for 2h; | 98% |
With dichloromethylsilane; iron(III) chloride In 1,2-dimethoxyethane for 4h; Heating; | 90% |
With chloro-trimethyl-silane; thionyl chloride; 1,1,3,3-Tetramethyldisiloxane; zinc(II) iodide at 70℃; for 0.25h; | 87% |
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / ethanol / 0.5 h 1.2: pH 2 2.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C 1.2: pH 2 2.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C View Scheme |
p-methoxymethylbenzylmercury chloride
A
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane byproducts: p-methylbenzyl methyl ether; to soln. of CH3OCH2(C6H4)CH2HgCl added soln. of HCl; kept in sealed ampul (6 h; 100°C); solvent vac.-distd.; crystals (HgCl2) filtered; | A 98% B 98% |
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane at 0℃; for 0.5h; | 97% |
With thionyl chloride In dichloromethane at 0℃; for 0.5h; | 97% |
With chloro-trimethyl-silane In N,N-dimethyl acetamide at 20℃; for 12h; | 95% |
Conditions | Yield |
---|---|
With triethylsilane; acetyl chloride; tin(ll) chloride In dichloromethane for 3h; Ambient temperature; | 89% |
Conditions | Yield |
---|---|
With chlorine UV-irradiation; | 83.6% |
With sulfuryl dichloride; zeolite NaX for 1h; Heating; Irradiation; | 72% |
With N-chloro-succinimide In 1,2-dichloro-ethane at 80℃; regiospecific reaction; | 61% |
Conditions | Yield |
---|---|
With tert-butylhypochlorite; Ag(Phen)2OTf In acetonitrile at 20℃; for 3h; Inert atmosphere; | 76% |
4-Methylbenzyl alcohol
A
bis(4-methylbenzyl) ether
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With chloro-trimethyl-silane In neat (no solvent) at 70 - 75℃; for 2h; Green chemistry; chemoselective reaction; | A 22 %Spectr. B 74% |
4-Methyl-thiobenzylchlorid
A
bis-(4-methyl-benzyl)-disulfide
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; pentane at 20 - 23℃; for 24h; | A 64% B 28% |
formaldehyd
toluene
A
1-methyl-2,4-bis(chloromethyl)benzene
B
1-chloromethyl-2-methylbenzene
C
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; 1-ethyl-3-methylimidazolium hexafluorophosphate at 70℃; for 5h; Ionic liquid; | A 63% B 7% C 28% |
With hydrogenchloride; 1-ethyl-3-methylimidazolium tetrafluoroborate at 70℃; for 5h; | A 62% B 7% C 28% |
Conditions | Yield |
---|---|
dichlorotris(triphenylphosphine)ruthenium(II) at 80℃; for 72h; | A 60% B 31% |
Conditions | Yield |
---|---|
With tetraphenylarsonium chloride In acetonitrile for 3h; Ambient temperature; | 60% |
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G; | 63 % Spectr. |
p-methylbenzyltri-n-butyl-stannane
A
4-Methylbenzyl alcohol
B
4-methyl-benzaldehyde
C
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With C2H2Cl2F3O2V In tert-butyl alcohol at 50℃; for 3h; | A 5% B 38% C 35% |
With C2H2Cl2F3O2V; argon In tert-butyl alcohol at 50℃; for 3h; | A 15% B 12% C 25% |
Conditions | Yield |
---|---|
With N-chloro-succinimide; barium(II) chloride at 102℃; under 2625.26 Torr; for 0.0666667h; Microwave irradiation; Darkness; chemoselective reaction; | A 33% B 32% |
With 4-chloromorpholine; ammonium peroxydisulfate; tris(bipyridine)ruthenium(II) dichloride hexahydrate In water; acetonitrile at 25℃; for 16h; Reagent/catalyst; Irradiation; Inert atmosphere; Overall yield = 9 %; | A n/a B n/a |
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; carbon tetrabromide; trichloroisocyanuric acid; copper(II) acetate monohydrate In dichloromethane at 25℃; for 22h; | A 31% B 12% |
With 2,2'-azobis(isobutyronitrile); 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril In tetrachloromethane at 81℃; for 2h; Inert atmosphere; | A 51 %Chromat. B 20 %Chromat. |
1-((trimethylsilyl)methyl)-4-methylbenzene
tert-butyl alcohol
A
1-(tert-butoxymethyl)-4-methylbenzene
B
4-methyl-benzaldehyde
C
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With C2H2Cl2F3O2V; oxygen at 70℃; for 72h; | A 3% B 2% C 6% |
Conditions | Yield |
---|---|
With hydrogenchloride; zinc(II) chloride |
Conditions | Yield |
---|---|
Irradiation.UV-Licht; |
4-methylphenylmethylazide
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride |
chloromethyl methyl ether
(E)-3-Ureido-but-2-enoic acid ethyl ester
toluene
A
4,4'-dimethyldiphenylmethane
B
4-Methylbenzyl chloride
formaldehyd
acetic acid
toluene
A
1-chloromethyl-2-methylbenzene
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
at 100 - 110℃; |
formaldehyd
toluene
A
1-chloromethyl-2-methylbenzene
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; sulfuric acid | |
With hydrogenchloride; acetic acid at 100 - 110℃; | |
With hydrogenchloride; zinc(II) chloride; Petroleum ether at 100℃; |
Conditions | Yield |
---|---|
With hydrogenchloride; zinc(II) chloride | |
With hydrogenchloride; sulfuric acid | |
With hydrogenchloride; sulfuric acid |
bis(2-chloromethyl)ether
(E)-3-Ureido-but-2-enoic acid ethyl ester
toluene
A
4,4'-dimethyldiphenylmethane
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With zinc(II) chloride |
bis(2-chloromethyl)ether
toluene
A
4,4'-dimethyldiphenylmethane
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
in Gegenwart von Zinkchlorid;reagiert analog mit Benzylchlorid und Benzylbromid; |
Conditions | Yield |
---|---|
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G; | 30 % Spectr. |
1,3-bis(4-methylphenyl)-2-propanone
A
1,2-di-p-tolylethane
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With cetyltrimethylammonium chloride; copper dichloride In water Quantum yield; Irradiation; cage effect under variety conditions; |
1,4-dimethoxy-1,4-dimethyl-2,5-cyclohexadiene
A
2-chloro-1,4-dimethyl-benzene
B
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; acetic acid various solvents; | A 23 % Chromat. B 38 % Chromat. |
4-Methylbenzyl chloride
triphenylphosphine
(4-methylbenzyl)triphenylphosphonium chloride
Conditions | Yield |
---|---|
In acetonitrile for 4.5h; Reflux; | 100% |
In acetonitrile for 4.5h; Reflux; | 100% |
In xylene for 18h; Heating; | 86% |
para-xylene
4-Methylbenzyl chloride
1,4-dimethyl-2-(4-methylbenzyl)benzene
Conditions | Yield |
---|---|
pyrographite for 24h; Heating; | 100% |
With iron(III) chloride for 6.5h; Heating; | 64% |
With aluminium trichloride |
4-Methylbenzyl chloride
phenylboronic acid
1-methyl-4-(phenylmethyl)benzene
Conditions | Yield |
---|---|
With potassium phosphate; SP-4-[1,3-bis[2,6-diisopropylphenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloro[2-(1-methyl-1H-imidazol-2-yl-κN3)phenyl-κC]palladium(II) In ethanol at 60℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere; | 100% |
With potassium phosphate; C114H132Cl6N10Pd3 In water; isopropyl alcohol at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 99% |
With C58H82Cl4N6Pd2; potassium tert-butylate In water; isopropyl alcohol at 80℃; for 4h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; | 99% |
(Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
4-Methylbenzyl chloride
(Z)-1-(4-methylbenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride
Conditions | Yield |
---|---|
In acetonitrile Reflux; | 100% |
(Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
4-Methylbenzyl chloride
(Z)-1-(4-methylbenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride
Conditions | Yield |
---|---|
In acetonitrile Reflux; | 100% |
(Z)-6-propoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
4-Methylbenzyl chloride
(Z)-1-(4-methylbenzyl)-4-((6-propoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride
Conditions | Yield |
---|---|
In acetonitrile Reflux; | 100% |
Conditions | Yield |
---|---|
With triethyl phosphite at 160℃; for 24h; | 100% |
O7-demethyl glaziovianin A
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 18h; Reflux; | 100% |
4-Methylbenzyl chloride
4-methylphenylmethylazide
Conditions | Yield |
---|---|
With sodium azide In dimethyl sulfoxide for 14h; Inert atmosphere; | 99% |
With trimethylsilylazide; tetrabutyl ammonium fluoride In tetrahydrofuran for 24h; Ambient temperature; | 97% |
With sodium azide In water at 80℃; for 4h; | 95% |
Conditions | Yield |
---|---|
With palladium dichloride In methanol at 40℃; for 1h; Green chemistry; chemoselective reaction; | 99% |
With Perbenzoic acid; tri-n-butyl-tin hydride In benzene at 90℃; for 12h; Mechanism; in the presence of α-chlorotoluene (competitor), relative reactivity; | |
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene at 80℃; Rate constant; |
4-Methylbenzyl chloride
1-(Trimethylsilyl)imidazole
1,3-bis(4-tolylmethyl)imidazolium chloride
Conditions | Yield |
---|---|
In toluene at 25℃; for 0.5h; Temperature; Solvent; | 99% |
In toluene Heating; | 98% |
4-Methylbenzyl chloride
2,2'-iminobis[ethanol]
2-[(2-Hydroxy-ethyl)-(4-methyl-benzyl)-amino]-ethanol
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 8h; Heating; | 99% |
99% | |
99% |
4-Methylbenzyl chloride
N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
3,4-Dihydro-4-hydroxy-N-(1,1-dimethyl)ethyl-2-(4-methylphenyl)methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide; mineral oil | 99% |
4-Methylbenzyl chloride
phenylacetylene
1-(4-methylbenzyl)-4-phenyl-1H-1,2,3-triazole
Conditions | Yield |
---|---|
With sodium azide; sodium carbonate In ethanol; water at 25℃; for 0.366667h; | 99% |
With sodium azide; copper(I) oxide In water at 70℃; for 1.5h; | 97% |
With sodium azide; C34H20Cl4CuN2O2 In water at 50℃; for 6h; Temperature; Time; Reagent/catalyst; | 97% |
carbon monoxide
salicylaldehyde
4-Methylbenzyl chloride
3-(4-methylphenyl)-2H-chromen-2-one
Conditions | Yield |
---|---|
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In 1,4-dioxane at 100℃; under 7500.75 Torr; for 16h; Inert atmosphere; Autoclave; | 99% |
Conditions | Yield |
---|---|
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation; | 98% |
With 4-methylmorpholine N-oxide; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; potassium iodide at 100℃; for 0.0333333h; Microwave irradiation; Ionic liquid; | 94% |
With 1-dodecyl-3-methylimidazolium iron chloride; periodic acid at 30℃; for 1.5h; | 93% |
4-morpholinecarboxaldehyde
4-Methylbenzyl chloride
4-(4-methylbenzyl)morpholine
Conditions | Yield |
---|---|
With NHC-Pd(II)-Im; sodium hydroxide In water at 50℃; for 3h; Inert atmosphere; Schlenk technique; | 98% |
With potassium hydroxide In water at 80℃; for 3h; Temperature; Green chemistry; | 96% |
tris-(4-ethoxy-phenyl)-bismuthine
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Schlenk technique; Inert atmosphere; | 98% |
o-propargyloxybenzaldehyde
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
With sodium azide; sodium carbonate In ethanol; water at 25℃; for 0.266667h; | 98% |
4-chloromethoxybenzene
4-Methylbenzyl chloride
1-(4-methoxybenzyl)-4-methylbenzene
Conditions | Yield |
---|---|
With Ni(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(PPh3)Br2; magnesium In tetrahydrofuran at 0 - 50℃; for 12.5h; Glovebox; Inert atmosphere; Schlenk technique; | 98% |
With Ni(IBiox-6)[P(OEt)3]Br2; magnesium In tetrahydrofuran at 50℃; for 1h; Schlenk technique; Glovebox; | 97% |
With C23H40Br2N2NiO5P; magnesium In tetrahydrofuran at 50℃; for 1h; Inert atmosphere; | 95% |
1-Fluoronaphthalene
4-Methylbenzyl chloride
α-(4-methylbenzyl)naphthalene
Conditions | Yield |
---|---|
With C23H40Br2N2NiO5P; magnesium In tetrahydrofuran at 65℃; for 10h; Inert atmosphere; | 98% |
With Ni(IBiox-6)[P(OEt)3]Br2; magnesium In tetrahydrofuran at 50℃; for 12h; Schlenk technique; Glovebox; | 92% |
2,3-dimethyl-2,3-diaminobutane
potassium methacrylate
4-Methylbenzyl chloride
Conditions | Yield |
---|---|
In toluene | 97.4% |
Conditions | Yield |
---|---|
With iron(III) sulfate; water In toluene at 110℃; for 0.7h; Ionic liquid; | 97% |
With water In acetonitrile at 25.9℃; Rate constant; different solvent compositions; kinetic deuterium isotope effects; | |
With potassium carbonate; acetone |
Conditions | Yield |
---|---|
With sodium iodide In acetone at 20℃; for 3.66667h; | 97% |
With pyridine; tributyltin iodide at 50℃; Thermodynamic data; Equilibrium constant; Δ G; | |
With sodium iodide In acetone Reflux; |
4-Methylbenzyl chloride
5,6-dichloro-2-mercapto-1-(β-D-ribofuranosyl)-benzimidazole
Conditions | Yield |
---|---|
With ammonium hydroxide In water; acetonitrile for 18h; Ambient temperature; | 97% |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol at 78℃; for 5h; | 97% |
Conditions | Yield |
---|---|
With ammonia; oxygen; VCrO; silica gel at 210℃; for 8h; | 97% |
With sodium azide; palladium diacetate; triphenylphosphine In acetone at 80℃; for 36h; Schlenk technique; | 92% |
With trichloroisocyanuric acid; ammonia In water at 20 - 60℃; | 90% |
The 4-Methylbenzyl chloride is an organic compound with the formula C8H9Cl. The IUPAC name of this chemical is 1-(chloromethyl)-4-methylbenzene. With the CAS registry number 104-82-5, it is also named as benzene, 1-(chloromethyl)-4-methyl-. The product's category is Aromatic Halides (substituted). Besides, it is clear colourless to light yellow liquid, which should be stored in a cool and ventilated place. It is used for organic synthesis and solvent.
Physical properties about 4-Methylbenzyl chloride are: (1)ACD/LogP: 2.95; (2)ACD/LogD (pH 5.5): 2.95; (3)ACD/LogD (pH 7.4): 2.95; (4)#Freely Rotating Bonds: 1; (5)Index of Refraction: 1.524; (6)Molar Refractivity: 40.84 cm3; (7)Molar Volume: 133.4 cm3; (8)Polarizability: 16.19×10-24cm3; (9)Surface Tension: 33.1 dyne/cm; (10)Density: 1.054 g/cm3; (11)Flash Point: 75.6 °C; (12)Enthalpy of Vaporization: 41.7 kJ/mol; (13)Boiling Point: 198.6 °C at 760 mmHg; (14)Vapour Pressure: 0.504 mmHg at 25°C.
Preparation: this chemical can be prepared by 4-Methyl-thiobenzylchlorid. This reaction will need reagent triethylamine and solvent pentane, CH2Cl2. The reaction time is 24 hours with reaction temperature of 20 - 23 °C. The yield is about 64%.
Uses of 4-Methylbenzyl chloride: it can be used to produce 1-azidomethyl-4-methyl-benzene at temperature of 75 °C. It will need reagent NaN3 and solvent ethanol, H2O.
When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and can cause burns. Please take off immediately all contaminated clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: Cc1ccc(CCl)cc1
(2)InChI: InChI=1/C8H9Cl/c1-7-2-4-8(6-9)5-3-7/h2-5H,6H2,1H3
(3)InChIKey: DMHZDOTYAVHSEH-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C8H9Cl/c1-7-2-4-8(6-9)5-3-7/h2-5H,6H2,1H3
(5)Std. InChIKey: DMHZDOTYAVHSEH-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | oral | 1100mg/kg (1100mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. |
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